Article
Biochemistry & Molecular Biology
Iwona Lesiak-Markowicz, Julia Walochnik, Angelika Stary, Ursula Furnkranz
Summary: This study characterized TV isolates from Austrian patients and found that 35% of the isolates carried TVV (TVV1, TVV2, or TVV3) and 28% of the isolates carried M. hominis. In some patients, M. hominis was detected both in the clinical samples and the respective TV isolates.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Health Care Sciences & Services
Ahinoam Lev-Sagie, Doris Strauss, Avraham Ben Chetrit
Summary: This study evaluated the performance of an automated microscope for the diagnosis of vaginitis and found that it has high sensitivity and specificity. It has the potential to improve the first-line evaluation of various types of vaginal disorders.
NPJ DIGITAL MEDICINE
(2023)
Review
Immunology
Saeed Bahadory, Selva Aminizadeh, Ali Taghipour, Farah Bokharaei-Salim, Khadijeh Khanaliha, Mohammad Hossein Razizadeh, Alireza Soleimani, Leila Beikzadeh, Alireza Khatami
Summary: This study aimed to estimate the global and regional status of Trichomonas vaginalis virus (TVV) in T. vaginalis. The results showed a high prevalence of TVV, especially in Brazil, emphasizing the importance of paying attention to parasite behavior and conducting more studies for a deeper understanding of this coexistence.
MICROBIAL PATHOGENESIS
(2021)
Article
Immunology
Christina A. Muzny, Jane R. Schwebke, Paul Nyirjesy, Gregory Kaufman, Leandro A. Mena, Gweneth B. Lazenby, Olivia T. Van Gerwen, Keonte J. Graves, Janeen Arbuckle, Belvia A. Carter, Connette P. McMahon, Scott Eder, Jackie Shaw, Brajesh Pandey, Steven E. Chavoustie
Summary: The study showed that a single oral dose of secnidazole was significantly more effective in treating trichomoniasis compared to placebo, with cure rates higher in the secnidazole group across different patient populations, including those with HIV and bacterial vaginosis.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Microbiology
Barbara Van der Pol, Arundhati Rao, Melinda B. Nye, Steven Chavoustie, Aaron Ermel, Clair Kaplan, David Eisenberg, Philip A. Chan, Leandro Mena, Sixto Pacheco, Ken B. Waites, Li Xiao, Smitha Krishnamurthy, Ruchika Mohan, Rasa Bertuzis, Chris L. McGowin, Rodney Arcenas, Elizabeth M. Marlowe, Stephanie N. Taylor
Summary: Trichomonas vaginalis is a prevalent sexually transmitted infection, with nucleic acid amplification tests showing higher sensitivity in diagnosis compared to microscopic analysis or culture. Men are often asymptomatic carriers of the organism, transmitting it to their female sexual partners. The cobas T. vaginalis/Mycoplasma genitalium assay demonstrates high sensitivity for detecting T. vaginalis DNA in both male and female patients, making it a suitable diagnostic tool for infection control efforts.
JOURNAL OF CLINICAL MICROBIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Fernanda Padoin dos Reis, Graziela Vargas Rigo, Cristina Wayne Nogueira, Tiana Tasca, Marcel Henrique Marcondes Sari, Leticia Cruz
Summary: This study designed and evaluated a vaginal hydrogel containing PhSe2-loaded Eudragit (R) RS100 and coconut oil nanocapsules for the treatment of trichomoniasis. The nanocapsules showed good chemical content and high encapsulation efficiency. The hydrogel displayed non-Newtonian pseudo-plastic behavior and high mucoadhesive properties, which could effectively deliver and maintain the drug's action. These formulations showed potential as a promising alternative for the treatment of trichomoniasis.
Article
Biochemistry & Molecular Biology
Nehuen Salas, Veronica M. Coceres, Tuanne dos Santos Melo, Antonio Pereira-Neves, Vanina G. Maguire, Tania M. Rodriguez, Bruna Sabatke, Marcel Ramirez, Jihui Sha, James A. Wohlschlegel, Natalia de Miguel
Summary: Trichomonas vaginalis is a sexually transmitted extracellular parasite that adheres to epithelial cells in the human urogenital tract. Extracellular vesicles (EVs) play an important role in its pathogenesis by delivering proteins and RNA into host cells and modulating parasite adherence. This study demonstrates that VPS32, a member of the ESCRTIII complex, contributes to the biogenesis and cargo sorting of EVs in T. vaginalis. Furthermore, overexpression of VPS32 leads to increased parasite adherence to host cells, highlighting its key role in mediating host-parasite interactions.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Microbiology
Ina Hoxha, Iwona Lesiak-Markowicz, Julia Walochnik, Angelika Stary, Ursula Fuernkranz
Summary: This study aimed to assess the prevalence of non-STI Mycoplasma infections through molecular-based analyses of vaginal specimens. The results showed a 28.2% prevalence of Mycoplasma species in the collected samples, with Mycoplasma hominis found in 21.5% of the specimens and Ureaplasma species found in 7.5% of the samples. Furthermore, a newly described species of Mycoplasma was detected for the first time in Austria. This study further confirmed the symbiotic relationship between Mycoplasma hominis and T. vaginalis.
