Article
Dermatology
Leszek Blicharz, Maryla Michalak, Ksenia Szymanek-Majchrzak, Grazyna Mlynarczyk, Krzysztof Skowronski, Lidia Rudnicka, Zbigniew Samochocki
Summary: The study suggests a potential link between the presence of Staphylococcus aureus strains producing biofilm in the anterior nares of patients with atopic dermatitis and the severity of the disease. The biofilm seems to play a crucial role in the spread and persistent colonization of large areas of the skin by this pathogen. Disruption of S. aureus biofilm may have a positive impact on the course of atopic dermatitis.
Article
Food Science & Technology
Muna M. Abbas, Motasim Almasri, Alaeddin Abu-Zant, Shadi Sharef, Sara Mahajne, Khalil Kananbi
Summary: This study investigated the prevalence of nasal carriage of Staphylococcus aureus (S. aureus) and MRSA among Palestinian diabetic patients and found a high proportion of patients colonized with S. aureus and MRSA in the nasal region. The proportion of nasal carriage of S. aureus or MRSA in Palestinian diabetic patients was also higher than that in diabetic patients in other countries.
QUALITY ASSURANCE AND SAFETY OF CROPS & FOODS
(2023)
Article
Microbiology
Ziyu Yang, Bijun Qiu, Danhong Cheng, Na Zhao, Yao Liu, Min Li, Qian Liu
Summary: This study aims to understand the colonization mechanisms of Staphylococcus aureus in the nasal cavity of pediatric patients and healthy children. The results showed that virulent clones of S. aureus were prevalent in pediatric patients and exhibited higher resistance to antibiotics. These strains were able to evade the immune system through an antimicrobial peptide resistance mechanism.
INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY
(2022)
Article
Microbiology
Saugat Poudel, Ying Hefner, Richard Szubin, Anand Sastry, Ye Gao, Victor Nizet, Bernhard O. Palsson
Summary: The study investigates the regulation of carbon and amino acid metabolism in Staphylococcus aureus through a modular transcriptional regulatory network and metabolic model. The results demonstrate the coordinated regulation of central carbon metabolism and amino acid biosynthesis by CcpA and CodY, as well as the link between metabolic cues and translation through the expression of ribosome hibernation-promoting factor.
Review
Infectious Diseases
Matipaishe Mashayamombe, Miguel Carda-Dieguez, Alex Mira, Robert Fitridge, Peter S. Zilm, Stephen P. Kidd
Summary: The ability of Staphylococcus aureus to colonise different niches across the human body is linked to its adaptable metabolic capability and ability to persist within specific tissues. The relapse of disease in S. aureus infections is due to the presence of suboptimal populations that persist even after the disease is cleared. The constant arousal of these populations is a key strategy for long-term infection and survival of S. aureus.
Review
Immunology
Dominique Missiakas, Volker Winstel
Summary: Host cell death programs are essential for cellular homeostasis, embryonic development, and tissue regeneration. Pathogens like Staphylococcus aureus use cell death pathways to establish infection, manipulating apoptotic, necroptotic, and pyroptotic modes to shape the immune environment conducive to persistence. This exploitation of cell death pathways is a virulence strategy that must be considered alongside immune evasion mechanisms for the development of effective therapeutics and interventions.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Mengyao Wang, Ziyao Fan, Hongbing Han
Summary: Staphylococcus aureus is a pathogen that can colonize various host organisms and evade host immune defenses through its accessory gene regulatory system. Host autophagy, a clearance pathway, plays a role in degrading S. aureus, and understanding the interaction between autophagy and the pathogen can help improve infection control.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Maricely Ramirez-Hernandez, Javiera Norambuena, Hongnan Hu, Belvin Thomas, Chaoyun Tang, Jeffrey M. Boyd, Tewodros Asefa
Summary: The urgent need for materials that can more efficiently deliver antimicrobial agents has arisen due to the increase in microbial resistance to traditional antibiotics. This study presents the synthesis of amine-functionalized SBA-15 mesoporous silica nanomaterials loaded with rafoxanide and anchored Cu(II) ions, which exhibit enhanced antimicrobial efficacy against pathogenic Staphylococcus aureus. The structurally characterized nanomaterials demonstrate 10 times the bactericidal action compared to nanomaterials loaded with rafoxanide only, and the synthetic sequence used in the production significantly impacts their bactericidal efficacy.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Review
Biochemistry & Molecular Biology
Isabella Hernandez-Aristizabal, Ivan Dario Ocampo-Ibanez
Summary: The emergence of bacteria resistant to conventional antibiotics, especially VRSA and VISA strains, poses a serious threat to global health. Developing new antimicrobial alternatives, such as antimicrobial peptides (AMPs), is urgently needed as a promising therapeutic strategy to combat resistant strains. Evaluating natural, artificial, and synthetic AMPs against VRSA and VISA strains shows great potential for clinical application.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Microbiology
Javier Seravalli, Frank Portugal
Summary: Most life forms synthesize the polyamine putrescine, but Staphylococcus aureus is an exception. However, our analysis confirms that S. aureus can produce putrescine and its derivative N-acetyl-putrescine.
