Journal
JOURNAL OF CLINICAL NEUROPHYSIOLOGY
Volume 27, Issue 1, Pages 12-16Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/WNP.0b013e3181cb4294
Keywords
EEG; Spike detection; Sensitivity; False-positive rate
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Purpose: Most seizure monitoring units use the Gotman algorithm or a variation on it for EEG spike detection, but the effect of various detection parameters on its accuracy has not been well established. The authors report sensitivities and false-positive rates for several different sets of detection parameters. Methods: Nine patients were studied. For each patient, 6 hours of EEG data were analyzed using five different sets of spike detection parameters including combinations of amplitude thresholds, state-dependent spike detection and advanced artifact rejection. Automated spike detections were compared with spikes found on visual EEG review. Results: Mean spike detection sensitivities for the different parameter sets ranged from 0.09 to 0.34. The highest sensitivity occurred with an amplitude threshold of 4, state-dependent spike detection turned on and advanced artifact rejection turned off. Mean rates of false-positives ranged from 4.2 to 48.6 per hour. The highest false-positive rate occurred with the same set of detection parameters that produced the highest sensitivity. Conclusions: The sensitivity of spike detection with the Gotman algorithm is relatively low. The data favor using a lower amplitude threshold and not using advanced artifact rejection. The false-positive rate increases with improved sensitivity, but it is still within an acceptable range for clinical application.
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