Article
Endocrinology & Metabolism
Jessica Pepe, Luciano Colangelo, Chiara Sonato, Marco Occhiuto, Carla Ferrara, Andrea del Fattore, Rachele Santori, Monia Mastrantonio, Alessandro Sgreccia, Salvatore Minisola, Cristiana Cipriani
Summary: This study compared echocardiographic parameters in postmenopausal women with normocalcemic primary hyperparathyroidism (NCPHPT) with those in patients with hypercalcemic primary hyperparathyroidism (PHPT) and controls. The results showed differences in biochemical and echocardiographic findings between NCPHPT and PHPT patients, but no significant differences in cardiovascular risk factors were observed between the two groups.
ENDOCRINE PRACTICE
(2021)
Review
Geriatrics & Gerontology
Lavanya Srinivasa Murthy, Natasha A. Grande de Franca, Guillaume Duval, Sara Vogrin, Cedric Annweiler, Gustavo Duque
Summary: This systematic review provides evidence of an association between higher PTH concentrations and reduced gait velocity in adults, indicating a need for further research through RCTs to assess the effects of correcting abnormal PTH levels on physical performance.
ARCHIVES OF GERONTOLOGY AND GERIATRICS
(2022)
Article
Urology & Nephrology
Charles Ginsberg, Lindsay M. Miller, Norma Ofsthun, Lorien S. Dalrymple, Joachim H. Ix
Summary: The study found that PTH and phosphate concentrations before dialysis session varied with the time of day in patients receiving maintenance hemodialysis, highlighting the potential impact on treatment decisions.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Endocrinology & Metabolism
Ana -Maria Chindris, Kaniksha Desai, Selmin Karatayli Ozgursoy, Michael G. Heckman, John D. Casler
Summary: This study aimed to determine the effect of a postoperative PTH-guided calcium and calcitriol supplementation protocol on the incidence of hypocalcemia and hospital readmissions in patients undergoing total thyroidectomy. The results showed that patients in the protocol group had significantly lower rates of hypocalcemia and hospital readmissions compared to the preprotocol group.
ENDOCRINE PRACTICE
(2023)
Article
Agriculture, Dairy & Animal Science
Hazem E. M. Hassanien, Michael L. Galyean, Michael A. Ballou, Awad M. M. Mahmoud, Elsayed M. Abdel-Raouf, Nabil M. Eweedah
Summary: The effects of pre- and postpartum dietary cation-anion difference (DCAD) on urine pH, serum calcium and hormone concentrations, and milk production were investigated in Holstein cows. The study found that negative prepartum DCAD improved postpartum calcium status without major effects on milk yield and composition.
ANIMAL SCIENCE JOURNAL
(2022)
Article
Transplantation
Sevcan A. Bakkaloglu, Justine Bacchetta, Alexander D. Lalayiannis, Maren Leifheit-Nestler, Stella Stabouli, Mathias Haarhaus, George Reusz, Jaap Groothoff, Claus Peter Schmitt, Pieter Evenepoel, Rukshana Shroff, Dieter Haffner
Summary: Mineral and bone disorder (MBD) is common in children with chronic kidney disease (CKD), leading to challenges in clinical diagnosis and management due to the lack of high-quality evidence and wide variations in clinical practice. Assessing bone disease in children with CKD requires careful consideration of clinical practice points (CPPs) and further research in this area is recommended.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2021)
Article
Medical Laboratory Technology
Fei Ding, Xin Nie, Xiaoling Li, Yong He, Guixing Li
Summary: This study assessed the impact of factors like sex, age, season, temperature, and sunshine hours on plasma PTH, 25-OH-VitD, and Ca levels. Results showed that season may be the main factor affecting the levels, and reference intervals should consider these factors to avoid influencing clinical investigations.
