Review
Biochemistry & Molecular Biology
Mohammad Enamul Hoque Kayesh, Michinori Kohara, Kyoko Tsukiyama-Kohara
Summary: Chronic hepatitis B virus (HBV) infection is a major global health problem, and the link between Toll-like receptors (TLRs) and chronic HBV infection is being increasingly recognized. TLR agonists have the potential to enhance the host immune response against HBV infection and improve CHB treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Infectious Diseases
Pham Thi Minh Huyen, Dang Thi Ngoc Dung, Peter Johann Weiss, Phan Quoc Hoan, Dao Phuong Giang, Ngo Thi Uyen, Nguyen Van Tuan, Ngo Tat Trung, Thirumalaisamy P. Velavan, Le Huu Song, Nghiem Xuan Hoan
Summary: This study found that PD-1.5 and PD-1.9 genetic variants, as well as plasma sPD-1 levels, are associated with hepatitis B virus infection and disease progression. Plasma sPD-1 levels are positively correlated with liver inflammation and fibrosis progression, while PD-1.5 and PD-1.9 genetic variants are associated with the risk of hepatocellular carcinoma.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Biochemistry & Molecular Biology
Tzu-Wei Wu, Chao-Liang Chou, Chuen-Fei Chen, Li-Yu Wang
Summary: This case-control study finds that response to the HB vaccine and susceptibility to chronic HBV infection have common genetic determinants, with HLA class II members being the main responsible host genetic factors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Mohammad Enamul Hoque Kayesh, Michinori Kohara, Kyoko Tsukiyama-Kohara
Summary: This review discusses the importance of TLR responses in HCV infection and the mechanisms adopted by HCV to avoid immune surveillance mediated by TLRs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Analytical
Youngung Seok, Qingtian Yin, Huiwen Bai, Haim H. Bau
Summary: Untreated HBV and HCV infections can lead to severe illnesses. To address the challenge of convenience and patient follow-up, a sensitive two-stage molecular test called Penn-RAMP was developed for test and treat strategy.
ANALYTICAL CHEMISTRY
(2022)
Article
Immunology
Jie Li, Hwai- Yang, Ming-Lun Yeh, Michael H. Le, An K. Le, Yee Hui Yeo, Chia-Yen Dai, Scott Barnett, Jian Q. Zhang, Jee-Fu Huang, Huy N. Trinh, Christopher Wong, Clifford Wong, Joseph K. Hoang, Ramsey Cheung, Ming-Lung Yu, Mindie H. Nguyen
Summary: This study found that concurrent FL in patients with CHB significantly reduces the risk of cirrhosis and HCC, as well as increases the rate of HBsAg seroclearance. Further research is needed to confirm these findings and investigate the underlying mechanisms of FL on CHB.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Zoology
Qianqian Su, Yi Chen, Bo Wang, Qingxun Zhang, Hongxuan He
Summary: The study investigated the genetic characteristics and evolution of Toll-like receptors in wild brown rats, revealing high genetic diversity in TLR8 and low genetic diversity in TLR2. Findings indicated that genetic variations in TLR2 and TLR8 were associated with Bartonella and HEV infection, respectively.
INTEGRATIVE ZOOLOGY
(2022)
Article
Immunology
Mengmeng Li, Ying Xu, Kexue Pu, Jie Fan, Zheng Cheng, Hao Chen, Li Zhou
Summary: This study revealed a significant association between CXCL10 gene polymorphisms and the risk of chronic HBV infection in Chinese Han population. The A allele of the rs4508917 in CXCL10 was identified as a risk factor for persistent HBV infection, affecting the response to nucleos(t)ide analogues treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Pharmacology & Pharmacy
Nikoo Bayan, Niloufar Yazdanpanah, Nima Rezaei
Summary: Diabetic retinopathy (DR) is a common complication of diabetes mellitus (DM) and is associated with inflammation, cellular apoptosis, neurodegeneration, oxidative stress, and neovascularization. Toll-like receptor 4 (TLR4) plays a crucial role in the development of DR, and microRNAs are involved in the pathogenesis of DR through their interaction with TLR4. Inhibitors of the TLR4 pathway have shown potential in the treatment of DR.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Virology
Yinan Yao, Yan Shen, Haifeng Shao, Yuchang Liu, Yan Ji, Guoming Du, Xiangyu Ye, Peng Huang, Haiming Chen
Summary: RLRs, specifically the DDX58 rs3824456, DHX58 rs2074160, and IFIH1 rs2111485 SNPs, may be predictive markers for spontaneous clearance of HBV in the Chinese Han population.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Cih-En Huang, Jung-Jung Chang, Yu-Ying Wu, Shih-Hao Huang, Wei-Ming Chen, Chia-Chen Hsu, Chang-Hsien Lu, Chao-Hung Hung, Chung-Sheng Shi, Kuan-Der Lee, Chih-Cheng Chen, Min-Chi Chen
Summary: This study compared the different risk factors and impacts of hepatitis C virus-associated thrombocytopenia (HCV-TP) and hepatitis B virus-associated thrombocytopenia (HBV-TP). The findings showed that the incidence of thrombocytopenia was higher in HCV patients compared to HBV patients. Additionally, the risk factors for thrombocytopenia varied with the severity and virus type, suggesting the need for different management approaches for HCV-TP and HBV-TP.
