Review
Endocrinology & Metabolism
Christos Papaioannou, Maralyn Druce
Summary: This review analyzes and evaluates the current evidence for the use of preoperative medications and different surgical approaches in acromegaly. The use of somatostatin receptor agonists (SAs) as preoperative treatment for acromegaly is controversial, with guidelines suggesting against their routine use. However, SAs have been found to reduce tumor volume and aid in total adenoma resection for invasive macroadenomas. Furthermore, endoscopic transsphenoidal surgery is considered the optimal method for hypophysectomy in terms of remission and safety profile.
CLINICAL ENDOCRINOLOGY
(2023)
Review
Allergy
Ines Roumeau, Adrien Coutu, Valentin Navel, Bruno Pereira, Julien S. Baker, Frederic Chiambaretta, Dominique Bremond-Gignac, Frederic Dutheil
Summary: This study systematically reviewed the efficacy of medical treatments for vernal keratoconjunctivitis (VKC) and found that mast cell stabilizers are effective in treating VKC, while there was no significant difference in the efficacy of cyclosporine and tacrolimus, suggesting that tacrolimus can be a good alternative for severe cases of VKC. Further studies are needed to compare other drugs and their exact place in the treatment strategy.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Review
Surgery
Sophia K. McKinley, Rebecca C. Dirks, Danielle Walsh, Celeste Hollands, Lauren E. Arthur, Noe Rodriguez, Joyce Jhang, Ahmed Abou-Setta, Aurora Pryor, Dimitrios Stefanidis, Bethany J. Slater
Summary: The review found that surgical treatment of GERD can improve short-term quality of life, but does not show significant superiority in short-term symptom control. Compared to total fundoplication, partial fundoplication leads to higher rates of prolonged PPI usage.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Review
Respiratory System
Tyler Pitre, Jasmine Mah, Wryan Helmeczi, Muhammad Faran Khalid, Sonya Cui, Melanie Zhang, Renata Husnudinov, Johnny Su, Laura Banfield, Brent Guy, Jade Coyne, Ciaran Scallan, Martin R. J. Kolb, Aaron Jones, Dena Zeraatkar
Summary: Through the evaluation of 48 eligible studies, it was found that nintedanib, pirfenidone, and sildenafil may reduce the mortality of IPF patients; nintedanib, nintedanib+sildenafil, pirfenidone, pamrevlumab, and pentraxin may reduce the decline in lung capacity in IPF patients; sildenafil may reduce the likelihood of acute exacerbation and hospitalizations; while corticosteroids+azathioprine+N-acetylcysteine increased the risk of serious adverse events compared to placebo.
Review
Endocrinology & Metabolism
Salvatore Crisafulli, Nicoletta Luxi, Janet Sultana, Andrea Fontana, Federica Spagnolo, Giuseppe Giuffrida, Francesco Ferrau, Daniele Gianfrilli, Alessia Cozzolino, Maria Cristina De Martino, Federico Gatto, Francesco Barone-Adesi, Salvatore Cannavo, Gianluca Trifiro
Summary: This study provided a systematic review and meta-analysis of the global epidemiology of acromegaly, finding considerable heterogeneity between studies in prevalence and incidence rates. Data source and geographic area explained about 50% of the total between-study variability, emphasizing the need for large-scale high-quality studies to aid public health decision-making.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2021)
Review
Public, Environmental & Occupational Health
Paul G. Shekelle, Meron M. Begashaw, Isomi M. Miake-Lye, Marika Booth, Bethany Myers, Andrew Renda
Summary: This article conducted a systematic review on the impacts of interventions aimed at reducing non-emergency transportation and non-medical transportation barriers on health and healthcare utilization. The study found that these interventions are associated with a reduction in missed appointments, but there is insufficient evidence on the effects on costs, utilization, and health outcomes.
Review
Gastroenterology & Hepatology
Achuthan Aruljothy, Siddharth Singh, Neeraj Narula, Gordon W. Moran, Sudheer K. Vuyyuru, Malcolm Hogan, Alexa Zayadi, John K. MacDonald, Benedicte Caron, Silvio Danese, Laurent Peyrin Biroulet, Christopher Ma, Vipul Jairath
Summary: This study assessed the efficacy of medical treatments for ulcerative proctitis (UP). The results showed that topical application of 5-aminosalicylic acid and corticosteroids were effective for active UP. They may also be effective for maintenance of remission. Tacrolimus may be effective for induction of remission.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Review
Obstetrics & Gynecology
Adam Rosen, Wilson Ventura Chan, John Matelski, Chris Walsh, Ally Murji
Summary: Medical management of uterine arteriovenous malformation has a high success rate, with progestins, gonadotropin-releasing hormone agonists, and methotrexate showing significantly different success rates compared to the null hypothesis. No clinical factors were found to predict treatment success. Recurrence of AVM was not reported in subsequent pregnancies.
