Article
Gastroenterology & Hepatology
Valeriia Dotsenko, Mikko Oittinen, Juha Taavela, Alina Popp, Markku Peraaho, Synnove Staff, Jani Sarin, Francisco Leon, Jorma Isola, Markku Maki, Keijo Viiri
Summary: Gluten challenge studies showed that even on a strict gluten-free diet, celiac disease patients exhibit patterns of ongoing disease, with changes in gene expression and mucosal morphology. A regression model using four gene transcripts described the extent of gluten-induced duodenal mucosal injury with high accuracy.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Nutrition & Dietetics
Lukasz Dembinski, Artur Mazur, Mariusz Dabrowski, Teresa Jackowska, Aleksandra Banaszkiewicz
Summary: This study in Poland found that there is a lack of awareness among medical students and healthcare professionals regarding nutritional deficiencies in patients with celiac disease on a gluten-free diet, particularly in terms of the risk of being overweight or obese. Better education for healthcare professionals on nutrition for celiac disease patients is needed.
Review
Nutrition & Dietetics
Bara Aljada, Ahmed Zohni, Wael El-Matary
Summary: The gluten-free diet is popular for treating immune-mediated disorders caused by gluten, but it has disadvantages like high costs, nutritional deficiencies, and social and psychological barriers. Close follow-up with patients following the diet is recommended, and more data is needed to assess its effectiveness in managing mental and cognitive disorders.
Review
Food Science & Technology
Xiaoxue Zhu, Xin-Huai Zhao, Qiang Zhang, Na Zhang, Olugbenga P. Soladoye, Rotimi E. Aluko, Yuhao Zhang, Yu Fu
Summary: This article reviews the latest research progress on the relationship between celiac disease (CD) and gluten. It emphasizes the structure and function of gluten peptides related to CD, gluten detection methods, the effects of processing on gluten, and gluten-free diets. The limitations in current CD research are also discussed. This study facilitates a comprehensive understanding of CD and gluten, providing a theoretical reference for future research.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Chemistry, Multidisciplinary
Asbjorn Christophersen, Stephanie Zuhlke, Eivind G. Lund, Omri Snir, Shiva Dahal-Koirala, Louise Fremgaard Risnes, Jorgen Jahnsen, Knut E. A. Lundin, Ludvig M. Sollid
Summary: The study found that after a 3-day gluten challenge in celiac disease patients, the phenotypic profile of gluten-specific cells undergoes profound changes with exposure to gluten, overlapping with that of untreated disease. This antigen-induced shift in phenotype of CD4(+) T cells is shared with other disease-associated T cells, which is relevant for the development of T-cell-directed therapies.
Article
Chemistry, Multidisciplinary
Jorunn Stamnaes, Daniel Stray, Maria Stensland, Vikas K. Sarna, Tuula A. Nyman, Knut E. A. Lundin, Ludvig M. Sollid
Summary: In patients with celiac disease (CeD) who have been effectively treated with a gluten-free diet, different degrees of tissue inflammation response are observed after gluten challenge, indicating the presence of low-grade tissue inflammation and antigluten immunity. Histological assessment alone may not be sufficient to evaluate the full recovery and gut mucosal healing of CeD patients. There is a concern that a seemingly proper gluten-free diet may not be able to completely control gut inflammation in all CeD patients.
Review
Gastroenterology & Hepatology
Benjamin Lebwohl, Alberto Rubio-Tapia
Summary: The incidence of celiac disease is increasing due to both improved recognition and a real increase of the disorder. The reasons for this true rise are unclear, but may be related to environmental factors. Early-life gluten exposure is a major focus of prevention efforts.
Review
Nutrition & Dietetics
Dimitri Poddighe, Kuanysh Dossybayeva, Diyora Abdukhakimova, Lyudmila Akhmaltdinova, Aigul Ibrayeva
Summary: This review analyzes the pathophysiological aspects and clinical evidence of gallbladder dysfunction in CD patients, highlighting the potential medical complications and research gaps. CD patients may develop gallbladder dysmotility, leading to impaired emptying during digestion. Although CD patients do not seem to be more susceptible to gallbladder complications, further clinical studies are needed to fully understand the clinical implications of gallbladder alterations in CD patients.
