4.7 Article

Gamma Interferon Release Assay for Monitoring of Treatment Response for Active Tuberculosis: an Explosion in the Spaghetti Factory

Journal

JOURNAL OF CLINICAL MICROBIOLOGY
Volume 51, Issue 2, Pages 607-610

Publisher

AMER SOC MICROBIOLOGY
DOI: 10.1128/JCM.02278-12

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Funding

  1. McGill University
  2. EDCTP (TB NEAT grant)
  3. CIHR [MOP-81362]
  4. Grand Challenges Canada
  5. Fonds de Recherche du Quebec-Sante

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Few studies have correlated the results of interferon (gamma interferon) release assays (IGRAs) with known markers of tuberculosis (TB) treatment response. We report the results of serial QuantiFERON-TB gold in-tube assay (QFT) testing on 149 patients with active tuberculosis and correlate the results with smear and culture conversion. We show that QFT results do not offer much value for treatment monitoring of TB disease.

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