Article
Immunology
Chunlin Xiang, Xiaoxiao Wu, Youkang Wei, Tianlong Li, Xuemei Tang, Yi Wang, Xiaoqin Zhang, Xiaobo Huang, Yiping Wang
Summary: This article reports a rare case of severe septic shock caused by human parvovirus B19 infection after cardiac surgery. The virus can lead to septicemia, rash, fever, and other symptoms, especially in immunocompromised patients.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Virology
Massimo De Paschale, Claudia Pavia, Teresa Cerulli, Debora Cagnin, Maria T. Manco, Luisa Belvisi, Alessia Paganini, Laura Pogliani, Elena Ceriani, Alessandro Porta, Luciana Parola, Paola Mirri, Bianca Osnaghi, Laura Vismara, Pierangelo Clerici
Summary: Parvovirus B19 (B19V) infection in pregnancy is common in Italy, with higher IgG seroprevalence among Italian women compared to non-Italian women. The prevalence of viremia is low and does not lead to significant fetal damage at birth.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Medicine, General & Internal
Bijun Xu, Weimin Zhang, Ximing Qian, Shiqiang Wang, Fan He
Summary: Patients may develop severe anemia due to B19V infection after heart transplantation, with diagnosis relying on viral DNA detection and successful treatment achieved with intravenous immunoglobulin.
Article
Biotechnology & Applied Microbiology
Fenting Lei, Fancai Zeng, Xin Yu, Yiping Deng, Zongquan Zhang, Maochang Xu, Nianhui Ding, Ji Tian, Chunhong Li
Summary: Due to the failure of oral nano-delivery systems to target the colon and achieve controlled drug release in the treatment of inflammatory bowel disease (IBD), there is an urgent need to develop a microenvironment responsive drug delivery system. In this study, a pH-responsive hydrogel-coated nanoemulsion was successfully developed for the co-delivery of curcumin and emodin. The prepared system showed promising therapeutic effects in IBD by alleviating inflammation, repairing mucosal damage, and clearing reactive oxygen species.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Nathalie Stummer, Daniel Weghuber, Rene G. Feichtinger, Sara Huber, Johannes A. Mayr, Barbara Kofler, Daniel Neureiter, Eckhard Klieser, Sarah Hochmann, Wanda Lauth, Anna M. Schneider
Summary: This study found differences in the expression of H2S-metabolizing enzymes between normal aging and inflammatory bowel disease (IBD). Healthy adults and children exhibited lower expression levels of these enzymes, while adults and children with IBD tended to have even lower expression levels.
Article
Oncology
Li Gong, Jing Tian, Yan Zhang, Zheng Feng, Qiannan Wang, Yan Wang, Fuqin Zhang, Wei Zhang, Gaosheng Huang
Summary: The presence of germinal centers (GCs) in thymomas is closely associated with the pathogenesis of myasthenia gravis (MG), and infection by human parvovirus B19 (B19V) may contribute to the formation of ectopic GCs in thymoma. This study provides new insights into the etiopathogenic mechanism of MG and the role of B19V in thymoma-associated MG.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Gastroenterology & Hepatology
Alka A. Potdar, Shishir Dube, Takeo Naito, Katherine Li, Gregory Botwin, Talin Haritunians, Dalin Li, David Casero, Shaohong Yang, Janine Bilsborough, Jacqueline G. Perrigoue, Lee A. Denson, Mark Daly, Stephan R. Targan, Phillip Fleshner, Jonathan Braun, Subra Kugathasan, Thaddeus S. Stappenbeck, Dermot P. B. McGovern
Summary: The study identified differences in intestinal ACE2 expression levels in patients with Crohn's disease and ulcerative colitis, associated with inflammation and disease severity. Treatment with anti-cytokine therapy restored ACE2 expression, potentially impacting outcomes of severe acute respiratory syndrome coronavirus 2 infection.
Article
Virology
Daniela P. Mendes-de-Almeida, Joanna Paes Barreto Bokel, Arthur Daniel Rocha Alves, Alexandre G. Vizzoni, Isabel Cristina Ferreira Tavares, Mayara Secco Torres Silva, Juliana dos Santos Barbosa Netto, Beatriz Gilda Jegerhorn Grinsztejn, Luciane Almeida Amado Leon
Summary: Parvovirus B19 (B19V) infection can cause chronic anemia and transient aplastic crisis in patients with immunosuppression or chronic hemolysis. We report three rare cases of Brazilian adults living with HIV with B19V infection. All cases presented severe anemia and required red blood cell transfusions.
