Article
Biochemistry & Molecular Biology
Haixiu Wang, Eric Cox, Bert Devriendt
Summary: Enterotoxigenic Escherichia coli (ETEC) strains recognize and respond to factors secreted by gut epithelial cells, leading to transcriptional modulation of key ETEC virulence genes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Xi Lu, Dingyan Wu, Xin Zhao, Mingxin Zhang, Ke Ren, Ningning Zhou, Yanni Zhao, Weisheng Qian
Summary: Enterotoxigenic Escherichia coli (ETEC), a diarrheal pathogen, can utilize ethanolamine (EA) as a nitrogen source, which enhances its virulence phenotype and causes damage to host intestinal cells. The concentration of EA in the intestine also impacts the metabolic profile and pathogenicity of ETEC.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Review
Food Science & Technology
Roberta Fontanive Miyahira, Adriane Elisabete Costa Antunes
Summary: The germination process changes the chemical composition of seeds, enhancing the nutritional value but decreasing microbiological safety of sprouts. Worldwide, consumption of sprouts has been linked to over 60 foodborne illness outbreaks, with alfalfa sprouts being the most commonly implicated. Good agricultural practices and microbiological analyses are crucial in ensuring the safety of sprout production.
INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Matthias Dierick, Ruben Ongena, Daisy Vanrompay, Bert Devriendt, Eric Cox
Summary: Lactoferrin, as an alternative for antimicrobials, shows potential in preventing ETEC infections in pigs by reducing fluid secretion and colonization ability of ETEC.
Review
Gastroenterology & Hepatology
Yucheng Zhang, Peng Tan, Ying Zhao, Xi Ma
Summary: This review focuses on recent discoveries about the etiology, pathogenesis, and clinical manifestation of enterotoxigenic Escherichia coli (ETEC), as well as the colonization resistances mediated by gut microbiota and preventative strategies against ETEC.
Article
Chemistry, Applied
Jin Wan, Jiao Zhang, Qingsong Xu, Heng Yin, Daiwen Chen, Bing Yu, Jun He
Summary: The study demonstrates that alginate oligosaccharide can protect the intestinal mucosa from inflammatory injury induced by Escherichia coli and achieve this effect by inhibiting the activation of NF-kappa B.
CARBOHYDRATE POLYMERS
(2021)
Article
Agriculture, Dairy & Animal Science
Lingfei Du, Bingnan Liu, Ziyi Han, Yaoyao Xia, Miaomiao Wu, Shaojuan Liu
Summary: This study investigated the changes in the serotonin pathway of porcine macrophages during ETEC infection and the effect of melatonin on porcine macrophage functions. The results showed that ETEC infection blocked melatonin production in porcine macrophages and melatonin altered porcine macrophage functions, including bacteriostatic and bactericidal activities, as well as reducing macrophage death caused by ETEC infection.
Article
Agriculture, Dairy & Animal Science
Lingfei Du, Bingnan Liu, Ziyi Han, Yaoyao Xia, Miaomiao Wu, Shaojuan Liu
Summary: This study investigated the changes in the serotonin pathway of porcine macrophages during ETEC infection and the effect of melatonin on porcine macrophage functions. The results showed that ETEC infection blocked melatonin production in porcine macrophages and melatonin altered macrophage functions, enhancing bacterial clearance and reducing macrophage death. Melatonin may play a crucial role in shaping porcine macrophage function during ETEC infection.
Article
Agriculture, Dairy & Animal Science
Alberto Prieto, Cynthia Lopez-Novo, Pablo Diaz, Jose Manuel Diaz-Cao, Gonzalo Lopez-Lorenzo, Claudia Anton, Susana Remesar, David Garcia-Dios, Ceferino Lopez, Rosario Panadero, Pablo Diez-Banos, Patrocinio Morrondo, Gonzalo Fernandez
Summary: Neonatal calf diarrhoea is a significant issue in cattle production worldwide, with enterotoxigenic Escherichia coli (ETEC) being one of the major pathogens. Veterinary surgeons commonly use antimicrobials to treat the disease, but this study found that all ETEC strains were resistant to three or more families of antimicrobials. Only a few antibiotics showed efficacy against most ETEC strains, while many strains were resistant to first-line antimicrobials used in veterinary practice. The study emphasizes the importance of performing antimicrobial susceptibility tests in each outbreak to ensure effective treatment and prevent the emergence of new resistance mechanisms.
