Article
Hematology
Pawel Szulc, Catherine Planckaert, Dominique Foesser, Janina Patsch, Roland Chapurlat
Summary: The study showed that severe peripheral arterial calcification is associated with a higher risk of acute coronary syndrome and major adverse cardiovascular events in older men. Even in men without cardiovascular risk factors, severe PAC was found to increase the risk of ACS.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Medicine, General & Internal
Lemei Hu, Quanjun Liu, Yunyao Ou, Dongdong Li, Yongdong Wu, Hengyi Li, Zhigang Zhu, Ming Liang
Summary: This study aimed to determine the relationship between dietary antioxidant intake and vascular calcification (VC), especially in the population with chronic kidney disease (CKD). The results showed that dietary lycopene was negatively associated with severe arterial calcification, but dietary antioxidants were not significantly associated with VC in CKD patients.
ANNALS OF MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Sheng Hu, Tian Lan, Silin Wang, Lang Su, Sheng Zou, Jiayue Ye, Yang Zhang, Deyuan Zhang, Qiang Guo, Wenxiong Zhang, Dongliang Yu, Jianjun Xu, Yiping Wei, Jinhua Peng
Summary: This study found a relationship between serum chloride level and abdominal artery calcification. Serum chloride levels below 92 mmol/L were associated with increased risk of abdominal aortic calcification, while levels above 92 mmol/L were associated with decreased risk of abdominal aortic calcification.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Fang Wang, Jingang Zheng
Summary: This study found a negative association between serum a-Klotho levels and the risk of severe AAC in a sample of US adults. The association remained stable in different subgroups. These findings suggest that serum a-Klotho may serve as a promising tool to predict the incidence and prognosis of CVD.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2022)
Article
Biochemistry & Molecular Biology
Yu-Yang Lu, Wei-Liang Chen
Summary: This study found that high serum selenium levels were independently associated with an increased mean aortic calcification score and aggravated calcification severity, possibly adversely affecting the cardiovascular system in noninstitutionalized US adults.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Abadi K. Gebre, Marc Sim, Alexander J. Rodriguez, Jonathan M. Hodgson, Lauren C. Blekkenhorst, Pawel Szulc, Nicola Bondonno, Kun Zhu, Catherine Bondonno, Douglas P. Kiel, John T. Schousboe, Richard L. Prince, Joshua R. Lewis
Summary: The presence of abdominal aortic calcification is associated with an increased risk of long-term fall-related hospitalizations in community-dwelling older women, independent of muscle function. Each unit increase in AAC24 score is associated with a 3% increase in relative hazards for fall-related hospitalization. Women with any AAC had a significantly higher risk for fall-related hospitalizations compared to those with no AAC, and this relationship was not affected by measures of muscle function.
Article
Endocrinology & Metabolism
Pawel Szulc, Dominique Foesser, Roland Chapurlat
Summary: In older men, higher areal bone mineral density, preserved cortical bone status, and higher estimated bone strength are associated with a lower risk of major adverse coronary events (MACE) after adjustment for relevant confounders.
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Article
Urology & Nephrology
Si-Jia Zhou, Xiao-Xiao Wang, Wen Tang, Qing-Feng Han, Lian He, Ai-Hua Zhang
Summary: This study evaluated serum irisin levels of peritoneal dialysis (PD) patients and their relationship with vascular calcification, finding a significant association between serum irisin levels and abdominal aortic calcification in PD patients. Lower irisin levels, diabetic mellitus, higher serum ultrasensitive C reactive protein, and older age could be potential predictive factors for vascular calcification in PD patients.
