Article
Multidisciplinary Sciences
Maarten Hulsmans, Maximilian J. Schloss, I-Hsiu Lee, Aneesh Bapat, Yoshiko Iwamoto, Claudio Vinegoni, Alexandre Paccalet, Masahiro Yamazoe, Jana Grune, Steffen Pabel, Noor Momin, Hana Seung, Nina Kumowski, Fadi E. Pulous, Daniel Keller, Constanze Bening, Ursula Green, Jochen K. Lennerz, Richard N. Mitchell, Andrew Lewis, Barbara Casadei, Oriol Iborra-Egea, Antoni Bayes-Genis, Samuel Sossalla, Chin Siang Ong, Richard N. Pierson, Jon C. Aster, David Rohde, Gregory R. Wojtkiewicz, Ralph Weissleder, Filip K. Swirski, George Tellides, George Tolis, Serguei Melnitchouk, David J. Milan, Patrick T. Ellinor, Kamila Naxerova, Matthias Nahrendorf
Summary: This study deciphered the role of immune and stromal cells in atrial fibrillation and identified SPP1(+) macrophages as potential targets for immunotherapy in atrial fibrillation.
Review
Cardiac & Cardiovascular Systems
Dongbo Yu, James K. Liao
Summary: This review discusses the development of statins, their non-lipid-lowering benefits, and proposes future research directions in this field.
CARDIOVASCULAR RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Ching-Han Liu, Shih-Chung Huang, Chun-Hao Yin, Wei-Chun Huang, Jin-Shuen Chen, Yao-Shen Chen, Su-Ting Gan, Shiow-Jyu Tzou, Ching-Tsai Hsu, Hao-Ming Wu, Wen-Hwa Wang
Summary: Individuals of Asian descent have a higher risk of developing hyperuricemia and gout compared to Western populations. Urate-lowering therapy is effective in treating hyperuricemia and gout. However, the association between febuxostat, a type of urate-lowering therapy, and atrial fibrillation (AF) in Asian populations has not been properly investigated.
Article
Medicine, Research & Experimental
Eva R. Meulendijks, Rushd F. M. Al-Shama, Makiri Kawasaki, Benedetta Fabrizi, Jolien Neefs, Robin Wesselink, Auriane C. Ernault, Sander Piersma, Thang V. Pham, Connie R. Jimenez, Jaco C. Knol, Wim J. P. van Boven, Antoine H. G. Driessen, Tim A. C. de Vries, Britt van der Leeden, Hans W. M. Niessen, Onno J. de Boer, Sebastien P. J. Krul, Joris R. de Groot
Summary: The secretome of epicardial adipose tissue (EAT) from patients with atrial fibrillation (AF) induces extracellular matrix (ECM) production in atrial fibroblasts. Myeloperoxidase is the most increased protein in the EAT secretome and EAT from patients with AF. Myeloperoxidase and neutrophil extracellular traps (NETs) play a role in the pathophysiology of AF.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Review
Cardiac & Cardiovascular Systems
Ascension M. de los Reyes-Garcia, Laura Zapata-Martinez, Sonia Aguila, Maria L. Lozano, Constantino Martinez, Rocio Gonzalez-Conejero
Summary: Atrial fibrillation is a complex disease and microRNAs play a crucial role in the development of major adverse cardiovascular events (MACE) in these patients. MicroRNAs have been investigated as potential biomarkers for various diseases, including cardiovascular diseases. Some studies have associated certain microRNAs in plasma with the occurrence of MACE in atrial fibrillation. However, the lack of standardization in the purification and detection of microRNAs has produced contradictory results. Additionally, microRNAs have a functional impact on MACE in atrial fibrillation through the dysregulation of immunothrombosis, suggesting their potential use as therapy against thromboinflammatory processes.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Review
Physiology
Yajun Yao, Mei Yang, Dishiwen Liu, Qingyan Zhao
Summary: Immune remodeling is a new direction for research and therapeutic strategies for atrial fibrillation (AF) as it has complex relationships with atrial electrical, structural, and neural remodeling. It may provide effective therapies for AF.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Pharmacology & Pharmacy
J. Robert Powell, Farah Al Qaraghuli, Jill Fiedler-Kelly, Daniel Gonzalez, Daniel Weiner
Summary: Dabigatran, a direct-acting oral anticoagulant, is more effective than warfarin in stroke reduction and has similar bleeding risk in adult patients with atrial fibrillation. Its efficacy and safety correlate with steady-state plasma concentrations. A population pharmacokinetic model based on clinical trial patients was used to compare different dosing regimens, and an improved regimen requiring five different dosing schedules was identified. This information can better inform patient outcomes and guide future dabigatran development.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Hematology
Kiyotaka Oi, Mie Shimizu, Tatsunori Natori, Keisuke Tsuda, Makiko Yoshida, Asami Kamada, Yoko Ishigaku, Shinsuke Narumi, Kazumasa Oura, Tetsuya Maeda, Yasuo Terayama
Summary: The study evaluated the expression and activation of PAR-1 and CD62P on platelets from NVAF patients before and after dabigatran treatment. The results showed lower PAR-1 expression in NVAF patients and inhibition of CD62P expression by dabigatran treatment, indicating potential antithrombotic activity with antiplatelet and anticoagulant effects.