Article
Genetics & Heredity
Martin Fayolle, Madjid Morsli, Anthony Gelis, Marion Chateauraynaud, Alex Yahiaoui-Martinez, Albert Sotto, Jean-Philippe Lavigne, Catherine Dunyach-Remy
Summary: This study found that Staphylococcus aureus has a certain persistence in patients with pressure ulcers, but its role in wound evolution is limited and does not have a significant impact on the evolution of pressure ulcers.
Article
Microbiology
Erick Adrian Cruz-Lopez, Gildardo Rivera, Maria Antonia Cruz-Hernandez, Ana Veronica Martinez-Vazquez, Graciela Castro-Escarpulli, Rebeca Flores-Magallon, Karina Vazquez, Wendy Lizeth Cruz-Pulido, Virgilio Bocanegra-Garcia
Summary: The CRISPR-Cas system provides defense mechanisms against mobile genetic elements in bacteria and archaea, but its role in Staphylococcus aureus is not fully understood. Analysis of over 700 genomes revealed that only a small percentage of S. aureus strains harbor the CRISPR-Cas system, with some spacer sequences matching plasmids and bacteriophages. Further research on a larger number of strains is needed to fully understand the implications of the CRISPR/Cas system in S. aureus.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Multidisciplinary Sciences
Markus Huemer, Srikanth Mairpady Shambat, Judith Bergada-Pijuan, Sandra Soderholm, Mathilde Boumasmoud, Clement Vulin, Alejandro Gomez-Mejia, Minia Antelo Varela, Vishwachi Tripathi, Sandra Gotschi, Ewerton Marques Maggio, Barbara Hasse, Silvio D. Brugger, Dirk Bumann, Reto A. Schuepbach, Annelies S. Zinkernagel
Summary: Staphylococcus aureus persisters, formed under host-mediated stress, display unique growth characteristics and molecular reprogramming, requiring specific metabolic pathways for maintenance. These non-metabolically active persisters regain virulence potential upon regrowth, exhibiting a reversible state crucial for recurrent infections. Targeted antipersister combination therapy significantly reduces lag-phase heterogeneity and persisters, providing insights into the difficulty of treating persistent S. aureus infections.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biotechnology & Applied Microbiology
Ramamoorthy Sivakumar, Parameswaran Sree Pranav, Madhavi Annamanedi, S. Chandrapriya, Shrikrishna Isloor, Jeyaprakash Rajendhran, Nagendra R. R. Hegde
Summary: This study conducted a comprehensive analysis of bovine mastitis-associated S. aureus isolates from India using whole genome sequencing and comparative genomic analysis. The results revealed 15 different sequence types and 5 clonal complexes. The genome of Indian mastitis-associated S. aureus strains is relatively closed. Phylogenetic analysis based on SNP variation differentiated the 41 strains into six major clades. Seventeen different antimicrobial resistance genes and 108 virulence-associated genes were identified among these isolates.
