Article
Obstetrics & Gynecology
Ismaela Maria Ferreira de Melo, Cintia Giselle Martins Ferreira, Erique Ricardo Alves, Carolline Guimaraes D'Assuncao, Clovis Jose Cavalcanti Lapa Neto, Yuri Mateus Lima de Albuquerque, Valeria Wanderley Teixeira, Alvaro Aguiar Coelho Teixeira
Summary: Gestational diabetes mellitus (GDM) promotes changes in the placenta and fetuses, but melatonin can prevent these effects.
REPRODUCTIVE SCIENCES
(2022)
Article
Obstetrics & Gynecology
Esa M. Davis, Kaleab Z. Abebe, Hyagriv N. Simhan, Patrick Catalano, Tina Costacou, Diane Comer, Steven Orris, Kathleen Ly, Alison Decker, Dara Mendez, Nancy Day, Christina M. Scifres
Summary: This study compared the short-term perinatal outcomes between the IADPSG and Carpenter-Coustan screening strategies for gestational diabetes mellitus, finding no significant differences in the incidence of large-for-gestational-age neonates, neonatal and maternal composite adverse perinatal outcomes, or other measures between the two groups.
OBSTETRICS AND GYNECOLOGY
(2021)
Article
Endocrinology & Metabolism
Fanny Goyette, Bi Lan Wo, Marie-Helene Iglesias, Evelyne Rey, Ariane Godbout
Summary: The glycemic thresholds used to diagnose GDM are still a topic of debate. This study compared maternal and neonatal outcomes in women with mild hyperglycemia who were treated or left untreated. The results showed that treating women with mild hyperglycemia decreased the risk of adverse outcomes.
DIABETES & METABOLISM
(2023)
Article
Medicine, General & Internal
Rana F. Chehab, Assiamira Ferrara, Mara B. Greenberg, Amanda L. Ngo, Juanran Feng, Yeyi Zhu
Summary: Glycemic control trajectories are associated with the risk of perinatal complications, with better glycemic control leading to lower risks.
Article
Biochemistry & Molecular Biology
Amy M. Valent, Haeri Choi, Kevin S. Kolahi, Kent L. Thornburg
Summary: The study revealed that maternal glycemia affects the placental metabolism of trophoblast cell types in pregnant women with gestational diabetes mellitus. It was found that the suppressed metabolic activity is mainly due to dysfunction of CTB cells, leading to decreased hormone expression and secretion.
Article
Medicine, General & Internal
David Simmons, Jincy Immanuel, William M. Hague, Helena Teede, Christopher J. Nolan, Michael J. Peek, Jeff R. Flack, Mark McLean, Vincent Wong, Emily Hibbert, Alexandra Kautzky-Willer, Juergen Harreiter, Helena Backman, Emily Gianatti, Arianne Sweeting, Viswanathan Mohan, Joanne Enticott, N. Wah Cheung
Summary: The effectiveness of early treatment for gestational diabetes before 20 weeks' gestation on maternal and infant health is not clear. In this study, women at risk of hyperglycemia and diagnosed with gestational diabetes were randomly assigned to receive immediate treatment or deferred/no treatment based on the results of an oral glucose-tolerance test at 24 to 28 weeks' gestation. The results showed that immediate treatment led to a slightly lower incidence of adverse neonatal outcomes, but no significant differences were observed for pregnancy-related hypertension or neonatal lean body mass.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Endocrinology & Metabolism
Yunzhen Ye, Yu Xiong, Qiongjie Zhou, Xirong Xiao, Xiaotian Li
Summary: There is an association between early-pregnancy intermediate hyperglycemia and adverse pregnancy outcomes among women without gestational diabetes. Women with intermediate hyperglycemia in early pregnancy have higher risks for adverse maternal-fetal outcomes, even with normal future OGTTs, and they tend to have higher age and body mass index.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Dentistry, Oral Surgery & Medicine
