Article
Plant Sciences
Yanna Shi, Bai-Jun Li, Donald Grierson, Kun-Song Chen
Summary: Insights into cell wall changes during fruit softening are gained from studies on transgenic and naturally occurring mutants. Excessive softening during fruit ripening can cause physical damage and infection, leading to quality reduction and supply chain losses. Changes in cell wall metabolism, including loosening and disassembly of macromolecules, are the main cause of softening.
Article
Multidisciplinary Sciences
Sezanur Rahman, M. Mahfuzur Rahman, Mojnu Miah, Mst Noorjahan Begum, Monira Sarmin, Mustafa Mahfuz, Mohammad Enayet Hossain, Mohammed Ziaur Rahman, Mohammod Jobayer Chisti, Tahmeed Ahmed, Shams El Arifeen, Mustafizur Rahman
Summary: This study investigated the rate of SARS-CoV-2 infection and its clinical features among infection-naive, infected, vaccinated, and post-infection-vaccinated individuals. The findings showed that naturally infected populations were less likely to be reinfected by SARS-CoV-2 than individuals who were infection-naive or vaccinated. However, a significant proportion of naturally infected or vaccinated individuals were (re)-infected by the emerging variants.
SCIENTIFIC REPORTS
(2022)
Review
Cell Biology
Chiaho Shih, Szu-Yao Wu, Shu-Fan Chou, Ta-Tung Thomas Yuan
Summary: Mutant 97L of HBc in chronic hepatitis B patients exhibits an immature secretion phenotype, contrary to the dogma of wild type HBV virion secretion predominantly containing mature double-stranded DNA genomes. Aberrant behaviors in virion secretion were observed in other naturally occurring HBc variants, possibly mediated by compensatory mutations. Virion secretion regulated by HBV genome maturity could be a potential target for antiviral drug development.
Review
Biochemistry & Molecular Biology
Mahmoud Salehi
Summary: Thermodynamic and kinetic parameters are crucial in evaluating enzyme stability and activity. This study addresses and corrects mistakes in the measurement of key parameters and introduces a new parameter, 8, for predicting the potential industrial application of enzymes. Additionally, this study provides a comprehensive collection of all thermodynamic and kinetic parameters for proteases, serving as a valuable resource for understanding the relationships between these parameters and the industrial potential of enzymes.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Immunology
Hiroo Katsuya, Lucy B. M. Cook, Aileen G. Rowan, Anat Melamed, Jocelyn Turpin, Jumpei Ito, Saiful Islam, Paola Miyazato, Benjy Jek Yang Tan, Misaki Matsuo, Toshikazu Miyakawa, Hirotomo Nakata, Shuzo Matsushita, Graham P. Taylor, Charles R. M. Bangham, Shinya Kimura, Yorifumi Satou
Summary: Coinfection with HIV-1 and HTLV-1 alters the distribution of viral integration sites and clonality of virus-infected cells, potentially impacting the risks associated with both HTLV-1 and HIV-1-related diseases.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Infectious Diseases
Maria A. Risalde, Mario Frias, Javier Caballero-Gomez, Pedro Lopez-Lopez, Christine Fast, Saul Jimenez-Ruiz, Irene Agullo-Ros, Martin Eiden, Debora Jimenez-Martin, Ignacio Garcia-Bocanegra, Antonio Rivero, Jose Carlos Gomez Villamandos, Antonio Rivero-Juarez
Summary: The study found that HEV was present in the testis of naturally infected wild boars, indicating potential implications for transmission and epidemiology.
TRANSBOUNDARY AND EMERGING DISEASES
(2022)
Article
Infectious Diseases
Ekta Gupta, Reshu Agarwal, Aayushi Rastogi, Nitiksha Rani, Ankur Jindal
Summary: The study found that BL-RAS are common among HCV-HIV co-infected patients, but do not affect the attainment of sustained virological response (SVR) among non-cirrhotic, treatment naive patients. Age over 30 and female gender were significant factors associated with achieving SVR.