CLINICAL BIOCHEMISTRY
(2021)
Article
Endocrinology & Metabolism
Josephine Matzen, Lise Sofie Bislev, Tanja Sikjaer, Lars Rolighed, Mette Friberg Hitz, Pia Eiken, Anne Pernille Hermann, Jens-Erik Beck Jensen, Bo Abrahamsen, Lars Rejnmark
Summary: This study aimed to compare the effects of PTX and non-surgical surveillance on kidney function in pHPT patients. The findings showed that compared to non-surgical surveillance, PTX is associated with a small but significant decrease in kidney function in pHPT patients.
BMC ENDOCRINE DISORDERS
(2022)
Article
Obstetrics & Gynecology
Marie J. J. Boller, Fei Xu, Catherine Lee, Sneha Sridhar, Mara B. B. Greenberg, Monique M. M. Hedderson
Summary: This study aimed to evaluate the perinatal outcomes of pregnant individuals after bariatric surgery. The results showed that pregnancy after bariatric surgery is associated with a decreased risk of preeclampsia, gestational diabetes, and LGA neonates, but an increased risk of SGA neonates.
OBSTETRICS AND GYNECOLOGY
(2023)
Article
Endocrinology & Metabolism
Pieter Evenepoel, Hanne Skou Jorgensen, Hirotaka Komaba, Sandro Mazzaferro, Marc Vervloet, Etienne Cavalier, Masafumi Fukagawa
Summary: This study found that Japanese patients receiving HD have lower bone turnover than their European counterparts, even at similar PTH levels. Male sex, obesity, and hyperphosphatemia were the main determinants of the bone turnover marker/PTH ratios.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Muhammad Fahad Arshad, Amardass Dhami, Gillian Quarrell, Saba Prakash Balasubramanian
Summary: Post-surgical hypoparathyroidism (POSH) typically resolves within months after thyroid surgery, but some patients require long-term supplementation. Late recovery is common, especially in patients with PTH levels ≥ 1.6 pmol/L at 6 months. Factors such as age, gender, and type of surgery did not significantly predict late recovery.
EUROPEAN THYROID JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Mahdi Golshan, Azadeh Hatef, Negar Kazori, Magdalena Socha, Miroslawa Sokolowska-Mikolajczyk, Hamid R. Habibi, Otomar Linhart, Sayyed Mohammad Hadi Alavi
Summary: This study reveals that exposure to bisphenol A (BPA) reduces sperm quality in goldfish and increases the levels of circulating LH and mRNA transcripts of upstream neuroendocrine regulators of reproduction.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2022)
Article
Cell & Tissue Engineering
Jiao Chen, Hao Zhang, Xianmin Wu, Fuxiao Wang, Yili Wang, Qianmin Gao, Han Liu, Yan Hu, Jiacan Su, Yingying Jing
Summary: Teriparatide, also known as 1-34 parathyroid hormone, is commonly used for treating osteoporosis in postmenopausal women. However, its therapeutic potential is limited by stability issues and low bioavailability. A glycosylated derivative, PTHG2, was designed to improve stability and anti-osteoporosis effects. In animal models and in vitro experiments, PTHG2 promoted bone formation, inhibited marrow adipogenesis, and directed BMSCs fate through the cAMP-PKA signaling pathway.
STEM CELLS INTERNATIONAL
(2021)
Article
Dentistry, Oral Surgery & Medicine
Mengting Xu, Yuan Li, Xiaoxia Feng, Wei Zheng, Zhihe Zhao, Yu Li
Summary: This study investigates the role of parathyroid hormone (PTH) in maxillary expansion using a rat model. The results show that PTH can promote maxillary expansion and reduce relapse, while regulating bone remodeling pathways. This suggests that PTH may serve as an adjunctive therapy in the treatment of maxillary constriction.
PROGRESS IN ORTHODONTICS
(2022)
Article
Multidisciplinary Sciences
Alvaro Rodriguez-Lopez, Soledad de Lemus, Marcin Bukowski, Anna Potoczek, Immo Fritsche
Summary: This article explores the relationship between personal and collective control in political elections during socio-economic crises. The findings suggest that when individuals perceive low personal control, they are more likely to reject a non-agentic political system. This effect is particularly pronounced when national agency is also low.
Article
Biochemistry & Molecular Biology
Joseph J. J. Matthews, Mark D. D. Turner, Livia Santos, Kirsty J. J. Elliott-Sale, Craig Sale
Summary: Type-2 diabetes is associated with metabolic dysregulation and carnosine has been shown to improve glycaemic control. This study investigated the effects of carnosine on skeletal muscle cells from T2D patients and found that carnosine increased insulin-stimulated glucose uptake and reduced modified proteins.
Article
Nutrition & Dietetics
Tommy Slater, William J. A. Mode, Mollie G. Pinkney, John Hough, Ruth M. James, Craig Sale, Lewis J. James, David J. Clayton
Summary: This study assessed the effects of 7-hr fasting before evening exercise on energy intake, metabolism, and performance. The study found that fasted evening exercise reduced net energy intake and increased fat oxidation, but also decreased exercise performance, motivation, and enjoyment.
INTERNATIONAL JOURNAL OF SPORT NUTRITION AND EXERCISE METABOLISM
(2023)
Article
Cell Biology
Arnold Tan, Awais Z. Younis, Alexander Evans, Jade V. Creighton, Clare Coveny, David J. Boocock, Craig Sale, Gareth G. Lavery, Amanda S. Coutts, Craig L. Doig
Summary: The PARP1 enzyme generates and applies ADP-Ribose, a post-translational modification. PARP1 plays important roles in genome maintenance, cellular identity, and energy homeostasis. In skeletal muscle cells, PARP1-mediated PARylation regulates the myogenic program and the muscle response to steroid hormones. PARylation is sensitive to glucose concentrations and glucocorticoids, which are crucial for muscle development and metabolism. PARP1 also influences the transcriptional activation of specific genes critical to skeletal muscle pathology, providing potential targets for selective glucocorticoid modulation.
CELL DEATH DISCOVERY
(2023)
Article
Public, Environmental & Occupational Health
Stephanie J. Hanley, Ian Varley, Craig Sale, Kirsty J. Elliott-Sale
Summary: This retrospective study explored the experiences of women with overweight or obesity regarding physical activity, diet and quality of life leading up to, during, and following pregnancy.
MATERNAL AND CHILD HEALTH JOURNAL
(2023)
Article
Endocrinology & Metabolism
Ian Varley, Marcus Ward, Chris Thorpe, Nathan Beardsley, Julie Greeves, Craig Sale, Chris Saward
Summary: This study explored the association between training load and changes in body composition and bone characteristics during a competitive season. The results showed significant changes in lean mass, fat mass, and bone mineral density (BMD) at different phases of the season, indicating the impact of training load on these factors.
Article
Sport Sciences
Reece Scott, Ruth James, Cleveland T. Barnett, Craig Sale, Ian Varley
Summary: This study aimed to investigate the external load measuring tools used by support staff to estimate bone load and assess if these methodologies were supported in research. The results showed that although most support staff (92%) monitored external load, only 28% used it to estimate bone load. GPS was the most commonly used method, but there is a lack of research on its association with bone load. Further research is needed to determine the best method of estimating bone load in an applied setting.
FRONTIERS IN SPORTS AND ACTIVE LIVING
(2023)
Article
Sport Sciences
Ian Varley, Craig Sale, Julie P. Greeves, John G. Morris, Caroline Sunderland, Chris Saward
Summary: We investigated the relationship between football-specific training and changes in bone structural properties in 15 male football players aged 16 years over a 12-week period. Tibial scans were performed before and after increased football-specific training, and training parameters were analyzed using GPS. The results suggest that while football training is associated with increased bone characteristics in male academy footballers, the specific training variables influencing bone structural properties may vary over a 12-week period. Further research is needed to fully understand the time-course of how certain football-specific training characteristics affect bone adaptation.
