Mosaic-variegated aneuploidy syndrome mutation or haploinsufficiency in Cep57 impairs tumor suppression

Detection and localization of surgically resectable cancers with a multi-analyte blood test

(2018) Joshua D. Cohen et al.   SCIENCE

Targeted next generation sequencing identifies functionally deleterious germline mutations in novel genes in early-onset/familial prostate cancer

(2018) Paula Paulo et al.   PLoS Genetics

Biallelic TRIP13 mutations predispose to Wilms tumor and chromosome missegregation

(2017) Shawn Yost et al.   NATURE GENETICS

Spartan deficiency causes accumulation of Topoisomerase 1 cleavage complexes and tumorigenesis

(2017) Reeja S. Maskey et al.   NUCLEIC ACIDS RESEARCH

Pten regulates spindle pole movement through Dlg1-mediated recruitment of Eg5 to centrosomes

(2016) Janine H. van Ree et al.   NATURE CELL BIOLOGY

Opposing post-translational modifications regulate Cep76 function to suppress centriole amplification

(2016) M Barbelanne et al.   ONCOGENE

Cep57 is a Mis12-interacting kinetochore protein involved in kinetochore targeting of Mad1–Mad2

(2016) Haining Zhou et al.   Nature Communications

TRIP13 Regulates Both the Activation and Inactivation of the Spindle-Assembly Checkpoint

(2016) Hoi Tang Ma et al.   Cell Reports

TRIP13 PCH-2 promotes Mad2 localization to unattached kinetochores in the spindle checkpoint response

(2015) Christian R. Nelson et al.   JOURNAL OF CELL BIOLOGY

Prognostic Significance and Functional Role of CEP57 in Prostate Cancer

(2015) Josef Mang et al.   Translational Oncology

CEP63 deficiency promotes p53-dependent microcephaly and reveals a role for the centrosome in meiotic recombination

(2015) Marko Marjanović et al.   Nature Communications

Plk1 relieves centriole block to reduplication by promoting daughter centriole maturation

(2015) Anil Shukla et al.   Nature Communications

TRIP13 is a protein-remodeling AAA+ ATPase that catalyzes MAD2 conformation switching

(2015) Qiaozhen Ye et al.   eLife

A Unique Set of Centrosome Proteins Requires Pericentrin for Spindle-Pole Localization and Spindle Orientation

(2014) Chun-Ting Chen et al.   CURRENT BIOLOGY

Cyclin B2 and p53 control proper timing of centrosome separation

(2014) Hyun-Ja Nam et al.   NATURE CELL BIOLOGY

Mutations in PLK4, encoding a master regulator of centriole biogenesis, cause microcephaly, growth failure and retinopathy

(2014) Carol-Anne Martin et al.   NATURE GENETICS

Causes and consequences of centrosome abnormalities in cancer

(2014) S. A. Godinho et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

CEP57 mutation in a girl with mosaic variegated aneuploidy syndrome

(2013) Lucile Pinson et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Selective Chemical Crosslinking Reveals a Cep57-Cep63-Cep152 Centrosomal Complex

(2013) Gražvydas Lukinavičius et al.   CURRENT BIOLOGY

FGF-2 Disrupts Mitotic Stability in Prostate Cancer through the Intracellular Trafficking Protein CEP57

(2012) R. Cuevas et al.   CANCER RESEARCH

Separase-dependent cleavage of pericentrin B is necessary and sufficient for centriole disengagement during mitosis

(2012) Kwanwoo Lee et al.   CELL CYCLE

Cep57, a NEDD1-binding pericentriolar material component, is essential for spindle pole integrity

(2012) Qixi Wu et al.   CELL RESEARCH

Kendrin Is a Novel Substrate for Separase Involved in the Licensing of Centriole Duplication

(2012) Kazuhiko Matsuo et al.   CURRENT BIOLOGY

Subdiffraction-resolution fluorescence microscopy reveals a domain of the centrosome critical for pericentriolar material organization

(2012) V. Mennella et al.   NATURE CELL BIOLOGY

Subdiffraction imaging of centrosomes reveals higher-order organizational features of pericentriolar material

(2012) Steffen Lawo et al.   NATURE CELL BIOLOGY

Structured illumination of the interface between centriole and peri-centriolar material