Fen Liu, Wen Sui, Zhi-Fei Zhou, Yang Mi, Tong-Qiang He, Zhi-Bin Li, Yong-Long Hong, Fa-Ming Chen
Summary: This study found an association between periodontitis and gestational diabetes mellitus (GDM), with treatment reducing the incidence of GDM. The presence of Porphyromonas gingivalis was associated with high levels of inflammatory mediators, highlighting a potential role in the development of GDM.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2022)
Article
Environmental Sciences
Waleed M. Aldahmash, Saleh H. Alwasel, Khaldoon Aljerian
Summary: Gestational diabetes mellitus poses significant risks to both the developing fetus and the mother, increasing the risk of maternal complications during pregnancy and later development of type 2 diabetes mellitus and cardiovascular disease. The study found that placental vasculopathies on both the maternal and fetal sides were significantly increased in the GDM group, indicating histopathological changes induced by GDM in the full-term placenta.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Medicine, General & Internal
Almudena Lara-Barea, Begona Sanchez-Lechuga, Alvaro Vidal-Suarez, Ana I. Arroba, Fernando Bugatto, Cristina Lopez-Tinoco
Summary: The alterations in ambulatory blood pressure monitoring have been associated with perinatal complications, especially in normotensive women with gestational diabetes mellitus and obesity. Nocturnal systolic blood pressure was found to be a predictor of hypertensive disorders of pregnancy in these patients. High blood pressure and a non-dipper pattern were observed in women who delivered preterm, indicating a potential association with poor obstetric and perinatal outcomes.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Obstetrics & Gynecology
Eesha D. Dave, Lisa M. Bodnar, Kavita Vani, Katherine P. Himes
Summary: Gestational diabetes is a risk factor for preeclampsia in twin pregnancies, while its association with neonatal outcomes remains unclear, although it may reduce the incidence of small for gestational age infants. Prospective studies are needed to explore if glycemic control can decrease the risk for preeclampsia in twin pregnancies with gestational diabetes.
AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY MFM
(2021)
Article
Medicine, General & Internal
David M. Nathan, GRADE Study Res Grp, John M. Lachin, Ashok Balsubramanyam, Henry B. Burch, John B. Buse, Nicole M. Butera, Robert M. Cohen, Jill P. Crandall, Steven E. Kahn, Heidi Krause-Steinrauf, Mary E. Larkin, Neda Rasouli, Margaret Tiktin, Deborah J. Wexler, Naji Younes
Summary: In this trial, all four glucose-lowering medications added to metformin were effective in reducing glycated hemoglobin levels. Glargine and liraglutide showed modestly superior efficacy in achieving and maintaining target glycated hemoglobin levels.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Biology
Amel Lamri, Jayneel Limbachia, Karleen M. Schulze, Dipika Desai, Brian Kelly, Russell J. de Souza, Guillaume Pare, Deborah A. Lawlor, John Wright, Sonia S. Anand
Summary: This study investigated the risk factors for gestational diabetes mellitus (GDM) in South Asian women, and found that a type 2 diabetes (T2D) polygenic risk score (PRS) and family history of diabetes were strongly and independently associated with GDM-related traits.
