Article
Infectious Diseases
Supavit Chesdachai, Zachary A. Yetmar, Hussam Tabaja, Isin Y. Comba, John R. Go, Douglas W. Challener, Anisha Misra, Omar M. Abu Saleh
Summary: This study aimed to describe the detailed clinical features, management, and outcomes of patients with bacteremia from Abiotrophia, Granulicatella, and Gemella. The findings revealed the association of these bacteremia with infective endocarditis and other clinical syndromes, emphasizing the need to consider their clinical significance, clinical syndrome, proclivity of endocarditis, and susceptibility pattern.
JOURNAL OF INFECTION
(2022)
Article
Food Science & Technology
Jong Min Lee, So Hee Park, Chun-Zhi Jin, Min-Kyoung Kang, Dong-Jin Park, Chang-Jin Kim
Summary: Analysis of untranscribed DNA sequences in intergenic spacer regions (ISR) in groESL resolved ambiguity between closely related GRAS and non-GRAS species. Using groESL-ISR-specific primers for PCR sequencing accurately differentiated L. plantarum and L. pentosus, showing more accuracy than 16S rRNA sequences. Major probiotics species were grouped based on ISR sequences, which correlated with core-genome differentiation, indicating ISR-based species identification provides more accurate results than 16S rRNA-based identification and represents genome-based speciation.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Infectious Diseases
Adrian Tellez, Juan Ambrosioni, Marta Hernandez-Meneses, Jaume Llopis, Marco Ripa, Stephen T. Chambers, David Holland, Manel Almela, Nuria Fernandez-Hidalgo, Benito Almirante, Emilio Bouza, Jacob Strahilevitz, Margaret M. Hannan, John Harkness, Zeina A. Kanafani, Tahaniyat Lalani, Selwyn Lang, Nigel Raymond, Kerry Read, Tatiana Vinogradova, Christopher W. Woods, Dannah Wray, Asuncion Moreno, Vivian H. Chu, Jose M. Miro
Summary: This study describes the clinical characteristics and outcome of Abiotrophia and Granulicatella infective endocarditis compared to Viridans group streptococci infective endocarditis. Patients with ABI/GRA-IE were younger and had similar clinical features and rates of surgery, but had a better prognosis compared to VGS-IE.
JOURNAL OF INFECTION
(2022)
Article
Microbiology
Julian Torres-Morales, Jessica L. Mark L. Welch, Floyd E. E. Dewhirst, Gary G. G. Borisy
Summary: By combining pangenomics and metagenomics, we evaluated the site-specificity of Gemella species in different habitats within the oral cavity. Our findings showed that G. haemolysans predominantly occurred on buccal mucosa and keratinized gingiva, G. sanguinis on the tongue dorsum, throat, and tonsils, and G. morbillorum in dental plaque.
JOURNAL OF ORAL MICROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Zheng-jun Bian, Hua-jian Shan, Yun-Rong Zhu, Ce Shi, Min-bin Chen, Yu-min Huang, Xiao-dong Wang, Xiao-zhong Zhou, Cong Cao
Summary: Overexpression of G alpha i3 protein promotes tumorigenesis and progression of osteosarcoma by mediating RTK-Akt signaling.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Microbiology
Maria A. Canas, Adrian Tellez, Cristina Garcia de la Maria, Anders Dahl, Javier Garcia-Gonzalez, Marta Hernandez-Meneses, Manel Almela, Juan Ambrosioni, Carlos Falces, Eduard Quintana, Barbara Vidal, Andres Perissinotti, Jose M. Tolosana, Elena Sandoval, Juan M. Pericas, Asuncion Moreno, Jose M. Miro
Summary: This study is the first to demonstrate rapid development of high-level daptomycin resistance in Abiotrophia and Granulicatella species in vitro. The resistance was stable, and most combination therapies did not prevent its development.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Multidisciplinary Sciences
Aurelie Schwing, Didier F. Pisani, Christelle Pomares, Alissa Majoor, Sandra Lacas-Gervais, Jennifer Jager, Emmanuel Lemichez, Pierre Marty, Laurent Boyer, Gregory Michel
Summary: Leishmania infantum is the causative agent of visceral leishmaniasis transmitted by sand flies. Despite recommended drugs, relapses raise doubts about treatment efficiency, and adipose tissue is suggested as a potential safe target for the parasite.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Jander Moreira Monteiro, Jaqueline Isadora Reis Ramos, Ian Sousa, Rayana Longo Bighetti-Trevisan, Jurandir Marcondes Ribas Filho, Gustavo Rassier Isolan
Summary: Medulloblastoma is the most common solid tumor in children, with a poor prognosis. The study aimed to assess the association between CD114 expression and mortality in patients with medulloblastoma. The findings showed different CD114 expressions between molecular subgroups, but no direct relationship was found between CD114 expression and mortality.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biology
Jinci Yan, Chengli Fang, Gaohua Yang, Jianxu Li, Yanqiang Liu, Lu Zhang, Pengjie Yang, Jingyuan Fang, Yang Gu, Yu Zhang, Weihong Jiang
Summary: BBR has been identified as directly targeting FtfL, a key enzyme in C1 metabolism, in Peptostreptococcus anaerobius, inhibiting its enzymatic activities and interfering with the pathogenic bacteria in the gut. This study sheds light on the molecular mechanisms underlying BBR's anti-CRC effects and provides a new approach for controlling CRC.
