Article
Infectious Diseases
Bin Lu, Bin Wang, Xinling Pan, Chenxin Liu, Chenyuan Jin, Yunzhen Shi, Yangxiao Zhou
Summary: This article reports the first case of a bloodstream infection caused by an NDM-positive E. hermannii strain. The patient's condition was controlled and discharged after treatment. This provides a new reference regimen for clinical practice.
BMC INFECTIOUS DISEASES
(2023)
Article
Infectious Diseases
Bin Lu, Yunzhen Shi, Yangxiao Zhou, Fenhua Zhao, Mengqi Wang, Xinling Pan
Summary: Aggregatibacter aphrophilus is a normal flora in the oropharynx and upper respiratory tract, but its culture and identification are challenging and easily misdiagnosed in clinical practice. In this case, a male patient presented with fever and right hip pain, and abnormal inflammatory markers were detected in blood tests. Aggregatibacter aphrophilus was identified through mass spectrometry in positive blood culture. Computed tomography revealed psoas abscess, pulmonary infection, and pleural effusion, which were relieved by antibiotic therapy and drainage. Therefore, multiple site infections caused by Aggregatibacter aphrophilus should be given sufficient attention in clinical diagnosis and treatment.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Microbiology
Silvia Colussi, Paolo Pastorino, Marino Prearo, Simona Sciuto, Fabio Bondavalli, Pier Luigi Acutis, Elena Bozzetta, Francesco Amisano, Angelo Salerno
Summary: This paper reports the first human urinary tract infection caused by Lactococcus petauri, highlighting the expected increase in human L. petauri infections and calling for further investigations to understand their role as pathogens and zoonotic agents.
Article
Infectious Diseases
Rebeca Carvalho Lacerda Garcia, Rodrigo Douglas Rodrigues, Ester Carvalho Lacerda Garcia, Maria Helena Rigatto
Summary: This study evaluated the impact of polymyxin B versus colistin on mortality and nephrotoxicity in carbapenem-resistant Acinetobacter baumannii and Pseudomonas aeruginosa bloodstream infections. The results showed that treatment with polymyxin B or colistin did not affect the 30-day mortality in patients with these bacterial infections.
Article
Integrative & Complementary Medicine
Lingyan Xiao, Tong Zhou, Jun Chen, Yanqing Hu, Yishan Zheng
Summary: This article reports a case of paravertebral abscess and bloodstream infection caused by Burkholderia pseudomallei after acupuncture. Acupuncture may lead to B.pseudomallei infection in high-risk groups, and inadequate treatment can lead to recurrent infections.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2022)
Article
Infectious Diseases
Changjun Zhu, Minjie Lv, Jianling Huang, Changwen Zhang, Lixu Xie, Tianming Gao, Bo Han, Wenjing Wang, Ganzhu Feng
Summary: This case report presents the details of a patient with Chlamydia abortus bloodstream infection and pneumonia. Next-generation sequencing (NGS) is advantageous in quickly and accurately identifying rare pathogens. While pneumonia generally has a good prognosis, Chlamydia infection can lead to serious visceral complications that clinicians should be aware of.
BMC INFECTIOUS DISEASES
(2022)
Article
Medicine, General & Internal
Da-Li Long, Yu-Hui Wang, Jin-Long Wang, Si-Jie Mu, Li Chen, Xian-Qing Shi, Jian-Quan Li
Summary: Klebsiella subspecies infections are often misdiagnosed and underestimated in clinical settings, and this case report highlights the clinical hazards posed by these infections and the limitations of classical laboratory methods in guiding treatment.
WORLD JOURNAL OF CLINICAL CASES
(2022)
Article
Infectious Diseases
Kai Yang, Tingting Xiao, Qingyi Shi, Yunying Zhu, Jing Ye, Yanzi Zhou, Yonghong Xiao
Summary: The study revealed that Pseudomonas aeruginosa bloodstream infections result in a significant economic burden, with significant differences in socioeconomic losses between carbapenem-resistant and carbapenem-susceptible strains. The direct and indirect economic burdens, as well as disability-adjusted life years loss caused by carbapenem-resistant Pseudomonas aeruginosa bloodstream infections, were significantly higher than those caused by susceptible strains.
JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE
(2021)
Article
Veterinary Sciences
Silvia Pavone, Roberto Rinoldo, Elisa Albini, Alessandro Fiorucci, Biagio Caponi, Anna Fratto, Elisabetta Manuali, Paola Papa, Chiara Francesca Magistrali
Summary: This is the first report of C. kerstersii infection in animals (goat), showing severe pyelonephritis and multi-organ vasculitis. The findings suggest C. kerstersii as a possible cause of urinary tract infection from extraintestinal sites.
BMC VETERINARY RESEARCH
(2021)
Article
Medicine, General & Internal
Zhao Li, Wen Gao, Yan-Ming Tian, Yun Xiao
Summary: This case describes a rare choroidal metastatic mucinous abscess caused by Pseudomonas aeruginosa. Despite initial suspicion of choroidal melanoma based on early clinical manifestations, the lesion was later confirmed to be a metastatic abscess. Surgical removal of the abscess successfully retained the eye structure, but bacterial re-growth led to local infection re-spreading post-surgery.
WORLD JOURNAL OF CLINICAL CASES
(2021)
Article
Infectious Diseases
Abolfazl Gilani, Roham Sarmadian, Manijeh Kahbazi, Parsa Yousefichaijan
Summary: This case report describes a 4-year-old female patient with a urinary tract infection caused by E. tarda. The patient's symptoms were relieved after treatment with ceftriaxone and nitrofurantoin. This is the first reported case of E. tarda infection in Iran and highlights the need for necessary precautions to prevent further infections.
BMC INFECTIOUS DISEASES
(2022)
Article
Infectious Diseases
Soyoung Haa, Kyungmin Huh, Doo Ryeon Chung, Jae-Hoon Ko, Sun Young Cho, Hee Jae Huh, Nam Yong Lee, Cheol-In Kang, Kyong Ran Peck, Jae-Hoon Song
Summary: This study compared the therapeutic efficacy of teicoplanin and vancomycin in the treatment of Enterococcus faecium bacteremia and found no significant differences in clinical outcomes, suggesting teicoplanin as a useful alternative to vancomycin.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Medicine, General & Internal
Xiangyuan Sun, Xiaocui Zou, Boting Zhou, Tao Yin, Ping Wang
Summary: The proportion of CRKP BSI has been gradually increasing over the past nine years, with prior use of carbapenems identified as an independent risk factor. The CRKP BSI group had more non-susceptibility to tested carbapenems and a higher mortality rate.
FRONTIERS IN MEDICINE
(2023)
Article
Immunology
Joachim Stark
Summary: Pseudomonas fulva is a rare human pathogen associated with invasive procedures and trauma. We report a case of urinary tract infection in an 85-year-old female, whose symptoms disappeared after empirical antibiotic treatment. The bacterial isolate from urine was identified as P. fulva. Specific examinations failed to identify any bleeding source or malignancy.
INDIAN JOURNAL OF MEDICAL MICROBIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Zhenwei Yu, Xiaofen Liu, Xiaoxing Du, Huiying Chen, Feng Zhao, Zhihui Zhou, Yu Wang, Yang Zheng, Phillip J. Bergen, Xi Li, Renhua Sun, Li Fang, Wanzhen Li, Yaxin Fan, Hailan Wu, Beining Guo, Jian Li, Yunsong Yu, Jing Zhang
Summary: This study evaluated the clinical pharmacokinetics/pharmacodynamics of polymyxin B in treating carbapenem-resistant K. pneumoniae bloodstream infections. The results showed that polymyxin B can effectively cure or improve patients with this infection, and PK/PD modeling can optimize the dosage and determine the breakpoints for treatment efficacy.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Public, Environmental & Occupational Health
E. H. Lee, S. K. Lee, J. H. Cheon, H. Koh, J. A. Lee, C. H. Kim, J. N. Kim, K. H. Lee, S. J. Lee, J. H. Kim, J. Y. Ahn, S. J. Jeong, N. S. Ku, D. E. Yong, S. S. Yoon, J. S. Yeom, J. Y. Choi
Summary: This study aimed to compare the efficacy of different FMT methods for decolonizing MDRO and found that the oral capsule is an effective method. Discontinuation of antibiotics after FMT is a key factor in the success of decolonization.
