Review
Oncology
Yi Zhang, Abdullah Al Mamun, Yuan Yuan, Qi Lu, Jun Xiong, Shulin Yang, Chengbiao Wu, Yanqing Wu, Jian Wang
Summary: Spinal cord injury is a debilitating traumatic condition involving two phases, primary damage and secondary damage. Mechanisms of SCI are associated with hyperflexion, hyperextension, axial loading, and rotation. Studies have explored specific pharmacological therapies to minimize SCI.
MOLECULAR MEDICINE REPORTS
(2021)
Review
Cell Biology
Yuanzhe Ding, Di Zhang, Sheng Wang, Xiaolei Zhang, Jingquan Yang
Summary: Spinal cord injury is a devastating disease causing loss of sensory and motor functions, with a pathological process involving mechanical primary injury and secondary injury. Macrophages play a crucial role in the pathology of SCI, and can be divided into different types. Hematogenous macrophages may have various roles in SCI but their specific function remains controversial.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Vaibhav Patil, Enda O'Connell, Leo R. Quinlan, Howard Fearnhead, Siobhan McMahon, Abhay Pandit
Summary: This study presents an in vitro model of mixed glial culture to induce inflammation by pro-inflammatory cytokines, replicating acute and chronic inflammatory phases associated with spinal cord injury. The researchers observed differential modulation of inflammatory pathways over 21 days, with mitochondrial dysfunction associated with cytokine treatment. The developed model, along with the high-throughput screening platform, facilitates the screening of anti-reactive glial therapeutics for SCI treatment.
Review
Chemistry, Multidisciplinary
Yiran Li, Ting Dong, Zhiwei Li, Shilei Ni, Fang Zhou, Olawale A. Alimi, Shaojuan Chen, Bin Duan, Mitchell Kuss, Shaohua Wu
Summary: Spinal cord injury is a devastating neurological condition, and neural tissue engineering combined with electrospinning technique shows great potential for its treatment.
MATERIALS TODAY CHEMISTRY
(2022)
Review
Biochemistry & Molecular Biology
Hidenori Suzuki, Yasuaki Imajo, Masahiro Funaba, Hiroaki Ikeda, Norihiro Nishida, Takashi Sakai
Summary: Spinal cord injury (SCI) is a devastating condition that causes significant neurological impairment and imposes substantial social and financial burdens. Current management approaches focus on symptomatic treatment, lacking effective therapeutic strategies. However, recent advancements in regenerative medicine have shown promise in preclinical and clinical studies. The utilization of biomaterial scaffolds, combined with stem cell therapy or other regenerative therapies, holds great potential in accelerating the development of novel therapeutic strategies for SCI. This review summarizes the latest insights from preclinical and clinical studies utilizing biomaterial scaffolds for regenerative therapy and provides a comprehensive overview of the biomaterial strategies employed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell & Tissue Engineering
Bin Lv, Xing Zhang, Jishan Yuan, Yongxin Chen, Hua Ding, Xinbing Cao, Anquan Huang
Summary: The spinal cord connects the brain to the peripheral nervous system and peripheral tissues through neurons and various types of glial cells. Neurons in the spinal cord process sensory input and control movement. Neurodegenerative disorders and traumatic injuries affecting the spinal cord result in motor deficits and loss of sensory inputs.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Chang Xu, Jiachen Sun, Miaomiao Tian, Jingwen Cui, Dingyuan Jiang, Hao Deng, Dan Li, Xifan Mei
Summary: Spinal cord injury is a complex neurological disorder with serious socioeconomic implications. Near-Infrared light-assisted therapy for SCI shows great promise in anti-inflammation and tissue regeneration effects. By summarizing the reported strategies, we can advance the research on NIR adjuvant therapy for SCI.
PROCESS BIOCHEMISTRY
(2023)
Article
Critical Care Medicine
Kristen D. Raue, Brian T. David, Richard G. Fessler
Summary: Spinal cord injury (SCI) affects approximately 1,300,000 people in the United States. Research efforts are now focused on understanding and treating the immune dysfunction and gut dysbiosis caused by SCI. The spinal cord-gut-immune axis is an important pathway that amplifies inflammation and impairs recovery in SCI, and its therapeutic potential should be further explored.
