Article
Multidisciplinary Sciences
Aura M. Rodriguez, Daniel A. Urrea, Carlos F. Prada
Summary: Helicobacter pylori is a pathogenic bacteria that causes diseases in the human stomach, with high genetic diversity among strains observed in different geographic lineages. Analysis of virulence factor genetic variability in H. pylori strains can provide key information in understanding their pathogenic behavior.
Article
Medicine, Research & Experimental
Rong Li, Yuxiao Luo, Qin Dong, Yuqing Yin, Yiwei Ma, Jiayu Pan, Yaping Pan, Dongmei Zhang
Summary: This study provides a novel perspective on the role of Helicobacter pylori (H. pylori) in the pathogenesis of periodontitis. The detection rates and genotypes of H. pylori in subgingival plaque were found to be associated with the status of periodontitis, and certain genotypes may serve as virulence markers of periodontitis.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2023)
Review
Microbiology
Lu Han, Xu Shu, Jian Wang
Summary: This review summarizes the oxidative stress response triggered by Helicobacter pylori (HP) in the gastric mucosa and the subsequent signaling pathways. The findings are expected to help in the formulation of new targeted drugs for preventing the occurrence of early gastric cancer and its progression to middle and advanced cancer.
FRONTIERS IN MICROBIOLOGY
(2022)
Review
Biotechnology & Applied Microbiology
Prateek Sharma, Shravani M. Phatak, Prisha Warikoo, Akshita Mathur, Shweta Mahant, Kunal Das, Rajashree Das
Summary: Gastroduodenal diseases, especially those caused by Helicobacter pylori, have been prevalent for a long time. However, recent studies have started unraveling the role of other gut microbiota in these diseases and the complex relationship between H. pylori and gastrointestinal microbiota.
Article
Medicine, Research & Experimental
Wareeporn Wattanawongdon, Theeraya Simawaranon Bartpho, Taweesak Tongtawee
Summary: This study aimed to identify Helicobacter pylori virulence factors and examine their associations with clinical outcomes in Thai patients. The cagA genotype was found to be significantly more common in patients with chronic gastritis and peptic ulcers, possibly being the main cause of serious inflammation of the gastric mucosa. The cagA gene is likely an important factor explaining gastroduodenal disease outcomes in Thai patients with H. pylori infection.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2023)
Article
Multidisciplinary Sciences
Bui Hoang Phuc, Vo Phuoc Tuan, Ho Dang Quy Dung, Tran Thanh Binh, Pham Huu Tung, Tran Dinh Tri, Ngo Phuong Minh Thuan, Vu Van Khien, Tran Thi Huyen Trang, Junko Akada, Takeshi Matsumoto, Yoshio Yamaoka
Summary: The acquisition of tfs3/4 ICE was common in H. pylori strains in patients with gastroduodenal disease in Vietnam, and the complete cluster of tfs3 ICE was a reliable marker for the severity of disease in the H. pylori infected population.
SCIENTIFIC REPORTS
(2021)
Article
Endocrinology & Metabolism
Yan Zhang, Xiangming Fang, Kui Tian
Summary: This study investigated the role of virulence factors in different H. pylori strains in the development of gastrointestinal diseases. A total of 501 patients diagnosed with gastrointestinal diseases were categorized into Type I, Type II, and Type III groups based on H. pylori virulence factors. The results showed that Type I patients had a higher risk of peptic ulcers, gastrointestinal bleeding, colon polyps, and cancer. The findings highlight the association between H. pylori virulence factors and gastrointestinal diseases, providing insights for clinical diagnosis and treatment.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Gastroenterology & Hepatology
Ahmed Morad Asaad, Gasser El-Azab, Eman Abdelsameea, Osama Elbahr, Ahmed Kamal, Mohamed Abdel-Samiee, Ahmed Abdelfattah, Heba Abdallah, Doha Maher, Ahmed El-Refaie, Samar Ebrahim Ghanem, Shamshul Ansari, Samah Mohammed Awad
Summary: This study investigates H. pylori infection and resistance patterns in Egyptian patients, as well as the impact of H. pylori virulence genetic determinants on the success of 14-day triple therapy. The results show a low eradication rate with the triple therapy and high resistance to clarithromycin, amoxicillin, and metronidazole. Successful eradication is significantly associated with vacA s1-positive strains, while failed eradication is significantly associated with clarithromycin and amoxicillin-resistant strains.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Infectious Diseases
Hector Javier Perez-Cano, Jimena Ceja-Martinez, Vanessa Tellezgiron-Lara, Stephanie Voorduin-Ramos, Oscar Morales-Lopez, Selma Alin Somilleda-Ventura
Summary: This study found a direct relationship between the presence of anti-H. pylori IgG antibodies and idiopathic non-granulomatous anterior uveitis, suggesting an association between the two without a causal or physiopathogenic relationship.
