Journal
JOURNAL OF CLINICAL INVESTIGATION
Volume 123, Issue 8, Pages 3206-3208Publisher
AMER SOC CLINICAL INVESTIGATION INC
DOI: 10.1172/JCI70799
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Funding
- NIGMS NIH HHS [GM049831, R01 GM049831] Funding Source: Medline
- NINDS NIH HHS [R01 NS084396, NS084396, R01 NS053898, NS053898] Funding Source: Medline
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Protection of hair cells by HSP70 released by supporting cells is reported by May et al. in this issue of the JCI. Their findings suggest a new way to reduce ototoxicity from therapeutic medications and raise larger questions about the role and integration of heat shock proteins in non-cell-autonomous responses to stress. Increasing evidence suggests an important role for extracellular heat shock proteins in both the nervous system and the immune system. The work also suggests that defective chaperones could cause ear disease and supports the potential use of chaperone therapeutics.
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