HSV-2: in pursuit of a vaccine

Human TLRs and IL-1Rs in Host Defense: Natural Insights from Evolutionary, Epidemiological, and Clinical Genetics

(2011) Jean-Laurent Casanova et al.   Annual Review of Immunology

Genital Shedding of Herpes Simplex Virus Among Symptomatic and Asymptomatic Persons With HSV-2 Infection

(2011) Elizabeth Tronstein   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Effects of HIV-1 and Herpes Simplex Virus Type 2 Infection on Lymphocyte and Dendritic Cell Density in Adult Foreskins from Rakai, Uganda

(2011) Kristine E. Johnson et al.   JOURNAL OF INFECTIOUS DISEASES

Immunization with Herpes Simplex Virus 2 (HSV-2) Genes plus Inactivated HSV-2 Is Highly Protective against Acute and Recurrent HSV-2 Disease

(2011) C. S. Morello et al.   JOURNAL OF VIROLOGY

A Live-Attenuated HSV-2 ICP0− Virus Elicits 10 to 100 Times Greater Protection against Genital Herpes than a Glycoprotein D Subunit Vaccine

(2011) William P. Halford et al.   PLoS One

Effects of herpes simplex virus type 2 glycoprotein vaccines and CLDC adjuvant on genital herpes infection in the guinea pig

(2011) David I. Bernstein et al.   VACCINE

Genotypic Characterization of UL23 Thymidine Kinase and UL30 DNA Polymerase of Clinical Isolates of Herpes Simplex Virus: Natural Polymorphism and Mutations Associated with Resistance to Antivirals

(2010) S. Burrel et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Immunization with a dominant-negative recombinant Herpes Simplex Virus (HSV) type 1 protects against HSV-2 genital disease in guinea pigs

(2010) Richard Brans et al.   BMC MICROBIOLOGY

Zoster Vaccine: Current Status and Future Prospects

(2010) Michael N. Oxman   CLINICAL INFECTIOUS DISEASES

Detailed Characterization of T Cell Responses to Herpes Simplex Virus-2 in Immune Seronegative Persons

(2010) C. M. Posavad et al.   JOURNAL OF IMMUNOLOGY

Overlapping Reactivations of Herpes Simplex Virus Type 2 in the Genital and Perianal Mucosa

(2010) Sunitha Tata et al.   JOURNAL OF INFECTIOUS DISEASES

Herpes Simplex Virus Immediate-Early ICP0 Protein Inhibits Toll-Like Receptor 2-Dependent Inflammatory Responses and NF-κB Signaling

(2010) Allison L. van Lint et al.   JOURNAL OF VIROLOGY

Crystal structure of the conserved herpesvirus fusion regulator complex gH–gL

(2010) Tirumala K Chowdary et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Acyclovir and Transmission of HIV-1 from Persons Infected with HIV-1 and HSV-2

(2010) C. Celum et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Virion Host Shut-Off (vhs) Protein Blocks a TLR-Independent Pathway of Herpes Simplex Virus Type 1 Recognition in Human and Mouse Dendritic Cells

(2010) Christopher R. Cotter et al.   PLoS One

Mucosal host immune response predicts the severity and duration of herpes simplex virus-2 genital tract shedding episodes

(2010) J. T. Schiffer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Painful Failure of Promising Genital Herpes Vaccine

(2010) J. Cohen   SCIENCE

A Pooled Analysis of the Effect of Condoms in Preventing HSV-2 Acquisition

(2009) Emily T. Martin et al.   ARCHIVES OF INTERNAL MEDICINE

Increasing Adolescent Vaccination: Barriers and Strategies in the Context of Policy, Legal, and Financial Issues

(2009) Carol A. Ford et al.   JOURNAL OF ADOLESCENT HEALTH

Protection from Herpes Simplex Virus (HSV)–2 Infection with Replication‐Defective HSV‐2 or Glycoprotein D2 Vaccines in HSV‐1–Seropositive and HSV‐1–Seronegative Guinea Pigs

(2009) Yo Hoshino et al.   JOURNAL OF INFECTIOUS DISEASES

Varicella‐Zoster Virus–Specific Immune Responses to Herpes Zoster in Elderly Participants in a Trial of a Clinically Effective Zoster Vaccine

(2009) Adriana Weinberg et al.   JOURNAL OF INFECTIOUS DISEASES

Evasion of the Mucosal Innate Immune System by Herpes Simplex Virus Type 2

(2009) T. Peng et al.   JOURNAL OF VIROLOGY

STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity

(2009) Hiroki Ishikawa et al.   NATURE

Memory T cells in nonlymphoid tissue that provide enhanced local immunity during infection with herpes simplex virus

