Article
Gastroenterology & Hepatology
Jonathan P. Segal, Alan Askari, Susan K. Clark, Ailsa L. Hart, Omar D. Faiz
Summary: The study found that patients with inflammatory bowel disease are more likely to develop anal and cervical cancers compared to non-IBD patients, and have a lower survival rate.
INFLAMMATORY BOWEL DISEASES
(2021)
Article
Gastroenterology & Hepatology
Jonathan P. Segal, Alan Askari, Susan K. Clark, Ailsa L. Hart, Omar D. Faiz
Summary: This study demonstrates that patients with inflammatory bowel disease have a higher rate of anal and cervical cancers compared with the general population. Additionally, survival is poorer for anal cancers in the IBD group.
INFLAMMATORY BOWEL DISEASES
(2021)
Article
Gastroenterology & Hepatology
Michiyo Yamazaki, Hsingwen Chung, Youran Xu, Hong Qiu
Summary: The purpose of this study was to estimate and compare the annual prevalence, incidence, and demographic characteristics of patients with ulcerative colitis (UC) in Japan and the United States (US). Data from large healthcare claims databases were used to identify patients with UC from 2010 to 2019. The study found that there were differences in the prevalence and incidence of UC between Japan and the US over a 10-year period.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2023)
Article
Surgery
J. A. Bunce, B. Doleman, J. N. Lund, G. M. Tierney
Summary: This study investigated the impact of surgeon subspeciality on outcomes after emergency laparotomy for inflammatory bowel disease (IBD). It found that colorectal surgeons had significantly better outcomes in terms of mortality and length of stay for the least urgent category of IBD emergency laparotomies. However, this association was not seen in more urgent cases.
WORLD JOURNAL OF SURGERY
(2023)
Article
Gastroenterology & Hepatology
Aurelien Amiot, Sayma Chaibi, Yoram Bouhnik, Melanie Serrero, Jerome Filippi, Xavier Roblin, Anne Bourrier, Guillaume Bouguen, Denis Franchimont, Guillaume Savoye, Anthony Buisson, Edouard Louis, Stephane Nancey, Vered Abitbol, Jean-Marie Reimund, Olivier DeWit, Lucine Vuitton, Nicolas Mathieu, Laurent Peyrin-Biroulet, Cyrielle Gilletta, Matthieu Allez, Stephanie Viennot, Catherine Le Berre, Nina Dib, Hedia Brixi, Claire Painchart, Laurianne Plastaras, Romain Altwegg, Mathurin Fumery, Ludovic Caillo, David Laharie, Maria Nachury
Summary: In this study, fatigue in patients with inflammatory bowel disease was found to be associated with age, gender, and disease activity. The determinants of fatigue were not limited to disease-related factors, but also included social factors, sleep, and emotional disturbances. Therefore, a holistic approach to care should be employed for IBD patients.
JOURNAL OF CROHNS & COLITIS
(2023)
Article
Gastroenterology & Hepatology
James D. Lewis, Lauren E. Parlett, Michele L. Jonsson Funk, Colleen Brensinger, Virginia Pate, Qufei Wu, Ghadeer K. Dawwas, Alexandra Weiss, Brad D. Constant, Maureen Mccauley, Kevin Haynes, Jeff Yufeng Yang, Douglas E. Schaubel, Andres Hurtado-Lorenzo, Michael David Kappelman
Summary: This study aimed to estimate the incidence, prevalence, and racial-ethnic distribution of physician-diagnosed inflammatory bowel disease (IBD) in the United States. Four administrative claims data sets were used, and corresponding estimates were obtained. The incidence of IBD remained relatively stable between the ages of 20 and 80, with variations in diagnosis rates among different races and ethnicities.