JOURNAL OF HOSPITAL INFECTION
(2023)
Article
Multidisciplinary Sciences
Yong Chan Kim, Heun Choi, Young Ah Kim, Yoon Soo Park, Young Hee Seo, Hyukmin Lee, Kyungwon Lee
Summary: Understanding the risk factors and microbiological features in recurrent E. coli BSI can aid clinicians in their management planning. Data from 2017 to 2018 were collected to assess antimicrobial resistance rates and molecular epidemiology. Risk factors for recurrence included vascular catheterization, ESBL phenotype, and high SOFA score. The highest proportion of ST131 and ESBL genotype was observed in early onset recurrent BSI. Whole genome sequencing revealed the presence of various virulence factors, resistant genes, and plasmid types in all types of BSI. This knowledge is important for clinicians in managing recurrent E. coli BSI.
Article
Multidisciplinary Sciences
Dongeun Yong, Hakbae Lee, Hyung-Gyu Min, Kyungnam Kim, Hyun-Seok Oh, Min Kyung Chu
Summary: This study investigated whether the composition of gut microbiota differed in participants with episodic migraine (EM) and chronic migraine (CM) compared to controls. The results showed significant differences in microbiota composition between the EM and CM groups and the control group. Moreover, a higher abundance of PAC000195_g was associated with lower headache frequency, while Agathobacter showed a significant negative association with severe headache intensity.
SCIENTIFIC REPORTS
(2023)
Article
Medical Laboratory Technology
Yu Jeong Choi, Young Ah Kim, Kim Junglim, Seok Hoon Jeong, Jong Hee Shin, Kyeong Seob Shin, Jeong Hwan Shin, Young Ree Kim, Hyun Soo Kim, Young Uh, Nam Hee Ryoo
Summary: IMP-6-producing Pseudomonas aeruginosa sequence type 235 is a dominant clone of carbapenemase-producing P. aeruginosa in Korea. The resistance rate of P. aeruginosa isolates from blood cultures has increased and there has been a shift in the molecular epidemiology of carbapenemase-producing P. aeruginosa.
ANNALS OF LABORATORY MEDICINE
(2023)
Article
Medical Laboratory Technology
Yangsoon Lee, Hye Gyung Bae, Dongju Won, Woobin Yun, Hyukmin Lee, Jong Rak Choi, Young Uh, Kyungwon Lee
Summary: In this study, the distribution of GBS isolates in pregnant Korean women was investigated. CC1 was the dominant lineage, followed by CC19, CC12, and CC17. The low prevalence of CC17 GBS colonization may explain the low frequency of neonatal GBS infections. Whole-genome sequencing is a useful tool for predicting antimicrobial susceptibility and capsular serotypes in GBS isolates.
ANNALS OF LABORATORY MEDICINE
(2023)
Article
Infectious Diseases
Min Hyuk Choi, Dokyun Kim, Kyoung Hwa Lee, Jae Hwa Cho, Seok Hoon Jeong
Summary: This study aimed to evaluate the changes in pathogens causing hospital-acquired bacterial pneumonia (HABP), their antimicrobial resistance patterns, and the risk factors for 28-day all-cause mortality in patients with HABP. The annual incidence of Staphylococcus aureus HABP decreased while that of Klebsiella pneumoniae HABP increased significantly. The resistance rate of S. aureus to methicillin decreased, while the non-susceptibility rate of K. pneumoniae to carbapenems increased. HABP caused by certain pathogens and preceded by COVID-19 was associated with increased mortality and incidence of bacteraemic pneumonia.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2023)
Article
Medical Laboratory Technology
Jong -Min Park, Mijung Kwon, Ki Ho Hong, Hyukmin Lee, Dongeun Yong
Summary: RAST is effective for early diagnosis and treatment of bloodstream infections caused by Klebsiella pneumoniae and Staphylococcus aureus, but not as accurate for Escherichia coli.