Article
Biochemistry & Molecular Biology
Chang Liu, Dan Liang
Summary: The study investigated the relationship between dietary copper intake and abdominal aortic calcification (AAC) in US adults using data from NHANES 2013-2014. The results showed a negative association between copper intake and AAC scores and risk of AAC and severe AAC. Higher copper intake was associated with decreased AAC scores and decreased likelihood of AAC and severe AAC.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Urology & Nephrology
Lian He, Wenling Yang, Ping Yang, Xianhua Zhang, Aihua Zhang
Summary: This study aims to evaluate the relationship between serum TMAO levels and vascular calcification (VC) in hemodialysis (HD) patients. The results show that higher serum TMAO levels, older age, longer HD duration, higher plasma iPTH levels, and diabetes mellitus are independent risk factors for VC in HD patients. Further investigations are needed to explore the underlying mechanisms and investigate TMAO as a potential target for VC treatment.
Article
Geriatrics & Gerontology
P. Szulc, R. Chapurlat
Summary: The study demonstrates that older men with low relative appendicular lean mass and poor physical function are at increased risk of rapid abdominal aortic calcification progression, suggesting they may have elevated cardiovascular risk.
JOURNAL OF NUTRITION HEALTH & AGING
(2021)
Article
Hematology
Benjamin H. Parmenter, Catherine P. Bondonno, Kevin Murray, John T. Schousboe, Kevin Croft, Richard L. Prince, Jonathan M. Hodgson, Nicola P. Bondonno, Joshua R. Lewis
Summary: This study found that higher habitual dietary flavonoid intake is associated with less extensive abdominal aortic calcification in older women.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Medicine, General & Internal
Tao Liu, Ronghua Zuo, Jia Wang, Bing Wang, Lifang Sun, Shasha Wang, Baoyin Li, Jianhui Yao, Conggang Huang, Yesheng Pan, Zhijian Zhu
Summary: The study found a U-shaped relationship between serum 25(OH)D concentration and the risk of abdominal aortic calcification (AAC) and severe AAC (SAAC). Regular monitoring and vitamin D supplementation may help mitigate the risk of AAC and SAAC.
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
(2023)
Article
Geriatrics & Gerontology
Carlos Heriberto Orces
Summary: The study found an inverse relationship between serum soluble klotho levels and severe abdominal aorta calcification in older adults.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Mingyue Wu, Yihai Liu, Chongxia Zhong, Biao Xu, Lina Kang
Summary: The study suggests that osteoporosis may be independently associated with severe abdominal aortic calcification, providing insights into the prevention and management of vascular disease.
ARCHIVES OF OSTEOPOROSIS
(2021)
Article
Endocrinology & Metabolism
Aliya A. Khan, Mishaela R. Rubin, Peter Schwarz, Tamara Vokes, Dolores M. Shoback, Claudia Gagnon, Andrea Palermo, Claudio Marcocci, Bart L. Clarke, Lisa G. Abbott, Lorenz C. Hofbauer, Lynn Kohlmeier, Susanne Pihl, Xuebei An, Walter Frank Eng, Alden R. Smith, Jenny Ukena, Christopher T. Sibley, Aimee D. Shu, Lars Rejnmark
Summary: TransCon PTH demonstrated efficacy in maintaining normocalcemia and allowing independence from conventional therapy in individuals with hypoparathyroidism. The treatment also showed significant improvements in health-related quality of life and hypoparathyroidism-related symptoms.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Review
Geriatrics & Gerontology
Abadi K. Gebre, Joshua R. Lewis, Kevin Leow, Pawel Szulc, David Scott, Peter R. Ebeling, Marc Sim, Germaine Wong, Wai H. Lim, John T. Schousboe, Douglas P. Kiel, Richard L. Prince, Alexander J. Rodriguez
Summary: Abdominal aortic calcification (AAC) is associated with lower bone mineral density (BMD) and increased fracture risk. Detecting AAC during BMD testing may provide guidance for diagnosing bone health and predicting fracture risk.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Endocrinology & Metabolism
Eva Maria Woelfel, Franziska Lademann, Haniyeh Hemmatian, Stephane Blouin, Phaedra Messmer, Lorenz C. Hofbauer, Bjoern Busse, Martina Rauner, Katharina Jaehn-Rickert, Elena Tsourdi
Summary: Hyperthyroidism causes secondary osteoporosis by promoting bone resorption. Osteocytic osteolysis and elevated tartrate-resistant acid phosphatase (TRAP) activity were observed in hyperthyroid mice. The bone microarchitecture and turnover recovered after treatment, but the osteocytic osteolysis effects were not reversed.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Endocrinology & Metabolism
Dylan Girard, Philippe P. P. Wagner, Danielle E. E. Whittier, Steven K. K. Boyd, Roland Chapurlat, Pawel Szulc
Summary: In older men, higher hsCRP concentrations are associated with faster endocortical expansion and slightly higher cortical bone loss, but not with fracture risk. High hsCRP levels have limited impact on bone decline in older men.
