Neuropilin-1 upregulation elicits adaptive resistance to oncogene-targeted therapies

Dual inhibition of IGF1R and ER enhances response to trastuzumab in HER2 positive breast cancer cells

(2017) Martina S.J. Mcdermott et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Adaptive resistance of melanoma cells to RAF inhibition via reversible induction of a slowly dividing de‐differentiated state

(2017) Mohammad Fallahi‐Sichani et al.   Molecular Systems Biology

The dark side of SOX2: cancer - a comprehensive overview

(2017) Erin L. Wuebben et al.   Oncotarget

Neuropilin-1 is upregulated by Wnt/β-catenin signaling and is important for mammary stem cells

(2017) Wei Liu et al.   Scientific Reports

Neuropilin-1 is associated with clinicopathology of gastric cancer and contributes to cell proliferation and migration as multifunctional co-receptors

(2016) Linhao Li et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

VEGF-A acts via neuropilin-1 to enhance epidermal cancer stem cell survival and formation of aggressive and highly vascularized tumors

(2016) D Grun et al.   ONCOGENE

Dual MET/EGFR therapy leads to complete response and resistance prevention in a MET-amplified gastroesophageal xenopatient cohort

(2016) M Apicella et al.   ONCOGENE

Integrative transcriptome-wide analyses reveal critical HER2-regulated mRNAs and lincRNAs in HER2+ breast cancer

(2015) Callie R. Merry et al.   BREAST CANCER RESEARCH AND TREATMENT

Acquired BRAF inhibitor resistance: A multicenter meta-analysis of the spectrum and frequencies, clinical behaviour, and phenotypic associations of resistance mechanisms

(2015) Douglas B. Johnson et al.   EUROPEAN JOURNAL OF CANCER

Co-clinical assessment identifies patterns of BRAF inhibitor resistance in melanoma

(2015) Lawrence N. Kwong et al.   JOURNAL OF CLINICAL INVESTIGATION

Epigenetic Changes of EGFR Have an Important Role in BRAF Inhibitor–Resistant Cutaneous Melanomas

(2015) Jinhua Wang et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Vascular endothelial growth factor is an autocrine growth factor, signaling through neuropilin-1 in non-small cell lung cancer

(2015) Martin P Barr et al.   Molecular Cancer

The role of the insulin-like growth factor-1 system in breast cancer

(2015) Panagiotis F Christopoulos et al.   Molecular Cancer

VEGF-A/NRP1 stimulates GIPC1 and Syx complex formation to promote RhoA activation and proliferation in skin cancer cells

(2015) A. Yoshida et al.   Biology Open

A new tumour suppression mechanism by p27Kip1: EGFR down-regulation mediated by JNK/c-Jun pathway inhibition

(2014) Yong Fang et al.   BIOCHEMICAL JOURNAL

ERBB Receptors: From Oncogene Discovery to Basic Science to Mechanism-Based Cancer Therapeutics

(2014) Carlos L. Arteaga et al.   CANCER CELL

miR-338 suppresses the growth and metastasis of OSCC cells by targeting NRP1

(2014) Chunxi Liu et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Reversible and adaptive resistance to BRAF(V600E) inhibition in melanoma

(2014) Chong Sun et al.   NATURE

SOX2 controls tumour initiation and cancer stem-cell functions in squamous-cell carcinoma

(2014) Soufiane Boumahdi et al.   NATURE

Acquired resistance to TKIs in solid tumours: learning from lung cancer

(2014) D. Ross Camidge et al.   Nature Reviews Clinical Oncology

MicroRNA-338 Inhibits Growth, Invasion and Metastasis of Gastric Cancer by Targeting NRP1 Expression

(2014) Yang Peng et al.   PLoS One

An endocytosis pathway initiated through neuropilin-1 and regulated by nutrient availability

(2014) Hong-Bo Pang et al.   Nature Communications

Impeding Macrophage Entry into Hypoxic Tumor Areas by Sema3A/Nrp1 Signaling Blockade Inhibits Angiogenesis and Restores Antitumor Immunity

(2013) Andrea Casazza et al.   CANCER CELL

The Emerging Role of SOX2 in Cell Proliferation and Survival and Its Crosstalk with Oncogenic Signaling in Lung Cancer

(2013) Yu-Ting Chou et al.   STEM CELLS

The Genetic Landscape of Clinical Resistance to RAF Inhibition in Metastatic Melanoma

(2013) E. M. Van Allen et al.   Cancer Discovery

Neuropilin-1-Dependent Regulation of EGF-Receptor Signaling

(2012) S. Rizzolio et al.   CANCER RESEARCH

Novel applications of nanobodies for in vivo bio-imaging of inflamed tissues in inflammatory diseases and cancer

(2012) Steve Schoonooghe et al.   IMMUNOBIOLOGY

Autocrine VEGF–VEGFR2–Neuropilin-1 signaling promotes glioma stem-like cell viability and tumor growth

(2012) Petra Hamerlik et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors

(2012) Timothy R. Wilson et al.   NATURE

Multifaceted Role of Neuropilins in Cancer

(2011) S. Rizzolio et al.   CURRENT MEDICINAL CHEMISTRY

Oncogene addiction as a foundational rationale for targeted anti-cancer therapy: promises and perils

(2011) Davide Torti et al.   EMBO Molecular Medicine

Developmental Regulation of MicroRNA Expression in Schwann Cells

(2011) N. G. Gokey et al.   MOLECULAR AND CELLULAR BIOLOGY

A vascular niche and a VEGF–Nrp1 loop regulate the initiation and stemness of skin tumours

(2011) Benjamin Beck et al.   NATURE

Autocrine VEGF Signaling Synergizes with EGFR in Tumor Cells to Promote Epithelial Cancer Development

(2010) Beate M. Lichtenberger et al.   CELL

Small Molecule Inhibitors of the Neuropilin-1 Vascular Endothelial Growth Factor A (VEGF-A) Interaction

(2010) Ashley Jarvis et al.   JOURNAL OF MEDICINAL CHEMISTRY