Article
Biochemistry & Molecular Biology
Nicola Bertazza Partigiani, Susanna Negrisolo, Andrea Carraro, Diana Marzenta, Elisabetta Manaresi, Giorgio Gallinella, Luisa Barzon, Elisa Benetti
Summary: Viral infections can lead to transplant dysfunction and may play a role in rejection. Analysis of protocol biopsies in 106 children at different time points after transplantation showed an increased prevalence of intrarenal viral infection between 6 and 12 months. Specifically, Parvovirus B19 infection was associated with antibody-mediated rejection. Monitoring and treatment of Parvovirus B19 infection in the early post-transplant period is important.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Gloria Bua, Pasquale Marrazzo, Elisabetta Manaresi, Chiara Gamberini, Laura Bonsi, Francesco Alviano, Giorgio Gallinella
Summary: Both BM-MSCs and FM-MSCs can be infected by B19V, although they cannot support viral replication, they allow persistence of the virus in the infected cultures. Further studies are needed to understand the potential role of MSCs in B19V transmission and the conditions that can favor a potential reactivation of the virus.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Infectious Diseases
Pengrui Cheng, Qian Jian, Zongli Fu, Yi Ma
Summary: This study presented a retrospective case series of adult liver transplant recipients with severe anemia associated with B19V infection, and reviewed the literature on this topic. The results showed that B19V infection should be considered early as a possible cause of severe anemia in adult liver transplant recipients. Most patients achieved long-term recovery from anemia after IVIG-based therapy, but some experienced relapses.
SURGICAL INFECTIONS
(2022)
Article
Nutrition & Dietetics
Julianne C. Yang, Jonathan P. Jacobs, Michael Hwang, Subrata Sabui, Fengting Liang, Hamid M. Said, Jonathan Skupsky
Summary: Biotin deficiency leads to intestinal inflammation and alterations in gut microbiome composition, favoring biotin-synthesizing opportunistic pathogens while reducing mucus-resident beneficial bacteria.
Article
Microbiology
Wei Wang, Xin Chen, Jie Pan, Xianhui Zhang, Liyun Zhang
Summary: This study found a high prevalence of EBV and CMV in Chinese IBD patients, and their prevalence is associated with clinical disease activities. Additionally, viral load in the intestinal mucosa is correlated with mucosal status. Quantitative real-time PCR is an effective method for monitoring EBV and CMV infection in IBD patients.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Medicine, General & Internal
Alexandros Toskas, Stefanos Milias, Georgios Delis, Soultana Meditskou, Antonia Sioga, Theodora Papamitsou
Summary: Interleukins are potential therapeutic targets for IBD. The expression of IL-21 was increased in UC and CD groups, while IL-33 expression was increased after treatment in UC and CD groups, suggesting a protective role against bowel inflammation. This study provides valuable insights into the use of interleukins as biomarkers and potential therapeutic targets for IBD.
Review
Medicine, General & Internal
Stergiani Keramari, Alexandros Poutoglidis, Stefanos Chatzis, Michael Keramaris, Christos Savopoulos, Georgia Kaiafa
Summary: B19V infection can lead to myocarditis in pediatric patients, which has a high mortality rate. Common symptoms include tachycardia, tachypnea, fever, and rash. Cardiac arrest, loss of consciousness, and systemic infection are associated with a worse prognosis. Treatment with immunosuppressive agents and immunoglobulin is beneficial for patients.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Nutrition & Dietetics
Ashley Bond, Maja Kopczynska, Thomas Conley, Antje Teubner, Michael Taylor, Arun Abraham, Loris Pironi, Simon Lal
Summary: This study found that the occurrence of fungal CRBSI does not increase the risk of death.
JOURNAL OF PARENTERAL AND ENTERAL NUTRITION
(2023)
Article
Nutrition & Dietetics
Loris Pironi, Kurt Boeykens, Federico Bozzetti, Francisca Joly, Stanislaw Klek, Simon Lal, Marek Lichota, Stefan Muehlebach, Andre Van Gossum, Geert Wanten, Carolyn Wheatley, Stephan C. Bischoff
Summary: This guideline provides information and recommendations for healthcare professionals and patients on appropriate and safe home parenteral nutrition (HPN) provision. It is based on previous guidelines and includes 71 recommendations covering various aspects of HPN. The evidence was evaluated and clinical recommendations were developed using the Scottish Intercollegiate Guidelines Network methodology. The guideline was commissioned and supported by ESPEN.
CLINICAL NUTRITION
(2023)
Article
Virology
Federica Bichicchi, Niccolo Guglietta, Arthur Daniel Rocha Alves, Erika Fasano, Elisabetta Manaresi, Gloria Bua, Giorgio Gallinella
Summary: This study investigated the genomic sequence heterogeneity of Parvovirus B19 (B19V) using Next Generation Sequencing (NGS) techniques and a bioinformatics tool. The results showed that NGS analysis and the developed tool can effectively study sequence diversity, providing a better understanding of viral evolution dynamics within the quasispecies framework.
