Article
Infectious Diseases
Kevin Simon, Wolfgang Pier, Alex Kruettgen, Hans-Peter Horz
Summary: The combination of Sb-1 phage and oxacillin showed enhanced antibacterial effects against most S. aureus isolates, with rare antagonism observed. This heterologous antimicrobial pair provides a robust approach for controlling MRSA.
Article
Infectious Diseases
Alessandro Bondi, Marco Peradotto, Gabriele Bianco, Davide Ghibaudo, Anna Maria Barbui, Cristina Costa, Rossana Cavallo
Summary: Both BD Phoenix and MiscroScan WalkAway systems exhibited poor concordance with the reference agar dilution method for fosfomycin susceptibility determination in Staphylococcus aureus clinical isolates.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Jun Wang, Xinxin Ma, Jing Li, Lu Shi, Lijuan Liu, Xinyao Hou, Sijin Jiang, Pu Li, Jia Lv, Lei Han, Yue Cheng, Bei Han
Summary: It is imperative to explore alternative antimicrobial treatments for methicillin-resistant Staphylococcus aureus (MRSA) infections. This study found that a combination of Nisin (NIS) and Oxacillin (OX) can effectively inhibit MRSA and potentially restore its sensitivity to OX by inhibiting the transcription of mecA gene. This research has important clinical implications for developing new anti-MRSA biomaterials.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Infectious Diseases
Minjun Kim, Yena Seo, Seon-Gyeong Kim, Yedam Choi, Hyun Jung Kim, Tae-Jong Kim
Summary: Resistant bacteria pose a critical problem in bacterial infection treatment, and the development of new antibiotics is not the optimal solution. Combining safe, plant-based compounds with conventional antibiotics may be a more reasonable approach to increase efficacy against resistant bacteria. This study investigates the synergistic antibiotic activity of Ricini Semen extract and its constituent fatty acids when mixed with oxacillin, showing that changes in cell membrane fluidity play a major role in this mechanism.
Article
Infectious Diseases
Trusha Nana, Olga Perovic, Vindana Chibabhai
Summary: This laboratory-based study compared the carbapenem MICs yielded by Sensititre, Vitek 2, MicroScan WalkAway plus, and Etest for OXA-48-like Klebsiella pneumoniae isolates. The results showed substantial variability in carbapenem MICs, emphasizing the need for performance characteristics verification of MIC methods to ensure accurate reporting.
CLINICAL MICROBIOLOGY AND INFECTION
(2022)
Article
Infectious Diseases
Elisabetta Buommino, Simona De Marino, Martina Sciarretta, Marialuisa Piccolo, Carmen Festa, Maria Valeria D'Auria
Summary: Oxadiazole compounds showed high efficacy against Gram-positive MRSA and were able to restore antibiotic activity, making them promising for the treatment of MRSA infections.
Article
Microbiology
Shengnan Jiang, Mengzhen Chen, Junxiong Zhang, Xiaoliang Ba, Hao Zhang, Yueqin Hong, Lu Sun, Zhengan Wang, Hemu Zhuang, Feiteng Zhu, Yiyi Chen, Haiping Wang, Feng Zhao, Yan Chen, Yunsong Yu, Shujuan Ji
Summary: Our study found a wide distribution of DAP resistance and heteroresistance in MRSA in China. The resistance to DAP in MRSA may threaten its effectiveness against MRSA infections.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2023)
Article
Pharmacology & Pharmacy
Wesley D. Kufel, Zoey Zagoria, Bruce E. Blaine, Jeffrey M. Steele, Rahul Mahapatra, Kristopher M. Paolino, Stephen J. Thomas
Summary: This study evaluated the effectiveness and safety of daptomycin plus oxacillin (D/O) for persistent methicillin-susceptible Staphylococcus aureus bacteremia (MSSAB). The results showed that D/O was an effective salvage regimen and may serve as a carbapenem-sparing option for persistent MSSAB.
ANNALS OF PHARMACOTHERAPY
(2023)
Article
Pharmacology & Pharmacy
Mohadeseh Mohammadi Tabar, Moj Khaleghi, Elham Bidram, Atefeh Zarepour, Ali Zarrabi
Summary: Infectious diseases are the second leading cause of death worldwide, and nanotechnology provides promising approaches to tackle antibiotic resistance. This study synthesized a carbon-based nanoplatform and successfully loaded two ineffective antibiotics to enhance their antibacterial activity.
Article
Infectious Diseases
Sabrina Di Gregorio, Maria Sol Haim, Angela Maria Rosa Famiglietti, Jose Di Conza, Marta Mollerach
Summary: This study characterized isogenic strains of S. aureus with vancomycin resistance, both in vivo and in vitro, and found genetic changes associated with cell wall and phosphate metabolism, staphylococcal growth, and biofilm formation. These changes are not commonly associated with vancomycin resistance in S. aureus.
Article
Chemistry, Medicinal
Tanveer Ali, Abdul Basit, Asad Mustafa Karim, Jung-Hun Lee, Jeong-Ho Jeon, Shafiq ur Rehman, Sang-Hee Lee
Summary: This study investigates the diversity and role of missense mutations of PBP2a in the antibiotic resistance mechanism in Staphylococcus aureus. The results show that the E239R mutation in the allosteric site of PBP2a induces conformational changes in the active site, hindering its interaction with cefoxitin and leading to high-level resistance.