Article
Immunology
Guoqiang Liu, Guisong He, Jie Zhang, Zhongmin Zhang, Liang Wang
Summary: This study identifies key genes in osteoarthritis synovial tissue and discovers that the SCRG1 gene can serve as a diagnostic marker for osteoarthritis. Additionally, SCRG1 is involved in regulating immune pathways, making it a potential therapeutic target for osteoarthritis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jie Zhang, De-pei Yin, Yan Zhang, Jia-nan Zhang, Yan Yang, Zhi-qing Zhang, Li Zhou, Yan Lv, Hai-wei Huang, Cong Cao
Summary: This study found that the expression of G alpha i3 is significantly increased in cervical cancer, and it is associated with poor survival in patients. Depletion of G alpha i3 has anti-cervical cancer activity, while overexpression promotes cervical cancer proliferation and migration. The binding of GATA4 to the promoter region of G alpha i3 is enhanced in cervical cancer. The results indicate that G alpha i3 could be a potential therapeutic target for cervical cancer.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Hong Tan, Huali Wang, Jinhu Ma, Hui Deng, Qinghua He, Qiang Chen, Qinglian Zhang
Summary: This study found that lactate dehydrogenase C (LDHC) is significantly expressed in lung cancer tissues, and overexpression of LDHC can promote tumor growth, while knock-down of LDHC can inhibit cancer cell proliferation. The crystal structure of human LDHC4 was determined and found to have a distinct conformation compared to LDHA4 and lactate dehydrogenase B4 (LDHB4). Additionally, (ethylamino) (oxo)acetic acid was shown to selectively inhibit LDHC4. These findings suggest that LDHC4 could be a potential target for anticancer drug discovery.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Multidisciplinary Sciences
Yumiko Saito, Keiko Taniguchi, Hiromi Ii, Mano Horinaka, Susumu Kageyama, Susumu Nakata, Osamu Ukimura, Toshiyuki Sakai
Summary: GGCT is highly expressed in cancer cells and its knockdown inhibits cancer cell growth. The knockdown of GGCT inhibits the MEK-ERK pathway and activates the tumor suppressor gene RB at the protein level. GGCT knockdown also decreases c-Met expression and reverses the inhibition of the STAT3-c-Met-MEK-ERK pathway through AMPK activation. These findings suggest that GGCT knockdown activates the RB protein by inhibiting the STAT3-c-Met-MEK-ERK pathway via AMPK activation.
SCIENTIFIC REPORTS
(2023)
Article
Chemistry, Multidisciplinary
Hai-yan Wang, Pian Yu, Xi-sha Chen, Hui Wei, Shi-jie Cao, Meng Zhang, Yi Zhang, Yong-guang Tao, Dong-sheng Cao, Feng Qiu, Yan Cheng
Summary: Physapubenolide (PB), a compound extracted from Physalis minima L., has shown cytotoxic effects on cancer cells by targeting HMGCR. This inhibition leads to decreased proliferation and migration in melanoma cells, as well as increased sensitivity to vemurafenib.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Food Science & Technology
Daniela M. Guglielmotti, Silvina A. Pujato, Andrea Quiberoni, Viviana B. Suarez
Summary: The taxonomic characterisation of Leuconostoc species remains controversial, with sequencing of the gene coding for 16S rRNA being commonly used but potentially leading to misidentifications. A phylogenetic tree constructed using a fragment from the hsp60 gene shows greater discrimination and can be considered an excellent molecular tool for identifying Leuconostoc species.
INTERNATIONAL DAIRY JOURNAL
(2022)
Article
Immunology
Tsai-Wen Wan, Yu-Jung Liu, Yu-Ting Wang, Yu-Tzu Lin, Jia-Chuan Hsu, Jui-Chang Tsai, Hao-Chieh Chiu, Po -Ren Hsueh, Wei-Chun Hung, Lee-Jene Teng
Summary: This study provides detailed genetic characterization of Tn6636, a multidrug-resistant mobile element, in clinical isolates of Staphylococcus aureus. The prevalence of Tn6636 in methicillin-susceptible S. aureus (MSSA) is higher than that in methicillin-resistant S. aureus (MRSA). The presence of this mobile element with various sequence types suggests its broad dissemination and the potential for continued spread of resistant plasmids.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2022)
Article
Microbiology
Yu-Lin Lee, Wen-Chien Ko, Po-Ren Hsueh
Summary: This study investigated the resistance patterns and mechanisms of Pseudomonas aeruginosa in the Asia-Pacific region from 2015 to 2019. The results showed significant variations in resistance patterns and associated genes among different countries in the region.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Letter
Infectious Diseases
Pin-Han Wu, Chih-Hao Chen, Chia-Huei Chou, Mao-Wang Ho, Yu-Hsuan Liu, Hsiu-Hsien Lin, Kuan-Fei Chen, Po-Ren Hsueh
JOURNAL OF INFECTION
(2022)
Letter
Infectious Diseases
Yu-Chang Chang, Chiung-Tzu Hsiao, Wan-Li Chen, Yang-Di Su, Po-Ren Hsueh
JOURNAL OF INFECTION
(2022)
Article
Microbiology
Jung-Yien Chien, Chong-Jen Yu, Po-Ren Hsueh
Summary: The performance of metagenomic next-generation sequencing (mNGS) was evaluated and compared with that of conventional culture testing in patients with sepsis. mNGS had higher detection rates than blood culture and BALF culture, especially for bacteria, viruses, and multipathogen infections. RNA-based mNGS increased the detection rate of several bacteria, fungi, and viruses. mNGS offers a sensitive diagnostic method for patients with sepsis, but clinical correlation is advised to interpret the data due to the lack of unified diagnostic criteria.
