Article
Biochemistry & Molecular Biology
Li Li, Pierre Galichon, Xiaoyan Xiao, Ana C. Figueroa-Ramirez, Diana Tamayo, Jake J-K Lee, Marian Kalocsay, David Gonzalez-Sanchez, Maria S. Chancay, Kyle W. McCracken, Nathan N. Lee, Takaharu Ichimura, Yutaro Mori, M. Todd Valerius, Julia Wilflingseder, Dario R. Lemos, Elazer R. Edelman, Joseph Bonventre
Summary: COUP-TFII plays a crucial role in fibrosis, with its overexpression suppressing fatty acid oxidation, enhancing glycolysis pathways, and inducing fibroblasts to produce collagen. Genetic ablation of COUP-TFII can mitigate kidney fibrosis after injury. The regulation of PGC1α by COUP-TFII serves as an important mechanism in fibrosis.
Article
Multidisciplinary Sciences
Paola Aguiari, Yan-Yun Liu, Astgik Petrosyan, Sheue-yann Cheng, Gregory A. Brent, Laura Perin, Anna Milanesi
Summary: Thyroid hormone signaling, particularly through the interaction between COUP-TFII and THRA, plays a crucial role in muscle development and function, as well as in the maintenance of muscle mass. COUP-TFII is identified as a key factor in the abnormal muscle phenotype observed in THRA-PV mice, contributing to accelerated skeletal muscle loss with aging and impaired muscle regeneration after injury.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Sang-Heum Han, Young Hee Kim, Su-Jeong Park, Jun-Gi Cho, Yoon Kyung Shin, Young Bin Hong, Jeanho Yun, Jin-Yeong Han, Hwan Tae Park, Joo-In Park
Summary: This study investigates the role of COUP-TFII in cAMP-induced Schwann cell differentiation. The results show that COUP-TFII regulates the expression of Oct6, Krox20, and myelin-related genes involved in Schwann cell differentiation and myelination. COUP-TFII may be involved in postnatal myelination by inducing Krox20 expression in Schwann cells.
JOURNAL OF NEUROCHEMISTRY
(2023)
Article
Immunology
Yuling Chen, Yuanchun Ye, Pierre-Louis Krauss, Pelle Loewe, Moritz Pfeiffenberger, Alexandra Damerau, Lisa Ehlers, Thomas Buttgereit, Paula Hoff, Frank Buttgereit, Timo Gaber
Summary: Metabolic reprogramming in human memory Th cells during aging increases ROS production and leads to increased expression of proinflammatory cytokines, which may contribute to the pathogenesis of inflammaging.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Xiaoyan Wu, Xiulian Miao, Tinghui Shao, Shifan Tang, Yanshan Lin, Yong Xu, Nan Li, Tao Zhang
Summary: This study reveals that Slug is involved in regulating fibroblast-myofibroblast transition and renal fibrosis by modulating the expression of key transcription factors and ROS levels.
Article
Reproductive Biology
Samir Mehanovic, Raifish E. Mendoza-Villarroel, Karine de Mattos, Philippe Talbot, Robert S. Viger, Jacques J. Tremblay
Summary: COUP-TFII plays a crucial role in steroidogenesis, androgen homeostasis, cellular defense, and differentiation in mouse Leydig cells, with in-depth high-throughput transcriptomic analysis revealing novel gene pathways and networks regulated by this orphan nuclear receptor in depleted cells.
BIOLOGY OF REPRODUCTION
(2021)
Article
Andrology
Samir Mehanovic, Kenley Joule Pierre, Robert S. Viger, Jacques J. Tremblay
Summary: In this study, the researchers found that GATA4 and COUP-TFII cooperatively regulate gene expression, particularly the Amhr2 gene, in MA-10 Leydig cells through physical and functional interaction.
Article
Cell Biology
Kristina Riegel, Hajime Yurugi, Janine Schloeder, Helmut Jonuleit, Manuel Kaulich, Friederike Kirschner, Danielle Arnold-Schild, Stefan Tenzer, Hansjorg Schild, Krishnaraj Rajalingam
Summary: Tumors suppress antitumor immune responses by secreting IL-6, which inhibits the production of IL-12p70 in dendritic cells. The classical mitogen-activated protein kinase ERK5/MAPK7 is essential for IL-6 production in tumor cells, suggesting a potential target for enhancing antitumor immune responses.
CELL DEATH & DISEASE
(2021)
Article
Environmental Sciences
Tongtong Li, Dongcan Tian, Mengtian Lu, Bijiao Wang, Jun Li, Baohua Xu, Hao Chen, Shijin Wu
Summary: The study reveals a connection between brain inflammation induced by polychlorinated biphenyl 126 (PCB126) and gut microbiota disturbance, providing new insights into the toxicity mechanisms of PCB126 and potential therapeutic targets for CNS disease caused by environmental pollution.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Multidisciplinary Sciences
Som Dev, Abigael Muchenditsi, Aline Gottlieb, Pragney Deme, Sean Murphy, Kathleen L. Gabrielson, Yixuan Dong, Robert Hughes, Norman J. Haughey, James P. Hamilton, Svetlana Lutsenko
Summary: This study identified an important regulatory pathway in Wilson disease with copper metabolism abnormalities, which can improve liver damage and restore function.
Article
Biology
Saad Idrees, Matthias-Philipp Baumann, Maria M. Korympidou, Timm Schubert, Alexandra Kling, Katrin Franke, Ziad M. Hafed, Felix Franke, Thomas A. Muench
Summary: Visual perception remains stable across saccades because of the reduction in visual sensitivity known as saccadic suppression. This suppression is achieved through three independent mechanisms in the retina.
COMMUNICATIONS BIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Xiaotao Xu, Yang Su, Kaixuan Wu, Fan Pan, Aizhong Wang
Summary: DOCK2 is a crucial regulator in macrophage activation and acute lung injury, controlling IKKβ activation and inflammatory cytokine release. Inhibition of DOCK2 may be a promising approach for treating endotoxemia-related ALI.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Immunology
Kevin Hendrawan, Melissa L. M. Khoo, Malini Visweswaran, Jennifer C. Massey, Barbara Withers, Ian Sutton, David D. F. Ma, John J. Moore
Summary: Autologous haematopoietic stem cell transplantation (AHSCT) is a therapy for hematological malignancies and autoimmune diseases, such as multiple sclerosis (MS). The immunological mechanisms of remission in MS patients post-AHSCT likely involve an anti-inflammatory shift in cytokine levels, particularly a suppression of proinflammatory cytokines. The study found that the suppression of Th17 cytokines is essential for the long-term remission in MS patients following AHSCT.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Yusra Habib Khan, Sumera Qasim, Ambreen Malik Uttra, Nasser H. Alotaibi, Abdullah Salah Alanazi, Abdulaziz I. Alzarea, Ahmed D. Alatawi, Tauqeer Hussain Mallhi
Summary: Enalapril, with documented anti-inflammatory potential, was evaluated for its efficacy in treating arthritis. The study utilized a CFA-induced arthritic model and assessed various parameters such as paw volume, body weight, arthritic index, hematological and biochemical parameters, cytokine levels, radiographic analysis, and histopathological changes. The results showed that enalapril demonstrated significant anti-arthritic activity by reducing paw volume and arthritic index, while preserving body weight. It also normalized hematological and biochemical alterations, suppressed proinflammatory cytokines, and increased anti-inflammatory cytokines. Radiographic and histopathological analysis further confirmed enalapril's anti-arthritic properties. However, further mechanistic studies are needed to determine the exact mechanism of action.
Review
Oncology
S. Leenen, M. Hermens, P. J. de Vos van Steenwijk, R. L. M. Bekkers, E. M. G. van Esch
Summary: Endometriosis is a risk factor for certain types of ovarian carcinoma, and immunological factors play a key role in the clinical outcome of both conditions. Chronic inflammation in endometriosis may drive carcinogenesis in endometriosis-associated ovarian carcinoma, but the exact immunological pathways and cellular processes involved remain unknown and require further investigation.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2021)
Article
Psychology, Clinical
Meng-Hsing Wu, Pei-Fang Su, Wei-Ying Chu, Chih-Wei Lin, New Geok Huey, Chung-Ying Lin, Huang-Tz Ou
Summary: Endometriosis-affected women had lower quality of life during IVF treatment compared to non-endometriosis women. Higher QoL scores in non-endometriosis women were significantly associated with successful IVF pregnancy, while this association was not statistically significant in endometriosis women.
