Review
Biochemistry & Molecular Biology
Swati Sucharita Mohanty, Prafulla Kumar Mohanty
Summary: Breast cancer is the second most prevalent cancer globally, with a significant relationship between obesity and increased risk of developing the disease. Premature menopause and premenopausal obesity decrease the risk, while postmenopausal obesity amplifies it due to adipose tissue being a major reservoir for estrogen biosynthesis. High estrogen levels in overweight postmenopausal women are seen as a major factor in breast cancer development.
Review
Endocrinology & Metabolism
Alleigh G. Wiggs, Justin K. Chandler, Aynur Aktas, Susan J. Sumner, Delisha A. Stewart
Summary: Endogenous estrogens are associated with breast cancer risk, particularly in postmenopausal women. Nutritional and exercise interventions have been shown to modify estrogen levels and metabolism, potentially reducing the risk of breast cancer. Studies combining diet and exercise interventions demonstrate better control of estrogen forms and levels, suggesting they may be the most effective strategies for preventing breast cancer in postmenopausal women.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Yuan Wu, Xu Li, Qiong Li, Chienshan Cheng, Lan Zheng
Summary: The review examines mechanistic evidence for the connection between obesity and breast cancer, exploring the factors that promote tumor development or metastasis. It highlights the role of adipokines, metabolic pathways, inflammatory microenvironment, adipose stem cells, and miRNAs in breast cancer progression. The review also discusses possible therapeutic directions and the risks associated with autologous breast remodeling and fat transplantation. Furthermore, it explores the causes of the obesity paradox and the impact of enhanced immunity. Evaluating the balance between inflammation and immunity in obesity-induced breast cancer warrants further investigation.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2022)
Article
Endocrinology & Metabolism
Davide Diacinti, Daniele Diacinti, Antonio Iannacone, Jessica Pepe, Luciano Colangelo, Luciano Nieddu, Endi Kripa, Martina Orlandi, Viviana De Martino, Salvatore Minisola, Cristiana Cipriani
Summary: This study found that postmenopausal women with chronic postsurgical hypoparathyroidism have increased bone marrow adipose tissue (BMAT) which is negatively associated with trabecular microarchitecture, using magnetic resonance imaging (MRI) and proton magnetic resonance spectroscopy (H-1-MRS).
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Nutrition & Dietetics
Seong-Hee Ko, YunJae Jung
Summary: Hormonal changes during menopause in women lead to body composition changes, muscle loss, and abdominal obesity, with increased visceral fat as a result. These changes in fat distribution also contribute to metabolic abnormalities, insulin resistance, and metabolic diseases, due to enhanced lipolysis of visceral fat.
Article
Food Science & Technology
P. Regal, C. A. Fente, A. Cepeda, E. G. Silva
Summary: Breast cancer is the most common cause of cancer death for women, with a multi-factorial origin that is influenced by environmental factors. Food and specific nutrients play crucial roles in the development of breast tumors, offering an interesting alternative for prevention and therapy of breast cancer.
CURRENT OPINION IN FOOD SCIENCE
(2021)
Article
Endocrinology & Metabolism
Julien Paccou, Sammy Badr, Daniela Lombardo, Huda Khizindar, Valerie Deken, Stefan Ruschke, Dimitrios C. Karampinos, Anne Cotten, Bernard Cortet
Summary: This study aimed to determine the association between proton density fat fraction (PDFF) and fractures. A case-control study was conducted on postmenopausal women, and it was found that MRI-based measurement of proximal femur PDFF can discriminate between postmenopausal women with and without clinical vertebral fractures, independent of age, CCI, and BMD.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Review
Biochemistry & Molecular Biology
Tamas Roeszer
Summary: Breastfeeding is a unique behavior of mammals, providing heat and metabolic fuel for offspring. The lipid signals in breast milk play a crucial role in infant lipid metabolism and metabolic development.
Article
Biology
Xiao Zhang, Hero Robles, Kristann L. Magee, Madelyn R. Lorenz, Zhaohua Wang, Charles A. Harris, Clarissa S. Craft, Erica L. Scheller
Summary: Bone marrow adipocytes accumulate with age and in diverse disease states. A novel secondary adipogenesis pathway unique to the bone marrow is activated with age and in states of metabolic stress, resulting in compromised lipid mobilization and cytokine expression within regions traditionally devoted to hematopoiesis. This finding further contributes to our understanding of bone marrow adipocyte origins, adaptations, and relationships with surrounding tissues.
Article
Medicine, General & Internal
Ian H. H. Kunkler, Linda J. J. Williams, Wilma J. L. Jack, David A. A. Cameron, J. Michael Dixon
Summary: This study suggests that omission of radiotherapy in older women with low-risk, hormone receptor-positive early breast cancer may increase the risk of local recurrence, but has no detrimental effect on distant recurrence and overall survival.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Francesca Piccotti, Ilona Rybinska, Elisabetta Scoccia, Carlo Morasso, Alessandra Ricciardi, Lorena Signati, Tiziana Triulzi, Fabio Corsi, Marta Truffi
Summary: Lipofilling is a commonly used technique in reconstructive and esthetic breast surgery, but there is ongoing debate and conflicting research results regarding its safety and suitability in breast cancer surgery.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Hannah Oh, Nazmus Saquib, Heather M. Ochs-Balcom, Ruth M. Pfeiffer, Phyllis A. Richey, Aladdin H. Shadyab, Robert A. Wild, Lisa Underland, Garnet L. Anderson, Xia Xu, Britton Trabert
Summary: This study found that prolonged sitting and physical inactivity are associated with higher estrogen-to-androgen ratios in postmenopausal women, but not with androgen metabolites. This contributes to our understanding of the link between physical activity, sitting, and cancer risk in this population.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2022)
Article
Cell Biology
Giulia Leanza, Caterina Conte, Francesca Cannata, Camilla Isgro, Alessandra Piccoli, Rocky Strollo, Carlo Cosimo Quattrocchi, Rocco Papalia, Vincenzo Denaro, Mauro Maccarrone, Nicola Napoli, Anna Maria Sardanelli
Summary: In this study, the oxidative stress states were compared between postmenopausal women with and without obesity. The results showed that women with obesity had doubled levels of oxidative stress markers compared to women of normal weight. The severity of oxidative stress was correlated with body mass index, visceral fat mass, and trunk fat percentage, but not with fasting glucose levels. These findings suggest that obesity and visceral fat increase oxidative stress in postmenopausal women, potentially increasing the risks of cardiometabolic and cancer diseases.
Article
Endocrinology & Metabolism
Fozia Ahmed, Prasad G. Kamble, Susanne Hetty, Giovanni Fanni, Milica Vranic, Assel Sarsenbayeva, Robin Kristofi, Kristina Almby, Maria K. Svensson, Maria J. Pereira, Jan W. Eriksson
Summary: This study found that reduced estrogen levels in postmenopausal women can lead to metabolic side effects, particularly insulin resistance and type 2 diabetes. The results suggest that estrogen receptor expression in adipose tissue is lower in postmenopausal women, and E2 inhibits glucose utilization in human adipocytes. These findings may explain changes in glucose utilization after menopause and have implications for hormone treatment in postmenopausal women.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Nutrition & Dietetics
En Cheng, Bette J. Caan, Wendy Y. Chen, Melinda L. Irwin, Carla M. Prado, Elizabeth M. Cespedes Feliciano
Summary: This study aimed to investigate the association between radiodensity of subcutaneous and visceral adipose tissue at diagnosis of breast cancer and patient prognosis. The results showed that high radiodensity of subcutaneous adipose tissue was significantly associated with increased risk of overall mortality, independent of other prognostic factors.
CLINICAL NUTRITION
(2022)
Article
Obstetrics & Gynecology
Christian Falconer, Daniel Altman, Georgios Poutakidis, Paivi Rahkola-Soisalo, Tomi Mikkola, Edward Morcos
Summary: The study found that for pelvic organ prolapse repair using a mesh-capturing device, the outcomes were better in a single-center approach compared to a multicenter trial. Recurrence rates and complications were higher in the multicenter study, indicating the benefits of centralizing the use of standardized procedures for this type of surgery.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2021)
Article
Biochemistry & Molecular Biology
Maria A. Ahonen, Muhammad Yasir Asghar, Suvi J. Parviainen, Gerhard Liebisch, Marcus Hoering, Marjut Leidenius, Pamela Fischer-Posovszky, Martin Wabitsch, Tomi S. Mikkola, Kid Tornquist, Hanna Savolainen-Peltonen, P. A. Nidhina Haridas, Vesa M. Olkkonen
Summary: miR-221-3p overexpression inhibits terminal differentiation of adipocytes, while its inhibitor increases triglyceride storage. The effects of miR-221-3p may be mediated through 14-3-3 gamma, and it also impacts lipid metabolism.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2021)
Article
Biochemistry & Molecular Biology
Natalia Hetemaki, Tomi S. Mikkola, Matti J. Tikkanen, Feng Wang, Esa Hamalainen, Ursula Turpeinen, Mikko Haanpaa, Veera Vihma, Hanna Savolainen-Peltonen
Summary: The study found that premenopausal adipose tissue demonstrates high levels of estrogenic enzyme activity and significant local estrogen concentrations, which may contribute to the typical distribution of adipose tissue in premenopausal women.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2021)
Article
Medicine, General & Internal
Johanna Joensuu, Hannu Saarijarvi, Hanna Rouhe, Mika Gissler, Veli-Matti Ulander, Seppo Heinonen, Paulus Torkki, Tomi Mikkola
Summary: The study aimed to examine the correlation between labor pain relief methods and childbirth experience as measured by Visual Analogue Scale (VAS). The findings revealed that the use of epidural or non-epidural pain relief methods reduced the likelihood of highly positive childbirth experience for both primiparous and multiparous women. However, the effects of epidural differed between the two groups. Additionally, the study suggests that the use of any medical pain relief decreased the odds of experiencing highly positive childbirth. Thus, the effect of pain relief on childbirth experience is strongly confounded by indication.
Article
Obstetrics & Gynecology
Johanna M. Joensuu, Hannu Saarijarvi, Hanna Rouhe, Mika Gissler, Veli-Matti Ulander, Seppo Heinonen, Paulus Torkki, Tomi S. Mikkola
Summary: This study assessed the impact of spontaneous labor and labor induction on maternal childbirth experience. The findings revealed that labor induction had a negative effect on childbirth experience in all modes of delivery, especially in cases of operative delivery. Labor induction also more than doubled the risk of caesarean section.
BMC PREGNANCY AND CHILDBIRTH
(2022)
Article
Urology & Nephrology
Anna-Maija Itkonen Freitas, Camilla Isaksson, Paivi Rahkola-Soisalo, Sari Tulokas, Maarit Mentula, Tomi S. Mikkola
Summary: This study compared the efficacy of polyacrylamide hydrogel (PAHG) and tension-free vaginal tape (TVT) in the treatment of primary stress urinary incontinence (SUI). The results showed that PAHG did not meet the noninferiority criteria set in the study, and TVT slings had better subjective and objective cure rates but were associated with more complications. Therefore, PAHG can be offered as a safe and durable alternative treatment for women with primary SUI.
JOURNAL OF UROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Alexandra Robciuc, Hanna Savolainen-Peltonen, Mikko Haanpaa, Jukka A. O. Moilanen, Tomi S. Mikkola
Summary: The sexual dimorphism in inflammatory/autoimmune diseases is mainly caused by sex hormone actions. Dry eye, a common eye disease, disproportionately affects women. The hormone levels in tears are correlated with serum levels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Minttu Venetkoski, Johanna Joensuu, Mika Gissler, Olavi Ylikorkala, Tomi Sakari Mikkola, Hanna Savolainen-Peltonen
Summary: Pre-eclampsia has a significant impact on the future cardiovascular risk of Finnish women, with elevated risks for ischemic heart disease, myocardial infarction, and stroke among women with a history of pre-eclampsia.
Article
Psychology, Clinical
Nico Vehmas, Elina Holopainen, Laura Suomalainen, Hanna Savolainen-Peltonen
Summary: The study found that Finnish adolescents seeking GAHT for gender dysphoria have good somatic health, but a higher proportion of overweight, depression, and anxiety compared to the general adolescent population.
TRANSGENDER HEALTH
(2022)
Article
Obstetrics & Gynecology
M. Venetkoski, O. Ylikorkala, J. M. Joensuu, M. Gissler, T. S. Mikkola, H. Savolainen-Peltonen
Summary: This study compared the trends of hormone therapy (HT) use between women with and without a history of pre-eclampsia. The results showed that the use of HT increased in women with a history of pre-eclampsia during the later half of the follow-up period, possibly due to changes in international recommendations, increased awareness of pre-eclampsia-related cardiovascular risk later in life, and the aim to reduce this risk through HT.
Article
Polymer Science
Rubina Ajdary, Guillermo Reyes, Jani Kuula, Eija Raussi-Lehto, Tomi S. Mikkola, Esko Kankuri, Orlando J. Rojas
Summary: Direct ink writing is used to synthesize layer-by-layer meshes using renewable polysaccharides, which demonstrate excellent mechanical performance, wet stability, and biocompatibility, making them suitable for biomedical implants.
Article
Obstetrics & Gynecology
Sari Tulokas, Maarit Mentula, Paivi Harkki, Tea Brummer, Tea Kuittinen, Tomi Mikkola, Paivi Rahkola-Soisalo
Summary: Hysterectomy after or concomitant with mid-urethral sling (MUS) does not appear to increase the risk for stress urinary incontinence (SUI) re-operation or hospital re-visits for urinary incontinence.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2022)