Article
Immunology
Christina Frank, Jonathan Wickel, Dirk Bramer, Jakob Matschke, Richard Ibe, Caroline Gazivoda, Albrecht Guenther, Christian Hartmann, Kordt Rehn, Daniel Cadar, Thomas E. Mayer, Kirsten Poertner, Hendrik Wilking, Jonas Schmidt-Chanasit, Dennis Tappe
Summary: In 2021, three cases of encephalitis caused by Borna disease virus 1 (BoDV-1) were diagnosed in Germany. These cases were from different states, with two being acute infections and one being diagnosed retrospectively. The report emphasizes the importance of testing for BoDV-1 in encephalitis cases in areas with known animal Borna disease endemicity in Europe.
EMERGING MICROBES & INFECTIONS
(2022)
Article
Virology
Takehiro Kanda, Masayuki Horie, Yumiko Komatsu, Keizo Tomonaga
Summary: This study focused on BoDV-2 in the Mammalian 1 orthobornavirus, demonstrating that the nucleoprotein and phosphoprotein of BoDV-2 can enhance the polymerase activity of BoDV-1, leading to increased efficiency of REVec recovery and gene expression levels.
JOURNAL OF VIROLOGY
(2021)
Article
Psychiatry
Daniel Braun, Jens Schlossmann, Ekkehard Haen
Summary: In patients with various psychiatric diseases, elevated serum concentrations of ADMA were found, suggesting its involvement in the pathophysiology of these disorders.
PSYCHIATRY RESEARCH
(2021)
Article
Infectious Diseases
Alexandra J. Malbon, Ralf Duerrwald, Jolanta Kolodziejek, Norbert Nowotny, Ralph Kobera, Dietrich Poehle, Aemero Muluneh, Eva Dervas, Christopher Cebra, Frank Steffen, Giulia Paternoster, Christian Gerspach, Monika Hilbe
Summary: Borna disease (BD), caused by Borna disease virus 1 (BoDV-1), is a frequently fatal neurological disorder observed in horses, sheep, and other mammals in certain regions of Europe. Recently, BoDV-1 has also been identified as a cause of fatal encephalitis in humans. Investigations on BoDV-1-infected llamas and alpacas show that New World camelids may play a role as a sentinel species for BoDV-1 infection.
TRANSBOUNDARY AND EMERGING DISEASES
(2022)
Review
Virology
Takehiro Kanda, Keizo Tomonaga
Summary: This review summarizes the research progress on the characteristics and pathogenic mechanisms of Borna disease virus 1, a neurotropic virus. It points out that the mechanism by which the virus causes fatal encephalitis in humans is still unclear, and effective vaccines or antiviral drugs are currently lacking. Furthermore, it explores the recent progress in rescuing the virus using reverse genetics.
Article
Clinical Neurology
Bernhard Neumann, Andreas Hierl, Silke Wunderlich, Helen Meier, Christina Bauer, Stefan T. Gerner, Georg Rieder, Tobias Geis, Juergen Kunkel, Markus Bauswein, Hans Helmut Niller, Barbara Schmidt, Dennis Rubbensroth, Martin Beer, Ralf A. Linker, Jonathan Jantsch, Klemens Angstwurm
Summary: This study is the first to analyze cerebrospinal fluid (CSF) changes in patients with Borna disease virus 1 (BoDV-1) encephalitis. The results showed that white blood cell count (WBC) in CSF was elevated in 13 out of 18 patients, with predominance of lymphocytes. BoDV-1 PCR testing was not always positive, and CSF changes in BoDV-1 encephalitis were similar to those of other viral encephalitis, making the diagnosis more challenging.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Yuka Kaneko, Yuui Naito, Rie Koide, Nicholas F. Parrish, Tomoko Takahashi
Summary: Viral infection can induce diverse cellular immune responses. In the case of Borna disease virus type 1 (BoDV-1), infection can lead to fatal immune-mediated encephalitis, but in vitro infection is usually persistent. This study shows that TRBP, an enhancer of RNA-silencing, positively regulates BoDV RNA levels in human cells. The interaction between TRBP and BoDV RNA plays a role in regulating persistent BoDV infection.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Editorial Material
Immunology
Liv Bode, Yujie Guo, Peng Xie
Summary: Recent fatal encephalitis cases in Germany caused by Borna disease virus 1 (BoDV-1) have attracted public attention. Previous studies have suggested a potential link between human BoDV-1 infection and psychiatric diseases. However, the clinical outcomes and epidemiology of BoDV-1 infection remain controversial.
