Article
Oncology
Dana A. Dominguez, Praveen Chatani, Ryan Murphy, Amy R. Copeland, Richard Chang, Samira M. Sadowski, Fady Hannah-Shmouni, Constantine A. Stratakis, Naris Nilubol
Summary: Contralateral suppression (CoS) was not found to be useful in predicting clinical cure of hypertension (ccHTN) following unilateral adrenalectomy for primary aldosteronism (PA) in this study. The aldosterone resolution score (ARS) remained a useful predictor for ccHTN after adjusting for clinical and biochemical factors.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Endocrinology & Metabolism
Adina F. Turcu, Richard Auchus
Summary: Recent studies have shown that primary aldosteronism (PA) has a higher prevalence among hypertensive patients than previously assumed, with the most common subtypes being aldosterone-producing adenomas (APAs) and bilateral hyperaldosteronism (BHA). Screening and distinguishing between different subtypes can be costly, and it is important to assess the likelihood of benefit from imaging and adrenal vein sampling before embarking on these studies.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Mirko Parasiliti-Caprino, Fabio Bioletto, Filippo Ceccato, Chiara Lopez, Martina Bollati, Maria Chiara Di Carlo, Giacomo Voltan, Denis Rossato, Giuseppe Giraudo, Carla Scaroni, Ezio Ghigo, Mauro Maccario
Summary: This study evaluated the reliability of simple and corrected aldosterone indices for assessing the selectivity and lateralization of adrenal vein sampling (AVS) in patients with primary aldosteronism. The results showed that the aldosterone index had high accuracy in predicting selectivity and moderate accuracy in predicting ipsi/contralateral aldosterone hypersecretion. The study also found that the use of corrected aldosterone indices significantly improved the accuracy in predicting ipsi/contralateral disease. The comparative aldosterone index showed high accuracy in predicting unilateral primary aldosteronism.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Surgery
Praachi Raje, Jordan M. Broekhuis, Barry A. Sacks, Benjamin C. James
Summary: Adrenal vein sampling (AVS) provides valuable information for determining appropriate management of adrenal Cushing's syndrome, especially in distinguishing unilateral from bilateral disease. Even in cases of bilateral disease, AVS may identify a dominant gland, allowing for staged unilateral adrenalectomy before considering complete adrenalectomy or medical management. Larger studies are needed to further establish the significant benefit of AVS for this population.
JOURNAL OF SURGICAL RESEARCH
(2021)
Article
Pathology
Nicola Sawyer, Paul Glendenning, Samuel D. Vasikaran, Michael M. Page, Sze Ling Wong, Jun Yang, Markus P. Schlaich, Greg Van Schie, Damon A. Bell
Summary: The objective of this study was to determine the clinical and biochemical success rates of adrenalectomy in patients with unilateral primary aldosteronism (PA), subtyped by adrenal vein sampling (AVS), using the Primary Aldosteronism Surgical Outcome (PASO) criteria. Clinical and biochemical outcomes were evaluated retrospectively in patients who underwent adrenalectomy according to AVS between September 2017 and September 2020. Follow-up data were collected through questionnaires, clinic letter reviews, and examination of pathology and radiological reports. The results showed high clinical and biochemical success rates in patients who underwent adrenalectomy for unilateral PA in Western Australia, but further standardization of post-operative follow-up care is needed.
Article
Endocrinology & Metabolism
Masatoshi Ogata, Hironobu Umakoshi, Tazuru Fukumoto, Yayoi Matsuda, Maki Yokomoto-Umakoshi, Hiromi Nagata, Norio Wada, Takashi Miyazawa, Ryuichi Sakamoto, Yoshihiro Ogawa
Summary: The study suggests that a significant left adrenal vein absolute aldosterone gradient may indicate unilateral excess aldosterone, especially in patients with spontaneous hypokalemia or left unilateral disease on computed tomography. This finding can be a useful tool in diagnosing the left unilateral subtype of primary aldosteronism during adrenal vein sampling.
