Article
Multidisciplinary Sciences
Cynthia R. Muller, Vasiliki Courelli, Alfredo Lucas, Alexander T. Williams, Joyce B. Li, Fernando Dos Santos, Clayton T. Cuddington, Savannah R. Moses, Andre F. Palmer, Erik B. Kistler, Pedro Cabrales
Summary: When accompanied by hemorrhagic shock after TBI, PolyhHb may serve as an effective alternative to blood for resuscitation, restoring hemodynamics and oxygen delivery.
SCIENTIFIC REPORTS
(2021)
Article
Clinical Neurology
Ren Wang, Dian-Xu Yang, Jun Ding, Yan Guo, Wan-Hai Ding, Heng-Li Tian, Fang Yuan
Summary: According to the pathoanatomic classification system, progressive hemorrhagic injury (PHI) can be categorized into different types. This study aimed to determine the predictors, clinical management, and outcomes of PHI according to this classification.
Review
Critical Care Medicine
Vijay Krishnamoorthy, Jordan M. Komisarow, Daniel T. Laskowitz, Monica S. Vavilala
Summary: Traumatic brain injury (TBI) is a significant global health issue with extracranial organ dysfunction being common after severe TBI, impacting clinical care and outcomes. However, extracranial organ dysfunction remains understudied compared to other critical care paradigms.
Article
Clinical Neurology
Yuheng Liu, Xuanhui Liu, Zhijuan Chen, Yuanzhi Wang, Jing Li, Junjie Gong, Anqi He, Mingyu Zhao, Chen Yang, Weidong Yang, Zengguang Wang
Summary: Decompressive craniectomy (DC) is crucial for decreasing intracranial pressure and improving neurological function after traumatic brain injury (TBI). This study investigated the effects of DC on a severe TBI mouse model and found that DC can reduce intracranial pressure, improve neurological and motor function, and attenuate blood-brain barrier damage, inflammatory response, and neuronal apoptosis. However, DC may also lead to brain edema and long-term impairment of neurological function.
FRONTIERS IN NEUROLOGY
(2022)
Article
Neurosciences
Ali Alawieh, Reda M. Chalhoub, Khalil Mallah, E. Farris Langley, Mikaela York, Henry Broome, Christine Couch, DeAnna Adkins, Stephen Tomlinson
Summary: The study identifies complement-mediated neuroinflammation as a key player in cognitive decline following traumatic brain injury. Inhibiting complement activity can reverse synaptic degeneration and cognitive decline, even when the treatment is delayed. These findings suggest that therapeutic interventions targeting complement may be effective in all stages of TBI.
JOURNAL OF NEUROSCIENCE
(2021)
Review
Cell Biology
Martin Cente, Katarina Matyasova, Nikoleta Csicsatkova, Adela Tomikova, Sara Porubska, Yun Niu, Marek Majdan, Peter Filipcik, Igor Jurisica
Summary: The history of traumatic brain injury (TBI) is a significant risk factor for the development of dementia and neurodegenerative disorders in later life. By analyzing peripheral blood microRNAs, this study identified genes, proteins, and pathways connected to neurodegenerative cascades following severe TBI. These findings have implications for potential therapeutic targets and biomarkers.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2023)
Review
Microbiology
Jennifer A. Munley, Stacey L. Kirkpatrick, Gwendolyn S. Gillies, Letitia E. Bible, Philip A. Efron, Ravinder Nagpal, Alicia M. Mohr
Summary: The intestinal microbiome is crucial for immune function and homeostasis in the host. Studies on patients and models of traumatic injuries have shown that trauma leads to dysregulation of immune function, systemic inflammation, and alterations in gut microbiome diversity and composition, possibly transitioning to a pathobiome state. Sex has also been identified as a variable influencing microbiome alterations after trauma. Therapies such as fecal transplantation have been used to mitigate these changes and aid in post-injury recovery.
Article
Clinical Neurology
Zorry Belchev, Asaf Gilboa, Malcolm Binns, Brenda Colella, Joanna Glazer, David J. Mikulis, Robin E. Green
Summary: This study examined the structural gray matter changes in individuals with severe traumatic brain injury (TBI) during two chronic recovery periods. The findings suggest that neurodegenerative processes occur in the months to years post-injury. The study found progressive degeneration in specific brain regions and highlighted the importance of interventions to offset degeneration and improve long-term functioning.