Editorial Material
Biochemistry & Molecular Biology
Eimear Dolan, Craig Sale, Michael S. Hedrick
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY
(2023)
Article
Physiology
Gabriel P. Esteves, Paul Swinton, Craig Sale, Bruno Gualano, Hamilton Roschel, Eimear Dolan
Summary: Bone mass and quality decline with age, and this study investigated the associations between bone and physical, dietary, and metabolic factors. The results showed that body composition (lean) and strength were positively associated with bone, while dietary intake relative to body mass was negatively associated with bone. Resistance training programs that improve lean mass and strength may benefit bone in older individuals.
JOURNAL OF APPLIED PHYSIOLOGY
(2023)
Article
Sport Sciences
Mark J. Hutson, Emma O'Donnell, Katherine Brooke-Wavell, Lewis J. James, Conor J. Raleigh, Brian P. Carson, Craig Sale, Richard C. Blagrove
Summary: Low energy availability (LEA) is common in active individuals and has negative impact on bone turnover in young females. High-impact exercise can promote bone health and may be beneficial during LEA periods. Restricting energy intake for 3 days reduces morning basal bone formation rate, but high-impact jumping can prevent an increase in bone resorption rate and benefit long-term bone health.
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
(2023)
Article
Cell & Tissue Engineering
Janelle Tarum, Hans Degens, Mark D. Turner, Claire Stewart, Craig Sale, Livia Santos
Summary: Healthy skeletal muscle has the ability to regenerate after injury, but this ability is impaired in aging muscle due to dysfunctional satellite cells and reduced myogenic capacity. This study developed a high-throughput in vitro model to assess muscle regeneration in young and aged muscle cell cultures. The results suggest that aged muscle cells have reduced regeneration capacity and show significant changes in signalling pathways associated with muscle development and contraction. Understanding these mechanisms can aid in the development of new therapies for impaired muscle regeneration in older age.
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2023)
Article
Endocrinology & Metabolism
Paul A. Swinton, Kirsty J. Elliott-Sale, Craig Sale
Summary: This large cohort study examined the reliability and validity of heel ultrasound for estimating bone mineral density. The reliability between left and right heels was poor, as was the agreement with dual-energy X-ray absorptiometry. Heel ultrasound should be used cautiously for estimating bone mineral density.
ARCHIVES OF OSTEOPOROSIS
(2023)
Article
Cell Biology
K. Habra, J. R. D. Pearson, P. Le Vu, C. Puig-Saenz, M. J. Cripps, M. A. Khan, M. D. Turner, C. Sale, S. E. B. McArdle
Summary: Carnosine has a significant inhibitory effect on the proliferation of prostate cancer cells and does not have detrimental effects on healthy cells. Further in vivo research is needed to determine the potential use of carnosine as a treatment for prostate cancer.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2023)
Review
Sport Sciences
Rita Civil, Eimear Dolan, Paul A. Swinton, Livia Santos, Ian Varley, Philip J. Atherton, Kirsty J. Elliott-Sale, Craig Sale
Summary: This study aimed to investigate the responses and variability of P1NP and beta-CTX-1 after prolonged, continuous running in young healthy adult males. The results showed that the increase in P1NP was likely due to biological artifacts, and the small decrease in beta-CTX-1 was related to the markers' circadian rhythm rather than the running intervention.
SPORTS MEDICINE-OPEN
(2023)
Article
Sport Sciences
Kirsty J. Elliott-Sale, Kathryn E. Ackerman, Constance M. Lebrun, Clare Minahan, Craig Sale, Trent Stellingwerff, Paul A. Swinton, Anthony Hackney
Summary: This article highlights the lack of sufficient high-quality studies in sport science using women as participants, which limits our understanding of female athletes in relation to their ovarian hormone profiles. The authors propose the use of consortia to accelerate learning and reduce research waste through collaboration. They also describe the formation of an international multisite team to investigate the effects of the menstrual cycle and contraceptive pill phase on exercise physiology and sports performance in female athletes, aiming to produce a well-powered, high-quality dataset to inform practices in this field.
BMJ OPEN SPORT & EXERCISE MEDICINE
(2023)