Article
Infectious Diseases
Fen Pan, Bingjie Wang, Hong Zhang, Yingying Shi, Qi Xu
Summary: This study enrolled 90 children, among whom 58 patients (64.4%) tested positive for 13 pathogens using FARP, with 18 patients showing multiple-virus infections. Human rhinovirus/enterovirus were most common in infants and toddlers, while adenovirus were common in the 3-5-year-old group. Only three pathogens were found in the 6-14-year-old group.
BMC INFECTIOUS DISEASES
(2021)
Article
Microbiology
Elena B. Popowitch, Sam Kaplan, Zenglin Wu, Yi-Wei Tang, Melissa B. Miller
Summary: This study compares the performance of three widely used panels for respiratory syndromic testing. The results show that BioFire and Luminex assays have similar overall accuracy, while significant differences are found between BioFire and GenMark, as well as between GenMark and Luminex.
MICROBIOLOGY SPECTRUM
(2022)
Article
Biochemistry & Molecular Biology
Ying-Ju Chen, Tze-Kiong Er
Summary: This study examined the distribution of respiratory viral pathogens during the COVID-19 pandemic in an emergency department. The most common pathogen detected was rhinovirus/enterovirus, followed by adenovirus and SARS-CoV-2. The results showed perfect agreement between the cobas Liat system and the FilmArray TM RP for SARS-CoV-2 detection. The FilmArray TM RP assay is a reliable method for detecting SARS-CoV-2 and other respiratory infections.
Article
Biophysics
Sophie Krokhine, Hadis Torabi, Ali Doostmohammadi, Pouya Rezai
Summary: The COVID-19 pandemic has highlighted the threat of infectious diseases to public health and safety, especially in developing countries. Airborne viruses like SARS-CoV-2 are difficult to control and require rapid detection methods for effective containment and precaution implementation.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Medicine, General & Internal
Harshad Lade, Jung-Min Kim, Yousun Chung, Minje Han, Eun-Kyung Mo, Jae-Seok Kim
Summary: This study evaluated the performance of two multiplex nucleic acid amplification assays for simultaneous detection of multiple respiratory pathogens. The results showed consistent performance between the Allplex Respiratory Panel and the BioFire FilmArray, with some variations in detection rates for specific pathogens.
Article
Infectious Diseases
Kirstine K. Sogaard, Vladimira Hinic, Daniel Goldenberger, Alexander Gensch, Michael Schweitzer, Veronika Battig, Martin Siegemund, Stefano Bassetti, Roland Bingisser, Michael Tamm, Manuel Battegay, Maja Weisser, Daiana Stolz, Nina Khanna, Adrian Egli
Summary: This study evaluated the diagnostic performance of the Biofire(©) FilmArray pneumonia (PN)-panel against standard culture in broncho-alveolar lavage (BAL) samples. The results showed that the PN-panel had high sensitivity and specificity, but low positive predictive value. The detection rate of bacterial pathogens was higher in the PN-panel compared to culture. Further evaluation is needed to assess the impact of the PN-panel on clinical management.
Article
Infectious Diseases
Kwadwo Mponponsuo, Jenine Leal, Eldon Spackman, Ranjani Somayaji, Daniel Gregson, Elissa Rennert-May
Summary: Through the evaluation of a decision analytic model, we found that the BioFire FilmArray Blood Culture Identification (BCID) Panel is a cost-saving approach compared to conventional methods in diagnosing Escherichia coli bloodstream infections.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)
Article
Microbiology
Kosuke Kosai, Norihiko Akamatsu, Kenji Ota, Fujiko Mitsumoto-Kaseida, Kei Sakamoto, Hiroo Hasegawa, Koichi Izumikawa, Hiroshi Mukae, Katsunori Yanagihara
Summary: This study investigated the diagnostic utility of the BioFire FilmArray Pneumonia Panel, and found that it enhanced the detection of pathogens and antimicrobial resistance markers in lower respiratory tract specimens.
ANNALS OF CLINICAL MICROBIOLOGY AND ANTIMICROBIALS
(2022)
Article
Infectious Diseases
Nabil Gastli, Julien Loubinoux, Matthieu Daragon, Jean-Philippe Lavigne, Pierre Saint-Sardos, Helene Pailhories, Carole Lemarie, Hanaa Benmansour, Camille D'Humieres, Lauranne Broutin, Olivier Dauwalder, Michael Levy, Gabriel Auger, Solen Kerneis, Vincent Cattoir
Summary: The study evaluated the performance of FA-PP in detecting bacterial pathogens and antibiotic resistance genes in respiratory specimens, showing that it performed well in detecting pathogens in most specimens. The positive and negative percentage agreement values of FA-PP compared to culture were high, but there were some false-negative results. In addition, there was some discordance between the semi-quantification results of FA-PP and culture results.