JOURNAL OF HEAD TRAUMA REHABILITATION
(2022)
Article
Critical Care Medicine
Kelly A. Fair, David H. Farrell, Belinda H. McCully, Elizabeth A. Rick, Elizabeth N. Dewey, Cole Hilliard, Rondi Dean, Amber Lin, Holly Hinson, Ronald Barbosa, Martin A. Schreiber, Susan E. Rowell
Summary: Traumatic intracranial hemorrhage is a significant cause of secondary brain injury in patients with traumatic brain injury. The severity of injury and D-dimer levels significantly differ between patients with and without PICH.
JOURNAL OF NEUROTRAUMA
(2021)
Review
Clinical Neurology
Cassidy Q. B. Mostert, Ranjit D. Singh, Maxime Gerritsen, Erwin J. O. Kompanje, Gerard M. Ribbers, Wilco C. Peul, Jeroen T. J. M. van Dijck
Summary: This systematic review investigated the long-term outcome after severe traumatic brain injury (sTBI) and found limited and heterogeneous literature in this area. Mortality and unfavorable outcome rates were high, but a considerable proportion of survivors achieved favorable outcomes.
ACTA NEUROCHIRURGICA
(2022)
Article
Clinical Neurology
Matthew Pease, Jonathan Elmer, Ameneh Zare Shahabadi, Arka N. Mallela, Juan F. Ruiz-Rodriguez, Daniel Sexton, Niravkumar Barot, Jorge A. Gonzalez-Martinez, Lori Shutter, David O. Okonkwo, James F. Castellano
Summary: By analyzing early electroencephalographic (EEG) features, it is possible to identify patients at high risk for posttraumatic epilepsy (PTE) in severe traumatic brain injury (TBI) cases. Quantitative EEG (qEEG) analysis showed that PTE patients had higher spectral power and power variance in the delta frequencies, as well as higher peak envelope. These findings have significant implications for early clinical management and patient selection in clinical trials.
Article
Microbiology
Weijian Yang, Qiang Yuan, Zhiqi Li, Zhuoying Du, Gang Wu, Jian Yu, Jin Hu
Summary: The study suggests that gut bacteria may translocate to the lungs after severe Traumatic Brain Injury (sTBI), leading to pathological changes in the lungs, with Paneth cells potentially regulating the balance and translocation of gut microbiota.
Article
Clinical Neurology
Dmitriy Petrov, Stephen P. Miranda, Ramani Balu, Connor Wathen, Alex Vaz, Vinodh Mohan, Christian Colon, Ramon Diaz-Arrastia
Summary: The objective of this study was to develop an algorithm capable of predicting the onset of intracranial pressure (ICP) crises in patients with severe traumatic brain injury (TBI). The random forest model demonstrated the highest accuracy and area under the curve (AUC) in predicting ICP crises. If implemented in clinical workflows, this algorithm can enable earlier intervention and more effective treatment of intracranial hypertension, potentially leading to improved outcomes for patients with severe TBI.
JOURNAL OF NEUROSURGERY
(2023)
Review
Medicine, General & Internal
Edoardo Picetti, Israel Rosenstein, Zsolt J. Balogh, Fausto Catena, Fabio S. Taccone, Anna Fornaciari, Danilo Votta, Rafael Badenes, Federico Bilotta
Summary: This narrative review focuses on the management of the acute phase after severe traumatic brain injury (TBI) with polytrauma. It summarizes the available evidence on perioperative brain protection, cardiorespiratory optimization, and preservation of the coagulative function, while also providing an overview on simultaneous multisystem surgery (SMS).
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Critical Care Medicine
Markus B. Skrifvars, Nora Luethi, Michael Bailey, Craig French, Alistair Nichol, Tony Trapani, Colin McArthur, Yaseen M. Arabi, Stepani Bendel, David J. Cooper, Rinaldo Bellomo, EPO TBI Investigators, ANZICS Clinical Trials Grp
Summary: Recombinant erythropoietin (EPO) did not decrease overall long-term mortality nor improve functional outcome in moderate or severe traumatic brain injury (TBI) patients treated in the intensive care unit (ICU). The limited sample size makes it difficult to draw final conclusions about the use of EPO in TBI.
INTENSIVE CARE MEDICINE
(2023)
