Article
Infectious Diseases
Dylan Dobbyn, Teagan Zeggil, Brendan Kudrowich, Nathan P. Beahm
Summary: The resistance of Escherichia coli to fluoroquinolones varies regionally in Canada, with only a few regions meeting the recommended treatment threshold. Outpatient populations have the highest susceptibility to fluoroquinolones, and rural populations generally have higher susceptibility than urban populations. Fluoroquinolone resistance in E. coli in Canada has increased rapidly in the past 20 years but is now plateauing. However, fluoroquinolones are rarely the first-line treatment option for urinary tract infections in Canada in the absence of other therapeutic options.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2022)
Article
Infectious Diseases
Toyotaka Sato, Shin-ichi Yokota, Tooru Tachibana, Satoshi Tamai, Shigeki Maetani, Yutaka Tamura, Motohiro Horiuchi
Summary: The study found that companion animals can carry fluoroquinolone-resistant Escherichia coli, which may be associated with human clinical infections and can potentially be transmitted to their owners.
Article
Cell Biology
Timothy Kudinha, Fanrong Kong
Summary: The prevalence of ST131, especially among ciprofloxacin resistant isolates, increased from fecal to clinical samples in women, men, and children. ST131 isolates showed higher virulence potential compared to non-ST131 isolates, particularly in urinary samples. There was a strong association between ST131 prevalence and fluoroquinolone resistance, with FQ resistant ST131 isolates harboring more virulence genes.
JOURNAL OF BIOMEDICAL SCIENCE
(2022)
Article
Infectious Diseases
Jose Vazquez-Villanueva, Karina Vazquez, Ana Veronica Martinez-Vazquez, Alfredo Wong-Gonzalez, Jesus Hernandez-Escareno, Omar Cabrero-Martinez, Wendy Lizeth Cruz-Pulido, Abraham Guerrero, Gildardo Rivera, Virgilio Bocanegra-Garcia
Summary: This study analyzed 336 samples from a bovine slaughterhouse and found that 83.3% of the samples were positive for E. coli infection. The study revealed that these E. coli isolates exhibited resistance to multiple antibiotics and carried various virulence factors and resistance genes. Therefore, E. coli poses a threat to public health.
Article
Agriculture, Dairy & Animal Science
Toshiyuki Murase, Hiroichi Ozaki
Summary: This study showed that the prevalence of phylogroup F was higher in colibacillosis-related isolates compared to healthy chicken-related isolates, while phylogroups A and B1 were more commonly found in the latter. APEC strains with virulence-associated genes were more prevalent in colibacillosis-related isolates, indicating that phylogroup F can predict colibacillosis in E. coli strains.
Article
Infectious Diseases
Yohannes E. Messele, Darren J. Trott, Mauida F. Hasoon, Tania Veltman, Joe P. McMeniman, Stephen P. Kidd, Steven P. Djordjevic, Kiro R. Petrovski, Wai Y. Low
Summary: The genetic characteristics and phylogenetic relationships among Escherichia coli isolates from cattle, pigs, poultry, and humans were analyzed using whole genome sequencing data. Most cattle and pig isolates belonged to phylogroups A and B1, while avian and human isolates belonged to B2 and D. Some cattle isolates carried extended-spectrum and AmpC beta-lactamase genes. The results indicate that cattle isolates from feedlots pose a reduced risk of being a source of clinically important antimicrobial-resistant E. coli.
Article
Microbiology
Wan-Ting Yang, I-Ju Chiu, Yao-Ting Huang, Po-Yu Liu
Summary: This study used comparative genomics to investigate the fluoroquinolone-resistant mechanisms of carbapenem-resistant E. coli (CREc) and identified a new carbapenem resistance mechanism. Additionally, the study examined the clinical characteristics of CREc and found it to be polyclonal and highly diverse in Taiwan.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Microbiology
Jullia A. S. Nascimento, Fernanda F. Santos, Jose F. Santos-Neto, Liana O. Trovao, Tiago B. Valiatti, Isabel C. Pinaffi, Monica A. M. Vieira, Rosa M. Silva, Ivan N. Falsetti, Ana C. M. Santos, Tania A. T. Gomes
Summary: This study evaluated E. coli isolates from 172 outpatient with UTI and found that phylogroup B2 strains were predominant, along with the presence of various virulence factors associated with diarrheagenic and extraintestinal pathogenic E. coli. Some strains showed uropathogenic potential, including a few classified as hybrid strains. These hybrid strains interacted with renal and bladder cells, highlighting their uropathogenic capabilities.