FERTILITY AND STERILITY
(2021)
Review
Endocrinology & Metabolism
Julia Simoes Correa Galendi, Afonso Nogueira Simoes Correa Neto, Michelle Demetres, Cesar Luiz Boguszewski, Vania dos Santos Nunes Nogueira
Summary: This systematic review evaluated the efficacy and safety of various medications for treating Cushing's disease. While the proportion of disease control varied among different drugs, further research is needed to explore new therapeutic options for patients with limited treatment efficacy and tolerability.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Computer Science, Interdisciplinary Applications
Jan Egger, Christina Gsaxner, Antonio Pepe, Kelsey L. Pomykala, Frederic Jonske, Manuel Kurz, Jianning Li, Jens Kleesiek
Summary: Deep learning has made remarkable impact in various scientific disciplines, such as image processing and autonomous driving. It has also shown great potential in the medical domain. However, obtaining a complete overview of the field of 'medical deep learning' is becoming increasingly difficult due to the abundance of patient data and the rapid growth of deep learning research.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2022)
Review
Dermatology
Hyun Jeong Ju, Jung Min Bae, Ro Woo Lee, Soo Hyung Kim, Davinder Parsad, Aunna Pourang, Iltefat Hamzavi, Jason Shourick, Khaled Ezzedine
Summary: Surgical interventions have been found to be effective for patients with refractory stable vitiligo, with treatment response influenced by patient age, subtype of vitiligo, and anatomical sites.
Review
Oncology
Naval G. G. Daver, Shahed Iqbal, Camille Renard, Rebecca J. J. Chan, Ken Hasegawa, Hao Hu, Preston Tse, Jiajun Yan, Michael J. J. Zoratti, Feng Xie, Giridharan Ramsingh
Summary: This study conducted a systematic review and meta-analysis to compare the treatment outcomes of different therapies for TP53-mutated AML in newly diagnosed patients. The results showed that although IC and VEN + HMA had better treatment responses compared to HMA, the overall survival was uniformly poor, highlighting the need for improved treatment for this difficult-to-treat population.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2023)
Review
Surgery
Mirte Langeveld, Caroline A. Hundepool, Liron S. Duraku, Dominic M. Power, Vaikunthan Rajaratnam, J. Michiel Zuidam
Summary: There is no consensus on the optimal surgical management of symptomatic peripheral nerve neuroma. Targeted muscle reinnervation shows promise for treating painful neuromas.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2022)
Review
Surgery
Max M. Lokhorst, Folkert Jolink, Sophie E. R. Horbach, Phyllis I. Spuls, Chantal M. A. M. van der Horst
Summary: Surgical treatment of vascular malformations appears to be effective and safe in many cases. However, it seems that surgery is performed predominantly in small lesions, and subtotal resection has a higher risk of recurrence than total resection.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2021)
Review
Health Care Sciences & Services
Eun Jeong Gong, Chan Hyuk Park, Da Hyun Jung, Sun Hyung Kang, Ju Yup Lee, Hyun Lim, Do Hoon Kim
Summary: This study comprehensively evaluated the efficacy of various endoscopic and surgical treatments for gastroesophageal reflux disease (GERD). The results showed that endoscopic plication, reinforcement of the lower esophageal sphincter (LES), and surgical fundoplication were effective in reducing the requirement of proton pump inhibitor (PPI) continuation compared to PPI therapy. Radiofrequency energy delivery also tended to reduce the requirement of PPI continuation. All endoscopic and surgical treatments were superior to PPI therapy in terms of GERD-health-related quality of life questionnaire score (GERD-HRQL).
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Medicine, General & Internal
Mohammad Hassan Murad, Abdalla Kara Balla, Muhammad Shahzeb Khan, Asim Shaikh, Samer Saadi, Zhen Wang
Summary: The fragility index (FI) is a useful measure for assessing the robustness of statistically significant results. This study identified a range of FI values (19-22) that can indicate the precision of treatment effects, providing a rule of thumb for evaluating the stability of treatment outcomes.