INFECTION AND DRUG RESISTANCE
(2021)
Article
Multidisciplinary Sciences
Hala Rady Ahmed, Nancy G. F. M. Waly, Rehab Mahmoud Abd El-Baky, Ramadan Yahia, Helal F. Hetta, Amr M. Elsayed, Reham Ali Ibrahem
Summary: This study identified several novel NS5B mutations, with K304R, E327D, and P300T substitutions being the most common in the tested samples. However, major resistance mutation S282T and other reported mutations (L320F/C), (C316Y/N) were not recognized in this study.
Article
Biology
George Elias, Pieter Meysman, Esther Bartholomeus, Nicolas De Neuter, Nina Keersmaekers, Arvid Suls, Hilde Jansens, Aisha Souquette, Hans De Reu, Marie-Paule Emonds, Evelien Smits, Eva Lion, Paul G. Thomas, Geert Mortier, Pierre Van Damme, Philippe Beutels, Kris Laukens, Viggo Van Tendeloo, Benson Ogunjimi
Summary: This study demonstrates the significant impact of preexisting memory CD4 T cell clones on vaccine-induced immunity to hepatitis B. The presence of these clones can predict the strength and timing of the immune response to vaccination.
Article
Biochemistry & Molecular Biology
Matthias Goehl, Linlin Zhang, Haifa El Kilani, Xinyuanyuan Sun, Kaixuan Zhang, Mark Broenstrup, Rolf Hilgenfeld
Summary: Structure-based design optimization of alpha-ketoamide inhibitors for betacoronavirus M-pro led to high potency against SARS-CoV-2, with promising but varied activity against other viruses. Crystal structures confirmed the design concept's validity, providing insight for further optimization in efficiently targeting other viruses.
Article
Biology
Sourav Das, Anirudh Singh, Sintu Kumar Samanta, Atanu Singha Roy
Summary: This study aimed to identify potential natural anthraquinones that could bind to the active site of SARS-CoV-2 main protease and stop viral replication. The results showed that several antiviral anthraquinones could be effective inhibitors for SARS-CoV-2 main protease of COVID-19. Among the anthraquinones studied, alterporriol-Q was found to be the most potent inhibitor.
Article
Immunology
Silvan R. Heeb, Monica Schaller, Johanna A. Kremer Hovinga
Summary: Rare immune-mediated thrombotic thrombocytopenic purpura (iTTP) is a life-threatening disease with high survival rate when treated appropriately, but at least half of the survivors will experience a relapse. The mechanisms of remission and relapse in iTTP are still poorly understood.
JOURNAL OF IMMUNOLOGY
(2022)
Article
Immunology
Stephanie Longet, Alexander Hargreaves, Saoirse Healy, Rebecca Brown, Hailey R. Hornsby, Naomi Meardon, Tom Tipton, Eleanor Barnes, Susanna Dunachie, Christopher J. A. Duncan, Paul Klenerman, Alex Richter, Lance Turtle, Thushan I. de Silva, Miles W. Carroll
Summary: Two doses of BNT162b2 mRNA vaccine induce a strong systemic humoral response to SARS-CoV-2, but mucosal immune response is important for defense against airborne transmission. This study characterizes the IgG responses to SARS-CoV-2 and other coronaviruses in oral fluid and plasma samples from UK healthcare workers. It also investigates the impact of previous infection and additional vaccine doses on the immune responses.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Virology
Shuwen Fu, Jing Zhang, Quan Yuan, Qianru Wang, Qiang Deng, Jisu Li, Ningshao Xia, Yongxiang Wang, Yumei Wen, Shuping Tong
Summary: Hepatitis B virus (HBV) transcribes various mRNAs of different lengths to produce different proteins, and the transcription process is influenced by naturally occurring deletions, which may lead to abnormal viral replication and protein synthesis, ultimately affecting viral spread and pathogenicity.
