Additive Neuroprotective Effects of the Multifunctional Iron Chelator M30 with Enriched Diet in a Mouse Model of Amyotrophic Lateral Sclerosis

A metabolic switch toward lipid use in glycolytic muscle is an early pathologic event in a mouse model of amyotrophic lateral sclerosis

(2015) L. Palamiuc et al.   EMBO Molecular Medicine

New insights into PGC-1 coactivators: redefining their role in the regulation of mitochondrial function and beyond

(2015) Josep A. Villena   FEBS Journal

Molecular targets of the multifunctional iron-chelating drug, M30, in the brains of mouse models of type 2 diabetes mellitus

(2014) Danit Mechlovich et al.   BRITISH JOURNAL OF PHARMACOLOGY

Blood-spinal cord barrier disruption contributes to early motor-neuron degeneration in ALS-model mice

(2014) E. A. Winkler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A plural role for lipids in motor neuron diseases: energy, signaling and structure

(2014) Florent Schmitt et al.   Frontiers in Cellular Neuroscience

Iron Metabolism Disturbance in a French Cohort of ALS Patients

(2014) Charlotte Veyrat-Durebex et al.   Biomed Research International

Mitochondrial dysfunction in amyotrophic lateral sclerosis - a valid pharmacological target?

(2013) H Muyderman et al.   BRITISH JOURNAL OF PHARMACOLOGY

High-caloric food supplements in the treatment of amyotrophic lateral sclerosis: A prospective interventional study

(2013) Johannes Dorst et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

Inappropriately chelated iron in the cerebrospinal fluid of amyotrophic lateral sclerosis patients

(2012) Aleksandar Ignjatović et al.   Amyotrophic Lateral Sclerosis

The Novel Multi-Target Iron Chelating-Radical Scavenging Compound M30 Possesses Beneficial Effects on Major Hallmarks of Alzheimer's Disease

(2012) Lana Kupershmidt et al.   ANTIOXIDANTS & REDOX SIGNALING

The Role of PGC-1α in the Pathogenesis of Neurodegenerative Disorders

(2012) Krisztina Rona-Voros et al.   CURRENT DRUG TARGETS

Understanding ALS: new therapeutic approaches

(2012) Antonio Musarò   FEBS Journal

Amyloid precursor protein (APP) contributes to pathology in the SOD1G93A mouse model of amyotrophic lateral sclerosis

(2012) J. Barney Bryson et al.   HUMAN MOLECULAR GENETICS

Relationships between Disease Progression and Serum Levels of Lipid, Urate, Creatinine and Ferritin in Japanese Patients with Amyotrophic Lateral Sclerosis: A Cross-Sectional Study

(2012) Ken Ikeda et al.   INTERNAL MEDICINE

Neuroprotection by the multitarget iron chelator M30 on age-related alterations in mice

(2012) Lana Kupershmidt et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Mutant SOD1G93A triggers mitochondrial fragmentation in spinal cord motor neurons: Neuroprotection by SIRT3 and PGC-1α

(2012) Wenjun Song et al.   NEUROBIOLOGY OF DISEASE

Iron Accumulation in Deep Cortical Layers Accounts for MRI Signal Abnormalities in ALS: Correlating 7 Tesla MRI and Pathology

(2012) Justin Y. Kwan et al.   PLoS One

Creatine in mouse models of neurodegeneration and aging

(2011) T. Klopstock et al.   AMINO ACIDS

Nutritional state, energy intakes and energy expenditure of amyotrophic lateral sclerosis (ALS) patients

(2011) L. Genton et al.   CLINICAL NUTRITION

Peroxisome proliferator activator receptor gamma coactivator-1alpha (PGC-1α) improves motor performance and survival in a mouse model of amyotrophic lateral sclerosis

(2011) Wei Zhao et al.   Molecular Neurodegeneration

PGC-1α protects neurons and alters disease progression in an amyotrophic lateral sclerosis mouse model

(2011) Huiyun Liang et al.   MUSCLE & NERVE

Prevention of Motor Neuron Degeneration by Novel Iron Chelators in SOD1G93A Transgenic Mice of Amyotrophic Lateral Sclerosis

(2011) Qian Wang et al.   Neurodegenerative Diseases

PGC-1α at the intersection of bioenergetics regulation and neuron function: From Huntington's disease to Parkinson's disease and beyond

(2011) Taiji Tsunemi et al.   PROGRESS IN NEUROBIOLOGY

PGC-1α-mediated adaptations in skeletal muscle

(2010) Jesper Olesen et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Recent advances in amyotrophic lateral sclerosis research: perspectives for personalized clinical application

(2010) Chen Benkler et al.   EPMA Journal

Neuroprotective and neuritogenic activities of novel multimodal iron-chelating drugs in motor-neuron-like NSC-34 cells and transgenic mouse model of amyotrophic lateral sclerosis

(2009) Lana Kupershmidt et al.   FASEB JOURNAL

Dysregulation of Iron Homeostasis in the CNS Contributes to Disease Progression in a Mouse Model of Amyotrophic Lateral Sclerosis

(2009) S. Y. Jeong et al.   JOURNAL OF NEUROSCIENCE

Do patients with amyotrophic lateral sclerosis (ALS) have increased energy needs?

(2009) Nachum Vaisman et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Design, power, and interpretation of studies in the standard murine model of ALS

(2008) Sean Scott et al.   Amyotrophic Lateral Sclerosis

High metabolic level in patients with familial amyotrophic lateral sclerosis

(2008) Benoit Funalot et al.   Amyotrophic Lateral Sclerosis

Creatine and Its Potential Therapeutic Value for Targeting Cellular Energy Impairment in Neurodegenerative Diseases

(2008) Peter J. Adhihetty et al.   NEUROMOLECULAR MEDICINE