MICROBIOLOGY SPECTRUM
(2022)
Letter
Infectious Diseases
Jia-Arng Lee, Shin-Hei Du, Tai-fen Lee, Yu-Shan Huang, Chun-Hsing Liao, Yu-Tsung Huang, Po-Ren Hsueh
JOURNAL OF INFECTION
(2023)
Letter
Infectious Diseases
Jia-Arng Lee, Tai-Fen Lee, Yu-Tsung Huang, Po-Ren Hsueh
JOURNAL OF INFECTION
(2022)
Letter
Infectious Diseases
Yuag-Meng Liu, Wen-Chien Ko, Mao-Wang Ho, Yu-Lin Lee, Po-Ren Hsueh
JOURNAL OF INFECTION
(2023)
Letter
Infectious Diseases
Jiaxin Yu, Hsiu-Hsien Lin, Kun-Hao Tseng, Ni Tien, Po-Ren Hsueh, Der-Yang Cho
JOURNAL OF INFECTION
(2023)
Review
Virology
Chih-Cheng Lai, Chi-Kuei Hsu, Shun-Chung Hsueh, Muh-Yong Yen, Wen-Chien Ko, Po-Ren Hsueh
Summary: Following the emergence of multisystem inflammatory syndrome in children (MIS-C), a similar clinical scenario called multisystem inflammatory syndrome in adults (MIS-A) has been observed. Although the prevalence of MIS-A is low and likely underdiagnosed, it can be associated with high mortality. MIS-A is a multisystem disease that affects the cardiovascular, respiratory, gastrointestinal, dermatologic, hematologic, and neurologic systems. The diagnosis of MIS-A requires clinical manifestations, laboratory evidence of inflammation, and SARS-CoV-2 infection. The appropriate treatment for MIS-A is still uncertain, but anti-inflammatory agents like intravenous immunoglobulin and corticosteroids are commonly used. Further research is needed to determine the true prevalence, pathogenesis, and effective treatment for MIS-A.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Review
Virology
Chih-Cheng Lai, Po-Ren Hsueh
Summary: Nirmatrelvir/ritonavir (NMV-r) is an effective antiviral agent for treating nonhospitalized COVID-19 patients. However, there have been rare cases of virologic and symptomatic rebound after NMV-r treatment, which is a cause for concern. This review provides comprehensive information on the frequency, mechanism, outcomes, and management of COVID-19 rebound after NMV-r. The incidence of rebound was less than 2% and most cases had mild symptoms, with favorable clinical outcomes.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Letter
Infectious Diseases
Pin-Han Wu, Chih-Hao Chen, Wen-Hsin Hsih, Chia-Huei Chou, Chih-Yu Chi, Mao-Wang Ho, Yu-Tzu Lin, Hsiu-Hsien Lin, Kun-Hao Tseng, Po-Ren Hsueh
JOURNAL OF INFECTION
(2023)
Article
Immunology
I-Ru Chen, Guei-Jane Wang, Po-Ren Hsueh, Chia-Hui Chou, Long-Bin Jeng, Hui-Ju Lin, Huang-Jiun Liao, Ping-Chin Lai, Jan-Gowth Chang, Chiu-Ching Huang
Summary: This study evaluated the immune responses and safety of COVID-19 vaccination in patients with atypical hemolytic uremic syndrome (aHUS) in Taiwan. The results showed that the vaccines effectively protected aHUS patients from severe COVID-19 complications without significant safety concerns. Transplant aHUS patients had lower immune response titers, indicating a need for additional vaccine doses.
Article
Microbiology
Yu-Tsung Huang, Yao-Wen Kuo, Nan-Yao Lee, Ni Tien, Chun-Hsing Liao, Lee-Jene Teng, Wen-Chien Ko, Po-Ren Hsueh
Summary: Detection of carbapenemase-producing Enterobacterales is important for therapeutic decisions and infection control. The Xpert CARBA-R and NG-Test CARBA 5 assays showed high sensitivity and specificity in detecting carbapenemases in carbapenem-resistant Enterobacterales isolates.
MICROBIOLOGY SPECTRUM
(2022)