☆ 4.7 Article

Serotyping Pneumococcal Meningitis Cases in the African Meningitis Belt by Use of Multiplex PCR with Cerebrospinal Fluid

JOURNAL OF CLINICAL MICROBIOLOGY (2010)

Journal

JOURNAL OF CLINICAL MICROBIOLOGY

Volume 48, Issue 2, Pages 612-614

Publisher

AMER SOC MICROBIOLOGY

DOI: 10.1128/JCM.01402-09

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Microbiology

Funding

PneumoADIP

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Abstract

We reformulated a multiplex PCR algorithm for serotyping of pneumococcal meningitis directly on cerebrospinal fluid (CSF). Compared to established methods on isolates, CSF-based PCR had at least 80% sensitivity and 100% specificity. In regional meningitis surveillance, CSF-based PCR increased the serotype information yield from 40% of cases (isolate testing) to 90%.

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