Article
Nutrition & Dietetics
Anne Marie Sowerbutts, Simon Lal, Loris Pironi, Debra Jones, Chloe French, Marianne Riis, Andrew Clamp, Jennifer McCracken, Leanne Williamson, Carolyn Wheatley, Bethany Johnson, Sorrel Burden
Summary: This study aimed to identify research questions regarding home parenteral nutrition in patients with chronic intestinal failure, using a five-stage process that involved surveying participants, data processing, and priority setting. The top research priorities included quality of life, survival, when to commence HPN, and ethical implications.
CLINICAL NUTRITION ESPEN
(2023)
Article
Nutrition & Dietetics
Benjamin Hess, Martin Cahenzli, Alastair Forbes, Rosa Burgos, Federico Coccolini, Olivier Corcos, Mette Holst, Oivind Irtun, Stanislaw Klek, Loris Pironi, Henrik Hojgaard Rasmussen, Mireille J. Serlie, Ronan Thibault, Simon Gabe, Annika Reintam Blaser
Summary: This survey assesses current attitudes and practices in managing acute mesenteric ischemia (AMI) worldwide. Results show that diagnosis of AMI is often delayed but rarely missed. Abdominopelvic CT-scan with intravenous contrast was suggested as the most useful diagnostic test. Treatment approaches vary greatly, indicating the need for updated guidelines.
CLINICAL NUTRITION ESPEN
(2023)
Article
Biochemistry & Molecular Biology
Nicola Bertazza Partigiani, Susanna Negrisolo, Andrea Carraro, Diana Marzenta, Elisabetta Manaresi, Giorgio Gallinella, Luisa Barzon, Elisa Benetti
Summary: Viral infections can lead to transplant dysfunction and may play a role in rejection. Analysis of protocol biopsies in 106 children at different time points after transplantation showed an increased prevalence of intrarenal viral infection between 6 and 12 months. Specifically, Parvovirus B19 infection was associated with antibody-mediated rejection. Monitoring and treatment of Parvovirus B19 infection in the early post-transplant period is important.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Gloria Bua, Pasquale Marrazzo, Elisabetta Manaresi, Chiara Gamberini, Laura Bonsi, Francesco Alviano, Giorgio Gallinella
Summary: Both BM-MSCs and FM-MSCs can be infected by B19V, although they cannot support viral replication, they allow persistence of the virus in the infected cultures. Further studies are needed to understand the potential role of MSCs in B19V transmission and the conditions that can favor a potential reactivation of the virus.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Nutrition & Dietetics
Loris Pironi, Johane P. P. Allard, Francisca Joly, Parnia Geransar, Elisabeth Genestin, Ulrich-Frank Pape
Summary: Short bowel syndrome (SBS) is a rare gastrointestinal disorder associated with intestinal failure (SBS-IF) and poor health-related outcomes. Patients with SBS-IF require long-term intravenous supplementation (IVS) and the goal of treatment is to reduce or eliminate the need for IVS. Teduglutide, a glucagon-like peptide 2 analog, has been shown to be effective in reducing IVS dependence and improving the quality of life for SBS-IF patients. The management of SBS-IF patients is complex and requires close monitoring.
NUTRITION IN CLINICAL PRACTICE
(2023)
Article
Gastroenterology & Hepatology
Claudio Ricci, Francesco Serbassi, Laura Alberici, Carlo Ingaldi, Leonardo H. Eusebi, Emilio De Raffele, Loris Pironi, Anna S. Sasdelli, Cristina Mosconi, Valentina Vicennati, Riccardo Casadei
Summary: Immunonutrition can reduce infectious complications and length of stay in patients undergoing pancreatic surgery. However, the small differences in mortality, morbidity, and postoperative pancreatic fistula rates make it impossible to exclude type II error due to large sample sizes.
Article
Oncology
Arianna Orsini, Luca Mastracci, Isotta Bozzarelli, Anna Ferrari, Federica Isidori, Roberto Fiocca, Marialuisa Lugaresi, Antonietta D'Errico, Deborah Malvi, Erica Cataldi-Stagetti, Paola Spaggiari, Anna Tomezzoli, Luca Albarello, Ari Ristimaki, Luca Bottiglieri, Kausilia K. Krishnadath, Riccardo Rosati, Uberto Fumagalli Romario, Giovanni De Manzoni, Jari Rasanen, Giovanni Martinelli, Sandro Mattioli, Elena Bonora
Summary: Esophageal adenocarcinoma (EAC) is a severe malignancy with increasing incidence, poorly understood pathogenesis, and low survival rates. TP53 gene alterations, especially missense mutations, negatively affect cancer-specific survival in EAC. HNF1alpha gene disruption is associated with other gene alterations and is identified as a new EAC-mutated gene.