JOURNAL OF VIROLOGY
(2021)
Article
Medicine, General & Internal
Alessandra Ruggiero, Chiara Piubelli, Lucia Calciano, Simone Accordini, Maria Teresa Valenti, Luca Dalle Carbonare, Gabriel Siracusano, Nigel Temperton, Natalia Tiberti, Silvia Stefania Longoni, Massimo Pizzato, Silvia Accordini, Tobia Fantoni, Lucia Lopalco, Alberto Beretta, Zeno Bisof, Donato Zipeto, Donato A.M.S.L.V group
Summary: A longitudinal study was conducted on healthcare workers who received the BNT162b2 vaccine to quantify anti-SARS-CoV-2 IgG and IgM levels. It was found that coordinated expression of IgG-S and IgM-S after vaccination was associated with a more efficient response in both antibody levels and virus-neutralizing activity. The unconventional responses may suggest a recruitment of cross coronaviruses immunity by vaccination, warranting further investigation.
Article
Infectious Diseases
Carlos Arturo Vazquez-Chacon, Felipe de Jesus Rodriguez-Gaxiola, Cruz Fernando Lopez-Carrera, Mayra Cruz-Rivera, Armando Martinez-Guarneros, Ricardo Parra-Unda, Eliakym Arambula-Meraz, Salvador Fonseca-Coronado, Gilberto Vaughan, Paul Alexis Lopez-Duran
Summary: Identifying tuberculosis resistance mutation patterns is crucial for patient management and disease control. Whole genome sequencing is becoming the preferred method for genetic characterization of tuberculosis isolates. Monitoring emergence of mutations related to multi and extensive drug resistance is essential for controlling transmission of drug-resistant TB strains.
PLOS NEGLECTED TROPICAL DISEASES
(2021)
Article
Microbiology
Thalia A. Alatorre-Garcia, Salvador Fonseca-Coronado, Fernando Gonzalez-Candelas
Summary: Bovine parainfluenza-3 virus (BPIV-3) is a major virus associated with bovine respiratory disease complex worldwide, causing a range of infections from subclinical to severe pneumonia. This study found high genetic variability in BPIV-3 and identified the importance of homologous recombination events in its evolution.
VETERINARY MICROBIOLOGY
(2021)
Article
Obstetrics & Gynecology
Alma Herrera-Salazar, Laura A. Flores-Hernandez, M. Y. Valdespino-Vazquez, Salvador Fonseca-Coronado, Elsa Romelia Moreno-Verduzco
Summary: This study aims to analyze the role of viral infections in stillbirths in Mexico and their epidemiological impact, within the context of the global Every Newborn Initiative. The findings show an increase in stillbirth rates in Mexico in recent years, but the goals of the Every Newborn Initiative have not been met. Only a small number of stillbirths are directly associated with viral infections, and the majority of cases have unspecified causes. The study suggests the implementation of routine viral diagnosis methods to improve the care and attention given to this global health problem.
JOURNAL OF PERINATAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Ali-Berenice Posada-Reyes, Yalbi I. Balderas-Martinez, Santiago avila-Rios, Pablo Vinuesa, Salvador Fonseca-Coronado
Summary: This study analyzed the polymorphic loci interactions in the genome of Mycobacterium tuberculosis, revealing key genes associated with pathogenicity and antibiotic resistance. The findings provide insights into the complex molecular interactions involved in the metabolism, virulence, and pathogenicity of M. tuberculosis, and can be applied to other bacterial populations.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Infectious Diseases
Carlos Arturo Vazquez-Chacon, Felipe de Jesus Rodriguez-Gaxiola, Alejandro Sanchez-Fores, Sarita Montano, Ciresthel Bello-Rios, Salvador Fonseca-Coronado, Cruz Fernando Lopez-Carrera, Armando Martinez-Guarneros, Ricardo Parra-Unda, Noemi Garcia-Magallanes, Eliakym Arambula-Meraz, Alejandro Escobar-Gutierrez, Mayra Cruz-Rivera, Paul Alexis Lopez-Duran
Summary: Drug resistant tuberculosis is a significant global public health issue, and different Mycobacterium tuberculosis complex variants show preferences for infecting certain hosts. However, these variants can also infect other hosts and contribute to the spread of drug resistance in different environments. This study identified high confidence drug-resistance mutations in 197 strains, belonging to different variants, highlighting the importance of detecting discrete intra-host populations carrying drug resistance mutations.