Article
Endocrinology & Metabolism
Ying Liu, Ping Shuai, Wanjing Chen, Yuping Liu, Dongyu Li
Summary: This study investigates the association between Helicobacter pylori (H. pylori) infection and metabolic syndrome (MetS) using five different criteria to define MetS. The results show that in males, the prevalence of MetS is higher in the H. pylori-positive group compared to the negative group, while in females, similar results are observed using three international criteria. Multivariate logistic regression analysis reveals a positive correlation between H. pylori infection and MetS in males. Additionally, H. pylori infection is found to be positively correlated with waist circumference in the general population, and with hypertension and hyperglycemia in males.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Nutrition & Dietetics
Fatema Habbash, Tariq Abdulkarim Alalwan, Simone Perna, Naila Ahmed, Omar Sharif, Adel Al Sayyad, Clara Gasparri, Cinzia Ferraris, Mariangela Rondanelli
Summary: This study investigated the prevalence of H. pylori infection among Bahraini adults and found that individuals with lower education levels, lower intake of green tea, coffee and honey, and vitamin D deficiency were more likely to have H. pylori infection. Higher education levels, consumption of honey, green tea, and coffee, as well as normal vitamin D levels were found to be protective factors against H. pylori infection.
Article
Oncology
Fengxia Wu, Cai Chen, Fulai Peng
Summary: The prevalence of Helicobacter pylori infection is high worldwide and is associated with gastric diseases such as gastric cancer and asthma. Coptidis rhizoma has been reported to have anti-inflammatory and anti-bacterial effects and may be effective in suppressing HPI and preventing asthma.
FRONTIERS IN ONCOLOGY
(2021)
Article
Microbiology
Claudia Troncoso, Monica Pavez, Alvaro Cerda, Victor Manriquez, Aurora Prado, Edmundo Hofmann, Eddy Rios, Armando Sierralta, Luis Copelli, Leticia Barrientos
Summary: Progranulin expression differs according to the lesions and virulence of H. pylori, impacting the progranulin response against gastric inflammation.
Review
Cell Biology
Jacek Baj, Alicja Forma, Monika Sitarz, Piero Portincasa, Gabriella Garruti, Danuta Krasowska, Ryszard Maciejewski
Summary: Gastric cancer is a prevalent malignancy worldwide and ranks as the fourth leading cause of cancer-related deaths. The pathogenesis of gastric cancer involves the interaction between genetic and environmental factors, with Helicobacter pylori infection playing a major role. Understanding the mechanisms of H. pylori pathogenicity is crucial for developing eradication strategies to prevent carcinogenesis.
Review
Biochemistry & Molecular Biology
Silvia Salvatori, Irene Marafini, Federica Laudisi, Giovanni Monteleone, Carmine Stolfi
Summary: H. pylori infection contributes to the onset and development of gastric cancer through the mechanisms of chronic inflammation and DNA damage to gastric epithelial cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Microbiology
Kiarash Ghazvini, Yoshio Yamaoka, Mohsen Karbalaei, Masoud Keikha
Summary: This study aims to assess the relationship between H. pylori infection and alopecia areata, and found a significant association between H. pylori infection and susceptibility to alopecia areata.
REVIEWS AND RESEARCH IN MEDICAL MICROBIOLOGY
(2022)
Article
Gastroenterology & Hepatology
Adi Wasis Prakosa, Muhammad Miftahussurur, Juniastuti Juniastuti, Langgeng Agung Waskito, Dalla Doohan, Kartika Afrida Fauzia, Yudith Annisa Ayu Rezkitha, Titong Sugihartono, Ari Fahrial Syam, Tomohisa Uchida, Yoshio Yamaoka
DIGESTIVE DISEASES
(2022)
Editorial Material
Medicine, General & Internal
Seiji Shiota, Ryoko Kuribayashi, Rie Utsunomiya, Eishi Miyazaki
JOURNAL OF GENERAL AND FAMILY MEDICINE
(2022)
Article
Medicine, General & Internal
Noboru Horinouchi, Seiji Shiota, Takeshi Takakura, Atsushi Yoshida, Ken Kikuchi, Akira Nishizono, Eishi Miyazaki
Summary: Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry can reduce the misidentification of bacteria as C. sakazakii and improve the reporting rate of E. asburiae.
JOURNAL OF MEDICAL CASE REPORTS
(2022)
Review
Gastroenterology & Hepatology
Langgeng Agung Waskito, Yudith Annisa Ayu Rezkitha, Ratha-korn Vilaichone, Titong Sugihartono, Syifa Mustika, I Dewa Nyoman Wibawa, Yoshio Yamaoka, Muhammad Miftahussurur
Summary: In the past decade, the development of next-generation sequencing for human microbiota has led to significant discoveries regarding the gastric microbiota. The dominance of Helicobacter pylori in the gastric microbiota is reduced as diseases progress from gastritis to precancerous lesions and gastric cancer, with other bacteria taking its place. These findings highlight the important role of gastric microbiota in the development of gastroduodenal diseases and suggest that H. pylori may not be the sole gastric pathogen.
