Journal
JOURNAL OF CLINICAL INVESTIGATION
Volume 118, Issue 12, Pages 3832-3835Publisher
AMER SOC CLINICAL INVESTIGATION INC
DOI: 10.1172/JCI37733
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Funding
- NCI NIH HHS [R01 CA131270, P01 CA100324, CA131270] Funding Source: Medline
- NICHD NIH HHS [R01 HD050614, HD050614, HD30820] Funding Source: Medline
- PHS HHS [P30-13330] Funding Source: Medline
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Successful embryo implantation requires complex interactions between the uterus and embryo, including the establishment of maternal immunologic tolerance of fetal material. The maternal-fetal interface is dynamically populated by a wide variety of innate immune cells; however, the relevance of uterine DCs (uDCs) within the decidua to the success of implantation has remained unclear. In this issue of the JCI, Plaks et al. show, in a transgenic mouse model, that uDCs are essential for pregnancy, as their ablation results in a failure of decidualization, impaired implantation, and embryonic resorption (see the related article beginning on page 3954). Depletion of uDCs altered decidual angiogenesis, suggesting that uDCs contribute to successful implantation via their effects on decidual tissue remodeling, including angiogenesis, and independent of their anticipated role in the establishment of maternal-fetal tolerance.
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