EMERGING MICROBES & INFECTIONS
(2022)
Article
Clinical Neurology
Paola Salvatore, Ross J. Baldessarini, Harimandir K. Khalsa, Mauricio Tohen
Summary: The study analyzed psychopathological details of prodromes leading to first-lifetime psychotic episodes and found that these features could predict and distinguish final diagnoses of MDD, BD-I, and SzAffD. The findings highlight the value of early psychopathology in predicting final diagnoses of major affective and schizoaffective disorders.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Psychiatry
Gael Galliot, Raquel Sanchez-Rodriguez, Alice Belloc, Hugo Phulpin, Adrien Icher, Philippe Birmes, Karine Faure, Tudi Goze
Summary: Good clinical insight has limited impact on subjective recovery in individuals with psychotic disorders, with only unawareness of current symptoms significantly associated with recovery. This study emphasizes the importance of considering patients' meaning-making process of morbid experiences in order to facilitate self-directed and medically-supported recovery.
PSYCHIATRY RESEARCH
(2022)
Article
Psychology, Clinical
Amy J. Lynham, Sian L. Cleaver, Ian R. Jones, James T. R. Walters
Summary: Cognitive impairments in schizoaffective disorder are found to be between those in schizophrenia and bipolar disorder. The severity of impairments increases from bipolar disorder to schizoaffective disorder to schizophrenia. Combining the subtypes of schizoaffective disorder may hinder efforts to understand its relationship with schizophrenia or bipolar disorder.
PSYCHOLOGICAL MEDICINE
(2022)
Article
Psychiatry
Yuanyuan Zhang, A. Alwin Prem Anand, Liv Bode, Hanns Ludwig, Hinderk M. Emrich, Detlef E. Dietrich
Summary: BoDV-1 infection may impact memory recollection processes in patients with OCD.
Article
Biotechnology & Applied Microbiology
Takehiro Kanda, Madoka Sakai, Akiko Makino, Keizo Tomonaga
Summary: The study found that exogenous expression of Matrix protein (M) and Glycoprotein (G), which are constituents of the viral lipid envelope, significantly facilitates the formation and propagation of BoDV-1 infectious particles without affecting viral RNA synthesis. Additionally, simultaneous transfection of M and G expression plasmids with N, P, and L helper plasmids improves the rescue efficiency of recombinant BoDV-1. The findings suggest that BoDV-1 may suppress excess expression of M and G to reduce cytopathic effects, leading to persistent infection.
JOURNAL OF GENERAL VIROLOGY
(2022)
Article
Virology
Da Teng, Keiji Ueda, Tomoyuki Honda
Summary: This study investigated the effects of BoDV-1 infection on neuronal differentiation and the transcriptome of differentiated neuronal cells. It was found that the infection caused transcriptomic changes in differentiation-related genes, some of which could be recovered by anti-BoDV-1 treatment. Furthermore, the study demonstrated that anti-BoDV-1 treatment could relieve the decrease in cell viability induced by differentiation processes in infected cells.
