Renal Impairment as a Surgical Indication in Primary Hyperparathyroidism: Do the Data Support This Recommendation?

Content: Management of primary hyperparathyroidism has evolved over the past two decades, yet impaired renal function has consistently been a surgical indication. This recommendation has been based upon the historical association between primary hyperparathyroidism and renal impairment, and a review of the literature is needed to determine whether such a recommendation is warranted. Evidence Acquisition and Synthesis: PubMed was utilized to identify English-language articles published between January 1990 and February 2014 using keywords related to hyperparathyroidism and renal function. The keywords were primary hyperparathyroidism, surgery, parathyroidectomy, kidney, renal, glomerular filtration rate, and creatinine. Of the 1926 articles obtained with this search, all articles germane to the topic that quantified the relationship between primary hyper-parathyroidism and renal function were included. All references within these articles were investigated for inclusion. When helpful, data tables were constructed to summarize the results succinctly. Conclusions: A secondary elevation of PTH levels has not been consistently shown to occur at the threshold currently indicated for surgical intervention. While renal impairment is seen with more significant disease, mild asymptomatic primary hyperparathyroidism has not been conclusively associated with renal impairment. Furthermore, there is no evidence to suggest that surgically curing primary hyperparathyroidism via a parathyroidectomy has any impact upon renal function.