INFECTION GENETICS AND EVOLUTION
(2022)
Correction
Infectious Diseases
Carlos Arturo Vazquez-Chacon, Felipe de Jesus Rodriguez-Gaxiola, Cruz Fernando Lopez-Carrera, Mayra Cruz-Rivera, Armando Martinez-Guarneros, Ricardo Parra-Unda, Eliakym Arambula-Meraz, Salvador Fonseca-Coronado, Gilberto Vaughan, Paul Alexis Lopez-Duran
PLOS NEGLECTED TROPICAL DISEASES
(2023)
Review
Endocrinology & Metabolism
J. A. Ruiz-Pacheco, L. A. Castillo-Diaz, R. Arreola-Torres, S. Fonseca-Coronado, B. Gomez-Navarro
Summary: This review discusses the association between Type 2 Diabetes Mellitus and the severity of monkeypox infection, focusing on the impact of poor glucose control on immunological mechanisms. The use of available antidiabetic drugs is emphasized.
PRIMARY CARE DIABETES
(2023)
Article
Immunology
Juan A. Ruiz-Pacheco, E. Jose Munoz-Medina, Luis A. Castillo-Diaz, Rommel Chacon-Salinas, Alejandro Escobar-Gutierrez
Summary: Dengue is a major global health problem, with 400 million infections reported annually. Neutrophils play a crucial role in the immune response during dengue infection. Their activation can lead to detrimental effects, while their involvement in the pathogenesis is regulated by various molecules. This study found that the expression of TREM-1 and CD10, as well as the production of sTREM-1, were significantly increased in human neutrophils infected with DENV-2 or treated with granulocyte-macrophage colony stimulating factor. These findings suggest that neutrophil CD10 and TREM-1 are involved in the pathogenesis of dengue infection.
Article
Public, Environmental & Occupational Health
Carlos-Victor Hernandez-Ramirez, Dulce-Carolina Sanchez-Garcia, Juan-Carlos Carpio-Pedroza, Isabel Alcantara-Anguiano, Antonio Meza-Lucas, Raquel Tapia-Romero, Jorge-Luis de-la-Rosa-Arana
Summary: A continuous decrease in the incidence of clinical taeniosis/cysticercosis has been observed in Mexico over the past 30 years. This study investigated the influence of improved socioeconomic conditions on the prevalence of Taenia solium in four endemic communities in northwestern Mexico. The results suggest that the risk of parasitic transmission is low, possibly due to improving socioeconomic conditions.
ZOONOSES AND PUBLIC HEALTH
(2023)
Article
Biochemistry & Molecular Biology
Diana Ramirez-Hernandez, Pedro Lopez-Sanchez, Martha C. Rosales-Hernandez, Salvador Fonseca-Coronado, Jazmin Flores-Monroy
Summary: The research found that the infarct area decreased in the proestrus group, while it increased in the estrus and OVX groups. Left ventricular systolic pressure and +/- dP/dt were reduced in the OVX groups, but left ventricular diastolic pressure increased. NO levels increased in the OVX + CO and estrus + CO groups, while ROS levels increased in OVX rats after myocardial infarction but remained unchanged in the proestrus and estrus groups.
FRONTIERS IN BIOSCIENCE-LANDMARK
(2021)
Meeting Abstract
Pharmacology & Pharmacy
Jazmin Flores-Monroy, Diana Ramirez-Hernandez, Salvador Fonseca-Coronado, Diego Lezama-Martinez
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Ana Elvia Sanchez Mendoza, Salvador Fonseca Coronado, Carlos Ignacio Soto Zarate, Luis Humberto Lopez Hernandez, Rosalia Melendez Perez, Jose Francisco Montiel Sosa
Summary: The study analyzed the association between SNPs and beef tenderness, finding that genetic groups have an impact on tenderness, but no genotypic or allelic association was found.