Article
Neurosciences
Rui Chen, Junxia Shi, Hongguang Yang, Minzhe Zhang, Qiutong Chen, Qiqiang He
Summary: The expression profile of extracellular vesicles (EVs)-derived miRNAs (EVs-miRNAs) in schizoaffective disorder (SAD) patients was analyzed through small RNA sequencing. The results showed 32 differentially expressed (DE) miRNAs in SAD patients compared to healthy controls. Weighted gene co-expression network analysis identified a module of 42 miRNAs closely related to SAD, with has-miR-15b-5p, has-miR-301a-3p, has-miR-342-3p, has-miR-219b-5p, and has-miR-145-5p identified as hub miRNAs. Further analysis revealed dysregulation of EVs-miRNAs in SAD patients, suggesting their potential as biomarkers.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Gastroenterology & Hepatology
Beatriz Piantoni Goncalves, Tamires Flauzino, Claudia Junko Inoue, Jaqueline Costa Castardo de Paula, Talita Cristina Galvao, Camila Cataldi de Alcantara, Paula Kikuchi Miyazaki, Lucilene Rosa, Silva Westmore, Marcell Alysson Batisti Lozovoy, Edna Maria Vissoci Reiche, Andrea Name Colado Simao
Summary: The study evaluated the IL6 genetic variants and their association with inflammatory bowel diseases (IBDs), disease activity, and response to TNF-alpha inhibitors. The G/C haplotype was associated with susceptibility to UC and endoscopic activity of CD. However, these IL6 variants did not predict the response to TNF-alpha inhibitor therapy.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2021)
Article
Immunology
Nicole Perugini Stadtlober, Tamires Flauzino, Lorena Flor da Rosa Franchi Santos, Tatiana Mayumi Veiga Iriyoda, Neide Tomimura Costa, Marcell Alysson Batisti Lozovoy, Edna Maria Vissoci Reiche, Andrea Name Colado Simao
Summary: The study showed that certain TGFB1 variants are associated with SLE susceptibility and disease activity, with the TGFB1 + 869 CC genotype linked to decreased C4 levels and TGF-beta 1 levels. Additionally, patients with the TGFB1 + 869 TC and CC genotypes had lower TGF-beta 1 levels compared to those with the TT genotype when positive for anti-dsDNA.
Article
Medicine, Research & Experimental
Ana Lucia Cruz Furstenberger Lehmann, Daniela Frizon Alfieri, Maria Caroline Martins de Araujo, Emanuelle Roberto Trevisani, Maisa Rocha Nagao, Francisco Spessatto Pesente, Jair Roberto Gelinski, Leonardo Bodner de Freitas, Tamires Flauzino, Marcio Francisco Lehmann, Marcell Alysson Batisti Lozovoy, Jose Wander Bregano, Andrea Name Colado Simao, Michael Maes, Edna Maria Vissoci Reiche
Summary: This study evaluated the prognostic validity of a combination of clinical, imaging, and laboratory biomarkers in predicting 1-year mortality of IS, finding that non-survivors showed significant differences in multiple indicators including IS severity, carotid intima-media thickness, coagulation factors, and inflammatory factors.
CLINICAL AND EXPERIMENTAL MEDICINE
(2022)
Article
Medicine, Research & Experimental
Tatiana Mayumi Veiga Iriyoda, Tamires Flauzino, Neide Tomimura Costa, Marcell Alysson Batisti Lozovoy, Edna Maria Vissoci Reiche, Andrea Name Colado Simao
Summary: The study evaluated the association between TGFB1 gene variants and susceptibility, disease activity, and other factors in rheumatoid arthritis (RA) patients. The findings suggest that the TGFB1 + 869 T > C and -509 C > T variants are not associated with RA susceptibility but can predict disease activity in different patient subgroups. Additionally, the interaction between the TGFB1 + 869 T > C variant and autoantibodies may modulate TGF-beta 1 plasma levels in RA patients.
CLINICAL AND EXPERIMENTAL MEDICINE
(2022)
Article
Endocrinology & Metabolism
Ana Lucia Cruz Furstenberger Lehmann, Daniela Frizon Alfieri, Maria Caroline Martins de Araujo, Emanuelle Roberto Trevisani, Maisa Rocha Nagao, Francisco Spessatto Pesente, Jair Roberto Gelinski, Leonardo Bodner de Freitas, Tamires Flauzino, Marcio Francisco Lehmann, Marcell Alysson Batisti Lozovoy, Jose Wander Bregano, Andrea Name Colado Simao, Michael Maes, Edna Maria Vissoci Reiche
Summary: This study highlights that poor prognosis in IS patients is related to carotid stenosis, type 2 diabetes mellitus, and NIHSS, while short-term mortality is closely associated with cIMT, NIHSS, and age. High values of cIMT and NIHSS at admission strongly predict short-term functional impairment as well as mortality three months after IS.
METABOLIC BRAIN DISEASE
(2021)
Article
Public, Environmental & Occupational Health
Marta Giovanetti, Luiz Carlos Junior Alcantara, Alfredo Souza Dorea, Qesya Rodrigues Ferreira, Willian de Almeida Marques, Jose Junior Franca de Barros, Talita Emile Ribeiro Adelino, Stephane Tosta, Hegger Fritsch, Felipe Campos de Melo Iani, Maria Angelica Mares-Guia, Alvaro Salgado, Vagner Fonseca, Joilson Xavier, Elisson Nogueira Lopes, Gilson Carlos Soares, Maria Fernanda de Castro Amarante, Vasco Azevedo, Alicia Kruger, Gustavo Correa Matta, Laisa Liane Paineiras-Domingos, Claudia Colonnello, Ana Maria Bispo de Filippis, Carla Montesano, Vittorio Colizzi, Fernanda Khouri Barreto
FRONTIERS IN PUBLIC HEALTH
(2021)
Review
Biochemistry & Molecular Biology
Michael Maes, Nikita G. Nikiforov, Kitiporn Plaimas, Apichat Suratanee, Daniela Frizon Alfieri, Edna Maria Vissoci Reiche
Summary: This study analyzed established biomarkers in ischemic stroke (IS) patients to identify crucial factors associated with death, including immune and hemostasis-related proteins. The immune subnetwork of IS death was strongly linked to pathways such as TLR2/4 and TNF, while the hemostasis network was enriched in processes like platelet activation and fibrin clot formation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Michael Maes, Walton Luiz Del Tedesco Junior, Marcell Alysson Batisti Lozovoy, Mayara Tiemi Enokida Mori, Tiago Danellii, Elaine Regina Delicato de Almeida, Alexandre Mestre Tejo, Zuleica Naomi Tano, Edna Maria Vissoci Reiche, Andrea Name Colado Simao
Summary: The NLRP3 inflammasome is activated in response to SARS-CoV-2 infection in COVID-19 patients. Acute infections are accompanied by a sickness symptom complex (SSC) that plays a protective role against COVID-19. Increased SSC can protect against severe COVID-19, while factors such as age, gender, and specific gene variants can attenuate this protection.
MOLECULAR PSYCHIATRY
(2022)
Article
Oncology
Cintya Mayumi Ishibashi, Carlos Eduardo Coral de Oliveira, Roberta Losi Guembarovski, Bruna Karina Banin Hirata, Glauco Akelinghton Freire Vitiello, Alda Losi Guembarovski, Marla Karine Amarante, Karen Brajao de Oliveira, Marina Okuyama Kishima, Carolina Batista Ariza, Maria Angelica Ehara Watanabe
Summary: This study investigated the TGFB1 genetic polymorphisms and haplotype structures in Wilms Tumor (WT) patients and neoplasia-free controls, finding positive and negative associations with certain alleles and haplotypes. The results suggest that TGFB1 polymorphisms may be associated with WT susceptibility and clinical presentation.
JOURNAL OF KIDNEY CANCER AND VHL
(2021)
Review
Psychiatry
Ana Cecilia Novaes de Oliveira Roldan, Luiz Carlos Cantanhede Fernandes Junior, Carlos Eduardo Coral de Oliveira, Sandra Odebrecht Vargas Nunes
Summary: This study conducted a systematic review and meta-analysis to investigate the relationship between CACNA1C-rs1006737 and ZNF804A-rs1344706 polymorphisms and cognitive performance in schizophrenia spectrum and bipolar disorder. The results suggest a slight association between CACNA1C-rs1006737 polymorphism and cognitive function alteration in severe mental disorders, while no significant association was found for ZNF804A-rs1344706 polymorphism.
WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
(2023)
Review
Psychiatry
Ana Cecilia Novaes Oliveira, Suzana Maria Menezes Guariente, Robson Zazula, Arthur Eumann Mesas, Carlos Eduardo Coral Oliveira, Edna Maria Vissosi Reiche, Sandra Odebrecht Vargas Nunes
Summary: This systematic review aimed to evaluate the effectiveness of digital interventions in reducing weight, body mass index (BMI), and abdominal circumference in individuals with severe mental illness. The findings suggest that the use of digital devices and strategies can effectively reduce sedentary behavior in this population. Most interventions utilized digital pedometers and mobile phone communication as main strategies, and significant outcomes were observed in favor of these interventions.
PSYCHIATRIC QUARTERLY
(2022)
Article
Pediatrics
Rachel A. Hill, Atul Malhotra, Vathana Sackett, Katrina Williams, Michael Fahey, Kirsten R. Palmer, Rod W. Hunt, Hayley Darke, Izaak Lim, Vesna Newman-Morris, Jeanie L. Y. Cheong, Clare Whitehead, Joanne Said, Paulo Bignardi, Evelin Muraguchi, Luiz Carlos C. Fernandes Jr, Carlos Oliveira, Suresh Sundram
Summary: This study aims to investigate the long-term impacts of SARS-CoV-2 exposure on children exposed in utero. Women infected with SARS-CoV-2 during pregnancy will be recruited and compared with non-exposed women. By conducting long-term observations and comparisons, we hope to reveal the potential effects of in utero exposure to SARS-CoV-2 on neurodevelopment.
Article
Endocrinology & Metabolism
Maria Caroline Martins de Araujo, Daniela Frizon Alfieri, Ana Lucia Cruz Furstenberger Lehmann, Tamires Flauzino Luz, Emmanuelle Roberto Trevisani, Maisa Rocha Nagao, Leonardo Bodner de Freitas, Andrea Name Colado Simao, Edna Maria Vissoci Reiche
Summary: This study aimed to investigate the association between cellular adhesion molecules (CAMs) and acute ischemic stroke (IS), as well as to identify biomarkers for predicting short-term mortality after IS. The results showed that a combination of baseline IS severity and soluble vascular cellular adhesion molecule 1 (sVCAM-1) levels could early predict the prognosis of IS patients. Additionally, this study suggests that VCAM-1 might be a potential target for therapeutic strategies in IS.
METABOLIC BRAIN DISEASE
(2023)
Article
Medicine, General & Internal
Claudia Junko Inoue, Tamires Flauzino, Beatriz Piantoni Goncalves, Jaqueline Costa Castardo de Paula, Talita Cristina Galvao, Paula Kikuchi Miyazaki, Camila Cataldi de Alcantara, Lucilene Rosa e Silva Westmore, Marcell Alysson Batisti Lozovoy, Edna Maria Vissoci Reiche, Andrea Name Colado Simao
Summary: This study evaluated the association of FOXP3 variants with susceptibility to inflammatory bowel disease, showing that FOXP3 variants are associated with susceptibility to inflammatory bowel disease and may have a role in Treg.
Article
Biology
Nathalia De Sousa-Pereira, Mayara Bocchi, Caroline Yukari Motoori-Fernandes, Bruna Karina Banin-Hirata, Luiz Gustavo Piccoli de Melo, Karen Brajao de Oliveira, Glauco Akelinghton Freire Vitiello, Carlos Eduardo Coral de Oliveira, Clodoaldo Zago Campos, Marla Karine Amarante, Maria Angelica Ehara Watanabe
Summary: This study evaluated the impact of chronic life stressors in breast cancer patients and found that stressful events in the period prior to diagnosis were associated with disease development. Patients who were separated, divorced, or widowed exhibited higher stress levels, and the high-risk group had a lower proportion of positivity for estrogen receptor. The study also showed an independent association between estrogen receptor and chronic stress with histological type of breast cancer and lymph nodes involvement.