THROMBOSIS RESEARCH
(2021)
Article
Nutrition & Dietetics
Youzheng Dong, Ting Huang, Zhenyu Zhai, Quanbin Dong, Zhen Xia, Zirong Xia, Jianhua Yu, Xinghua Jiang, Kui Hong, Yanqing Wu, Xiaoshu Cheng, Juxiang Li
Summary: In H-type hypertensive AF patients treated with first RFCA, folic acid supplementation is associated with a reduced risk of AF recurrence.
FRONTIERS IN NUTRITION
(2022)
Article
Cell Biology
Julian Friebel, Marco Witkowski, Max Wegner, Leon Bloebaum, Stella Lammel, Philipp-Alexander Schencke, Kai Jakobs, Marianna Puccini, Daniela Reissner, Daniel Steffens, Verena Moos, Heinz-Peter Schutheiss, Ulf Landmesser, Ursula Rauch
Summary: This study investigates the role of thrombin receptor (PAR1) in thrombo-inflammation mediated by cytotoxic CD8(+) T lymphocytes in patients with first-diagnosed atrial fibrillation (AF). The results demonstrate that PAR1 activation is associated with inflammation and cytotoxic function, and its activation is correlated with adverse cardiac remodeling and atrial dysfunction biomarkers. Interventions targeting this cascade may be a promising approach for reducing disease progression and vascular complications of AF.
Article
Multidisciplinary Sciences
Xia Zhong, Huachen Jiao, Dongsheng Zhao, Jing Teng
Summary: The study found a negative association between apolipoprotein B (APOB) and atrial fibrillation (AF) in both men and women, suggesting its potential value as a biomarker for AF.
SCIENTIFIC REPORTS
(2022)
Article
Cardiac & Cardiovascular Systems
Yoshiko Murakata, Fumi Yamagami, Nobuyuki Murakoshi, DongZhu Xu, Zhonghu Song, Siqi Li, Yuta Okabe, Kazuhiro Aonuma, ZiXun Yuan, Haruka Mori, Kazutaka Aonuma, Kazuko Tajiri, Masaki Ieda
Summary: Inflammatory atrial cardiomyopathy can lead to atrial fibrillation, characterized by enlarged atria, infiltration of inflammatory cells, and fibrosis. These changes increase susceptibility to arrhythmias by affecting electrical conduction, genetic factors, and autonomic regulation. Therefore, reducing inflammation is important in preventing atrial fibrillation.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Olga Shaihov-Teper, Eilon Ram, Nimer Ballan, Rafael Y. Brzezinski, Nili Naftali-Shani, Rula Masoud, Tamar Ziv, Nir Lewis, Yeshai Schary, La-Paz Levin-Kotler, David Volvovitch, Elchanan M. Zuroff, Sergei Amunts, Neta Regev-Rudzki, Leonid Sternik, Ehud Raanani, Lior Gepstein, Jonathan Leor
Summary: This study revealed, for the first time, a distinctive proinflammatory, profibrotic, and proarrhythmic signature of epicardial fat-derived extracellular vesicles in patients with atrial fibrillation, uncovering another pathway by which epicardial fat promotes the development of atrial myopathy and fibrillation.