ANNALS OF LABORATORY MEDICINE
(2023)
Article
Immunology
Han Sang Kim, Chang Gon Kim, Won Kyu Kim, Kyung-A Kim, Jinseon Yoo, Byung Soh Min, Soonmyung Paik, Sang Joon Shin, Hyukmin Lee, Kyungwon Lee, Hoguen Kim, Eui-Cheol Shin, Tae-Min Kim, Joong Bae Ahn
Summary: This study found that Fusobacterium nucleatum (FN) in colorectal cancer tissues is associated with immune regulation in the tumor microenvironment, and its infection is correlated with poor prognosis and altered distribution of immune cells.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Letter
Public, Environmental & Occupational Health
Si Hyun Kim, Gyu Ri Kim, Young Ree Kim, Young Ah Kim, Hyun Soo Kim, Kyeong Seob Shin, Jong Hee Shin, Young Uh, Seok Hoon Jeong, Namhee Ryoo, Jeong Hwan Shin
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2023)
Article
Microbiology
Jungho Park, Naeun Kwak, Jong-Chan Chae, Eun-Jeong Yoon, Seok Hoon Jeong
Summary: Tuberculosis (TB) and nontuberculous mycobacteria (NTM) infections are ongoing threats to public health. A two-step PCR method was developed to accurately diagnose patients with suspected mycobacterial infections, distinguishing between TB and NTM, and identifying specific NTM species. This method showed promising results, comparable to commercially available PCR kits, and enabled the identification of mycobacterial species in most NTM infection cases.
MICROBIOLOGY SPECTRUM
(2023)
Article
Microbiology
Seung A. Byun, Yong Jun Kwon, Ga Yeong Lee, Min Ji Choi, Seok Hoon Jeong, Dokyun Kim, Min Hyuk Choi, Seung-Jung Kee, Soo Hyun Kim, Myung Geun Shin, Eun Jeong Won, Jong Hee Shin
Summary: This study analyzed the virulence traits and azole resistance mechanisms of 104 Candida auris isolates collected from Korean hospitals from 1996 to 2022. The results showed a high fluconazole resistance rate among C. auris isolates in Korean hospitals, with two clades identified and clade II isolates exhibiting higher resistance. The isolates from different clades were sensitive to other drugs, and clade II isolates displayed reduced thermotolerance, competitive growth, and virulence.
Article
Medicine, General & Internal
Mi Hyun Bae, Min -Sun Kim, Taek Soo Kim, Sunjoo Kim, Dongeun Yong, Gyoung Yim Ha, Nam Hee Ryoo, Young Uh, Jong Hee Shin, Hye Soo Lee, Yong-Hak Sohn, Sue Shin, Mi-Na Kim
Summary: The distribution and antimicrobial susceptibility of pathogenic bacteria in Korea have changed significantly over the past 20 years. Staphylococcus aureus prevalence initially increased and then decreased, while Escherichia coli became the most common species with an increase in cefotaxime resistance. Pseudomonas aeruginosa and Acinetobacter baumannii also increased in prevalence, along with imipenem resistance. Streptococcus agalactiae became the most common streptococcal species, and pneumococcal penicillin and levofloxacin susceptibility decreased.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2023)
Article
Medical Laboratory Technology
Gyu Ri Kim, Eun-Young Kim, Si Hyun Kim, Hae Kyung Lee, Jaehyeon Lee, Jong Hee Shin, Young Ree Kim, Sae Am Song, Joseph Jeong, Young Uh, Yu Kyung Kim, Dongeun Yong, Hyun Soo Kim, Sunjoo Kim, Young Ah Kim, Kyeong Seob Shin, Seok Hoon Jeong, Namhee Ryoo, Jeong Hwan Shin
Summary: After the introduction of PCV13 in Korea, there have been changes in the serotype distribution and antimicrobial resistance of invasive S. pneumoniae causing IPD. Non-PCV13 serotypes are increasing, and there are differences in antimicrobial resistance according to specific serotypes. Continuous monitoring of serotypes and antimicrobial resistance is crucial for the appropriate management of S. pneumoniae infections.
ANNALS OF LABORATORY MEDICINE
(2023)
Letter
Medical Laboratory Technology
Kyunghee Yu, Junhyup Song, Dokyun Kim, Yongjung Park, Seok Hoon Jeong
ANNALS OF LABORATORY MEDICINE
(2023)