Article
Microbiology
Jiun-Liang Chen, Tsung-Yu Huang, Wei-Bin Hsu, Chiang-Wen Lee, Yao-Chang Chiang, Pey-Jium Chang, Kuo-Ti Peng
Summary: This study investigated the genotypic and phenotypic characteristics of MRSA clones isolated from PJI patients in a hospital in Taiwan. The findings showed that ST239 MRSA isolates were highly resistant to multiple antibiotics, had a high biofilm formation ability, and infected patients typically exhibited fever and inflammation. Additionally, knee infections were mainly attributed to ST59 MRSA, and there was an increasing trend of infections caused by ST8 and other MRSA genotypes in PJI patients.
Article
Microbiology
Ryota Miyazawa, So Shimoda, Keiichi Matsuda, Ryuta Tobe, Tasuke Ando, Hiroshi Yoneyama
Summary: Staphylococcus aureus is a major pathogen in humans and livestock, causing serious issues such as bovine mastitis. This study monitored cases of intramammary infection caused by S. aureus in the Miyagi Prefecture, Japan, and analyzed the strains obtained from dairy farms. The study found recurrent cases of infection and identified a Methicillin-Sensitive SA (MSSA) ST398 strain isolated from mastitis-containing cows, which is the first confirmed case in Japan. The results highlight the importance of nationwide surveillance to manage the distribution of ST398 strains in dairy farms for human and animal health.
Article
Immunology
Xinyi Wang, Huilin Zhao, Bingjie Wang, Ying Zhou, Yanlei Xu, Lulin Rao, Wenxiu Ai, Yinjuan Guo, Xiaocui Wu, Jingyi Yu, Longhua Hu, Lizhong Han, Shuying Chen, Liang Chen, Fangyou Yu
Summary: This study characterized six ST8 strains collected from three tertiary hospitals in China, and found that two MRSA strains exhibited similar virulence potential as the epidemic USA300 strain. These findings highlight the need for enhanced surveillance of these highly virulent MRSA strains in China.
EMERGING MICROBES & INFECTIONS
(2022)
Article
Microbiology
Jinglong Liang, Teng Yi Huang, Yuzhu Mao, Xuejie Li
Summary: The biofilm formation of two genetically diverse Staphylococcus aureus isolates, 10379 and 121940, was evaluated under different concentrations of beta-lactam antibiotics. Despite their genetic differences, sub-inhibitory concentrations of beta-lactam antibiotics promoted biomass and biofilm viability of both isolates.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Immunology
Lennart Marlinghaus, Kordula Becker, Miriam Korte, Sandra Neumann, Soeren G. Gatermann, Florian Szabados
Article
Infectious Diseases
F. Szabados, M. Michels, M. Kaase, S. Gatermann
CLINICAL MICROBIOLOGY AND INFECTION
(2011)
Article
Infectious Diseases
F. Szabados, J. Woloszyn, M. Kaase, S. G. Gatermann
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2011)
Article
Infectious Diseases
J. Kehrmann, M. Kaase, F. Szabados, S. G. Gatermann, J. Buer, P-M Rath, J. Steinmann
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2011)
Review
Polymer Science
C. E. Fernandez, M. Bermudez, R. M. Versteegen, E. W. Meijer, G. J. Vancso, S. Munoz-Guerra
EUROPEAN POLYMER JOURNAL
(2010)
Article
Microbiology
Florian Szabados, Lennart Marlinghaus, Miriam Korte, Sandra Neumann, Martin Kaase, Soeren G. Gatermann
FEMS MICROBIOLOGY LETTERS
(2011)
Article
Microbiology
Florian Szabados, Karsten Becker, Christof von Eiff, Martin Kaase, Soeren Gatermann
INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY
(2011)
Article
Polymer Science
C. E. Fernandez, M. Bermudez, A. Alla, M. Mancera, M. G. Garcia-Martin, E. Benito, I. Roffe, J. A. Galbis, S. Munoz-Guerra
JOURNAL OF APPLIED POLYMER SCIENCE
(2010)
Article
Microbiology
Florian Szabados, Jaroslaw Woloszyn, Cindy Richter, Martin Kaase, Soeren Gatermann
JOURNAL OF MEDICAL MICROBIOLOGY
(2010)
Correction
Polymer Science
C. E. Fernandez, M. Bermudez, R. M. Versteegen, E. W. Meijer, A. J. Muller, S. Munoz-Guerra
JOURNAL OF POLYMER SCIENCE PART B-POLYMER PHYSICS
(2010)
Article
Polymer Science
C. E. Fernandez, M. Bermudez, S. Munoz-Guerra, S. Leon, R. M. Versteegen, E. W. Meijer
Article
Polymer Science
C. E. Fernandez, M. Bermudez, A. Alla, S. Munoz-Guerra, E. Tocha, G. J. Vancso
Letter
Microbiology
Florian Szabados, Anke Albrecht, Britta Kleine, Martin Kaase, Soeren Gatermann
VETERINARY MICROBIOLOGY
(2009)
