Review
Chemistry, Medicinal
Mingming Zhao, Ziyan Zhang, Zhiyu Pan, Sijia Ma, Meiying Chang, Jiao Fan, Shunxuan Xue, Yuejun Wang, Hua Qu, Yu Zhang
Summary: This meta-analysis of 12 randomized controlled trials demonstrates that N-/T-type calcium channel blockers are more effective than L-type calcium channel blockers in reducing urine albumin/protein excretion in patients with chronic kidney disease treated with renin-angiotensin system inhibitors, without affecting serum creatinine, glomerular filtration rate, and adverse effects.
Article
Pharmacology & Pharmacy
Kung-Ming Laio, Chuan-Wei Shen, Yun-Hui Huang, Chun-Hui Lu, Hsuan-Lin Lai, Chung-Yu Chen
Summary: The prescription pattern and effectiveness of antihypertensive drugs in surgical patients with aortic dissection were investigated. The study found that no specific type of antihypertensive drug was associated with a better outcome in patients with type A aortic dissection, while the use of beta-blockers and calcium channel blockers (CCBs) was related to a significantly lower risk of the composite outcome in patients with type B aortic dissection.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Nutrition & Dietetics
Chu-Lin Chou, Ching-Hao Li, Te-Chao Fang
Summary: High fructose intake is associated with obesity and metabolic syndrome, but the blockers of renin-angiotensin system and calcium channel can reduce triacylglycerol storage in fructose-induced adiposity by inhibiting PU.1 activation.
Review
Biochemistry & Molecular Biology
Ting Huang, Jingyi Zhou, Jianliu Wang
Summary: Intracellular calcium ions act as important regulators in cancer progression, with estrogen playing a role in inducing calcium increases and kinase cascades. Modulating calcium channels may offer a new approach for treating endometrial cancer.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Peripheral Vascular Disease
Junxiong Lin, Qinghui Guo, Zhuoqiang Lu, Dajun Chai, Feng Peng, Jinxiu Lin
Summary: This retrospective study compared cardiovascular outcomes between initial beta-blocker + calcium channel blocker dual therapy (B + C) and other initial dual therapies in Chinese newly diagnosed hypertensive patients. After propensity score matching, patients receiving B + C had a significantly lower risk of major adverse cardiovascular events (MACE), non-fatal stroke, and non-fatal chronic heart failure (CHF) compared to patients receiving other initial dual therapies. The study suggests that B + C initial dual therapy may be more beneficial for Chinese newly diagnosed hypertensive patients in terms of cardiovascular outcomes.
JOURNAL OF CLINICAL HYPERTENSION
(2023)
Article
Cardiac & Cardiovascular Systems
Jung Min Choi, Seung-Hwa Lee, Yu Jeong Jang, Mira Kang, Jin-Ho Choi
Summary: The study found that patients taking a fixed-dose combination of ARB and statin showed higher medication persistence and adherence compared to those taking a free combination, but the risk of all-cause death did not differ between the two groups.
CIRCULATION JOURNAL
(2021)
Article
Medicine, General & Internal
Kiyotsugu Iede, Terumasa Yamada, Masami Ueda, Yujiro Tsuda, Shinsuke Nakashima, Katsuya Ohta, Tsukasa Tanida, Jin Matsuyama, Masakazu Ikenaga, Shusei Tominaga
Summary: This study retrospectively investigated the baseline differences between hypertensive (HT) and non-hypertensive (non-HT) patients with advanced pancreatic cancer (APC). It found significant differences in characteristics between the two groups, suggesting a major selection bias. Although no significant difference was found in treatment response, HT patients had significantly longer overall survival. The use of antihypertensive drugs was not identified as an independent prognostic factor.
Correction
Medicine, General & Internal
Kiyotsugu Iede, Terumasa Yamada, Masami Ueda, Yujiro Tsuda, Shinsuke Nakashima, Katsuya Ohta, Tsukasa Tanida, Jin Matsuyama, Masakazu Ikenaga, Shusei Tominaga
Summary: This study retrospectively analyzed the baseline differences between patients with advanced pancreatic cancer (APC) with and without hypertension. It found that patients with hypertension had a significantly longer overall survival. Therefore, hypertension may affect the prognosis of patients with advanced pancreatic cancer.
Correction
Medicine, General & Internal
Kiyotsugu Iede, Terumasa Yamada, Masami Ueda, Yujiro Tsuda, Shinsuke Nakashima, Katsuya Ohta, Tsukasa Tanida, Jin Matsuyama, Masakazu Ikenaga, Shusei Tominaga
Summary: This study retrospectively analyzed the efficacy of antihypertensive drugs in patients with advanced pancreatic cancer and found that hypertensive patients had longer survival and significant differences in baseline characteristics compared to non-hypertensive patients. This suggests that antihypertensive drugs may lack antitumor activity.
Article
Anesthesiology
Kazuyo Takeuchi, Masakazu Hayashida, Osamu Kudoh, Naoko Niimi, Kumi Kataoka, Maho Kakemizu-Watanabe, Makiko Yamamoto, Atsuko Hara, Izumi Kawagoe, Keisuke Yamaguchi
Summary: This study compared the effects of continuing versus withholding ARB/CCB combination tablets on perioperative hemodynamics and clinical outcomes. The results showed that continuing the medication increased the incidence of intraoperative hypotension and may slightly worsen postoperative renal function. Therefore, withholding the medication preoperatively is preferable.
JOURNAL OF ANESTHESIA
(2022)
Article
Medicine, General & Internal
Maddalena Ardissino, Eric A. W. Slob, Skanda Rajasundaram, Rohin K. Reddy, Benjamin Woolf, Joanna Girling, Mark R. Johnson, Fu Siong Ng, Dipender Gill
Summary: This study investigates the effects of beta-blocker and calcium channel blocker antihypertensive drugs on maternal and foetal outcomes. The results suggest that beta-blocker use may lower birthweight, while calcium channel blocker use may reduce the risk of pre-eclampsia and eclampsia.
Review
Endocrinology & Metabolism
Michael M. Gezalian, Luigi Mangiacotti, Padmesh Rajput, Nicklaus Sparrow, Konrad Schlick, Shouri Lahiri
Summary: Adrenoceptor and calcium channel modulating medications have cerebrovascular-specific effects related to the unique characteristics of cerebrovascular anatomy, which differ from their systemic effects. Future research should consider lesion location when selecting vasoactive medications, aiming to improve neurological outcomes in acute neurological and systemic disorders.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Pharmacology & Pharmacy
Hae-Young Lee, Kwang-Il Kim, Sang Hyun Ihm, Moo-Yong Rhee, Il Suk Sohn, Sungha Park, Eun-Seok Jeon, Jong-Min Song, Wook Bum Pyun, Ki-Chul Sung, Moo Hyun Kim, Sang-Hyun Kim, Seok-Yeon Kim, Shin-Jae Kim, Eung Ju Kim, Jinho Shin, Sung Yun Lee, Kook-Jin Chun, Jin-Ok Jeong, Shung Chull Chae, Ki Dong Yoo, Young Jin Choi, Yong Hwan Park, Cheol-Ho Kim
Summary: This study aimed to assess the efficacy and tolerability of fimasartan compared with perindopril in elderly Korean patients with essential hypertension, showing that fimasartan was noninferior to perindopril and exhibited a higher blood pressure-lowering effect. Both groups had similar tolerability with a high compliance rate.
CLINICAL THERAPEUTICS
(2021)
Article
Psychiatry
Miao Li, Ning Yuan, John Nurnberger, Ney Alliey-Rodriguez, Jiaqi Zhou, Fangyuan Duan, Jiacheng Dai, Yu Chen, Jiaqi Lu, Li Xie, Fang Liu, Xuli Yang, Philippe Tapon, Vijay Gorrepati, Xuejun Liu, Chao Chen, Chunyu Liu, Elliot S. Gershon
Summary: Common genetic variants in calcium channel genes are important markers of genetic susceptibility for bipolar disorder (BD). Previous clinical trials have shown that Calcium Channel Blocker (CCB) medication can improve mood stability in some BD patients. In this pilot study, 50 BD patients (39 from China and 11 from the US) hospitalized for manic episodes were given add-on CCB treatment. The study found that certain intronic variants of the Calcium Voltage-Gated Channel Subunit Alpha1 B (CACNA1B) were associated with treatment outcomes for manic patients, suggesting that these variants could be predictors for response to add-on CCB treatment for bipolar mania patients.
