Journal
JOURNAL OF CLINICAL HYPERTENSION
Volume 16, Issue 6, Pages 459-466Publisher
WILEY-BLACKWELL
DOI: 10.1111/jch.12327
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Funding
- Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan [21390247]
- MEXT
- Foundation for Development of the Community
- Department of Sleep and Circadian Cardiology, Jichi Medical University School of Medicine
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Obstructive sleep apneas syndrome (OSAS) is associated with nocturnal hypertension with higher sleep blood pressure (BP) and its variability, both of which increase cardiovascular risk. In this crossover design study, the effect of nighttime single-dose administration of vasodilating (nifedipine 40mg) vs sympatholytic (carvedilol 20mg) antihypertensive agents on sleep BP in 11 hypertensive OSAS patients was evaluated. The authors recently developed a trigger sleep BP monitor with an oxygen-triggered function that initiates BP measurement when oxygen desaturation falls. The BP-lowering effects of nifedipine on the mean (P<.05) and minimum sleep systolic BPs (SBPs) (P<.01) were stronger than those of carvedilol. Sleep SBP surge (difference between the hypoxia-peak SBP measured by oxygen-triggered function and SBPs within 30minutes before and after the peak SBP) was only significantly reduced by carvedilol (P<.05). The nighttime dosing of both vasodilating and sympatholytic antihypertensive drugs is effective to reduce sleep BP but with different BP-lowering profiles.
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