BIOMEDICAL JOURNAL
(2022)
Article
Gastroenterology & Hepatology
Edward J. Gane, P. Rod Dunbar, Anna E. Brooks, Fangqiu Zhang, Diana Chen, Jeffrey J. Wallin, Nicholas van Buuren, Priyanka Arora, Simon P. Fletcher, Susanna K. Tan, Jenny C. Yang, Anuj Gaggar, Shyamasundaran Kottilil, Lydia Tang
Summary: Selgantolimod treatment showed positive effects on hepatitis B surface antigen, but only a few patients achieved the primary efficacy endpoint. The common adverse events during treatment included nausea, upper respiratory tract infection, and vomiting. Overall, this treatment approach showed potential in a small proportion of patients.
JOURNAL OF HEPATOLOGY
(2023)
Article
Immunology
Milan J. Sonneveld, Bettina E. Hansen, Willem P. Brouwer, Henry L-Y Chan, Teerha Piratvisuth, Ji-Dong Jia, Stefan Zeuzem, Rong-Nan Chien, Robert J. de Knegt, Cynthia Wat, Vedran Pavlovic, Anuj Gaggar, Qing Xie, Maria Buti, Robert A. de Man, Harry L. A. Janssen
Summary: This study investigated the relationship between HBsAg levels and hepatic fibrosis and cirrhosis in patients with chronic hepatitis B. The results showed that lower HBsAg levels were associated with higher rates of fibrosis and cirrhosis in HBeAg-positive patients, but not in HBeAg-negative patients. Additionally, genotype-specific HBsAg cutoffs could be used to rule out the presence of cirrhosis. These findings are important for the diagnosis and treatment of chronic hepatitis B patients.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Biochemistry & Molecular Biology
Theodoros Androutsakos, Athanasios-Dimitrios Bakasis, Abraham Pouliakis, Maria Gazouli, Christos Vallilas, Gregorios Hatzis
Summary: This study aimed to investigate the role of two common single-nucleotide polymorphisms (SNPs) of Toll-like receptor-4 in the development of hepatocellular carcinoma (HCC). The results showed that TLR4 SNPs had no correlation with the occurrence or death of HCC, except for a shorter duration between HCC development and death in patients with TLR4 mutations. However, patients with TLR4 SNPs that developed HCC had lower survival rates.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Zhiwei Liu, Chih-Jen Huang, Yu-Han Huang, Mei-Hung Pan, Mei-Hsuan Lee, Kelly J. Yu, Ruth M. Pfeiffer, Mathias Viard, Yuko Yuki, Xiaojiang Gao, Mary Carrington, Chien-Jen Chen, Allan Hildesheim, Hwai- Yang
Summary: The study found that an increase in the number of homozygous HLA class II loci is associated with an increased risk of chronic HBV infection and HBV-associated HCC. Specifically, HLA-DQB1 homozygosity is significantly associated with HCC risk.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Gastroenterology & Hepatology
Philippe Merle, Jean-Frederic Blanc, Jean-Marc Phelip, Gilles Pelletier, Jean-Pierre Bronowicki, Yann Touchefeu, Georges Pageaux, Rene Gerolami, Francois Habersetzer, Eric Nguyen-Khac, Andrea Casadei-Gardini, Ivan Borbath, Albert Tran, Henning Wege, Amr Shafik Saad, Massimo Colombo, Armand Abergel, Carine Richou, Imam Waked, Nelson S. Yee, Audrey Mole, Pierre Attali, Julie Le Boulicaut, Berangere Vasseur