Article
Medicine, Research & Experimental
Juliana Ines Weber, Graziela Vargas Rigo, Debora Assumpcao Rocha, Isadora Serraglio Fortes, Adriana Seixas, Saulo Fernandes de Andrade, Tiana Tasca
Summary: The study demonstrated that a new compound, PH100, has the ability to kill Trichomonas vaginalis, showing activity against both clinical isolates and ATCC strains with a synergistic effect with metronidazole. The mechanism of action of PH100 involves apoptosis-like characteristics towards ATCC 30236, but distinct profiles were observed in the fresh clinical isolate.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Infectious Diseases
Rehnuma Parvez, Alwin Vins, Varadharajaperumal Radhakrishnan, Nisha Beniwal, Lipika Biswas, Nithu Thankachan, Harpreet Kaur, Nagarajan Muruganandam
Summary: This study was the first-ever conducted on the prevalence of Trichomonas vaginalis (TV) in the Andaman and Nicobar Islands. The study found a 0.9% infection rate, with the majority of infected individuals having lower education levels and being unemployed. The detection of the TV G3 strain may be important for understanding the prevalence of TV infection and associated risk factors. More research is needed to understand the TV-associated risk factors among suspected patients in hospital settings.
INFECTIOUS DISEASES
(2023)
Article
Biochemistry & Molecular Biology
Graziela Vargas Rigo, Angelica Rocha Joaquim, Alexandre Jose Macedo, Saulo Fernandes de Andrade, Tiana Tasca
Summary: In this study, a derivative with selective anti-Trichomonas vaginalis activity was reported. Cytotoxicity assays showed selectivity for the parasite, and low toxicity was confirmed in animal models. The mode of action was related to the disruption of Fe-S clusters-dependent enzyme activities in the parasite. Proteomic analysis indicated inhibition of metallopeptidases related to T. vaginalis virulence mechanisms and metabolic pathways.
BIOORGANIC CHEMISTRY
(2022)
Article
Biology
Jitka Kucerova, Alois Zdrha, Abhishek Shinde, Karel Harant, Ivan Hrdy, Jan Tachezy
Summary: This study investigated the distribution of ERMES in organisms with hydrogenosomes and used Trichomonas vaginalis as a model to estimate the cellular localization, structure, and function of ERMES.
Article
Immunology
Shang-Ying Hu, Sabrina H. Tsang, Feng Chen, Qin-Jing Pan, Wen-Hua Zhang, Ying Hong, Joshua N. Sampson, Allan Hildesheim, Fang-Hui Zhao, Aimee R. Kreimer
Summary: The study found that vaginal infections are associated with incident non-HPV16/18 infections in the cervix, but do not impact the persistence of non-HPV16/18 infections after 6 months among women vaccinated with HPV16/18.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Parasitology
Mina Ebrahimi, Mahbobeh Montazeri, Amirhosien Ahmadi, Sanam Nami, Hamed Hamishehkar, Firooz Shahrivar, Nayer Mehdizad Bakhtiar, Veeranoot Nissapatorn, Adel Spotin, Ehsan Ahmadpour
Summary: The study compared the anti-Trichomonas effects of nano-liposomal metronidazole (NLMTZ) and metronidazole (MTZ) in vitro, and found that NLMTZ had a higher inhibitory effect on Trichomonas growth, completely lysing the parasites in a shorter period of time, with higher IC50 values and inducing higher levels of apoptosis.
Article
Biotechnology & Applied Microbiology
Ricardo Rubio-Sanchez, Rocio Rios-Reina, Cristina Ubeda
Summary: Trichomoniasis, caused by Trichomonas vaginalis, is the most common non-viral sexually transmitted infection worldwide. Its importance lies in its ease of transmission and the absence of symptoms in most cases. The study aimed to identify volatile biomarkers in vaginal discharge and urine of patients with Trichomonas vaginalis infection. Potential biomarkers were identified in both samples, suggesting their potential as a diagnostic tool.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2023)