Article
Veterinary Sciences
Pouya Reshadi, Fatemeh Heydari, Reza Ghanbarpour, Mahboube Bagheri, Maziar Jajarmi, Mohadese Amiri, Hesam Alizade, Mahdi Askari Badouei, Shademan Sahraei, Nasrin Adib
Summary: The study determined the phylogenetic background and prevalence of diarrheagenic E. coli and antimicrobial resistance in healthy riding-horses in Iran. The most prevalent antimicrobial resistance phenotypes were against amoxicillin/clavulanic acid and ceftriaxone. The study also found that 26.15% of the E. coli isolates were multi-drug resistant (MDR).
BMC VETERINARY RESEARCH
(2021)
Article
Environmental Sciences
Shaqiu Zhang, Shuling Chen, Mujeeb Ur Rehman, Hong Yang, Zhishuang Yang, Mingshu Wang, Renyong Jia, Shun Chen, Mafeng Liu, Dekang Zhu, Xinxin Zhao, Ying Wu, Qiao Yang, Juan Huan, Xumin Ou, Sai Mao, Qun Gao, Di Sun, Bin Tian, Anchun Cheng
Summary: The study revealed that healthy waterfowls harbor E. coli with multiple ARGs and various ExPEC-associated VAGs. The findings suggest the need for regulated antibiotic use to prevent the direct or indirect spread of these resistant and potentially pathogenic microbes to the natural environment.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Ecology
Ayush Pathak, Daniel C. Angst, Ricardo Leon-Sampedro, Alex R. Hall
Summary: Some bacterial resistance mechanisms can degrade antibiotics, potentially protecting neighboring susceptible cells. However, the effects of such mechanisms on bacterial communities of more than two species are not well understood. By conducting experiments on multispecies communities, we found that resistance in one species reduced antibiotic inhibition of other species, but the extent of benefit varied among species.
Article
Immunology
Bongyoung Kim, Jeoungyeon Kim, Hyun-uk Jo, Ki Tae Kwon, Seong-yeol Ryu, Seong-Heon Wie, Jieun Kim, Se Yoon Park, Kyung-Wook Hong, Hye In Kim, Mi Hyun Bae, Hyun ah Kim, Mi-Hee Kim, Yong-Hak Sohn, Yangsoon Lee, Hyunjoo Pai
Summary: This study examines the changes in characteristics of community-onset fluoroquinolone-resistant E. coli isolates causing community-acquired acute pyelonephritis in South Korea. The results show an increase in antimicrobial resistance against cephalosporins, as well as the prevalence of ST131 and the presence of ESBL and/or PMQR determinants in the isolates from 2017-2018 compared to those from 2010-2011.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2022)
Article
Microbiology
Anna Dziuba, Sylwia Dzierzak, Anna Sodo, Monika Wawszczak-Kasza, Katarzyna Zegadlo, Jakub Bialek, Natalia Zych, Wojciech Kiebzak, Jaroslaw Matykiewicz, Stanislaw Gluszek, Wioletta Adamus-Bialek
Summary: In this study, we demonstrated significant differences between urine-derived E. coli and other clinical E. coli isolates in terms of pathogenicity. We suggest excluding penicillins from use in E. coli infection at this time and monitoring strains with a high pathogenicity potential.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Immunology
Razie Kamali Dolatabadi, Hossein Fazeli, Mohammad Hassan Emami, Vajihe Karbasizade, Fatemeh Maghool, Alireza Fahim, Hojatollah Rahimi
Summary: The study investigated the incidence and features of AIEC and cyclomodulins in colorectal cancer patients, finding that AIEC strains from B2 phylogroup were more likely to colonize left-sided colon carcinoma and adenocarcinoma T >= 1 stage. Rep-PCR analysis showed close genetic relatedness among AIEC isolates.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Xi Lu, Dingyan Wu, Xin Zhao, Mingxin Zhang, Ke Ren, Ningning Zhou, Yanni Zhao, Weisheng Qian
Summary: Enterotoxigenic Escherichia coli (ETEC), a diarrheal pathogen, can utilize ethanolamine (EA) as a nitrogen source, which enhances its virulence phenotype and causes damage to host intestinal cells. The concentration of EA in the intestine also impacts the metabolic profile and pathogenicity of ETEC.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2022)