Review
Peripheral Vascular Disease
Muhammad Haisum Maqsood, Franz H. Messerli, Adam H. Skolnick, Jonathan D. Newman, Jeffrey S. Berger, Sripal Bangalore
Summary: This study compared the efficacy of morning versus evening dosing of antihypertensive drugs and found that evening dosing significantly reduced ambulatory blood pressure parameters and cardiovascular events, but this effect was mainly driven by trials by the Hermida group. Therefore, the timing of antihypertensive drug administration should be chosen based on convenience and minimizing undesirable effects.
Editorial Material
Endocrinology & Metabolism
Mei Qiu, Li-Min Zhao, Ze-Lin Zhan
Summary: The study showed that the use of SGLT2is was not significantly associated with the occurrence of 980 types of serious adverse events, but was significantly associated with a lower risk of 29 types of serious adverse events, particularly including several important respiratory diseases.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Medicine, General & Internal
Anastasios Makris, Fotios Barkas, Petros P. Sfikakis, Evangelos Liberopoulos, Aris P. Agouridis
Summary: This study systematically investigated the effect of upadacitinib on lipid profile and cardiovascular disease risk. The results showed that upadacitinib treatment increased both LDL-C and HDL-C levels, but had no significant effect on MACE risk.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Bo Yang, Ping-Tao Tseng, Xiang Hu, Bing-Yan Zeng, Jane Pei-Chen Chang, Yang Liu, Wei-Jie Chu, Shuang-Shuang Zhang, Zhi-Liang Zhou, Chih-Sheng Chu, Cheng-Ho Chang, Yu-Kang Tu, Yi-Cheng Wu, Brendon Stubbs, Andre F. Carvalho, Pao -Yen Lin, Yutaka J. Matsuoka, Mein-Woei Suen, Kuan-Pin Su
Summary: This study found that omega-3 polyunsaturated fatty acids (PUFAs) have a positive effect in secondary prevention but not in primary prevention. The mechanisms of cardiovascular protection by omega-3 PUFAs may be related to their anti-inflammatory and endothelial function stabilization effects.
PROGRESS IN LIPID RESEARCH
(2022)
Article
Physiology
Yi-Bang Cheng, Jia-Hui Xia, Yan Li, Ji-Guang Wang
Summary: Newer antihypertensive agents, such as RAS inhibitors and CCBs, were found to be significantly more efficacious than older agents in their effects on central hemodynamics.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Endocrinology & Metabolism
Donna Shu-Han Lin, Jen-Kuang Lee, Wen-Jone Chen
Summary: This study found that SGLT2is demonstrate overall good safety profile, but may increase the risk of genital infections while providing protection against AKI. The risk of amputation is higher in ASCVD patients, and close monitoring of patients is essential after the use of SGLT2is.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Review
Cardiac & Cardiovascular Systems
Chen Gong, Shi-Chun Shen, Ke Zhang, Lei Zhou, Jun-Jie Shen, Jia-Ying Zhao, Sheng-Gang Ding, Li-kun Ma, Hui Gao
Summary: SGLT2 inhibitors have positive effects in reducing the risk of all-cause death, CV death, MACE, HHF, and AKI, but increase the risk of DKA. The application of SGLT2 inhibitors in the primary prevention of ACD also has certain clinical benefits in reducing MI.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Public, Environmental & Occupational Health
Y. Feng, M. Han, R. Qie, S. Huang, Q. Li, C. Guo, G. Tian, Y. Zhao, X. Yang, Y. Li, X. Wu, Q. Zhou, Y. Zhang, Y. Wu, D. Liu, F. Hu, M. Zhang, Y. Yang, X. Shi, L. Sun, D. Hu
Summary: This study found a negative association between adherence to antihypertensive medications and the risk of recurrence of cardiovascular disease events, with higher adherence associated with lower risk. Additionally, for every 20% increase in adherence, the risk of cardiovascular disease events decreased by 9%. Results of sensitivity analysis and subgroup analysis were consistent.