Article
Medicine, General & Internal
Maria Chaparro, Ana Garre, Andrea Nunez Ortiz, Maria Teresa Diz-Lois Palomares, Cristina Rodriguez, Sabino Riestra, Milagros Vela, Jose Manuel Benitez, Estela Fernandez Salgado, Eugenia Sanchez Rodriguez, Vicent Hernandez, Rocio Ferreiro-Iglesias, Angel Ponferrada Diaz, Jesus Barrio, Jose Maria Huguet, Beatriz Sicilia, Maria Dolores Martin-Arranz, Xavier Calvet, Daniel Ginard, Inmaculada Alonso-Abreu, Luis Fernandez-Salazar, Pilar Varela Trastoy, Montserrat Rivero, Isabel Vera-Mendoza, Pablo Vega, Pablo Navarro, Monica Sierra, Jose Luis Cabriada, Mariam Aguas, Raquel Vicente, Merce Navarro-Llavat, Ana Echarri, Fernando Gomollon, Elena Guerra del Rio, Concepcion Pinero, Maria Jose Casanova, Katerina Spicakova, Jone Ortiz de Zarate, Emilio Torrella Cortes, Ana Gutierrez, Horacio Alonso-Galan, Alvaro Hernandez-Martinez, Jose Miguel Marrero, Rufo Lorente Poyatos, Margalida Calafat, Lidia Marti Romero, Pilar Robledo, Orencio Bosch, Nuria Jimenez, Maria Esteve Comas, Jose Maria Duque, Ana Maria Fuentes Coronel, Manuela Josefa Sampedro, Eva Sese Abizanda, Belen Herreros Martinez, Liliana Pozzati, Hipolito Fernandez Rosaenz, Belen Crespo Suarez, Pilar Lopez Serrano, Alfredo J. Lucendo, Margarita Munoz Vicente, Fernando Bermejo, Jose Joaquin Ramirez Palanca, Margarita Menacho, Amalia Carmona, Raquel Camargo, Sandra Torra Alsina, Nuria Maroto, Juan Nerin de la Puerta, Elena Castro, Ignacio Marin-Jimenez, Belen Botella, Amparo Sapina, Noelia Cruz, Jose Luis F. Forcelledo, Abdel Bouhmidi, Carlos Castano-Milla, Veronica Opio, Isabel Nicolas, Marcos Kutz, Alfredo Abraldes Bechiarelli, Jordi Gordillo, Yolanda Ber, Yolanda Torres Dominguez, Maria Teresa Novella Duran, Silvia Rodriguez Mondejar, Francisco J. Martinez-Cerezo, Lilyan Kolle, Miriam Sabat, Cesar Ledezma, Eduardo Iyo, Oscar Roncero, Rebeca Irisarri, Laia Lluis, Isabel Blazquez Gomez, Eva Maria Zapata, Maria Jose Alcala, Cristina Martinez Pascual, Maria Montealegre, Laura Mata, Ana Monrobel, Alejandro Hernandez Camba, Luis Hernandez, Maria Tejada, Alberto Mir, Maria Luisa Galve, Marta Soler, Daniel Hervias, Jose Antonio Gomez-Valero, Manuel Barreiro-de Acosta, Fernando Rodriguez-Artalejo, Esther Garcia-Esquinas, Javier P. Gisbert
Summary: The study found a high incidence of inflammatory bowel disease (IBD) in Spain, similar to that reported in Northern Europe. IBD patients require substantial therapeutic resources, especially in cases of Crohn's disease (CD) and in hospitals with high resources, which are much higher than previously reported.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Pediatrics
Maya Ruban, Adam Slavick, Achiya Amir, Amir Ben-Tov, Hadar Moran-Lev, Yael Weintraub, Adi Anafy, Shlomi Cohen, Anat Yerushalmy-Feler
Summary: The rate of a positive family history of IBD in the pediatric IBD population is increasing, and patients with a positive family history are more likely to have a severe phenotype, receive more nutritional therapy, and less corticosteroids. Patients with a negative family history may require intensified biologic therapy.
EUROPEAN JOURNAL OF PEDIATRICS
(2022)
Article
Multidisciplinary Sciences
Ivana Kern, Olaf Schoffer, Wieland Kiess, Jobst Henker, Martin W. Laass, Ulf Winkler, Juergen Quietzsch, Olaf Wenzel, Marlen Zurek, Katrin Buettner, Peter Fischer, Jan de Laffolie, Ulf Manuwald, Thoralf Stange, Ronny Zenker, Jens Weidner, Klaus-Peter Zimmer, Hildebrand Kunath, Joachim Kugler, Thomas Richter, Ulrike Rothe
Summary: The incidence of inflammatory bowel disease (IBD) in children and adolescents in Saxony, Germany, was slightly higher than the average of other countries during the same time period and showed a trend towards a general increase. The age at diagnosis exhibited a very unfavorable downward trend.
Article
Biochemistry & Molecular Biology
Javier Conde, Marlene Schwarzfischer, Egle Katkeviciute, Janine Hafliger, Anna Niechcial, Nathalie Brillant, Roberto Manzini, Katharina Babler, Kirstin Atrott, Silvia Lang, Michael Scharl
Summary: This study investigated the interaction between the food additive TiO2 and the IBD risk gene Ptpn2 in the development of intestinal inflammation. Results showed that TiO2 exacerbated intestinal inflammation in Ptpn2 deficient mice by impacting the differentiation of intestinal macrophages. Furthermore, TiO2 was found to induce the secretion of IL-1 beta and suppress the expression of IL-10 in macrophages through different signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Gastroenterology & Hepatology
Mira Y. Stulman, Noa Asayag, Gili Focht, Ilan Brufman, Amos Cahan, Natan Ledderman, Eran Matz, Yehuda Chowers, Rami Eliakim, Shomron Ben-Horin, Shmuel Odes, Iris Dotan, Ran D. Balicer, Eric Benchimol, Dan Turner
Summary: Based on health-administrative data in Israel, the prevalence of inflammatory bowel diseases is still increasing but with a gradually decelerating trend, likely due to a decrease in overall incidence. However, the incidence rate in children is still increasing. Over time, the narrowing gap in incidence rates between Jews and Arabs may indicate shared environmental factors.
INFLAMMATORY BOWEL DISEASES
(2021)
Article
Pharmacology & Pharmacy
Snjezana Cuzic, Maja Antolic, Anja Ognjenovic, Darija Stupin-Polancec, Adriana Petrinic Grba, Boska Hrvacic, Miroslava Dominis Kramaric, Sanja Musladin, Lidija Pozgaj, Ivo Zlatar, Denis Polancec, Gorana Aralica, Marko Banic, Marija Urek, Brankica Mijandrusic Sincic, Aleksandar Cubranic, Ines Glojnaric, Martina Bosnar, Vesna Erakovic Haber
Summary: This study explored the expression of claudins in human disease and two different animal models of IBD. The diverse alterations in claudin expression by epithelial and inflammatory cells were recorded in IBD and both animal models. The results suggest that claudins are not exclusively expressed by epithelial cells, and changes in claudin mRNA levels should be interpreted in the context of overall tissue alterations.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Tyler Atagozli, David E. Elliott, Mirac Nedim Ince
Summary: Helminths are multicellular invertebrates that live in the gut of vertebrate animals, including humans. They can cause pathology and require treatment, but can also have commensal or symbiotic relationships with their hosts. Epidemiological data suggests that helminth exposure may provide protection against immune disorders, such as allergies and autoimmune illnesses.
Article
Biochemistry & Molecular Biology
Nikolas Dovrolis, Anastasia Moschoviti, Smaragdi Fessatou, George Karamanolis, George Kolios, Maria Gazouli
Summary: This study examines the role of the microbiome in the onset of pediatric inflammatory bowel disease (IBD). Through analyzing the microbiota of nine IBD families, specific patterns of microbial taxa were identified among patients and their families. The results suggest a potential role of maternal factors in the establishment and modulation of the early life microbiome.
Article
Medicine, General & Internal
Rahma Elmahdi, Camilla E. Lemser, Sandra B. Thomsen, Kristine H. Allin, Manasi Agrawal, Tine Jess
Summary: This meta-analysis revealed that patients with pediatric-onset IBD have a more than 2-fold increased rate of cancer compared to the general pediatric population, primarily due to an increased rate of gastrointestinal cancers.