Review
Medicine, General & Internal
Shamshul Ansari, Yoshio Yamaoka
Summary: H. pylori infection is associated with gastric mucosal diseases and gastric cancer, and animal models are useful for studying the pathophysiology of these complications.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Rumiko Suzuki, Naruya Saitou, Osamu Matsuari, Seiji Shiota, Takashi Matsumoto, Junko Akada, Nagisa Kinjo, Fukunori Kinjo, Kuniko Teruya, Makiko Shimoji, Akino Shiroma, Mototsugu Kato, Kazuhito Satou, Takashi Hirano, Masahiro Asaka, Kirill Kryukov, Yoshan Moodley, Yoshio Yamaoka
Summary: Helicobacter pylori, a virulence bacterium, can be used as a marker for tracing human migration. This study identified indigenous H. pylori strains hspOkinawa and hpRyukyu in Okinawa, Japan and revealed their origin and divergence patterns.
Article
Gastroenterology & Hepatology
Deasy Natalia Adriana, Titong Sugihartono, Iswan Abbas Nusi, Poernomo Boedi Setiawan, Herry Purbayu, Ummi Maimunah, Ulfa Kholili, Budi Widodo, Husin Thamrin, Amie Vidyani, Hasan Maulahela, Yoshio Yamaoka, Muhammad Miftahussurur
Summary: This study showed a close relationship between fecal calprotectin levels and the severity of hypoxemia in COVID-19 patients. There were also significant differences in fecal calprotectin levels based on the severity of ARDS. A strong negative correlation between the P/F ratio and fecal calprotectin levels was found.
Editorial Material
Medicine, General & Internal
S. Shiota, Y. Horinouchi, E. Doi, E. Miyazaki
QJM-AN INTERNATIONAL JOURNAL OF MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Titong Sugihartono, Kartika Afrida Fauzia, Muhammad Miftahussurur, Langgeng Agung Waskito, Purwo Sri Rejeki, Reny I'tishom, Ricky Indra Alfaray, Dalla Doohan, Rizki Amalia, Camilia Metadea Aji Savitri, Yudith Annisa Ayu Rezkitha, Junko Akada, Takashi Matsumoto, Yoshio Yamaoka
Summary: We evaluated the microbiota in the stomach of GERD patients using 16S rRNA approach and found that the presence of ERD can alter microbiome diversity, while H. pylori is negatively correlated with ERD.
Article
Sport Sciences
Adi Pranoto, Maulana Bagus Adi Cahyono, Reinaldi Yakobus, Nabilah Izzatunnisa, Roy Novri Ramadhan, Purwo Sri Rejeki, Muhammad Miftahussurur, Wiwin Is Effendi, Citrawati Dyah Kencono Wungu, Yoshio Yamaoka
Summary: A sedentary lifestyle and unhealthy diet increase the risk of obesity, which leads to the production of proinflammatory cytokines and higher morbidity and mortality rates. This study examined the effects of different types of exercise on reducing proinflammatory cytokines in young adult females with obesity.
Article
Medicine, General & Internal
Yasuo Horinouchi, Seiji Shiota, Ryo Kaimori, Katsuhiko Yoshimura, Rie Utsunomiya-Nishimizu, Kyoko Yamamoto, Eishi Miyazaki
Summary: Tumor-induced osteomalacia (TIO) is a rare disease that is often misdiagnosed. It can be diagnosed through blood tests and tumor localization. One of the current treatment methods for TIO is the use of monoclonal antibodies against FGF23.
INTERNATIONAL MEDICAL CASE REPORTS JOURNAL
(2023)
Article
Primary Health Care
Seiji Shiota, Aika Shibata, Noboru Horinouchi, Kyoko Yamamoto, Eishi Miyazaki
Summary: This study found that factors associated with erosive esophagitis (EE) differed between obese and non-obese males. In obese males, avoiding going to bed within 2 hours after dinner was associated with preventing the occurrence of EE. In non-obese males, prevention of obesity, quitting smoking, and avoiding heavy alcohol consumption were important for preventing the development of EE.
JOURNAL OF PRIMARY CARE AND COMMUNITY HEALTH
(2023)
Article
Medicine, General & Internal
Muhammad Miftahussurur, Chyntia Dewi Maharani Putri, Titong Sugihartono, Ari Fahrial Syam, Herry Purbayu, Diah Priyantini, Hartono Kahar, Yudith Annisa Ayu Rezkitha, Iswan Abbas Nusi, Poernomo Boedi Setiawan, Ummi Maimunah, Langgeng Agung Waskito, Ulfa Kholili, Budi Widodo, Amie Vidyani, Husin Thamrin, Gontar Alamsyah Siregar, Reny I'tishom, Tomohisa Uchida, Yoshio Yamaoka
Summary: This study found that the urease levels were higher in patients with acute and chronic gastritis as detected by the (14C)-Urea Breath Test. However, the test was not sufficient to predict cases of atrophic gastritis.
ACTA MEDICA INDONESIANA
(2022)
Review
Environmental Sciences
Masoud Keikha, Amirhossein Sahebkar, Yoshio Yamaoka, Mohsen Karbalaei
Summary: This study found that infection with cagA-positive H.pylori strains does not have a significant effect on the formation of gastric MALT lymphoma, while translocated CagA antigen plays a crucial role in the development of diffuse large B-cell lymphoma. Additionally, there is an inverse association between vacA and gastric MALT lymphoma risk.
JOURNAL OF HEALTH POPULATION AND NUTRITION
(2022)
