Small ubiquitin-like modifier/sentrin-specific peptidase 1 associates with chemotherapy and is a risk factor for poor prognosis of non-small cell lung cancer

SENP1 activity sustains cancer stem cell in hypoxic HCC

(2017) Alice Conigliaro et al.   GUT

SENP1 promotes hypoxia-induced cancer stemness by HIF-1α deSUMOylation and SENP1/HIF-1α positive feedback loop

(2017) Chun-Ping Cui et al.   GUT

Delphinidin inhibits angiogenesis through the suppression of HIF-1α and VEGF expression in A549 lung cancer cells

(2016) Mun-Hyeon Kim et al.   ONCOLOGY REPORTS

SENP1 promotes proliferation of clear cell renal cell carcinoma through activation of glycolysis

(2016) Baijun Dong et al.   Oncotarget

SENP1 inhibition induces apoptosis and growth arrest of multiple myeloma cells through modulation of NF-κB signaling

(2015) Jun Xu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Induction of SENP1 in myocardium contributes to abnormities of mitochondria and cardiomyopathy

(2015) Rong Cai et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Low Molecular Weight Fucoidan Inhibits Tumor Angiogenesis through Downregulation of HIF-1/VEGF Signaling under Hypoxia

(2015) Meng-Chuan Chen et al.   Marine Drugs

SENP1 regulates hepatocyte growth factor-induced migration and epithelial-mesenchymal transition of hepatocellular carcinoma

(2015) Wenwen Zhang et al.   TUMOR BIOLOGY

De-SUMOylation of FOXC2 by SENP3 promotes the epithelial-mesenchymal transition in gastric cancer cells

(2015) Yan-hua Ren et al.   Oncotarget

SENP1 desensitizes hypoxic ovarian cancer cells to cisplatin by up-regulating HIF-1α

(2015) Qilin Ao et al.   Scientific Reports

HIF-1 Alpha Overexpression Correlates with Poor Overall Survival and Disease-Free Survival in Gastric Cancer Patients Post-Gastrectomy

(2014) Li Chen et al.   PLoS One

Transcriptional activation of hypoxia-inducible factor-1 (HIF-1) in myeloid cells promotes angiogenesis through VEGF and S100A8

(2014) G.-O. Ahn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The long non-coding RNA HOTAIR indicates a poor prognosis and promotes metastasis in non-small cell lung cancer

(2013) Xiang-hua Liu et al.   BMC CANCER

HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations

(2013) Gregg L. Semenza   JOURNAL OF CLINICAL INVESTIGATION

The SUMO proteases SENP1 and SENP2 play a critical role in nucleoporin homeostasis and nuclear pore complex function

(2013) Kin-Hoe Chow et al.   MOLECULAR BIOLOGY OF THE CELL

Inhibition of SENP1 induces radiosensitization in lung cancer cells

(2013) RUO-TIAN WANG et al.   Experimental and Therapeutic Medicine

Clinicopathological significance of hypoxia-inducible factor-1 alpha (HIF-1α) expression in gastric cancer

(2012) Taro Isobe et al.   International Journal of Clinical Oncology

SUMO-specific protease 1 promotes prostate cancer progression and metastasis

(2012) Q Wang et al.   ONCOGENE

SUMOylation in carcinogenesis

(2011) Kira Bettermann et al.   CANCER LETTERS

SUMOylation and de-SUMOylation in response to DNA damage

(2011) Hong Dou et al.   FEBS LETTERS

Suppression of STAT3 and HIF-1 Alpha Mediates Anti-Angiogenic Activity of Betulinic Acid in Hypoxic PC-3 Prostate Cancer Cells

(2011) Jimin Shin et al.   PLoS One

A SUMOylation-Dependent Transcriptional Subprogram Is Required for Myc-Driven Tumorigenesis

(2011) J. D. Kessler et al.   SCIENCE

miR-210 is overexpressed in late stages of lung cancer and mediates mitochondrial alterations associated with modulation of HIF-1 activity

(2010) M-P Puisségur et al.   CELL DEATH AND DIFFERENTIATION

Hypoxia and energetic tumour metabolism

(2010) M Christiane Brahimi-Horn et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Induction of SENP1 in Endothelial Cells Contributes to Hypoxia-driven VEGF Expression and Angiogenesis

(2010) Ying Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY