Journal
NEUROSURGERY
Volume 77, Issue 3, Pages 418-423Publisher
OXFORD UNIV PRESS INC
DOI: 10.1227/NEU.0000000000000851
Keywords
Central reorganization; Nerve injury; Nerve transfer; Plasticity; Regeneration
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The optimal refinement in nerve repair techniques has reached a plateau, making it imperative to continually explore newer avenues for improving the clinical outcome of peripheral nerve regeneration. The aim of this short review is to discuss the role and mechanism of brain plasticity in nerve regeneration, as well as to explore the possible application of this knowledge for improving the clinical outcome following nerve repair.ABBREVIATIONS:BDNF, brain-derived neurotrophic factorGABA, Gamma amino-butyric acidICN-MCN, intercosto-musculocutaneous nerveLTD, long-term depressionLTP, long-term potentiationNGF, nerve growth factorNT-4, neurotrophinTMS, transcranial magnetic stimulation
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