JOURNAL OF NEUROTRAUMA
(2023)
Article
Biochemistry & Molecular Biology
Erik Leemhuis, Francesca Favieri, Giuseppe Forte, Mariella Pazzaglia
Summary: This review article provides an overview of the latest interventions for the treatment of spinal cord injury (SCI), including rehabilitation, neuromodulation, and virtual reality applications. Combining existing resources has the potential to improve the short to medium-term living conditions of patients.
Article
Clinical Neurology
Tobias Zrzavy, Carmen Schwaiger, Isabella Wimmer, Thomas Berger, Jan Bauer, Oleg Butovsky, Jan M. Schwab, Hans Lassmann, Romana Hoeftberger
Summary: This study provides a detailed characterization of inflammatory responses and oxidative tissue injury in human traumatic spinal cord injury lesions. It reveals that ongoing inflammatory responses and neurotoxicity could lead to sustained neuronal damage long after the initial trauma, potentially impacting the response to rehabilitation and recovery in patients.
Article
Pharmacology & Pharmacy
Jiaqi Bi, Peiyu Sun, Erwei Feng, Jianxiong Shen, Chong Chen, Haining Tan, Zheng Li, Youxi Lin
Summary: This study demonstrated the synergistic therapeutic effects of melatonin and half-dose methylprednisolone for treating spinal cord injury. The combination of melatonin and half-dose methylprednisolone significantly reduced the dosage of methylprednisolone and limited its adverse reactions. The PI3K-AKT1 pathway was involved in the amelioration of acute SCI.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Cell Biology
Ciara Shortiss, Linda Howard, Siobhan S. McMahon
Summary: Spinal cord injury is a devastating trauma that can lead to permanent disability and chronic issues, presenting a significant socioeconomic burden. Regenerative medicine aims to overcome injury and restore function through gene therapy and tissue engineering. Combining biomaterials and lentiviral vectors has been shown to be more effective in promoting repair and function restoration post SCI.
Article
Neurosciences
Lasse Christiansen, Bing Chen, Yuming Lei, M. A. Urbin, Michael S. A. Richardson, Martin Oudega, Milap Sandhu, W. Zev Rymer, Randy D. Trumbower, Gordon S. Mitchell, Monica A. Perez
Summary: The study investigated the effects of acute intermittent hypoxia on spinal synaptic plasticity induced by paired corticospinal-motoneuronal stimulation (PCMS). The results suggest that acute intermittent hypoxia can enhance the plasticity induced by PCMS, leading to improvements in spinal and muscular function.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Engineering, Biomedical
Xin Wang, Baokun Zhang, Zhiheng Chen, Qiang Shi, Erzhu Yang, Jianguang Xu, Xiaofeng Lian
Summary: Following spinal cord injury, the disruption of the blood-spinal cord barrier (BSCB) and hemorrhage lead to progressive secondary injuries. Bazedoxifene, a third-generation estrogen receptor modulator, has been found to inhibit inflammation and blood-brain barrier disruption caused by traumatic brain injury. In this study, a new biomaterial carrier was developed to deliver Bazedoxifene to the site of spinal cord injury and effectively attenuate BSCB disruption through the NF-KB pathway, providing potential therapeutic benefits for spinal cord repair.
ACTA BIOMATERIALIA
(2023)
Review
Clinical Neurology
Yohannes Tsehay, Carly Weber-Levine, Timothy Kim, Alejandro Chara, Safwan Alomari, Tolulope Awosika, Ann Liu, Jeffrey Ehresman, Kurt Lehner, Brian Hwang, Andrew M. Hersh, Ian Suk, Eli Curry, Fariba Aghabaglou, Yinuo Zeng, Amir Manbachi, Nicholas Theodore
Summary: Spinal cord injury is a devastating condition that requires advanced monitoring techniques for accurate assessment. This review discusses various SCI monitoring modalities and suggests that the next-generation monitoring setup should integrate multiple modalities to improve patient outcomes.
