Review
Microbiology
Sushil Kumar, Girijesh Kumar Patel, Uday C. Ghoshal
Summary: Gastric cancer is associated with chronic inflammation, parasitic infections, dietary habits, and host genetic factors. Research on the process of H. pylori-induced inflammation and gastric precursor lesions suggests that gut microbiota and parasitic infections may modulate risk, while genetic polymorphisms and exosomes play a role in the development of gastric carcinoma.
Editorial Material
Microbiology
Agustina Taglialegna
Summary: In this study, Sharafutdinov et al. report the identification of a single nucleotide polymorphism in the gene encoding the HtrA protease of Helicobacter pylori that is linked to gastric cancer.
NATURE REVIEWS MICROBIOLOGY
(2023)
Article
Oncology
JunJian He, WeiChao Hu, Qin Ouyang, ShengWei Zhang, LiJiao He, WeiYan Chen, XinZhe Li
Summary: This paper reviews the pathogenic mechanisms by which H. pylori induces gastric stem cell-like properties and CSCs, and supplements the existing Correa model. H. pylori infection leads to dysfunction of developmental signaling pathways and alteration of gastric mucosal microenvironment, potentially promoting gastric stem cell-like properties through epithelial-mesenchymal transition.
Article
Multidisciplinary Sciences
Tomohiko Yasuda, Hyun Seok Lee, Su Youn Nam, Hiroto Katoh, Yuko Ishibashi, Somay Yamagata Murayama, Hidenori Matsui, Hiroki Masuda, Emiko Rimbara, Nobuyuki Sakurazawa, Hideyuki Suzuki, Hiroshi Yoshida, Yasuyuki Seto, Shumpei Ishikawa, Seong Woo Jeon, Masahiko Nakamura, Sachiyo Nomura
Summary: Genetic analysis and culturing techniques for gastric non-Helicobacter pylori Helicobacter (NHPH) are advancing, with NHPH reported to accompany certain gastric conditions. A study on Korean gastric cancer patients found a low percentage positive for NHPH, suggesting it may play a role in gastric cancer development, albeit with lower pathogenicity compared to H. pylori.
SCIENTIFIC REPORTS
(2022)
Review
Pharmacology & Pharmacy
Faisal Aziz, Imran Khan, Shruti Shukla, Debasish Kumar Dey, Qiu Yan, Abhijit Chakraborty, Hisae Yoshitomi, Seung-Kyu Hwang, Sonam Sonwal, Hoomin Lee, Yuvaraj Haldorai, Jianbo Xiao, Yun Suk Huh, Vivek K. Bajpai, Young-Kyu Han
Summary: Helicobacter pylori and its cytotoxin associated antigen A play significant roles in the development of gastric cancer. Glycosylation alterations and overexpression of Lewis Y may serve as potential biomarkers for the prognosis of gastric cancer.
PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Medicine, General & Internal
Yoshiaki Usui, Yukari Taniyama, Mikiko Endo, Yuriko N. Koyanagi, Yumiko Kasugai, Isao Oze, Hidemi Ito, Issei Imoto, Tsutomu Tanaka, Masahiro Tajika, Yasumasa Niwa, Yusuke Iwasaki, Tomomi Aoi, Nozomi Hakozaki, Sadaaki Takata, Kunihiko Suzuki, Chikashi Terao, Masanori Hatakeyama, Makoto Hirata, Kokichi Sugano, Teruhiko Yoshida, Yoichiro Kamatani, Hidewaki Nakagawa, Koichi Matsuda, Yoshinori Murakami, Amanda B. Spurdle, Keitaro Matsuo, Yukihide Momozawa
Summary: This study reveals that certain genetic variants associated with Helicobacter pylori infection can increase the risk of gastric cancer. Individuals carrying these genetic variants and infected with H. pylori have an even higher risk of developing gastric cancer.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Medicine, General & Internal
Yaodong Zhu, Fangyuan Zhu, He Ba, Jie Chen, Xiuliang Bian
Summary: This meta-analysis found a significant association between Helicobacter pylori infection and the expression of programmed death ligand-1 (PD-L1) in patients with gastric cancer. Subgroup analyses showed a stronger association in studies with a higher prevalence of HP infection.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Review
Biochemistry & Molecular Biology
Silvia Salvatori, Irene Marafini, Federica Laudisi, Giovanni Monteleone, Carmine Stolfi
Summary: H. pylori infection contributes to the onset and development of gastric cancer through the mechanisms of chronic inflammation and DNA damage to gastric epithelial cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemical Research Methods
Lusheng Song, Minkyo Song, Charles S. Rabkin, Stacy Williams, Yunro Chung, Jennifer Van Duine, Linda M. Liao, Kailash Karthikeyan, Weimin Gao, Jin G. Park, Yanyang Tang, Jolanta Lissowska, Ji Qiu, Joshua LaBaer, M. Constanza Camargo
Summary: This study evaluated humoral responses to a nearly complete H. pylori immunoproteome among GC cases and controls, finding higher prevalence of certain antibodies in controls and lower seroprevalence in GC cases, suggesting immune protection and potential changes in specific proteins.