CLINICAL MICROBIOLOGY AND INFECTION
(2021)
Article
Infectious Diseases
Barend Mitton, Roxanne Rule, Mohamed Said
Summary: The study evaluated the diagnostic performance of the FAPP panel in lower respiratory tract specimens, demonstrating high sensitivity and specificity in bacterial detection and antibiotic resistance testing.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2021)
Article
Biology
Noha A. Kamel, Mohammad Y. Alshahrani, Khaled M. Aboshanab, Mervat El Borhamy
Summary: BFPP has shown promising diagnostic performance in rapid detection of pathogens and genetic markers in hospital-acquired pneumonia cases. It has the potential to improve microbiological diagnosis, guide antibiotic therapy, and implement infection control measures.
Article
Infectious Diseases
Mimi R. Precit, Kaidi He, Kanokporn Mongkolrattanothai, Babak Moghimi, Marisa Glucoft, Jennifer Dien Bard
Summary: The study investigated the use of FA-RP in pediatric BMT patients, demonstrating that FA-RP can provide rapid diagnosis, guide treatment, and inform infection control measures in patients, showing its clinical significance in patient care.
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2022)
Article
Critical Care Medicine
Guillaume Dumas, Maxime Bertrand, Virginie Lemiale, Emmanuel Canet, Francois Barbier, Achille Kouatchet, Alexandre Demoule, Kada Klouche, Anne-Sophie Moreau, Laurent Argaud, Florent Wallet, Jean-Herle Raphalen, Djamel Mokart, Fabrice Bruneel, Frederic Pene, Elie Azoulay
Summary: This study found that viruses are a major cause of respiratory failure in immunocompromised patients, with influenza being the most common virus. The overall mortality rate for immunocompromised patients with virus-detected acute respiratory failure was high, but lower than patients with non-viral respiratory failure. Clinical severity and poor general status were factors associated with mortality.
ANNALS OF INTENSIVE CARE
(2023)
Article
Medicine, General & Internal
In Young Yoo, Hyun Soo Seok, Joo An Kwon, Jongmin Lee, Sungjin Jo, Soo Young Kim, Yeon-Joon Park
Summary: We compared the performance of the BioFire® FilmArray® Pneumonia panel (PN-panel) in detecting bacterial pathogens with conventional cultures and the leukocyte esterase (LE) urine strip test. The PN-panel showed high concordance with culture when the bacterial burden was high (107 copies/mL), but low concordance when it was low (104-6 copies/mL). Overall, the positive rates of culture and PN-panel were higher among LE-positive specimens. The ancillary use of LE test is helpful in interpreting PN-panel results, especially when the copy number of bacterial pathogens is low.
Article
Medicine, General & Internal
Tomoaki Nakamura, Ryosuke Imai, Atsushi Kitamura, Clara So, Shosei Ro, Kohei Okafuji, Yutaka Tomishima, Torahiko Jinta, Naoki Nishimura
Summary: This retrospective study assessed the usefulness of the FilmArray Respiratory Panel 2.1 (FARP) in detecting viral causes of pneumonia in immunosuppressed patients. The results showed low positive detection by FARP in comprehensive infectious disease testing using bronchoalveolar lavage samples collected from lung lesions in immunosuppressed patients.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
Article
Immunology
Nathan B. Pincus, Kelly E. R. Bachta, Egon A. Ozer, Jonathan P. Allen, Olivia N. Pura, Chao Qi, Nathaniel J. Rhodes, Francisco M. Marty, Alisha Pandit, John J. Mekalanos, Antonio Oliver, Alan R. Hauser
CLINICAL INFECTIOUS DISEASES
(2020)
Letter
Immunology
Tyler D. Bold, Matthew P. Cheng, Francisco M. Marty
CLINICAL INFECTIOUS DISEASES
(2020)
Article
Rheumatology
Candace H. Feldman, Cameron Speyer, Rachel Ashby, Bonnie L. Bermas, Shamik Bhattacharyya, Eliza Chakravarty, Brendan Everett, Elizabeth Ferucci, Aimee O. Hersh, Francisco M. Marty, Joseph F. Merola, Rosalind Ramsey-Goldman, Brad H. Rovin, Mary Beth Son, Laura Tarter, Sushrut Waikar, Jinoos Yazdany, Joel S. Weissman, Karen H. Costenbader
Summary: The study aimed to define a set of SLE-specific adverse outcomes that could be prevented with timely, effective ambulatory care. Through a modified Delphi process, 25 SLE-specific conditions were identified as potentially preventable and important on a population level, falling into categories of vaccine-preventable illnesses, medication-related complications, reproductive health-related complications, and SLE-related complications.