Article
Biochemistry & Molecular Biology
Marta Woroszylo, Daria Ciecholewska-Jusko, Adam Junka, Radoslaw Drozd, Marcin Wardach, Pawel Migdal, Patrycja Szymczyk-Ziolkowska, Daniel Styburski, Karol Fijalkowski
Summary: The combination of rotating magnetic field (RMF) with beta-lactam antibiotics shows promising results in enhancing the antibacterial effects against methicillin-resistant Staphylococcus aureus (MRSA) by causing morphological alterations in bacterial cells. This study provides potential new treatment options for MRSA infections by utilizing the disruptive effect of RMF on bacterial cell walls.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Mycology
Paul Misael Garza-Lopez, Gerardo Suarez-Vergel, Aida Hamdan-Partida, Octavio Loera
Article
Microbiology
Estela T. Mendez-Olvera, Jaime A. Bustos-Martinez, Yolanda Lopez-Vidal, Antonio Verdugo-Rodriguez, Daniel Martinez-Gomez
JUNDISHAPUR JOURNAL OF MICROBIOLOGY
(2016)
Article
Microbiology
Aida Hamdan-Partida, Samuel Gonzalez-Garcia, Estela de la Rosa Garcia, Jaime Bustos-Martinez
INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY
(2018)
Article
Infectious Diseases
Aida Hamdan-Partida, Teresita Sainz-Espunes, Jaime Bustos-Martinez
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2014)
Article
Microbiology
Raul Alvarez-Castro, Jaime Bustos-Martinez, A. Enrique Acosta-Gio, Aida Hamdan-Partida, Leonor Sanchez-Perez
JUNDISHAPUR JOURNAL OF MICROBIOLOGY
(2019)
Article
Immunology
Alina Uribe-Garcia, Gloria Luz Paniagua-Contreras, Eric Monroy-Perez, Jaime Bustos-Martinez, Aida Hamdan-Partida, Javier Garzon, Jesica Alanis, Rosalia Quezada, Felipe Vaca-Paniagua, Sergio Vaca
Summary: This study characterized Staphylococcus aureus strains isolated from periodontal lesions of patients, finding high-level expression of virulence genes and multidrug resistance. The strains could complicate the successful treatment of the disease.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2021)
Article
Fisheries
Hortencia Hernandez-Ruiz, Hugo H. Montaldo, Jaime Bustos-Martinez, Gabriel R. Campos-Montes, Hector Castillo-Juarez
JOURNAL OF THE WORLD AQUACULTURE SOCIETY
(2020)
Article
Fisheries
Julio Cesar Meneses-Marquez, Aida Hamdan-Partida, Maria Del Monroy-Dosta, Jorge Castro-Mejia, Abraham Faustino-Vega, Elizabeth Soria-Castro, Jaime Bustos-Martinez
DISEASES OF AQUATIC ORGANISMS
(2019)
Article
Entomology
Miguel Angel Zavala-Sanchez, Jose Luis Rodriguez-Chavez, Rodolfo Figueroa-Brito, Cinthia Magali Quintana-Lopez, Mamadou Moustapha Bah, Juan Campos-Guillen, Jaime Amadeo Bustos-Martinez, Daniel Zamora-Avella, Miguel Angel Ramos-Lopez
FLORIDA ENTOMOLOGIST
(2019)
Article
Multidisciplinary Sciences
Eric Monroy-Perez, Areli Bautista Ceron, Luis Rey Garcia Cortes, Nancy Nolasco Alonso, Pablo Dominguez-Trejo, Tania Hernandez-Jaimes, Jaime Bustos-Martinez, Aida Hamdan-Partida, Ernesto Arturo Rojas Jimenez, Sergio Vaca, Felipe Vaca-Paniagua, Gloria Luz Paniagua-Contreras
Article
Chemistry, Multidisciplinary
Samuel Gonzalez-Garcia, Aida Hamdan-Partida, Emma Elisa Ortiz Islas, Miguel Angel Zavala Sanchez, Julia Perez Ramos, Ruben del Muro Delgado, Jaime Bustos-Martinez
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
(2020)