(2012) J. Fu et al.   Open Biology

Reduced Life- and Healthspan in Mice Carrying a Mono-Allelic BubR1 MVA Mutation

(2012) Tobias Wijshake et al.   PLoS Genetics

3D-structured illumination microscopy provides novel insight into architecture of human centrosomes

(2012) Katharina F. Sonnen et al.   Biology Open

Fibroblast Growth Factor 2 Stimulation of Osteoblast Differentiation and Bone Formation Is Mediated by Modulation of the Wnt Signaling Pathway

(2011) Yurong Fei et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PLK1 phosphorylation of pericentrin initiates centrosome maturation at the onset of mitosis

(2011) Kwanwoo Lee et al.   JOURNAL OF CELL BIOLOGY

Mutations in CEP57 cause mosaic variegated aneuploidy syndrome

(2011) Katie Snape et al.   NATURE GENETICS

A primary microcephaly protein complex forms a ring around parental centrioles

(2011) Joo-Hee Sir et al.   NATURE GENETICS

Continuous polo-like kinase 1 activity regulates diffusion to maintain centrosome self-organization during mitosis

(2011) R. Mahen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Translokin (Cep57) Interacts with Cyclin D1 and Prevents Its Nuclear Accumulation in Quiescent Fibroblasts

(2011) Maria Ruiz-Miró et al.   TRAFFIC

CDK5RAP2 Regulates Centriole Engagement and Cohesion in Mice

(2010) Jose A. Barrera et al.   DEVELOPMENTAL CELL

Cdc20 hypomorphic mice fail to counteract de novo synthesis of cyclin B1 in mitosis

(2010) Liviu Malureanu et al.   JOURNAL OF CELL BIOLOGY

Cep152 acts as a scaffold for recruitment of Plk4 and CPAP to the centrosome

(2010) Onur Cizmecioglu et al.   JOURNAL OF CELL BIOLOGY

Cep152 interacts with Plk4 and is required for centriole duplication

(2010) Emily M. Hatch et al.   JOURNAL OF CELL BIOLOGY

Asterless is a scaffold for the onset of centriole assembly

(2010) Nikola S. Dzhindzhev et al.   NATURE

CEP152 is a genome maintenance protein disrupted in Seckel syndrome

(2010) Ersan Kalay et al.   NATURE GENETICS

Whole Chromosome Instability Caused by Bub1 Insufficiency Drives Tumorigenesis through Tumor Suppressor Gene Loss of Heterozygosity

(2009) Darren J. Baker et al.   CANCER CELL

BubR1 N Terminus Acts as a Soluble Inhibitor of Cyclin B Degradation by APC/CCdc20 in Interphase

(2009) Liviu A. Malureanu et al.   DEVELOPMENTAL CELL

Polo Kinase and Separase Regulate the Mitotic Licensing of Centriole Duplication in Human Cells

(2009) Meng-Fu Bryan Tsou et al.   DEVELOPMENTAL CELL

Ciliary and centrosomal defects associated with mutation and depletion of the Meckel syndrome genes MKS1 and MKS3

(2009) Rachaneekorn Tammachote et al.   HUMAN MOLECULAR GENETICS

A mechanism linking extra centrosomes to chromosomal instability

(2009) Neil J. Ganem et al.   NATURE

Pivotal Role of Translokin/CEP57 in the Unconventional Secretion Versus Nuclear Translocation of FGF2

(2009) Sylvain Meunier et al.   TRAFFIC

Clinical and genetic heterogeneity in patients with mosaic variegated aneuploidy: Delineation of clinical subtypes

(2008) Herbert García‐Castillo et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Cep57, a multidomain protein with unique microtubule and centrosomal localization domains

(2008) Ko Momotani et al.   BIOCHEMICAL JOURNAL

Mechanisms to suppress multipolar divisions in cancer cells with extra centrosomes

(2008) M. Kwon et al.   GENES & DEVELOPMENT

Control of daughter centriole formation by the pericentriolar material

(2008) Jadranka Loncarek et al.   NATURE CELL BIOLOGY

Opposing roles for p16Ink4a and p19Arf in senescence and ageing caused by BubR1 insufficiency

(2008) Darren J. Baker et al.   NATURE CELL BIOLOGY