Article
Medicine, General & Internal
Gregory F. Michaud, William G. Stevenson
Summary: A 63-year-old healthy male with atrial fibrillation presents with symptoms of dyspnea and irregular heartbeat. Physical examination reveals high blood pressure, irregular pulse, and ECG confirms atrial fibrillation. Further evaluation and treatment plan are needed.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Engineering, Biomedical
Sen Liu, Jiacheng He, Aiguo Wang, Cuiwei Yang
Summary: In this study, an adaptive system for atrial fibrillation (AF) detection based on electrocardiogram (ECG) was proposed. The system achieved improved accuracy and performance through the use of transfer learning and data augmentation techniques. After model adaptation and post-processing, the detection accuracy was significantly improved. The results demonstrate that this method can promote research on AF detection based on atrial activity.
BIOMEDICAL SIGNAL PROCESSING AND CONTROL
(2024)
Article
Hematology
Karina Meijer, Waander van Heerde, Keith Gomez
Summary: Rare bleeding disorders have significant morbidity but are often underdiagnosed globally. Advances in genomic testing and specialist laboratory assays have greatly improved the diagnostic capabilities, leading to the discovery of new genetic causes for rare diseases and a better understanding of their underlying molecular pathology.
Letter
Hematology
Lars L. F. G. Valke, Erik A. M. Beckers, Nicole M. A. Blijlevens, Waander L. van Heerde, Saskia E. M. Schols
Article
Hematology
Lars L. F. G. Valke, Laura H. Bukkems, Wideke Barteling, Britta A. P. Laros-van Gorkom, Nicole M. A. Blijlevens, Ron A. A. Mathot, Waander L. van Heerde, Saskia E. M. Schols
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2020)
Article
Hematology
Joline L. Saes, Marieke J. A. Verhagen, Karina Meijer, Marjon H. Cnossen, Roger E. G. Schutgens, Marjolein Peters, Laurens Nieuwenhuizen, Felix J. M. van der Meer, Ilmar C. Kruis, Waander L. van Heerde, Saskia E. M. Schols
Article
Pharmacology & Pharmacy
Laura H. Bukkems, Lars L. F. G. Valke, Wideke Barteling, Britta A. P. Laros-van Gorkom, Nicole M. A. Blijlevens, Marjon H. Cnossen, Waander L. van Heerde, Saskia E. M. Schols, Ron A. A. Mathot
Summary: The study aimed to develop a population PK/PD model based on FVIII activity levels and NHA patterns, in order to assess the relationship between individual hemostatic capacity and dosing methods in hemophilia A patients.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2022)
Article
Hematology
Dominique P. M. S. M. Maas, Joline L. Saes, Nicole M. A. Blijlevens, Marjon H. Cnossen, Paul L. den Exter, Ilmar C. Kruis, Karina Meijer, Laurens Nieuwenhuizen, Marjolein Peters, Roger E. G. Schutgens, Waander L. van Heerde, Saskia E. M. Schols
Summary: Patients with rare inherited bleeding disorders (RBDs) exhibit heterogeneity in treatment plans and frequently experience bleeding after invasive procedures. Adequate peri-procedural therapy can reduce bleeding risk. Improved guidelines should include specific treatment recommendations for each type of RBD and emphasize the relevance of individual bleeding history.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Hematology
Dominique P. M. S. M. Maas, Ferdows Atiq, Nicole M. A. Blijlevens, Paul P. T. Brons, Sandy Krouwel, Britta A. P. Laros-van Gorkom, Frank W. G. Leebeek, Laurens Nieuwenhuizen, Selene C. M. Schoormans, Annet Simons, Danielle Meijer, Waander L. van Heerde, Saskia E. M. Schols
Summary: This study reveals the clinical and laboratory characteristics of genetically confirmed VWD type 2M patients, showing that they have a relatively mild clinical phenotype, except for bleeding after surgery and delivery. Laboratory phenotype varies and depends on the underlying genetic variant. The addition of genotyping to the current phenotypic characterization may improve diagnosis and classification of VWD.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Biochemistry & Molecular Biology
Daan Sondag, Jona Merx, Emiel Rossing, Thomas J. Boltje, Dennis W. P. M. Lowik, Frank H. T. Nelissen, Mark van Geffen, Cornelis van 't Veer, Waander L. van Heerde, Floris P. J. T. Rutjes
Summary: This article introduces a luminescent assay using a peptide-based probe to screen and validate M-Pro inhibitors. The method has been proven effective in screening potential inhibitors.