Article
Nutrition & Dietetics
Loris Pironi, Denise Jezerski, Jacek Sobocki, Simon Lal, Tim Vanuytsel, Miriam Theilla, Anna S. Sasdelli, Cecile Chambrier, Konrad Matysiak, Umberto Aimasso, Henrik H. Rasmussen, Amelia Jukes, Marek Kunecki, David Seguy, Stephane M. Schneider, Joanne Daniels, Florian Poullenot, Manpreet S. Mundi, Przemyslaw Matras, Marcin Folwarski, Adriana Crivelli, Nicola Wyer, Lars Ellegard, Lidia Santarpia, Marianna Arvanitakis, Corrado Spaggiari, Georg Lamprecht, Francesco W. Guglielmi, Antonella Lezo, Sabrina Layec, Esther Ramos Boluda, Anat Guz-Mark, Paolo Gandullia, Cristina Cuerda, Emma Osland, Maria I. Spagnuolo, Zeljko Krznaric, Luisa Masconale, Brooke Chapman, Maria Maiz-Jimenez, Paolo Orlandoni, Mariana Hollanda Martins da Rocha, M. Nuria Virgili-Casas, Maryana Doitchinova-Simeonova, Laszlo Czako, Andre Van Gossum, Lorenzo D'Antiga, Looi C. Ee, Daruneewan Warodomwichit, Marina Taus, Sanja Kolacek, Ronan Thibault, Giovanna Verlato, Aurora E. Serralde-Zuniga, Jose I. Botella-Carretero, Pilar Serrano Aguayo, Gabriel Olveira, Sirinuch Chomtho, Veeradej Pisprasert, Georgijs Moisejevs, Ana Zugasti Murillo, Ma Estrella Petrina Jauregui, Marta Bueno Diez, Mohammad Shukri Jahit, Narumon Densupsoontorn, Ali Tamer, Giorgia Brillanti, Francisca Joly
Summary: This study investigated the incidence and severity of COVID-19 infection in patients receiving home parenteral nutrition (HPN) for chronic intestinal failure (CIF) from a European database. The results showed a significant variation in infection rates among countries, with the majority of cases being asymptomatic or mild but a significant proportion of infected patients experiencing severe or fatal outcomes. Lack of vaccination was associated with a higher risk of death.
CLINICAL NUTRITION ESPEN
(2023)
Article
Nutrition & Dietetics
Parnia Geransar, Simon Lal, Palle B. Jeppesen, Loris Pironi, Ewelina Rzepa, Stephane M. Schneider
Summary: The ATLAS Programme increased awareness and addressed inconsistencies in the care of patients with chronic intestinal failure across Europe. A survey showed that multidisciplinary team collaboration is important, improving quality of life is the top treatment goal, but challenges include lack of disease awareness and insufficient referral centers.
CLINICAL NUTRITION ESPEN
(2023)
Article
Nutrition & Dietetics
Loris Pironi, Cristina Cuerda, Palle Bekker Jeppesen, Francisca Joly, Cora Jonkers, Zeljko Krznaric, Simon Lal, Georg Lamprecht, Marek Lichota, Manpreet S. Mundi, Stephane Michel Schneider, Kinga Szczepanek, Andre Van Gossum, Geert Wanten, Carolyn Wheatley, Arved Weimann
Summary: ESPEN has published guidelines for Chronic Intestinal Failure (CIF) in adults and has now updated the guidelines specifically for CIF caused by benign diseases. The new guidelines include new evidence and provide recommendations on various topics such as IF centers, chronic enterocutaneous fistulas, caring for CIF patients during pregnancy, and transition of patients from pediatric to adult centers.
CLINICAL NUTRITION
(2023)
Article
Virology
Giorgio Gallinella, Antonio Marchini
Summary: The XVIII International Parvovirus Workshop was held in Italy in 2022, covering various aspects of research in the field, including virus-host interactions and clinical and veterinarian virology. The conference included oral communications, poster exhibitions, and served as a platform for academic exchange and discussion. The workshop was dedicated to honoring the memory of Mavis Agbandje-McKenna.
Article
Psychiatry
Lucia Brodosi, Michele Stecchi, Francesca Marchignoli, Elisabetta Lucia, Lucia Magnani, Valeria Guarneri, Maria Letizia Petroni, Giulio Marchesini, Loris Pironi
Summary: This study aimed to evaluate the association between metabolic dysfunction-associated steatotic liver disease (MASLD) and eating disorders. The results showed that binge eating disorder (BED) was present in approximately 17.8% of MASLD patients screened in a specialized metabolic disorders unit. This study highlights the importance of addressing eating disorders in the treatment of MASLD.
EATING AND WEIGHT DISORDERS-STUDIES ON ANOREXIA BULIMIA AND OBESITY
(2023)