Review
Chemistry, Medicinal
Zeynab Kavyani, Vali Musazadeh, Ehsan Safaei, Mina Mohammadi Asmaroud, Fatemeh Khashakichafi, Sana Sedgh Ahrabi, Parvin Dehghan
Summary: This study aims to examine the effects of N. sativa on blood pressure in adults. The meta-analysis suggests that N. sativa supplementation can effectively reduce both systolic and diastolic blood pressure, indicating that it could be used as an effective approach to blood pressure management.
PHYTOTHERAPY RESEARCH
(2023)
Review
Nutrition & Dietetics
Jiaqi Yang, Yulin Zhang, Xiaona Na, Ai Zhao
Summary: This study conducted a systematic review and meta-analysis on the associations between beta-carotene supplementation and cardiovascular disease (CVD) risk. The results showed that beta-carotene supplementation had no beneficial effects on CVD incidence and could potentially increase cardiovascular mortality. Smoking behavior was also found to be associated with increased cardiovascular incidence and mortality in the beta-carotene intervention group.
Article
Medicine, General & Internal
Wei-Te Lei, Ling-Sai Chang, Bing-Yan Zeng, Yu-Kang Tu, Ritei Uehara, Yutaka J. Matsuoka, Kuan-Pin Su, Pi-Chang Lee, Joao L. Cavalcante, Brendon Stubbs, Pao-Yen Lin, Yi-Cheng Wu, Chih-Wei Hsu, Tien-Yu Chen, Yen-Wen Chen, Pin-Yang Yeh, Cheuk-Kwan Sun, Ping-Tao Tseng, Yu-Hsuan Kao
Summary: This network meta-analysis compared different interventions for Kawasaki disease (KD) and found that medium-dosage IVIG + aspirin + infliximab exhibited the shortest fever duration and the smallest incidence of coronary artery lesion (CAL) in the initial-stage KD. In the refractory-stage KD, high-dosage IVIG + pulse steroid therapy had the best rate of decline of fever, while high-dosage IVIG + ciclosporin exhibited the smallest incidence of CAL. Infliximab significantly improved resolution in refractory-stage KD. Further evidence from randomized trials is needed to support these findings.
Review
Nutrition & Dietetics
Wei Luo, Jin Zhang, Dan Xu, Yao Zhou, Zhen Qu, Qin Yang, Qiujv Lv
Summary: This meta-analysis found that low-carbohydrate ketogenic diets have positive effects on cardiovascular risk factors in overweight or obese patients, especially those with T2DM. Low-carbohydrate ketogenic diets can lower blood glucose, weight, and lipid levels, improving overall cardiovascular health.
FRONTIERS IN NUTRITION
(2022)
Review
Plant Sciences
Jiayu Lv, Shixu Liu, Shasha Guo, Jialiang Gao, Qingqiao Song, Xiangning Cui
Summary: This meta-analysis indicates that Tongxinluo Capsule (TXLC) supplementation has beneficial effects in preventing adverse cardiovascular events in patients with coronary heart disease, especially in cases of target vessel revascularization or instent restenosis after coronary revascularization, and reducing the occurrence of first or recurrent myocardial infarction and heart failure within 12 months. However, the stability of these results is limited due to insufficient sample size. The effects of TXLC on cardiovascular mortality, cerebrovascular events, and unscheduled readmission for cardiovascular diseases cannot be confirmed. Future research with large-sample clinical trials and extended follow-up time is needed.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Mohamed M. G. Mohamed, Mohammed Osman, Babikir Kheiri, Maryam Saleem, Alexandre Lacasse, Mohamad Alkhouli
Summary: This meta-analysis demonstrates that the use of polypills is significantly associated with reductions in blood pressure and blood lipid levels compared to standard of care, leading to a significant decrease in cardiovascular events.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Review
Nutrition & Dietetics
Shuaishuai Zhou, Teng Xu, Xu Zhang, Junjie Luo, Peng An, Yongting Luo
Summary: The supplementation of casein hydrolysate can effectively reduce blood pressure without affecting blood lipids or glycemic status.