Article
Endocrinology & Metabolism
Malgorzata M. M. Brzozowska, Anita Puvanendran, Dana Bliuc, Andrew Zuschmann, Agata K. K. Piotrowicz, Anthony O'Sullivan
Summary: This study aimed to compare perinatal outcomes for women with gestational diabetes who received dietary intervention with those who received pharmacological treatment, and to identify predictors for the need of pharmacological treatment. The results suggest that metformin may be a safe alternative to insulin treatment for gestational diabetes. Fasting glucose value was the strongest predictor for the need of pharmacological intervention.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Medicine, General & Internal
Teresa A. Hillier, Kathryn L. Pedula, Keith K. Ogasawara, Kimberly K. Vesco, Caryn E. S. Oshiro, Suzanne L. Lubarsky, Jan Van Marter
Summary: In this study comparing one-step screening with two-step screening for gestational diabetes mellitus, the one-step approach resulted in more diagnoses of gestational diabetes mellitus but did not have a significant impact on the incidence of adverse perinatal and maternal outcomes.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Obstetrics & Gynecology
Maria J. O. Miele, Renato T. Souza, Iracema M. Calderon, Francisco E. Feitosa, Debora F. Leite, Edilberto A. Rocha Filho, Janete Vettorazzi, Jussara Mayrink, Matias C. Vieira, Rodolfo C. Pacagnella, Jose G. Cecatti
Summary: This study highlighted that pregnant women in the northeast region of Brazil consumed more unprocessed/minimally processed and processed foods, with lower intake of dairy products and vegetables compared to women in the southern/southeastern region. There was also a deficiency in essential nutrients like vitamins and minerals in their diets, pointing to the importance of regional nutritional guidance and local culinary diversity.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2022)
Correction
Obstetrics & Gynecology
Nathalia C. D. Macedo, Isabela L. Iessi, Franciane Q. Gallego, Aline O. Netto, Yuri K. Sinzato, Gustavo T. Volpato, Elena Zambrano, Debora C. Damasceno
REPRODUCTIVE SCIENCES
(2021)
Article
Obstetrics & Gynecology
Nathalia C. D. Macedo, Isabela L. Iessi, Franciane Q. Gallego, Aline O. Netto, Yuri K. Sinzato, Gustavo T. Volpato, Elena Zambrano, Debora C. Damasceno
Summary: The study aims to confirm the effects of moderate-intensity swimming on glycemic control and oxidative stress levels in diabetic rats, as well as its influence on pancreatic adaptations, embryo implantation, and placental efficiency. The results show that moderate exercise can improve glucose metabolism and reduce post-implantation loss in diabetic rats, but may cause muscle and lipid membrane damages that need to be addressed with adjusted exercise intensity.
REPRODUCTIVE SCIENCES
(2021)
Article
Public, Environmental & Occupational Health
Carolina M. Saullo, Yuri K. Sinzato, Veronyca G. Paula, Franciane Q. Gallego, Jose E. Corrente, Isabela L. Iessi, Gustavo T. Volpato, Debora C. Damasceno
Summary: Maternal hyperglycemia can alter offspring programming, leading to increased periovarian fat and body weight in adult female offspring. High-fat diet post-weaning exacerbates these changes, potentially affecting future reproductive function.
JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Fernanda Cristina Bergamo Alves, Rafael Guilen de Oliveira, David Rafael Abreu Reyes, Gabriela Azevedo Garcia, Juliana Ferreira Floriano, Raghavendra Hallur Lakshmana Shetty, Edson Assuncao Mareco, Maeli Dal-Pai-Silva, Spencer Luiz Marques Payao, Fatima Pereira de Souza, Steven S. Witkin, Luis Sobrevia, Angelica Mercia Pascon Barbosa, Marilza Vieira Cunha Rudge
Summary: Gestational diabetes mellitus (GDM) is a window of opportunity for predicting future complications such as type 2 diabetes mellitus and pelvic floor muscle disorders. This study focuses on the transcriptome profiling of the rectus abdominis muscle (RAM) in GDM women and identifies differentially expressed genes associated with muscle structure, muscle protein synthesis, muscle damage repair, and glycogenesis. These findings shed light on the molecular mechanisms of GDM and may lead to innovative interventions for preventing and treating post-GDM urinary incontinence.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Obstetrics & Gynecology
Eduardo Kloppel, Yuri K. Sinzato, Tiago Rodrigues, Franciane Q. Gallego, Barshana Karki, Gustavo T. Volpato, Jose E. Corrente, Sayon Roy, Debora C. Damasceno
Summary: This study evaluates the effects of vitamin D supplementation on pre-existing diabetes in pregnant rats and their fetuses. The results show that vitamin D treatment can lower blood glucose levels and indicators of membrane lipid peroxidation, while improving the intrauterine environment for better fetal development.
REPRODUCTIVE SCIENCES
(2023)
Article
Andrology
Veronyca Goncalves Paula, Maysa Rocha de Souza, Yuri Karen Sinzato, Ana Izabel Silva Balbin Villaverde, Jose Eduardo Corrente, Gustavo Tadeu Volpato, Debora Cristina Damasceno
Summary: Maternal diabetes has detrimental effects on the health of female pups, both during pregnancy and in adulthood. This study showed that maternal hyperglycemia leads to glucose intolerance, insulin resistance, oxidative stress, and impaired fetal growth.