OSTEOPOROSIS INTERNATIONAL
(2023)
Article
Engineering, Biomedical
Sofie Dragoun Kolibova, Eva Maria Woelfel, Haniyeh Hemmatian, Petar Milovanovic, Herbert Mushumba, Birgit Wulff, Maximilian Neidhardt, Klaus Pueschel, Antonio Virgilio Failla, Annegreet Vlug, Alexander Schlaefer, Benjamin Ondruschka, Michael Amling, Lorenz C. Hofbauer, Martina Rauner, Bjoern Busse, Katharina Jaehn-Rickert
Summary: Type 1 diabetes mellitus (T1DM) is associated with increased bone fragility. Our study found accelerated osteocyte apoptosis and local mineralization in T1DM patients, suggesting that T1DM speeds up bone aging and impairs its biomechanical competence. Dysfunction of the osteocyte network hampers bone remodeling and repair, contributing to the increased fracture risk in T1DM individuals.
ACTA BIOMATERIALIA
(2023)
Article
Endocrinology & Metabolism
Manuel Gado, Annett Heinrich, Denise Wiedersich, Katrin Sameith, Andreas Dahl, Vasileia I. Alexaki, Michael M. Swarbrick, Ulrike Baschant, Ingo Grafe, Nikolaos Perakakis, Stefan R. Bornstein, Martina Rauner, Lorenz C. Hofbauer, Holger Henneicke
Summary: This study demonstrates that activation of the sympathetic nervous system through cold exposure or selective I33-adrenergic receptor agonist can alleviate the adverse metabolic effects caused by chronic glucocorticoid exposure. Cold exposure preserves the function of brown adipose tissue and reverses white adipose tissue lipid accumulation, correcting obesity, hyperinsulinemia, and hyperglycemia caused by glucocorticoids.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2023)
Article
Engineering, Biomedical
Gloria Ruiz-Gomez, Juliane Salbach-Hirsch, Jan-Niklas Duerig, Linda Koehler, Kanagasabai Balamurugan, Sandra Rother, Sophie-Luise Heidig, Stephanie Moeller, Matthias Schnabelrauch, Giulia Furesi, Sophie Paehlig, Pedro M. Guillem-Gloria, Christine Hofbauer, Vera Hintze, M. Teresa Pisabarro, Joerg Rademann, Lorenz C. Hofbauer
Summary: The WNT signaling pathway is important for bone development and regeneration, and abnormalities in WNT ligands and inhibitors are associated with various bone diseases. This study focused on glycosaminoglycan (GAG) recognition by DKK1, a WNT inhibitor, and aimed to develop WNT signaling regulators. Through a multidisciplinary approach, researchers designed and synthesized GAG derivatives with improved neutralizing properties for DKK1. These derivatives showed increased WNT pathway activity and improved bone regeneration in experimental models. The findings suggest that rationally engineered GAG variants could be used as novel therapeutic approaches.