JOURNAL OF PSYCHOSOMATIC OBSTETRICS & GYNECOLOGY
(2021)
Article
Developmental Biology
Hsiu-Chi Lee, Shih-Chieh Lin, Meng-Hsing Wu, Shaw-Jenq Tsai
Summary: The study identified that NTRK2 is upregulated in endometriotic lesions and its expression is induced by hypoxia through hypoxia-inducible factor 1 alpha. Treatment with NTRK2 antagonist ANA-12 induced cell death in endometriotic stromal cells and caused regression of ectopic lesions in a mouse model. These findings suggest a potential therapeutic target for endometriosis.
Review
Developmental Biology
Wan-Ning Li, Meng-Hsing Wu, Shaw-Jenq Tsai
Summary: Endometriosis is a benign gynecological disease affecting approximately 10% of women of reproductive age, leading to symptoms such as dysmenorrhea, dyspareunia, and infertility. Hypoxia plays a critical role in the disease phenotypes of endometriosis, influencing factors such as adhesion ability, estrogen biosynthesis, proinflammatory cytokines, angiogenic ability, and immune functions. Targeting HIF and downstream effectors may offer potential therapeutic options for endometriosis treatment.
Article
Cell Biology
Yi-Shyun Lai, Ya-Han Chang, Yong-Yi Chen, Jixuan Xu, Chi-Sian Yu, Su-Jing Chang, Pai-Sheng Chen, Shaw-Jenq Tsai, Wen-Tai Chiu
Summary: This study demonstrates the integral role of Ca2+ signals in cell biology, and optogenetic technology can be used to modulate Ca2+ waves and activate specific signaling pathways to explore the regulation of cell migration.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Neurosciences
Issa Olakunle Yusuf, Hsiu-Mei Chen, Pei-Hsun Cheng, Chih-Yi Chang, Shaw-Jenq Tsai, Jih-Ing Chuang, Chia-Ching Wu, Bu-Miin Huang, H. Sunny Sun, Chuan-Mu Chen, Shang-Hsun Yang
Summary: Proper development of neuronal cells is crucial for brain functions, and impairment may lead to disorders. Studies suggest that FGF9 may enhance total neuronal length through upregulation of NF-kB signaling in Huntington's disease (HD), potentially serving as a neuroprotective mechanism.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Medicine, Research & Experimental
Issa Olakunle Yusuf, Hsiu-Mei Chen, Pei-Hsun Cheng, Chih-Yi Chang, Shaw-Jenq Tsai, Jih-Ing Chuang, Chia-Ching Wu, Bu-Miin Huang, H. Sunny Sun, Chuan-Mu Chen, Shang-Hsun Yang
Summary: This study demonstrates the importance of the ERK pathway in FGF9-induced neurite outgrowth in HD striatal models. Suppression of ERK signaling inhibits neurite outgrowth, cytoskeletal markers, and synaptic proteins, as well as NF-kB activation induced by FGF9. These findings suggest a sequential activation mechanism where FGF9 first activates the ERK signaling pathway, leading to NF-kB upregulation and subsequent enhancement of neurite outgrowth in HD striatal cells.
Article
Obstetrics & Gynecology
Pei-Hsiu Yu, Pei-Yi Chou, Wan-Ning Li, Shaw-Jenq Tsai, Meng-Hsing Wu
Summary: The study demonstrated that the use of hyaluronic acid in endometriosis may induce both proinflammatory and anti-inflammatory responses. Elevated COX-2 expression and reduced endometriosis lesion size and COX-2 expression score were observed after hyaluronic acid treatment in in vivo and in vitro models. The findings suggest that hyaluronic acid may initiate an acute proinflammatory response followed by a chronic anti-inflammatory reaction in the development of endometriosis.
TAIWANESE JOURNAL OF OBSTETRICS & GYNECOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Chung-Hwan Chen, Tsung-Lin Cheng, Chi-Fen Chang, Hsuan-Ti Huang, Sung-Yen Lin, Meng-Hsing Wu, Lin Kang
Summary: This study showed that RLX could alleviate GlcN-induced insulin resistance and beta-cell dysfunction by reducing ER stress-related proteins. This suggests that RLX may be a potential therapeutic option for postmenopausal women with OA and OP.
Article
Cell Biology
Yu-Ying Chao, Bu-Miin Huang, I-Chen Peng, Pei-Rong Lee, Yi-Shyun Lai, Wen-Tai Chiu, Yi-Syuan Lin, Shih-Chieh Lin, Jung-Hsuan Chang, Pai-Sheng Chen, Shaw-Jenq Tsai, Chia-Yih Wang
Summary: Loss of primary cilia is associated with chemoresistance in pancreatic ductal adenocarcinoma (PDAC). Disruption of primary ciliogenesis sensitizes PDAC cells to cisplatin treatment, indicating a potential therapeutic strategy.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Obstetrics & Gynecology
Shih-Chieh Lin, Wan-Ning Li, Shin-Chih Lin, Haun-Tzu Hou, Ya-Chuan Tsai, Tin-Chien Lin, Meng-Hsing Wu, Shaw-Jenq Tsai
Summary: YAP1 inhibition can alleviate progesterone resistance in endometriosis. Through in vitro and in vivo experiments, it has been found that YAP1 inhibition can reduce progesterone resistance. It is known that progesterone resistance not only causes treatment failure for endometriosis but also inhibits eutopic endometrial cell proliferation, dysregulates decidualization, and reduces the success rates of pregnancy.
HUMAN REPRODUCTION
(2023)
Article
Cell Biology
Yi-Shyun Lai, Cheng-Chi Chang, Yong-Yi Chen, Thi My Hang Nguyen, Jixuan Xu, Ying-Chi Chen, Yu-Fen Chang, Chia-Yih Wang, Pai-Sheng Chen, Shih-Chieh Lin, I-Chen Peng, Shaw-Jenq Tsai, Wen-Tai Chiu
Summary: In this study, the effects of optogenetically engineered Ca2+ signaling on mitochondrial dynamics were investigated. It was found that customized illumination conditions could trigger specific signaling pathways by generating unique Ca2+ oscillation waves. Modulating Ca2+ oscillations through increasing light frequency, intensity, and exposure time resulted in mitochondrial fission, dysfunction, autophagy, and cell death. The phosphorylation of the mitochondrial fission protein DRP1 at the Ser616 residue was activated by Ca2+-dependent kinases CaMKII, ERK, and CDK1, but not at Ser637. Calcineurin phosphatase was not activated by optogenetically engineered Ca2+ signaling to dephosphorylate DRP1 at Ser637. Furthermore, light illumination had no effect on the expression levels of the mitochondrial fusion proteins MFN1 and MFN2.
JOURNAL OF CELL SCIENCE
(2023)
Article
Multidisciplinary Sciences
Pei -Ling Hsu, Chun -Wei Chien, Yen-An Tang, Bo -Wen Lin, Shih-Chieh Lin, Yi-Syuan Lin, Sih-Yu Chen, H. Sunny Sun, Shaw-Jenq Tsai
Summary: Metastasis is the main cause of death in many cancers including colorectal cancer (CRC), but the underlying mechanisms are largely unknown. This study found that the nuclear TYRO3 receptor tyrosine kinase is a strong predictor of poor overall survival in patients with CRC. The function of nuclear TYRO3 in promoting metastasis requires its kinase activity and MMP-2-mediated cleavage, independent of ligand binding. The research also identified BRD3 as one of nuclear TYRO3's substrates and demonstrated that TYRO3-phosphorylated BRD3 regulates genes involved in anti-apoptosis and epithelial-mesenchymal transition.
Article
Biochemistry & Molecular Biology
Chih-Wei Lin, Chung-Hwan Chen, Meng-Hsing Wu, Fong-Ming Chang, Lin Kang
Summary: This study investigated the association between two promoter polymorphisms in the TNF genes and preeclampsia (PE). It found that the polymorphism at the -308 position in the TNF-a gene promoter region is associated with severe PE in Taiwanese Han populations.
Editorial Material
Biochemistry & Molecular Biology
Huan-Tzu Hou, Ting-Chien Lin, Meng-Hsing Wu, Shaw-Jenq Tsai
Summary: Recent research has found that Fusobacterium nucleatum, a Gram-negative anaerobic bacterium, is present in the uterus of 64% of women with endometriosis. This bacterium infection leads to macrophage infiltration, transforming growth factor-beta production, and upregulation of transgelin in the human and mouse endometria, as well as the development of endometriotic lesions in a mouse model of endometriosis.
TRENDS IN MOLECULAR MEDICINE
(2023)