ARTHRITIS CARE & RESEARCH
(2021)
Article
Immunology
Jessica W. Crothers, Liangge Hsu, Francisco M. Marty
OPEN FORUM INFECTIOUS DISEASES
(2020)
Article
Surgery
Martin Kauke-Navarro, Bianief Tchiloemba, Valentin Haug, Branislav Kollar, Yannick Diehm, Ali-Farid Safi, Nathaniel S. Treister, Donald J. Annino, Francisco M. Marty, Christine G. Lian, George F. Murphy, Bohdan Pomahac
Summary: This retrospective study analyzed changes in oral and nasal mucous membranes of nine facial vascularized composite allotransplant patients. The study found that mucosal lesions were more common than previously reported, with ulcerations, edema, and erythema being the most common types. Sirolimus and skin Banff grade were identified as independent predictors of mucosal inflammation.
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2021)
Article
Medicine, General & Internal
R. L. Gottlieb, C. E. Vaca, R. Paredes, J. Mera, B. J. Webb, G. Perez, G. Oguchi, P. Ryan, B. U. Nielsen, M. Brown, A. Hidalgo, Y. Sachdeva, S. Mittal, O. Osiyemi, J. Skarbinski, K. Juneja, R. H. Hyland, A. Osinusi, S. Chen, G. Camus, M. Abdelghany, S. Davies, N. Behenna-Renton, F. Duff, F. M. Marty, M. J. Katz, A. A. Ginde, S. M. Brown, J. T. Schiffer, J. A. Hill
Summary: In symptomatic, nonhospitalized high-risk Covid-19 patients, a 3-day course of remdesivir significantly reduced the risk of hospitalization or death compared to placebo, with acceptable safety profile.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Multidisciplinary Sciences
Alexandre Pellan Cheng, Matthew Pellan Cheng, Conor James Loy, Joan Sesing Lenz, Kaiwen Chen, Sami Smalling, Philip Burnham, Kaitlyn Marie Timblin, Jose Luis Orejas, Emily Silverman, Paz Polak, Francisco M. Marty, Jerome Ritz, Iwijn De Vlaminck
Summary: Allogeneic hematopoietic cell transplantation (HCT) is an effective treatment for hematologic malignancies and immune disorders. This study shows that cell-free DNA (cfDNA) in blood can be used for monitoring posttransplant complications, including graft-versus-host disease (GVHD), infection, relapse of underlying disease, and graft failure. The study demonstrates the potential of cfDNA to improve the care of HCT recipients by enabling earlier detection and better prediction of these complications.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Oncology
Jessica P. Hwang, Andy S. Artz, Parth Shah, Banu Symington, Jordan J. Feld, Sarah P. Hammond, Emmy Ludwig, Amy Pai, Scott D. Ramsey, Ilana Schlam, Jennifer M. Suga, Su H. Wang, Mark R. Somerfield
JCO ONCOLOGY PRACTICE
(2022)
Review
Infectious Diseases
Zoe Freeman Weiss, Jessica Little, Sarah Hammond
Summary: The current armamentarium of antifungal agents has significantly improved over the last 50 years. However, existing therapies still have their limitations and novel antifungals are needed to address the increasing prevalence of invasive mold infections and antifungal resistance.
EXPERT REVIEW OF ANTI-INFECTIVE THERAPY
(2023)
Article
Hematology
Sarah P. Hammond, Vincent T. Ho, Francisco M. Marty
Summary: Reactivation of resolved HBV infection is a significant concern for allogeneic HCT recipients, but post-HCT HBV vaccination appears to reduce the risk of reactivation.
TRANSPLANTATION AND CELLULAR THERAPY
(2022)
Article
Medicine, Research & Experimental
Alexandre Pellan Cheng, Matthew Pellan Cheng, Wei Gu, Joan Sesing Lenz, Elaine Hsu, Erwin Schurr, Guillaume Bourque, Mathieu Bourgey, Jerome Ritz, Francisco M. Marty, Charles Y. Chiu, Donald C. Vinh, Iwijn De Vlaminck
Summary: The study developed a blood test to quantify cell-, tissue-, and organ-specific injury due to COVID-19, finding evidence of lung and liver injury and involvement of red blood cell progenitors. The concentration of cell-free DNA correlated with disease progression and was significantly increased in patients requiring intubation, suggesting the utility of cell-free DNA as an analyte for monitoring and studying COVID-19.
Article
Microbiology
Muneerah M. Aleissa, Emily A. Silverman, Luisa M. Paredes Acosta, Cameron T. Nutt, Aaron Richterman, Francisco M. Marty
Summary: Remdesivir has been approved for treating hospitalized patients with COVID-19, showing improved survival rates and decreased viral RNA levels when used early in the course of the disease.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Letter
Medicine, General & Internal
Apostolos Karligkiotis, Alberto Arosio, Paolo Castelnuovo
NEW ENGLAND JOURNAL OF MEDICINE
(2020)
Letter
Medicine, General & Internal
Francisco M. Marty, Kaiwen Chen, Kelly A. Verrill
NEW ENGLAND JOURNAL OF MEDICINE
(2020)
Article
Chemistry, Multidisciplinary
Mazen Erfan, Leonce Martine Gnambodoe-Capochichi, Frederic Marty, Yasser M. Sabry, Tarik Bourouina, Yamin Leprince-Wang