BMJ EVIDENCE-BASED MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Yaqi Jing, Mohammad Hassan Murad, Lifeng Lin
Summary: This article proposes a Bayesian hierarchical model to synthesize different types of study results. The Bayesian method generally produces more accurate results compared to the conventional conversion method. However, the Bayesian method relies on the normality assumption for continuous measures and may lead to biases for non-normal data.
JOURNAL OF BIOPHARMACEUTICAL STATISTICS
(2023)
Editorial Material
Medicine, General & Internal
Mohammad Hassan Murad, Samer Saadi
BMJ EVIDENCE-BASED MEDICINE
(2022)
Editorial Material
Medicine, General & Internal
Madelin R. Siedler, M. Hassan Murad, Rebecca L. Morgan, Yngve Falck-Ytter, Reem A. Mustafa, Shahnaz Sultan, Philipp Dahm
BMJ EVIDENCE-BASED MEDICINE
(2023)
Review
Endocrinology & Metabolism
Ghada El-Hajj Fuleihan, Gregory A. Clines, Mimi Hu, Claudio Marcocci, M. Hassan Murad, Thomas Piggott, Catherine Van Poznak, Joy Y. Wu, Matthew T. Drake
Summary: Hypercalcemia of malignancy (HCM) is a common complication of malignancies, but its incidence may be decreasing. Despite the availability of effective medications, there are no evidence-based recommendations for managing HCM. A panel of experts developed guidelines for the treatment of adults with HCM, recommending the use of denosumab or intravenous bisphosphonate. Treatment of the primary malignancy is crucial for controlling HCM.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Anthony L. McCall, David C. Lieb, Roma Gianchandani, Heidemarie MacMaster, Gregory A. Maynard, M. Hassan Murad, Elizabeth Seaquist, Joseph Wolfsdorf, Robin Fein Wright, Wojtek Wiercioch
Summary: This study reviewed and updated the management of hypoglycemia in people with diabetes, aiming to reduce and prevent it. A multidisciplinary panel of experts identified 10 clinical questions and made 10 recommendations. These recommendations can be used to inform clinical practice and improve healthcare systems, as hypoglycemia is an important complication for people with diabetes.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Editorial Material
Medicine, General & Internal
M. Hassan Murad, Melanie D. Swift, Raymund R. Razonable, Aaron J. Tande, John W. Wilson, Mary J. Kasten, Irene G. Sia, Jennifer N. Matey, Greg Vanichkachorn, Natalie A. Caine, Vijay Shah, Jack O'Horo, Molly J. Destro Borgen, Clayton T. Cowl, Elie F. Berbari
MAYO CLINIC PROCEEDINGS
(2023)
Article
Medicine, General & Internal
Zhen Wang, Muayad A. Alzuabi, Rebecca L. Morgan, Reem A. Mustafa, Yngve Falck-Ytter, Philipp Dahm, Shahnaz Sultan, Mohammad Hassan Murad
Summary: This study empirically evaluated five commonly used meta-analysis methods and their impact on imprecision judgements about effect estimates. The results showed that different pooling methods led to different conclusions about the precision of effect estimates, particularly when the number of studies was small and statistical heterogeneity was substantial. Therefore, sensitivity analyses using multiple methods may be necessary in these two scenarios.
BMJ EVIDENCE-BASED MEDICINE
(2023)
Article
Medicine, General & Internal
Bala Munipalli, Stefan Paul, Arya Mohabbat, Habeeba Siddiqui, Zhuo Li, Abd Moain Abu Dabrh
Summary: COVID-19, caused by SARS-CoV-2, has resulted in significant mortality and morbidity since its emergence in Wuhan, China in December 2019. A retrospective cohort study investigated the prevalence and predicting factors of post-acute sequelae of COVID-19 (PASC). Survey data revealed that the most commonly reported PASC symptoms included fatigue, dyspnea, cognitive dysfunction, myalgias, lightheadedness or vertigo, chest pain, palpitations, headaches, arthralgias, and unrefreshing sleep. There is increasing evidence of higher prevalence of PASC in women, White/Caucasian individuals, and middle-aged people, which can guide clinical practices in anticipating and supporting the needs of high-risk patients.