Article
Biotechnology & Applied Microbiology
Indranil Mondal, Debjyoti Bhakat, Goutam Chowdhury, Asis Manna, Sandip Samanta, Alok Kumar Deb, Asish Kumar Mukhopadhyay, Nabendu Sekhar Chatterjee
Summary: ETEC strains with CS6 and elt+est toxin genes co-occurred in 51% of isolates. CS21 was found in most strains with est genes (43%). The presence of EatA was associated with the presence of ST alone or with LT, while CS6-harboring strains showed resistance to Ciprofloxacin. Identifying prevalent virulence determinants in Kolkata, India can aid in developing region-specific ETEC vaccines and understanding antibiotic resistance patterns for appropriate treatment.
JOURNAL OF APPLIED MICROBIOLOGY
(2022)
Article
Infectious Diseases
Pei Yee Woh, May Pui Shan Yeung, William Bernard Goggins
Summary: This study aimed to determine the multiple antibiotic resistance index (MARI) of Salmonella isolated from children hospitalized for gastroenteritis in Hong Kong. The results showed that Salmonella had the highest resistance to ampicillin, ciprofloxacin, and tetracycline, while MDR strains had high resistance towards ampicillin, tetracycline, cotrimoxazole, chloramphenicol, and ciprofloxacin. MARI revealed that 80.2% of Salmonella, including all MDR strains, had indexes greater than 0.2.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Article
Microbiology
Frederick Matthew Kuhlmann, Vadim Grigura, Timothy J. Vickers, Michael G. Prouty, Lora L. Iannotti, Sherlie Jean Louis Dulience, James M. Fleckenstein
Summary: Enterotoxigenic Escherichia coli (ETEC) is a common cause of infectious diarrhea in young children and travelers in low- and middle-income countries. This study compared immune responses to ETEC antigens in populations from endemic regions and sporadic infection regions, and found elevated immune responses in individuals from endemic regions. These findings support further evaluation of certain ETEC antigens as potential vaccine candidates.
Article
Microbiology
Masahiro Kusumoto, Yukino Tamamura-Andoh, Yuna Hikoda-Kogiku, Asami Magome, Erina Okuhama, Keisuke Sato, Yoshino Mizuno, Nobuo Arai, Ayako Watanabe-Yanai, Taketoshi Iwata, Yoshitoshi Ogura, Yasuhiro Gotoh, Keiji Nakamura, Tetsuya Hayashi, Masato Akiba
Summary: Pathogenic Escherichia coli strains in swine in Japan have shown increased antimicrobial resistance, resulting in significant economic losses. The emergence of highly multidrug-resistant strains and the decrease in efficacy of traditional antibiotics pose a threat to the swine industry. However, new antimicrobials have shown promising results against these highly resistant strains.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Immunology
Yining Zheng, Guoyan Wang, Rongnuo Li, Huijun Geng, Xinjian Lei, Lei Chen, Shengru Wu, Junhu Yao, Lu Deng
Summary: In this study, the researchers investigated the mechanism of Enterotoxigenic Escherichia coli (ETEC)-induced diarrhea and found that the mTORC1 pathway plays a role in the host response to ETEC F4 infection. The study also found that ZnSO4 supplementation is an effective strategy for blocking the effect of ETEC F4 on mTORC1 activation and may have potential clinical applications in the treatment of ETEC F4-induced diarrhea.
MICROBES AND INFECTION
(2023)
Article
Veterinary Sciences
Yukari Furuya, Mari Matsuda, Saki Harada, Mio Kumakawa, Takahiro Shirakawa, Mariko Uchiyama, Ryoko Akama, Manao Ozawa, Michiko Kawanishi, Yoko Shimazaki, Hideto Sekiguchi
Summary: The study investigated the antimicrobial resistance of Escherichia coli and Enterococcus spp. isolates from diseased and healthy dogs and cats. The results showed significantly higher resistance rates in isolates from diseased animals compared to healthy animals, indicating the potential selection of resistant bacteria through antimicrobial use.
FRONTIERS IN VETERINARY SCIENCE
(2022)