PSYCHIATRY RESEARCH
(2023)
Article
Clinical Neurology
Jin Ho Jung, Han Kyu Na, Seong Ho Jeong, Seok Jong Chung, Han Soo Yoo, Yang Hyun Lee, Kyoungwon Baik, Sang Jin Kim, Young H. Sohn, Phil Hyu Lee
Summary: This study suggests that Dihydropyridines (DHPs) may have neuroprotective effects in patients with Parkinson's disease (PD) and hypertension. The use of DHPs was associated with a lower risk of developing dementia in hypertensive patients with PD.
MOVEMENT DISORDERS
(2023)
Article
Endocrinology & Metabolism
Seda Hanife Oguz, Meltem Koca, Bulent Okan Yildiz
Summary: COVID-19 severe cases are associated with mortality due to acute respiratory distress syndrome, cytokine storm, and thrombotic events. While all contributing factors are not yet clear, older age remains a major risk factor. Age-related immune and hormonal changes play a significant role in the severity of COVID-19.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2022)
Review
Endocrinology & Metabolism
Nafiye Helvaci, Bulent O. Yildiz
Summary: PCOS in women of reproductive age is associated with increased risk of diabetes and cardiometabolic diseases, but the risk seems to decrease with ageing. Limited data suggest that cardiometabolic profile does not further deteriorate in women with PCOS after menopause, and the risk of cardiovascular disease in ageing women with PCOS appears to be similar to those without PCOS.
CLINICAL ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
A. Giustina, M. Marazuela, M. Reincke, B. O. Yildiz, M. Puig-Domingo
Summary: COVID-19 brought about changes in endocrine daily practice and highlighted the impact of endocrine and metabolic comorbidities on COVID-19 outcomes. European endocrinologists disclosed the endocrine phenotype of COVID-19, with diabetes, obesity, and hypovitaminosis D playing a key role in this clinical setting, emphasizing the importance for disease prevention and management. The European Society of Endocrinology (ESE) served as a reference point for the endocrine community during the pandemic, redirecting its educational and advocacy efforts.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2021)
Review
Geriatrics & Gerontology
Ralitsa Robeva, Dusan Mladenovic, Milena Veskovic, Dragan Hrncic, Jelica Bjekic-Macut, Olivera Stanojlovic, Sarantis Livadas, Bulent O. Yildiz, Djuro Macut
Summary: The hypoestrogenic period after menopause may contribute to the development of non-alcoholic fatty liver disease (NAFLD) in women, alongside metabolic imbalance. Lifestyle interventions remain the primary preventive and therapeutic option for NAFLD, while the effects of menopausal hormonal therapy (MHT) on NAFLD are inconclusive and warrant further investigation.
Article
Behavioral Sciences
Sila Cetik, Aylin Acikgoz, Bulent Okan Yildiz
Summary: This study found that taste perception is reduced in PCOS patients compared to healthy women, but there is no significant difference in eating behavior. The free androgen index is associated with taste function scores, and short-term oral contraceptive use does not alter taste functions in the syndrome.
Review
Pharmacology & Pharmacy
Nafiye Helvaci, Bulent Okan Yildiz
Summary: This article provides an overview of pharmacotherapies for the management of women with polycystic ovary syndrome (PCOS) who do not seek pregnancy. It emphasizes the need for individualized treatment and targeting specific symptoms. However, the complexity and heterogeneity of PCOS pose challenges in finding safer and more effective therapeutic strategies.
EXPERT OPINION ON PHARMACOTHERAPY
(2023)
Review
Medicine, Research & Experimental
Seda Hanife Oguz, Bulent Okan Yildiz
Summary: The interaction between COVID-19 and the endocrine system has been studied extensively. Obesity and diabetes are recognized as significant risk factors for COVID-19 severity, and SARS-CoV-2 can affect multiple endocrine organs. New-onset endocrine disorders related to COVID-19 have been reported, but long-term effects are still uncertain. Stay-at-home measures during the pandemic have disrupted care for patients with pre-existing endocrine disorders and hindered the diagnosis and treatment of new cases. This review aims to summarize the complex interaction between COVID-19 and endocrine disorders and highlight considerations for future research.
ANNUAL REVIEW OF MEDICINE
(2023)
Review
Endocrinology & Metabolism
Begum Aydogan Mathyk, Esra Cetin, Bulent O. Yildiz
Summary: This review focuses on the role of anti-Mullerian hormone in ovulatory dysfunction in polycystic ovarian syndrome, highlighting the impact of AMH levels on PCOS and the significance of standardizing serum AMH measurements.