SYSTEMS BIOLOGY IN REPRODUCTIVE MEDICINE
(2022)
Review
Obstetrics & Gynecology
Carlos Izaias Sartorao Filho, Angelica Mercia Pascon Barbosa, Iracema de Mattos Paranhos Calderon, Marilza Vieira Cunha Rudge
Summary: Gestational diabetes mellitus (GDM) has an impact on the women's pelvic floor and may lead to future urinary incontinence. Evaluation and prediction can be done using three-dimensional ultrasonography.
REVISTA BRASILEIRA DE GINECOLOGIA E OBSTETRICIA
(2022)
Article
Obstetrics & Gynecology
Larissa Lopes da Cruz, Vinicius Soares Barco, Veronyca Goncalves Paula, Franciane Quintanilha Gallego, Maysa Rocha Souza, Jose Eduardo Corrente, Elena Zambrano, Gustavo Tadeu Volpato, Debora Cristina Damasceno
Summary: In this study, uncontrolled maternal diabetes was used as a model to induce fetal growth restriction in the first generation (F-1) and investigate the effects on reproductive outcomes and metabolic changes during pregnancy, as well as the consequences at birth in the second generation (F-2). Results showed that pups from severely diabetic dams exhibited rapid neonatal catch-up growth, glucose intolerance, and insulin resistance. Additionally, the F-2 offspring had lower fetal weight and placental efficiency, indicating the influence of fetal programming.
REPRODUCTIVE SCIENCES
(2023)
Article
Obstetrics & Gynecology
Eduardo Kloppel, Maysa Rocha Souza, Vinicius Soares Barco, Franciane Quintanilha Gallego, Yuri Karen Sinzato, Jose Eduardo Corrente, Tiago Rodrigues, Gustavo Tadeu Volpato, Debora Cristina Damasceno
Summary: Diabetes mellitus increases the risk of obstetric complications, morbidity, and infant mortality. Controlled nutritional therapy with micronutrients has been employed. However, the effect of calcium (Ca2+) supplementation on diabetic pregnancy is unclear.
REPRODUCTIVE SCIENCES
(2023)
Article
Multidisciplinary Sciences
Vinicius S. Barco, Franciane Q. Gallego, Veronyca G. Paula, Larissa L. Cruz, Barshana Karki, Gustavo T. Volpato, Debora C. Damasceno
Summary: Pregestational hyperglycemia has adverse effects on mothers and their offspring. A study on diabetic rats found that diabetic mothers and their descendants exhibited glucose intolerance, and early embryos showed delayed development, degeneration, and losses.
ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS
(2022)
Article
Biology
G. A. Garcia, R. G. Oliveira, R. Dariolli, M. V. C. Rudge, A. M. P. Barbosa, J. F. Floriano, J. T. Ribeiro-Paes
Summary: This article describes a protocol for isolating and cultivating ASCs from farm pigs as an alternative to obtaining ASCs from minipigs. Rigorous disinfection procedures were necessary when extracting samples from pigs raised in an uncontrolled environment.
BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
(2022)
Review
Obstetrics & Gynecology
Meline Rossetto Kron-Rodrigues, Marilza Vieira Cunha Rudge, Silvana Andrea Molina Lima
REVISTA BRASILEIRA DE GINECOLOGIA E OBSTETRICIA
(2021)
Article
Health Care Sciences & Services
Daniela Mendes dos Santos Magalhaes, Joao Marcos Bernardes, Carlos Ruiz-Frutos, Juan Gomez-Salgado, Iracema de Mattos Paranhos Calderon, Adriano Dias
Summary: Through a case-control study, the risk factors for severe maternal morbidity in Brazil were identified, including ethnicity, family income, partner status, obesity, prenatal care, prenatal appointment frequency, inter-hospital transfer, and labor status upon admission. The study emphasized the high incidence of potential life-threatening complications in Brazilian women, highlighting the need for more complex interventions and expanded primary care coverage.