LANCET GASTROENTEROLOGY & HEPATOLOGY
(2019)
Review
Gastroenterology & Hepatology
Jose C. R. Nascimento, Gabriella A. Matos, Lianna C. Pereira, Anderson E. C. C. B. Mourao, Aline M. Sampaio, Reinaldo B. Oria, Pierluigi Toniutto
ANNALS OF HEPATOLOGY
(2020)
Article
Gastroenterology & Hepatology
Alberto Ferrarese, Maria Cristina Morelli, Paola Carrai, Martina Milana, Mario Angelico, Giovanni Perricone, Luca Saverio Belli, Giuseppe Marrone, Antonio Grieco, Silvia Martini, Matteo Angelo Manini, Stefano Fagiuoli, Pierluigi Toniutto, Alfonso Galeota Lanza, Sherrie Bhoori, Salvatore Petta, Edoardo G. Giannini, Patrizia Burra
LIVER TRANSPLANTATION
(2020)
Article
Urology & Nephrology
Delia Colombo, Alessandro Zullo, Lucia Simoni, Emanuela Zagni, Stefano Fagiuoli, Paolo De Simone, Donato Donati, Mauro Salizzoni, Paolo Angeli, Patrizia Burra, Umberto Cillo, Pierluigi Toniutto, Massimo Rossi, Giovanni Vennarecci, Luciano De Carlis, Francesca Donato, Matteo Cescon, Alfredo Di Leo, Giovanni Giuseppe Di Costanzo, Alfonso Avolio
Article
Gastroenterology & Hepatology
Lars Bossen, Paola Rebora, Francesca Bernuzzi, Peter Jepsen, Alessio Gerussi, Pietro Andreone, Andrea Galli, Benedetta Terziroli, Domenico Alvaro, Giancarlo Labbadia, Chiara Aloise, Leonardo Baiocchi, Edoardo Giannini, Ludovico Abenavoli, Pierluigi Toniutto, Fabio Marra, Marco Marzioni, Grazia Niro, Annarosa Floreani, Holger J. Moller, Maria G. Valsecchi, Marco Carbone, Henning Gronbaek, Pietro Invernizzi
LIVER INTERNATIONAL
(2020)
Article
Gastroenterology & Hepatology
Ching Ngar Wong, Petros Fessas, Kathy Dominy, Francesco A. Mauri, Takahiro Kaneko, Persephone Du Parcq, Jamshid Khorashad, Pierluigi Toniutto, Robert D. Goldin, Claudio Avellini, David J. Pinato
Summary: In this pilot study, targeted next-generation sequencing (tNGS) was optimized to estimate tumour mutational burden (TMB) in hepatocellular carcinoma (HCC). The results showed that FFPE samples had higher TMB values compared to FF samples, while UDG-treated samples had lower TMB values. TMB values from fresh HCC samples may limit its role as a predictor of response to immunotherapy in HCC.
LIVER INTERNATIONAL
(2021)
Review
Medicine, General & Internal
Pierluigi Toniutto, Giacomo Germani, Alberto Ferrarese, Davide Bitetto, Alberto Zanetto, Ezio Fornasiere, Elisa Fumolo, Sarah Shalaby, Patrizia Burra
Summary: With the increasing long-term survival after liver transplantation, the care for medical problems that arise over time in liver-transplanted patients has become important. The most common causes of death occurring more than 1 year after liver transplantation are unrelated to liver diseases and are facilitated by immunosuppressive treatments. Primary care physicians are increasingly exposed to liver-transplanted patients and should be aware of the common risks and complications faced by these patients to enhance their care. Collaboration with transplant hepatologists is crucial for implementing long-term follow-up care.