Article
Endocrinology & Metabolism
Elina Gunsing, Philippe P. P. Wagner, Danielle E. E. Whittier, Steven K. K. Boyd, Roland Chapurlat, Pawel Szulc
Summary: Rapid cortical bone loss at the distal radius is associated with a higher risk of fracture in older men. However, repeated HR-pQCT measurements did not improve the assessment of fracture risk.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Endocrinology & Metabolism
Danielle E. Whittier, Elizabeth J. Samelson, Marian T. Hannan, Lauren A. Burt, David A. Hanley, Emmanuel Biver, Pawel Szulc, Elisabeth Sornay-Rendu, Blandine Merle, Roland Chapurlat, Eric Lespessailles, Andy Kin On Wong, David Goltzman, Sundeep Khosla, Serge Ferrari, Mary L. Bouxsein, Douglas P. Kiel, Steven K. Boyd
Summary: This study developed a fracture risk assessment tool based on high-resolution peripheral quantitative compute tomography (HR-pQCT) to evaluate patient-specific fracture risk. The tool, called mu FRAC, outperformed the current Fracture Risk Assessment Tool (FRAX) and models based on bone mineral density (BMD). It provides an alternative approach by utilizing direct measures of bone density and structure.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Maria G. Ledesma-Colunga, Ulrike Baschant, Heike Weidner, Tiago C. Alves, Peter Mirtschink, Lorenz C. Hofbauer, Martina Rauner
Summary: In this study, the authors investigated the role of transferrin receptor 2 (Tfr2) in the pathogenesis of inflammatory arthritis. They found that Tfr2-deficient mice developed more severe joint inflammation and bone erosion compared to control mice. Further experiments suggested that Tfr2 deficiency promoted macrophage polarization towards a pro-inflammatory state, contributing to the progression of arthritis.
Article
Endocrinology & Metabolism
Jack Dalla Via, Abadi K. Gebre, Cassandra Smith, Zulqarnain Gilani, David Suter, Naeha Sharif, Pawel Szulc, John T. Schousboe, Douglas P. Kiel, Kun Zhu, William D. Leslie, Richard L. Prince, Joshua R. Lewis, Marc Sim
Summary: Abdominal aortic calcification (AAC), a measure of vascular disease, is associated with increased cardiovascular risk and poorer prognosis. An automated machine-learning algorithm has been developed for assessing AAC, which is associated with long-term incident fractures and falls.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Endocrinology & Metabolism
Alexandre Mercier-Guery, Marjorie Millet, Blandine Merle, Corinne Collet, Flora Bagouet, Olivier Borel, Elisabeth Sornay-Rendu, Pawel Szulc, Emmanuelle Vignot, Deborah Gensburger, Elisabeth Fontanges, Martine Croset, Roland Chapurlat
Summary: miRNAs are potential prognostic markers in bone diseases, regulating gene expression as epigenetic factors. This study aims to identify circulating miRNAs associated with the severity of osteogenesis imperfecta (OI) and found a miRNA signature in OI patients. The study validates the expression of specific miRNAs in OI patients and explores the relationship between miRNA expression and clinical characteristics of OI. The findings suggest a potential role of miRNAs in regulating the physiopathology of OI.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Endocrinology & Metabolism
Souad Daamouch, Sylvia Thiele, Lorenz Hofbauer, Martina Rauner
Summary: The link between obesity and low bone strength is a significant medical concern. Previous research has shown that Dkk1, a Wnt inhibitor, is upregulated in bone tissue in obesity and drives obesity-induced bone loss. This study investigated the role of adipogenic Dkk1 in bone homeostasis and obesity-induced bone loss in mice. The results suggest that adipogenic Dkk1 plays a transient role in bone mass regulation during adolescence, but does not contribute to bone homeostasis or obesity-induced bone loss later in life.
ENDOCRINE CONNECTIONS
(2023)
Article
Medicine, Research & Experimental
Lorenz C. Hofbauer, Franziska Lademann, Martina Rauner
Summary: Osteocytes, senescent cells implicated in bone loss disorders, have been shown to be effectively cleared through systemic senolysis, preventing age-related bone loss and mitigating bone marrow adiposity. Cell-specific senolysis in osteocytes alone had only a partial effect. Surprisingly, transplantation of senescent fibroblasts into young mice led to osteocyte senescence and bone loss. These findings on osteocyte senescence and the effects of remote senolysis suggest potential strategies against multisystem aging.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Endocrinology & