Journal
JOURNAL OF CLINICAL INVESTIGATION
Volume 123, Issue 2, Pages 563-565Publisher
AMER SOC CLINICAL INVESTIGATION INC
DOI: 10.1172/JCI67460
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Funding
- NCI NIH HHS [CA101860, P30 CA046592, CA66233, R01 CA101860, P30CA46592] Funding Source: Medline
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There is increasing evidence that prostate cancers in rodent models and in men contain a cellular subpopulation that displays stem cell properties. These prostate cancer stem cells (PCSCs) lack androgen receptor expression and are increased in castration-resistant disease. In this issue of the JCI, a study from Yoshioka et al. demonstrates that PCSCs are regulated by a pathway in which alpha 6 beta 4 integrin amplifies signaling through ErbB2 and c-Met receptors. Targeting this pathway provides a novel therapeutic strategy for hormone refractory prostate cancer.
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