Article
Multidisciplinary Sciences
Maddalena De Bernardo, Livio Vitiello, Michela Battipaglia, Francesca Mascolo, Claudio Iovino, Luigi Capasso, Carolina Ciacci, Nicola Rosa
Summary: An observational case-control study revealed that patients with celiac disease have a thicker choroid compared to healthy subjects, due to a proportional increase in both the vascular and stromal components, which does not alter the choroidal vascularity index.
SCIENTIFIC REPORTS
(2021)
Review
Nutrition & Dietetics
Fardowsa Abdi, Saania Zuberi, Jedid-Jah Blom, David Armstrong, Maria Ines Pinto-Sanchez
Summary: A gluten-free diet is essential for treating celiac disease and may improve symptoms in non-celiac gluten/wheat sensitivity. However, adopting a gluten-free diet or a gluten-restricted diet may increase the risk of malnutrition and nutrient deficiencies. Therefore, patients with these conditions should undergo nutritional assessment and monitoring, and receive multidisciplinary care for long-term nutrition management.
Article
Nutrition & Dietetics
Valentina Ponzo, Ilario Ferrocino, Ilaria Goitre, Marianna Pellegrini, Mauro Bruno, Marco Astegiano, Gianni Cadario, Eleonora Castellana, Fabio Bioletto, Maria Rita Corvaglia, Patrizia Malfa, Luca Cocolin, Ezio Ghigo, Simona Bo
Summary: By conducting a double-blind placebo-controlled gluten challenge test, this study found that almost half of individuals suspected of gluten sensitivity reported symptoms even with the placebo. These individuals showed lower mental health scores, increased risk for eating disorders, and a different gut microbiota composition compared to placebo-responsive participants.
Review
Immunology
Renata Auricchio, Riccardo Troncone
Summary: Celiac disease is an autoimmune disorder triggered by gluten, with prevention strategies focusing on identifying at-risk individuals and eliminating risk factors. Research has shown that both genetic and environmental factors play a role in the development of the disease, suggesting that future interventions could involve protection from infections, manipulation of microbiota, and modulation of T cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jorma Isola, Markku Maeki, Martin Hils, Ralf Pasternack, Keijo Viiri, Valeriia Dotsenko, Toni Montonen, Timo Zimmermann, Ralf Mohrbacher, Roland Greinwald, Detlef Schuppan
Summary: In this study, the accumulation of ZED1227 after oral administration of the drug was studied. It was found that ZED1227 mainly accumulated in the villous enterocytes and had an inhibitory effect on TG2 activity. These findings are significant for the treatment of celiac disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Elisa Farina, Leda Roncoroni, Vincenza Lombardo, Alice Scricciolo, Maurizio Vecchi, Luisa Doneda, Luca Elli
Summary: This study evaluated the significance of tTGA in monitoring celiac disease patients and found that tTGA positivity did not have relevant clinical significance, with no association with autoimmune comorbidities or mucosal damage.
Review
Gastroenterology & Hepatology
Peter H. R. Green, Shirley Paski, Cynthia W. Ko, Alberto Rubio-Tapia
Summary: This article summarizes the diagnosis and management of refractory celiac disease, providing guidance on evaluation, nutritional support, potential therapeutic options, and surveillance for complications. The article emphasizes the importance of regular follow-up and multidisciplinary care for patients with refractory celiac disease.
Article
Gastroenterology & Hepatology
Quazim A. Alayo, Edward Loftus Jr, Andres Yarur, David Alvarado, Matthew A. Ciorba, Lisa de las Fuentes, Parakkal Deepak
Summary: Population-based studies have shown that patients with inflammatory bowel disease (IBD) have an increased risk of acute arterial events (AAEs). This study aimed to assess the risk of incident AAEs and premature AAEs in participants with IBD in the UK Biobank (UKB) and found that IBD patients had a higher risk of AAEs and premature AAEs compared to non-IBD controls.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Letter
Gastroenterology & Hepatology
Quazim A. Alayo, Parakkal Deepak
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Meeting Abstract
Gastroenterology & Hepatology
Tara Fehlmann, Sarah Harvey, Parakkal Deepak, Sirimon O'Charoen
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Gastroenterology & Hepatology
Aakash Desai, Parakkal Deepak, Raymond K. Cross, Julie Murone, Francis A. Farraye, Ryan C. Ungaro, Gursimran S. Kochhar
Summary: Vaccinated patients with inflammatory bowel disease have a lower risk of severe COVID-19 outcomes compared with unvaccinated patients. A third dose of COVID-19 vaccine decreases the risk of hospitalization in patients with IBD, but does not reduce the risk of breakthrough infection.