CLINICAL ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Fabrizio Buffolo, Jacopo Pieroni, Federico Ponzetto, Vittorio Forestiero, Denis Rossato, Paolo Fonio, Antonello Nonnato, Fabio Settanni, Paolo Mulatero, Giulio Mengozzi, Silvia Monticone
Summary: This study assessed the impact of asymmetrical cortisol secretion on the lateralization index during adrenal venous sampling, and the effectiveness of metanephrines as a normalization factor for aldosterone levels. The results showed that 18% of patients with primary aldosteronism had asymmetrical cortisol secretion, and the use of metanephrines as a normalization factor improved the accuracy of diagnosis compared to aldosterone to cortisol lateralization index.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Sophie Dream, Sandra Park, Tina W. Yen, William Rilling, Lisa Rein, Kara Doffek, James W. Findling, Steven B. Magill, Srividya Kidambi, Douglas B. Evans, Tracy S. Wang
Summary: This study investigates the utility of AV epinephrine levels in assessing successful AV cannulation for patients with primary aldosteronism. The results show that measuring epinephrine levels can help determine the success of AV catheter placement during AVS, thereby preventing unnecessary repeat AVS.
ENDOCRINE PRACTICE
(2022)
Article
Endocrinology & Metabolism
Nathalie Voss, Sara Morup, Caroline Clausen, Claus Larsen Feltoft, Jan Viberg Jepsen, Mads Hornum, Mikkel Andreassen, Jesper Krogh
Summary: This study found that contralateral suppression (CLS) is a strong predictor of decreased kidney function and increased risk of hyperkalemia after adrenalectomy in patients with primary aldosteronism (PA).
CLINICAL ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Davis Sam, Gregory A. Kline, Benny So, Janice L. Pasieka, Adrian Harvey, Alex Chin, Stefan J. Przybojewski, Alexander A. Leung
Summary: The study found that patients with unilateral PA and normal adrenal imaging had favorable outcomes following adrenalectomy, with a majority of patients showing complete or partial response in both biochemical and clinical outcomes. Therefore, patients with lateralizing disease should be considered for surgery even if their adrenal imaging appears normal.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Cardiac & Cardiovascular Systems
Gian Paolo Rossi, Giacomo Rossitto, Laurence Amar, Michel Azizi, Anna Riester, Martin Reincke, Christoph Degenhart, Jiri Widimsky, Mitsuhide Naruse, Jaap Deinum, Leo Schultze Kool, Tomaz Kocjan, Aurelio Negro, Ermanno Rossi, Gregory Kline, Akiyo Tanabe, Fumitoshi Satoh, Lars Christian Rump, Oliver Vonend, Holger S. Willenberg, Peter J. Fuller, Jun Yang, Nicholas Yong Nian Chee, Steven B. Margill, Zulfiya Shafigullina, Marcus Quinkler, Anna Oliveras, Bo-Ching Lee, Vin Cent Wu, Zuzana Kratka, Teresa M. Seccia, Livia Lenzini
Summary: This study aimed to determine the rate of drug-resistant arterial hypertension in patients with primary aldosteronism (PA) and investigate the diagnostic performance of adrenal vein sampling (AVS). The results showed that resistant hypertension was common in PA patients, and AVS-guided adrenalectomy effectively resolved treatment-resistant hypertension.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2022)
Article
Peripheral Vascular Disease
Mirko Parasiliti-Caprino, Fabio Bioletto, Filippo Ceccato, Chiara Lopez, Martina Bollati, Giacomo Voltan, Denis Rossato, Giuseppe Giraudo, Carla Scaroni, Ezio Ghigo, Mauro Maccario
Summary: The study demonstrated the high accuracy of clinical/imaging-corrected unconventional indices for predicting unilateral primary aldosteronism, aiding in the selection of patients for adrenalectomy.
JOURNAL OF HYPERTENSION
(2021)
Article
Endocrinology & Metabolism
Foteini Christou, Edward Pivin, Alban Denys, Karim A. Abid, Tobias Zingg, Maurice Matter, Antoinette Pechere-Bertschi, Marc Maillard, Eric Grouzmann, Gregoire Wuerzner
Summary: This study is the first to calculate the SIs of cortisol, free metanephrine, and the FTMR indices for the AVS procedure, confirming that free metanephrine-based SIs are better than those based on cortisol.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Surgery
Olivia M. DeLozier, Sophie Dream, James W. Findling, William Rilling, Srividya Kidambi, Steven B. Magill, Douglas B. Evans, Tracy S. Wang
Summary: This study analyzed adrenal vein epinephrine and norepinephrine levels in nonpheochromocytoma patients to determine the normal range. The study found that there is a wide range of normal adrenal vein catecholamine levels in patients without pheochromocytoma, suggesting limited utility of adrenal venous sampling in determining the laterality of pheochromocytoma in patients with bilateral adrenal nodules.
JOURNAL OF SURGICAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Youichi Ohno, Mitsuhide Naruse, Felix Beuschlein, Florentine Schreiner, Mirko Parasiliti-Caprino, Jaap Deinum, William M. Drake, Francesco Fallo, Carmina T. Fuss, Marianne A. Grytaas, Takamasa Ichijo, Nobuya Inagaki, Miki Kakutani, Darko Kastelan, Ivana Kraljevic, Takuyuki Katabami, Tomaz Kocjan, Silvia Monticone, Paolo Mulatero, Sam O'Toole, Hiroki Kobayashi, Masakatsu Sone, Mika Tsuiki, Norio Wada, Tracy Ann Williams, Martin Reincke, Akiyo Tanabe
Summary: AVS is the standard lateralization technique in PA. International data showed lower rates of unilateral PA and adrenalectomy in Japanese centers compared to European centers. Reasons for not performing adrenalectomy in patients with unilateral PA were more likely to be physician-derived in Japan and patient-derived in Europe.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Cardiac & Cardiovascular Systems
Gian Paolo Rossi, Giacomo Rossitto, Laurence Amar, Michel Azizi, Anna Riester, Martin Reincke, Christoph Degenhart, Jiri Widimsky, Mitsuhide Naruse, Jaap Deinum, Leo Schultze Kool, Tomaz Kocjan, Aurelio Negro, Ermanno Rossi, Gregory Kline, Akiyo Tanabe, Fumitoshi Satoh, Lars Christian Rump, Oliver Vonend, Holger S. Willenberg, Peter J. Fuller, Jun Yang, Nicholas Yong Nian Chee, Steven B. Margill, Zulfiya Shafigullina, Marcus Quinkler, Anna Oliveras, Bo-Ching Lee, Vin Cent Wu, Zuzana Kratka, Teresa M. Seccia, Livia Lenzini
Summary: This study aimed to determine the rate of drug-resistant arterial hypertension in patients with primary aldosteronism (PA) and investigate the diagnostic performance of adrenal vein sampling (AVS). The results showed that resistant hypertension was common in PA patients, and AVS-guided adrenalectomy effectively resolved treatment-resistant hypertension.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2022)
Article
Urology & Nephrology
Fabio Salvatori, Marco Macchini, Marzia Rosati, Pietro Boscarato, Salvatore Alborino, Enrico Paci, Roberto Candelari
Summary: The study found that endovascular treatment for vascular renal injuries had satisfactory results with no worsening of renal function in patients. Iatrogenic injury group showed higher clinical success and more frequently presented as pseudoaneurysms compared to blunt trauma group.
Article
Medicine, General & Internal
Alessandro Prete, Anuradhaa Subramanian, Irina Bancos, Vasileios Chortis, Stylianos Tsagarakis, Katharina Lang, Magdalena Macech, Danae A. Delivanis, Ivana D. Pupovac, Giuseppe Reimondo, Ljiljana Marina, Timo Deutschbein, Maria Balomenaki, Michael W. O'Reilly, Lorna C. Gilligan, Carl Jenkinson, Tomasz Bednarczuk, Catherine D. Zhang, Tina Dusek, Aristidis Diamantopoulos, Miriam Asia, Agnieszka Kondracka, Dingfeng Li, Jimmy R. Masjkur, Marcus Quinkler, Grethe A. Ueland, M. Conall Dennedy, Felix Beuschlein, Antoine Tabarin, Martin Fassnacht, Miomira Ivovic, Massimo Terzolo, Darko Kastelan, William F. Young, Konstantinos N. Manolopoulos, Urszula Ambroziak, Dimitra A. Vassiliadi, Angela E. Taylor, Alice J. Sitch, Krishnarajah Nirantharakumar, Wiebke Arlt
Summary: Patients with mild autonomous cortisol secretion (MACS), especially MACS-2 and CS, have a higher prevalence and severity of hypertension and type 2 diabetes. MACS predominantly affects women and regular assessment for cardiometabolic diseases is warranted.
ANNALS OF INTERNAL MEDICINE
(2022)
Article
Endocrinology & Metabolism
Roberta Armignacco, Anne Jouinot, Lucas Bouys, Amandine Septier, Thomas Lartigue, Mario Neou, Cassandra Gaspar, Karine Perlemoine, Leah Braun, Anna Riester, Fideline Bonnet-Serrano, Anne Blanchard, Laurence Amar, Carla Scaroni, Filippo Ceccato, Gian Paolo Rossi, Tracy Ann Williams, Casper K. Larsen, Stephanie Allassonniere, Maria-Christina Zennaro, Felix Beuschlein, Martin Reincke, Jerome Bertherat, Guillaume Assie
Summary: This study aimed to identify biomarkers for assessing glucocorticoid action. By evaluating the whole blood DNA methylome of 94 patients with different glucocorticoid states (Cushing's syndrome, eucortisolism, adrenal insufficiency), the study found that the whole blood methylation profile could discriminate samples based on their glucocorticoid status. A methylation predictor for glucocorticoid excess was built and potential CpG sites associated with specific complications were identified.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2022)
Article
Peripheral Vascular Disease
Gian Paolo Rossi, Filippo Crimi, Giacomo Rossitto, Laurence Amar, Michel Azizi, Anna Riester, Martin Reincke, Christoph Degenhart, Jiri Widimsky, Mitsuhide Naruse, Jaap Deinum, Leo Schultze Kool, Tomaz Kocjan, Aurelio Negro, Ermanno Rossi, Gregory Kline, Akiyo Tanabe, Fumitoshi Satoh, Lars Christian Rump, Oliver Vonend, Holger S. Willenberg, Peter J. Fuller, Jun Yang, Nicholas Yong Nian Chee, Steven B. Magill, Zulfiya Shafigullina, Marcus Quinkler, Anna Oliveras, Vin Cent Wu, Zuzana Kratka, Giulio Barbiero, Michele Battistel, Teresa Maria Seccia
Summary: Imaging can accurately identify unilateral primary aldosteronism in most young patients, especially those with a unilateral adrenal nodule and hypokalemia, but adrenal vein sampling is still necessary for patients without nodules/bilateral nodules or hypokalemia.
Article
Transplantation
Jacopo Burrello, Silvia Monticone, Alessio Burrello, Sara Bolis, Carlotta Pia Cristalli, Giorgia Comai, Valeria Corradetti, Cristina Grange, Giuseppe Orlando, Massimiliano Bonafe, Gaetano La Manna, Lucio Barile, Benedetta Bussolati
Summary: This study explored the use of extracellular vesicle (EV) surface antigens as potential predictors of kidney transplant outcome. It found that endothelial cells and platelet markers in serum EVs were higher in patients with persistent kidney dysfunction, while mesenchymal progenitor cell markers in urine EVs increased in patients with renal recovery. These markers correlated with kidney function indicators and were able to predict patient outcomes.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Medicine, Research & Experimental
Sadayoshi Ito, Yasuyuki Okuda, Kotaro Sugimoto
Summary: This study examined factors associated with the antihypertensive effects of esaxerenone and the incidence of serum potassium elevation in patients with hypertension. Results showed that factors such as sex, weight, hypertension duration, prior antihypertensive treatment, plasma aldosterone concentration, urinary albumin-to-creatinine ratio, and smoking were associated with changes in blood pressure. Factors significantly associated with serum potassium elevation included baseline serum potassium, renal function, urinary albumin-to-creatinine ratio, blood pressure, and hypertension grade. The study concluded that esaxerenone is effective for patients with various backgrounds, but careful management is needed for those at risk of elevated serum potassium.
ADVANCES IN THERAPY
(2023)
Review
Endocrinology & Metabolism
Elisa Sconfienza, Martina Tetti, Vittorio Forestiero, Franco Veglio, Paolo Mulatero, Silvia Monticone
Summary: This study investigated the prevalence of autonomous/possible autonomous cortisol secretion (ACS), primary aldosteronism (PA), pheochromocytoma (PHEO), and Cushing syndrome (CS) in patients with adrenal incidentaloma (AI). The overall prevalence of functioning AIs was 27.5%, with ACS/possible ACS being the most frequent hormonal alteration (prevalence of 11.7%) and PA occurring in 4.4% of the patients. Asian patients had a higher prevalence of PA, while ACS/possible ACS had a lower prevalence in Asian countries. The prevalence of ACS/possible ACS was influenced by the proportion of female patients, while the prevalence of PA was positively associated with hypertension and the publication year. The prevalence of PHEO and CS were 3.8% and 3.1% respectively. Rating: 9/10.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Biochemistry & Molecular Biology
Federico Ponzetto, Mirko Parasiliti-Caprino, Fabio Settanni, Antonello Nonnato, Giulio Mengozzi, Ezio Ghigo, Roberta Giordano
Summary: The simultaneous measurement of dexamethasone and cortisol has shown to improve the diagnostic performance of the overnight dexamethasone-suppression test. Additionally, monitoring the levels of corticosteroid drugs can help investigate unexpected changes in steroid hormone levels. This study developed and validated an LC-MS/MS method for quantifying cortisol, cortisone, dexamethasone, and other corticosteroids in serum/plasma samples. The method was successfully applied to patients undergoing the dexamethasone-suppression test and those receiving immunosuppressive treatment after kidney transplant.
Article
Agriculture, Dairy & Animal Science
Barbara Bruno, Cristiana Maurella, Paola Gianella, Giulio Mengozzi, Erica Ferraris, Antonio Borrelli
Summary: This study observed the haemostasis characteristics in dogs undergoing surgery for malignancies, using rotational thromboelastometry and thrombin generation. The results showed a trend of hypercoagulability 24 hours after surgery and a return to pre-surgery state after 2 weeks.
Article
Chemistry, Analytical
Federico Ponzetto, Mirko Parasiliti-Caprino, Iacopo Gesmundo, Lorenzo Marinelli, Antonello Nonnato, Raul Nicoli, Tiia Kuuranne, Giulio Mengozzi, Ezio Ghigo, Fabio Settanni
Summary: The urinary steroidal module of Athlete Biological Passport is currently used to detect anti-doping rule violations related to the abuse of endogenous anabolic androgenic steroids. However, alternative strategies such as the measurement of blood concentrations of endogenous steroid hormones by LC-MS have been proposed due to limitations of the urine test. This study presents a UHPLC-MS/MS method for quantifying major circulating steroid hormones and their metabolites, showing promising results for measuring blood steroid profile markers.
Article
Biology
Claudia Altomare, Chiara Bartolucci, Luca Sala, Carolina Balbi, Jacopo Burrello, Nicole Pietrogiovanna, Alessio Burrello, Sara Bolis, Stefano Panella, Martina Arici, Rolf Krause, Marcella Rocchetti, Stefano Severi, Lucio Barile
Summary: An in silico hybrid model and an unsupervised learning algorithm were used to classify differentiated hiPSC-derived cardiomyocytes from a mixed population. The model derived electrical biomarkers and employed the dynamic clamp technique for classification. Pharmacological validation was performed to improve the translational relevance of the model.
COMMUNICATIONS BIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Maximilian Y. Emmert, Jacopo Burrello, Petra Wolint, Monika Hilbe, Gabriella Andriolo, Carolina Balbi, Elena Provasi, Lucia Turchetto, Marina Radrizzani, Timo Z. Nazari-Shafti, Nikola Cesarovic, Sebastian Neuber, Volkmar Falk, Simon P. Hoerstrup, Rayyan Hemetsberger, Mariann Gyoengyoesi, Lucio Barile, Giuseppe Vassalli
EUROPEAN HEART JOURNAL
(2023)
Review
Medicine, General & Internal
Roberta Bevilacqua, Federico Barbarossa, Lorenzo Fantechi, Daniela Fornarelli, Enrico Paci, Silvia Bolognini, Cinzia Giammarchi, Fabrizia Lattanzio, Lucia Paciaroni, Giovanni Renato Riccardi, Giuseppe Pelliccioni, Leonardo Biscetti, Elvira Maranesi
Summary: The use of radiomics and artificial intelligence for the diagnosis and monitoring of Alzheimer's disease has shown promising results, but further research is still needed before it can be applied in clinical practice. This systematic review analyzed studies from the past five years and found that this approach can differentiate Alzheimer's disease patients from healthy older people. However, caution should be exercised as imaging alone is not sufficient for dementia diagnosis.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Health Care Sciences & Services
Francesco Chiara, Sarah Allegra, Jacopo Mula, Maria Paola Puccinelli, Giuliana Abbadessa, Giulio Mengozzi, Silvia De Francia
Summary: Orotic acid is an intermediate metabolite of pyrimidine nucleotide biosynthesis and plays a role in various physiological processes. Measurement of its concentration in urine can help diagnose hereditary metabolic diseases. This study found that females had higher levels of orotic acid in pediatric age, suggesting potential gender differences in pyrimidine intermediate biosynthesis. These findings have implications for understanding the biochemical aspects of pyrimidine biosynthesis and its related disorders.
JOURNAL OF PERSONALIZED MEDICINE
(2023)