Article
Hematology
Karina Meijer, Waander van Heerde, Keith Gomez
Summary: Advancements in genomic testing and specialist laboratory assays have greatly improved the diagnostic accuracy of rare bleeding disorders, leading to the discovery of new genetic causes and a better understanding of the underlying molecular pathology.
Letter
Hematology
Dominique P. M. S. M. Maas, Waander L. van Heerde, Saskia E. M. Schols
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Hematology
Ferdows Atiq, Jessica Heijdra, Fleur Snijders, Johan Boender, Eva Kempers, Waander L. van Heerde, Dominique P. M. S. M. Maas, Sandy Krouwel, Selene C. Schoormans, Joke de Meris, Saskia E. M. Schols, Karin P. M. van Galen, Johanna G. van der Bom, Marjon H. Cnossen, Karina Meijer, Karin Fijnvandraat, Jeroe Eikbenboom, Frank W. G. Leebeek
Summary: Patients with type 1 von Willebrand disease who have a VWF gene variant show a weaker response to desmopressin, compared to those without a variant. On the other hand, patients without a VWF gene variant have a complete response to desmopressin. Desmopressin response in patients with the same variant is comparable.
Article
Hematology
Ferdows Atiq, Johan Boender, Waander L. van Heerde, Juan M. Tellez Garcia, Selene C. Schoormans, Sandy Krouwel, Marjon H. Cnossen, Britta A. P. Laros-van Gorkom, Joke de Meris, Karin Fijnvandraat, Johanna G. van der Bom, Karina Meijer, Karin P. M. van Galen, Jeroen Eikenboom, Frank W. G. Leebeek
Summary: Genotyping plays an important role in understanding the pathogenic mechanisms and phenotypic variability of von Willebrand disease (VWD). By analyzing the VWF gene in 390 VWD patients, various gene variants associated with VWD were identified, and the mechanisms of VWF level reduction were determined. Additionally, significant differences in clinical features were observed between type 1 VWD patients with and without VWF gene variants, highlighting the importance of genotyping in clinical management.
Article
Hematology
Lars L. F. G. Valke, Danielle Meijer, Laurens Nieuwenhuizen, Britta A. P. Laros-van Gorkom, Nicole M. A. Blijlevens, Waander L. van Heerde, Saskia E. M. Schols
Summary: Analysis of fibrinolytic disorders in selected patients has a high diagnostic yield. Incorporating fibrinolytic analysis in the diagnostic workup of patients with bleeding of unknown cause can improve diagnosis and management of their bleeding episodes.
RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Medicine, General & Internal
F. Atiq, J. L. Saes, M. C. Punt, K. P. M. van Galen, R. E. G. Schutgens, K. Meijer, M. H. Cnossen, B. A. P. Laros-Van Gorkom, M. Peters, L. Nieuwenhuizen, M. J. H. A. Kruip, J. de Meris, J. G. van der Bom, F. J. M. van der Meer, K. Fijnvandraat, I. C. Kruis, W. L. van Heerde, H. C. J. Eikenboom, Frank W. G. Leebeek, S. E. M. Schols
Summary: In autosomal inherited bleeding disorders, women are more likely to be referred for bleeding, have a longer diagnostic delay, and often require treatment for sex-specific bleeding.
Article
Hematology
Britta Laros-van Gorkom, Pal Andre Holme, Christine Joch, Tobias Rogosch, Annette Feussner, William McKeand, John Roberts, Waander van Heerde