CURRENT OPINION IN ENDOCRINOLOGY DIABETES AND OBESITY
(2022)
Article
Medicine, General & Internal
Larisa Suturina, Daria Lizneva, Alina Atalyan, Ludmila Lazareva, Aleksey Belskikh, Tatyana Bairova, Leonid Sholokhov, Maria Rashidova, Irina Danusevich, Iana Nadeliaeva, Lilia Belenkaya, Zorikto Darzhaev, Eldar Sharifulin, Natalia Belkova, Ilia Igumnov, Tatyana Trofimova, Anastasiya Khomyakova, Kseniia Ievleva, Natalia Babaeva, Irina Egorova, Madinabonu Salimova, Bulent O. Yildiz, Richard S. Legro, Frank Z. Stanczyk, Ricardo Azziz
Summary: This study determined the upper normal limits of androgens in healthy control women, which is important for diagnosing polycystic ovary syndrome and conducting epidemiological studies. The study found that the upper normal limits for total testosterone and free androgen index varied by ethnicity, while the upper normal limits for DHEAS were comparable among the ethnicities studied.
Review
Medicine, General & Internal
Sarantis Livadas, Rodis Paparodis, Panagiotis Anagnostis, Alessandra Gambineri, Jelica Bjekic-Macut, Tijana Petrovic, Bulent O. Yildiz, Dragan Micic, George Mastorakos, Djuro Macut
Summary: Women with polycystic ovary syndrome (PCOS) are at higher risk for dysglycemia and type 2 diabetes compared to healthy BMI-matched women of reproductive age. The incidence of this disorder varies among studies, and there is no consensus on the best screening method and frequency. Universal screening with oral glucose tolerance test is suggested to identify and manage glycemic abnormalities in young women with PCOS, regardless of age or BMI status. Regular follow-up and lifestyle interventions, such as balanced diet and exercise, are important for this specific population.
Article
Endocrinology & Metabolism
Seren Aksun, Ece Ersal, Oytun Portakal, Bulent Okan Yildiz
Summary: The aim of this study was to assess the alterations of IL-22/IL-22BP axis in PCOS patients and the impact of short-term oral contraceptive (OC) therapy. The results showed that PCOS patients had similar concentrations of IL-22 and IL-22BP compared to healthy controls. However, after receiving OC therapy, the IL-22/IL-22BP ratio in the PCOS group significantly increased. Therefore, oral contraception may increase the biological activity of the IL-22 system in PCOS patients.
Article
Psychiatry
Nesrin Damla Eyupoglu, Seren Aksun, Mervenur Ozturk, Bulent Okan Yildiz
Summary: During the COVID-19 social isolation period, weight changes are similar in women with polycystic ovary syndrome (PCOS) and healthy women. However, among those who gain weight, the increase in BMI is more pronounced in women with PCOS. Weight gain appears to be related to alterations in sleep quality and eating habits rather than reduced physical activity.
EATING AND WEIGHT DISORDERS-STUDIES ON ANOREXIA BULIMIA AND OBESITY
(2022)
Review
Endocrinology & Metabolism
Ozlem Celik, Bulent O. Yildiz
Summary: Obesity is a major health problem globally, and physical exercise combined with energy restriction diets has been shown to be the most effective approach for significant weight loss. High levels of exercise are associated with improved weight maintenance for patients seeking to keep off weight. Weight loss is correlated with improvements in various obesity-related comorbidities such as diabetes and hypertension.
MINERVA ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
M. Puig-Domingo, M. Marazuela, B. O. Yildiz, A. Giustina
Summary: The COVID-19 pandemic has led to significant changes in our daily clinical practice and social relations. The endocrine system plays a crucial role in the disease, with diabetes being a major comorbidity associated with severity and mortality of COVID-19. Obesity, lack of vitamin D, adrenal insufficiency, and other factors also impact the outcome of COVID-19 patients. Adequate management and consideration of endocrine implications in vaccination are essential.
Review
Endocrinology & Metabolism
Basak Ozgen Saydam, Bulent Okan Yildiz
Summary: PCOS is closely linked to obesity, weight loss is associated with improved metabolic, endocrine, reproductive, cardiovascular, and psychological features in women with PCOS. Current therapeutic approaches include lifestyle interventions, anti-obesity medications, and bariatric surgery. Further large-scale studies are needed to determine the long-term effects and potential benefits beyond weight loss.
EXPERT REVIEW OF ENDOCRINOLOGY & METABOLISM
(2021)