INFLAMMATORY BOWEL DISEASES
(2023)
Meeting Abstract
Gastroenterology & Hepatology
Parakkal Deepak, Dustin Stwalley, Jeffrey McCurdy
INFLAMMATORY BOWEL DISEASES
(2023)
Meeting Abstract
Gastroenterology & Hepatology
Ankita Tirath, Jyoti Arora, Matthew Ciorba, Parakkal Deepak
INFLAMMATORY BOWEL DISEASES
(2023)
Review
Gastroenterology & Hepatology
Siyan Cao, Marco Colonna, Parakkal Deepak
Summary: Perianal Crohn's disease is a common and debilitating presentation of the disease, and its treatment remains a challenge due to the lack of understanding of its pathophysiology. This review discusses the potential roles of genetic predisposition, mucosal immunity, and gut microbiome in the disease, as well as the contribution of epithelial-to-mesenchymal transition to its pathogenesis. Recent advances in animal models and new therapies are also summarized. Future research directions are proposed to improve our understanding and develop novel therapeutic strategies for this condition.
JOURNAL OF CROHNS & COLITIS
(2023)
Article
Gastroenterology & Hepatology
Parakkal Deepak, Edward L. Barnes, Aasma Shaukat
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Editorial Material
Gastroenterology & Hepatology
Parakkal Deepak, Edward L. Barnes, Aasma Shaukat
Article
Gastroenterology & Hepatology
Scott McHenry, Matthew Glover, Ali Ahmed, Quazim Alayo, Maria Zulfiqar, Daniel R. Ludwig, Matthew A. Ciorba, Nicholas O. Davidson, Parakkal Deepak
Summary: This study found that active intestinal inflammation in patients with Crohn's disease (CD) increases the risk of nonalcoholic fatty liver disease (NAFLD). Specifically, CD patients have a higher prevalence of NAFLD during radiographically quiescent disease, independent of body mass index/visceral adipose tissue. Additionally, the cytokine interleukin-8 (IL-8) is associated with predicting NAFLD, while traditional proinflammatory cytokines are not.
INFLAMMATORY BOWEL DISEASES
(2023)
Meeting Abstract
Gastroenterology & Hepatology
Siyan Cao, Guadalupe Oliva Escudero, Parakkal Deepak, Marina Cella, Marco Colonna
INFLAMMATORY BOWEL DISEASES
(2023)
Meeting Abstract
Gastroenterology & Hepatology
Lea Ann Chen, Keith Sultan, Melissa Weidner, Dana Lukin, Jordan Axelrad, Lawrence Saubermann, Parakkal Deepak, Caterina Oneto, Huimin Yu, Oriana Damas, Jenny Sauk, Maria Oliva-Hemker, Sarah Sheibani, Karen Hills, Lediona Ardolli, James Lee
INFLAMMATORY BOWEL DISEASES
(2023)
Meeting Abstract
Gastroenterology & Hepatology
Siyan Cao, Guadalupe Oliva Escudero, Parakkal Deepak, Marina Cella, Marco Colonna
Meeting Abstract
Gastroenterology & Hepatology
Lea Ann Chen, Keith Sultan, Melissa Weidner, Dana Lukin, Jordan Axelrad, Lawrence Saubermann, Parakkal Deepak, Caterina Oneto, Huimin Yu, Oriana Damas, Jenny Sauk, Maria Oliva-Hemker, Sarah Sheibani, Karen Hills, Lediona Ardolli, James Lee
Meeting Abstract
Gastroenterology & Hepatology
Parakkal Deepak, Dustin Stwalley, Jeffrey McCurdy