AMERICAN JOURNAL OF MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Pierluigi Toniutto, Edmondo Falleti, Sara Cmet, Annarosa Cussigh, Laura Veneto, Davide Bitetto, Ezio Fornasiere, Elisa Fumolo, Carlo Fabris, Assunta Sartor, Roberto Peressutti, Francesco Curcio, Laura Regattin, Lucrezia Grillone
Summary: This study explores the long-term antibody response and failure mechanism of COVID-19 vaccines in liver transplant recipients, revealing significantly lower antibody titers after vaccination compared to controls and identifying MMF as a major predictor of vaccination failure.
JOURNAL OF HEPATOLOGY
(2022)
Editorial Material
Medicine, General & Internal
Pierluigi Toniutto
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Pierluigi Toniutto, Annarosa Cussigh, Sara Cmet, Davide Bitetto, Ezio Fornasiere, Elisa Fumolo, Martina Fabris, Federica D'Aurizio, Carlo Fabris, Lucrezia Grillone, Assunta Sartor, Francesco Curcio, Edmondo Falleti
Summary: The third dose of the BNT16b2 vaccine increased the rate of positive anti-SARS-CoV-2 antibody response in liver transplant recipients, but some patients still did not respond. Predictors of antibody response failure after the third dose included higher dose of mycophenolate mofetil and lower estimated glomerular filtration rate.
LIVER INTERNATIONAL
(2023)
Letter
Gastroenterology & Hepatology
Pierluigi Toniutto, Annarosa Cussigh, Sara Cmet, Edmondo Falleti
LIVER INTERNATIONAL
(2022)
Article
Health Care Sciences & Services
Stefano Fagiuoli, Pierluigi Toniutto, Nicola Coppola, Domenica Daniela Ancona, Margherita Andretta, Fausto Bartolini, Fulvio Ferrante, Alessandro Lupi, Stefano Palcic, Francesca Vittoria Rizzi, Davide Re, Gema Alvarez Nieto, Candido Hernandez, Francesca Frigerio, Valentina Perrone, Luca Degli Esposti, Alessandra Mangia
Summary: This study investigates the impact of polymedication and aging on the prevalence of drug-drug interactions (DDIs) in HCV patients treated with SOF/VEL or GLE/PIB. The study finds that SOF/VEL patients are older and have more comorbidities and polypharmacy compared to GLE/PIB patients. The simultaneous use of multiple medications can lead to DDIs and increase treatment risks.
THERAPEUTICS AND CLINICAL RISK MANAGEMENT
(2023)
Article
Medicine, General & Internal
Pierluigi Toniutto, Michela Zorzi, Lorenzo D'Ali, Annarosa Cussigh, Sara Cmet, Davide Bitetto, Ezio Fornasiere, Elisa Fumolo, Carla Di Loreto, Edmondo Falleti
Summary: This study aimed to assess treatment responses in 39 patients with autoimmune hepatitis (AIH). The study found that the absence of cirrhosis and a >= 50% decrease in serum alanine aminotransferase (ALT) levels were independent predictors for complete biochemical response (CBR) at six months. Additionally, a baseline GLUCRE score may help identify patients maintaining longer CBR.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Immunology
Pierluigi Toniutto, Annarosa Cussigh, Sara Cmet, Martina Fabris, Francesco Curcio, Davide Bitetto, Ezio Fornasiere, Elisa Fumolo, Edmondo Falleti
Summary: This study aimed to evaluate whether temporary MMF interruption might improve the immunogenicity of the fourth anti-SARS-CoV-2 BNT16b2 vaccine dose in nonresponsive LT recipients. The results showed that suspending MMF prior to the fourth dose could restore vaccine-induced immunogenicity in a large portion of previously nonresponsive LT recipients.
Article
Gastroenterology & Hepatology
Edmondo Falleti, Sara Cmet, R. Anna Cussigh, Elena Salvador, Davide Bitetto, Ezio Fornasiere, Elisa Fumolo, Carlo Fabris, Pierluigi Toniutto
Summary: The study found that the incidence of SBP in cirrhosis patients was 13.9%, and it was associated with higher MELD score, serum glucose value, elevated CRP serum levels, and higher potassium serum levels. The occurrence of SBP is associated with more severe liver dysfunction and inflammation, while failure of first-line antibiotic treatment and SBP recurrence appear to strongly influence the mortality rate.
JOURNAL OF CLINICAL AND EXPERIMENTAL HEPATOLOGY
(2021)