(2009) Thomas Gebhardt et al.   NATURE IMMUNOLOGY

Persistence of HIV-1 receptor–positive cells after HSV-2 reactivation is a potential mechanism for increased HIV-1 acquisition

(2009) Jia Zhu et al.   NATURE MEDICINE

Frequent Release of Low Amounts of Herpes Simplex Virus from Neurons: Results of a Mathematical Model

(2009) J. T. Schiffer et al.   Science Translational Medicine

Assessing Neonatal Herpes Reporting in the United States, 2000–2005

(2009) Thu-Ha Dinh et al.   SEXUALLY TRANSMITTED DISEASES

Use of the designation "shedder" in mucosal detection of herpes simplex virus DNA involving repeated sampling

(2009) A S Magaret et al.   SEXUALLY TRANSMITTED INFECTIONS

Increasing role of herpes simplex virus type 1 in first-episode anogenital herpes in heterosexual women and younger men who have sex with men, 1992-2006

(2009) N Ryder et al.   SEXUALLY TRANSMITTED INFECTIONS

The adjuvant CLDC increases protection of a herpes simplex type 2 glycoprotein D vaccine in guinea pigs

(2009) David I. Bernstein et al.   VACCINE

An estimate of the global prevalence and incidence of herpes simplex virus type 2 infection

(2008) Katharine Looker   BULLETIN OF THE WORLD HEALTH ORGANIZATION

Phase I Dose-Escalation Study of a Monovalent Heat Shock Protein 70-Herpes Simplex Virus Type 2 (HSV-2) Peptide-Based Vaccine Designed To Prime or Boost CD8 T-Cell Responses in HSV-Naive and HSV-2-Infected Subjects

(2008) D. M. Koelle et al.   Clinical and Vaccine Immunology

Phase I Study of a Herpes Simplex Virus Type 2 (HSV-2) DNA Vaccine Administered to Healthy, HSV-2-Seronegative Adults by a Needle-Free Injection System

(2008) A. Cattamanchi et al.   Clinical and Vaccine Immunology

Enhancement of protective humoral immune responses against Herpes simplex virus-2 in DNA-immunized guinea-pigs using protein boosting

(2008) Fatemeh Fotouhi et al.   FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY

Immune response to human papillomavirus after prophylactic vaccination with AS04-adjuvanted HPV-16/18 vaccine: Improving upon nature

(2008) Tino F. Schwarz et al.   GYNECOLOGIC ONCOLOGY

Cytomegalovirus Strain Diversity in Seropositive Women

(2008) Z. Novak et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Dendritic cells and B cells maximize mucosal Th1 memory response to herpes simplex virus

(2008) Norifumi Iijima et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Rapidly Cleared Episodes of Herpes Simplex Virus Reactivation in Immunocompetent Adults

(2008) Karen E. Mark et al.   JOURNAL OF INFECTIOUS DISEASES

Role for Plasmacytoid Dendritic Cells in the Immune Control of Recurrent Human Herpes Simplex Virus Infection

(2008) H. Donaghy et al.   JOURNAL OF VIROLOGY

A Replication-Competent, Neuronal Spread-Defective, Live Attenuated Herpes Simplex Virus Type 1 Vaccine

(2008) E. E. Brittle et al.   JOURNAL OF VIROLOGY

Effect of aciclovir on HIV-1 acquisition in herpes simplex virus 2 seropositive women and men who have sex with men: a randomised, double-blind, placebo-controlled trial

(2008) Connie Celum et al.   LANCET

Effect of Herpes Simplex Suppression on Incidence of HIV among Women in Tanzania

(2008) Deborah Watson-Jones et al.   NEW ENGLAND JOURNAL OF MEDICINE

Noncytotoxic Lytic Granule-Mediated CD8+ T Cell Inhibition of HSV-1 Reactivation from Neuronal Latency

(2008) J. E. Knickelbein et al.   SCIENCE

Comparison of immunogenicity and protective efficacy of genital herpes vaccine candidates herpes simplex virus 2 dl5-29 and dl5-29-41L in mice and guinea pigs

(2008) Yo Hoshino et al.   VACCINE

Population-level effect of potential HSV2 prophylactic vaccines on HIV incidence in sub-Saharan Africa

(2008) Esther E. Freeman et al.   VACCINE

Replication-defective virus vaccine-induced protection of mice from genital herpes simplex virus 2 requires CD4 T cells

(2008) Lynda A. Morrison   VIROLOGY

The Use of Nonhuman Primate Models in HIV Vaccine Development

(2008) Cecilia Morgan et al.   PLOS MEDICINE