JOURNAL OF INVESTIGATIVE MEDICINE
(2023)
Article
Education & Educational Research
Sarah R. Williams, Stefanie S. Sebok-Syer, Holly Caretta-Weyer, Laurence Katznelson, Ann M. Dohn, Yoon Soo Park, Michael A. Gisondi, Ara Tekian
Summary: Safe and effective physician-to-physician handoffs are crucial for patient safety, but poor handoffs remain a major cause of medical errors. This study fills a gap in the literature by exploring trainees' perspectives on handoffs across multiple specialties and provides recommendations for training programs and institutions.
BMC MEDICAL EDUCATION
(2023)
Article
Medicine, General & Internal
M. Hassan Murad, Zhen Wang, Ye Zhu, Samer Saadi, Haitao Chu, Lifeng Lin
Summary: Trading off benefits and harms requires knowledge of the absolute risk reduction or risk difference, making risk difference a critical measure for decision making. However, estimating risk difference is not straightforward and the available methods have various limitations. This article discusses four methods for estimating risk difference and provides recommendations on when to use each approach.
BMJ-BRITISH MEDICAL JOURNAL
(2023)
Review
Clinical Neurology
Juan Yang, Kyung-Min Shin, Alex Do, Dennis M. Bierle, Abd Moain Abu Dabrh, Ziying Yin, Brent A. Bauer, Arya B. Mohabbat
Summary: 《Safety and efficacy of low-dose naltrexone for fibromyalgia treatment》This study aimed to systematically assess the current evidence on the safety and efficacy of low-dose naltrexone (LDN) for the treatment of fibromyalgia (FM). A comprehensive search produced 805 articles, and 9 articles were selected for evaluation. LDN was found to be effective in the symptomatic management of FM, with no severe adverse events reported. However, the level of scientific evidence is limited, and future well-designed trials with large sample sizes are required.
JOURNAL OF PAIN RESEARCH
(2023)
Review
Medicine, General & Internal
Mohammad Hassan Murad, Zhen Wang, Haitao Chu, Lifeng Lin, Ibrahim K. El Mikati, Joanne Khabsa, Elie Akl, Robby Nieuwlaat, Holger J. Schuenemann, Irbaz Bin Riaz
Summary: Living systematic reviews (LSRs) are continuously updated reviews that incorporate new evidence as it becomes available. It is important to determine when to retire LSRs from the living mode, and we propose triggers for making that decision. The first trigger is retiring LSRs when there is conclusive evidence for decision-making. The second trigger is retiring LSRs when the question becomes less pertinent for decision-making or when resources are unavailable.
BMJ EVIDENCE-BASED MEDICINE
(2023)
Article
Health Care Sciences & Services
M. Hassan Murad, Jos Verbeek, Lukas Schwingshackl, Tommaso Filippini, Marco Vinceti, Elie A. Akl, Rebecca L. Morgan, Reem A. Mustafa, Dena Zeraatkar, Emily Senerth, Renee Street, Lifeng Lin, Yngve Falck-Ytter, Gordon Guyatt, Holger J. Schunemann
Summary: This article discusses the impact of dose-response gradients on the certainty of evidence in intervention and exposure studies. By determining the credibility of the gradient and applying the gradient domain, ratings can be increased.
JOURNAL OF CLINICAL EPIDEMIOLOGY
(2023)
Review
Endocrinology & Metabolism
Stephan Petersenn, Maria Fleseriu, Felipe F. Casanueva, Andrea Giustina, Nienke Biermasz, Beverly M. K. Biller, Marcello Bronstein, Philippe Chanson, Hidenori Fukuoka, Monica Gadelha, Yona Greenman, Mark Gurnell, Ken K. Y. Ho, Juergen Honegger, Adriana G. Ioachimescu, Ursula B. Kaiser, Niki Karavitaki, Laurence Katznelson, Maya Lodish, Dominique Maiter, Hani J. Marcus, Ann Mccormack, Mark Molitch, Christopher A. Muir, Sebastian Neggers, Alberto M. Pereira, Rosario Pivonello, Kalmon Post, Gerald Raverot, Roberto Salvatori, Susan L. Samson, Ilan Shimon, Joanna Spencer-Segal, Greisa Vila, John Wass, Shlomo Melmed
Summary: This Consensus Statement provides evidence-based graded consensus recommendations and key summary points for clinical practice on the diagnosis and management of prolactinomas. It covers various aspects including epidemiology, pathogenesis, clinical presentation, assessment, imaging strategies, complications, and treatment in special situations. The workshop emphasizes the need for additional therapeutic options to address clinical challenges in treating these patients.
NATURE REVIEWS ENDOCRINOLOGY
(2023)