IgG4 subclass antibodies impair antitumor immunity in melanoma

Isotype and glycoform selection for antibody therapeutics

(2012) Roy Jefferis   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Neogenesis of Lymphoid Structures and Antibody Responses Occur in Human Melanoma Metastases

(2012) Arcadi Cipponi et al.   CANCER RESEARCH

Immunotype and Immunohistologic Characteristics of Tumor-Infiltrating Immune Cells Are Associated with Clinical Outcome in Metastatic Melanoma

(2012) G. Erdag et al.   CANCER RESEARCH

Significance of immunoglobulin G4 (IgG4)-positive cells in extrahepatic cholangiocarcinoma: Molecular mechanism of IgG4 reaction in cancer tissue

(2012) Kenichi Harada et al.   HEPATOLOGY

Allergen specificity of IgG4-expressing B cells in patients with grass pollen allergy undergoing immunotherapy

(2012) Louisa K. James et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

IgG4 Production Against Adalimumab During Long Term Treatment of RA Patients

(2012) Pauline A. van Schouwenburg et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Functional T Cells Targeting NY-ESO-1 or Melan-A Are Predictive for Survival of Patients With Distant Melanoma Metastasis

(2012) Benjamin Weide et al.   JOURNAL OF CLINICAL ONCOLOGY

Resident CD141 (BDCA3)+dendritic cells in human skin produce IL-10 and induce regulatory T cells that suppress skin inflammation

(2012) Chung-Ching Chu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

TLR4, IL-6, IL-18, MyD88 and HMGB1 are highly expressed in intracranial inflammatory lesions and the IgG4/IgG ratio correlates with TLR4 and IL-6

(2012) Hirofumi Hirano et al.   NEUROPATHOLOGY

IgG4-Related Disease

(2012) John H. Stone et al.   NEW ENGLAND JOURNAL OF MEDICINE

Functional rather than immunoreactive levels of IgG4 correlate closely with clinical response to grass pollen immunotherapy

(2011) M. H. Shamji et al.   ALLERGY

Down-modulation of TNFSF15 in ovarian cancer by VEGF and MCP-1 is a pre-requisite for tumor neovascularization

(2011) Weimin Deng et al.   ANGIOGENESIS

Serum antibodies to the HPV16 proteome as biomarkers for head and neck cancer

(2011) K S Anderson et al.   BRITISH JOURNAL OF CANCER

Prognostic impact of B-cell density in cutaneous melanoma

(2011) Andrea Ladányi et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

An amplification of IL-10 and TGF-beta in patients with IgG4-related tubulointerstitial nephritis

(2011) H. Nakashima et al.   CLINICAL NEPHROLOGY

Long-term clinical and immunological effects of allergen immunotherapy

(2011) Aarif O. Eifan et al.   Current Opinion in Allergy and Clinical Immunology

Functional Characteristics of the High Affinity IgG Receptor, Fc RI

(2011) C. E. van der Poel et al.   JOURNAL OF IMMUNOLOGY

Interferon-γ links ultraviolet radiation to melanomagenesis in mice

(2011) M. Raza Zaidi et al.   NATURE

CSPG4, a potential therapeutic target, facilitates malignant progression of melanoma

(2011) Matthew A. Price et al.   Pigment Cell & Melanoma Research

Monitoring the Systemic Human Memory B Cell Compartment of Melanoma Patients for Anti-Tumor IgG Antibodies

(2011) Amy E. Gilbert et al.   PLoS One

Eradication of melanomas by targeted elimination of a minor subset of tumor cells

(2011) P. Schmidt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

B regulatory cells and the tumor-promoting actions of TNF-  during squamous carcinogenesis

(2011) T. Schioppa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Intraepithelial T Cell Response to NKG2D-Ligands Links Lymphoid Stress Surveillance to Atopy

(2011) J. Strid et al.   SCIENCE

IL-6 increases B-cell IgG production in a feed-forward proinflammatory mechanism to skew hematopoiesis and elevate myeloid production

(2010) K. Maeda et al.   BLOOD

FcRγ Activation Regulates Inflammation-Associated Squamous Carcinogenesis

(2010) Pauline Andreu et al.   CANCER CELL

Pathogenesis of IgG4-related disease

(2010) Yoh Zen et al.   CURRENT OPINION IN RHEUMATOLOGY

Allergen immunotherapy

(2010) Anthony J. Frew   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Internalization and Coreceptor Expression Are Critical for TLR2-Mediated Recognition of Lipoteichoic Acid in Human Peripheral Blood

(2010) S. Bunk et al.   JOURNAL OF IMMUNOLOGY

Immunoglobulin G4: an odd antibody

(2009) R. C. Aalberse et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Evidence of Systemic Th2-Driven Chronic Inflammation in Patients with Metastatic Melanoma

(2009) W. K. Nevala et al.   CLINICAL CANCER RESEARCH

Final Version of 2009 AJCC Melanoma Staging and Classification

(2009) Charles M. Balch et al.   JOURNAL OF CLINICAL ONCOLOGY

Human IgG4 Binds to IgG4 and Conformationally Altered IgG1 via Fc-Fc Interactions

(2009) T. Rispens et al.   JOURNAL OF IMMUNOLOGY

Lymphocyte-specific TRAF3 transgenic mice have enhanced humoral responses and develop plasmacytosis, autoimmunity, inflammation, and cancer

(2008) Juan M. Zapata et al.   BLOOD

Specificity and affinity of human Fc  receptors and their polymorphic variants for human IgG subclasses

(2008) P. Bruhns et al.   BLOOD

Characterisation of an engineered trastuzumab IgE antibody and effector cell mechanisms targeting HER2/neu-positive tumour cells

(2008) Panagiotis Karagiannis et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

When binding is enough: nonactivating antibody formats

(2008) Aran F Labrijn et al.   CURRENT OPINION IN IMMUNOLOGY

Grass pollen immunotherapy: IL-10 induction and suppression of late responses precedes IgG4 inhibitory antibody activity

(2008) James N. Francis et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Melanoma Stem Cells: The Dark Seed of Melanoma

(2008) Susan E. Zabierowski et al.   JOURNAL OF CLINICAL ONCOLOGY