JOURNAL OF PROTEOME RESEARCH
(2021)
Article
Gastroenterology & Hepatology
Emily Taillieu, Chloe De Witte, Heiko De Schepper, Wouter Van Moerkercke, Sophie Rutten, Stijn Michiels, Yuna Arnst, Sofie De Bruyckere, Sven Francque, Frauke van Aert, Christophe George, Emma Callewaert, Tiene Callewaert, Glenn Vanneste, Erik Vanderstraeten, Nina Van Heddegem, Margaux Vansteelant, Koen Chiers, Freddy Haesebrouck, Christophe Van Steenkiste
Summary: This study reveals that gastric non-Helicobacter pylori Helicobacter (NHPH) species naturally associated with animals are linked with gastric disease in human patients. The findings suggest that routine PCR testing for zoonotic gastric NHPHs should be conducted on patients with gastric complaints to diagnose potential pathogens.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Review
Microbiology
Ling Zhang, Ming Zhao, Xiangsheng Fu
Summary: Helicobacter pylori (H. pylori) infection is a common cause of gastric disease, but the increase in antibiotic resistance has made it challenging to eradicate. The stomach has a unique microecology that can have positive, negative, or neutral effects on microbial fitness and function. This article reviews the imbalance of gastric microecology and its relationship with H. pylori, as well as potential methods for modulating gastric microecology to facilitate H. pylori eradication, such as probiotics, prebiotics, postbiotics, synbiotics, and microbiota transplantation.
FRONTIERS IN MICROBIOLOGY
(2023)
Review
Gastroenterology & Hepatology
Fabian Fellipe Bueno Lemos, Marcel Silva Luz, Samuel Luca Rocha Pinheiro, Kadima Nayara Teixeira, Fabricio Freire de Melo
Summary: Gastric mucosa-associated lymphoid tissue lymphoma (GML) is a low-grade B-cell neoplasia commonly associated with chronic gastritis induced by Helicobacter pylori (H. pylori) infection. However, a subset of GML patients are H. pylori-negative. Despite previous beliefs, it has been found that a considerable proportion of H. pylori-negative GML patients show complete remission after bacterial eradication therapy. The mechanisms underlying this treatment responsiveness are not fully understood, and further research is needed to establish the causal relationship between non-H. pylori gastric helicobacters (NHPHs) and GML.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Immunology
Dongsheng Liu, Jinyun Wang, Yong Xie
Summary: Refractory Helicobacter pylori infection leads to significant alterations in gastric microbiota, inhibiting the growth of beneficial Lactobacillus. Patients with refractory H. pylori infection may be more prone to developing gastric cancer.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Maria Fernanda Gonzalez, Paula Diaz, Alejandra Sandoval-Borquez, Daniela Herrera, Andrew F. G. Quest
Summary: Extracellular vesicles are important in host-pathogen interactions, playing a role in modulating inflammatory responses and promoting disease development. Both EVs from cells infected with H. pylori and H. pylori-OMVs are involved in the development of gastric cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Daniela Eletto, Megi Vllahu, Fatima Mentucci, Pasquale Del Gaudio, Antonello Petrella, Amalia Porta, Alessandra Tosco
Summary: H. pylori infection is a major risk factor for gastric cancer development, with TFF1 playing a protective role by affecting the aggregation and motility of the bacterium, as well as reducing gene transcription. This interaction may explain the persistent presence of H. pylori in the human host without causing disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
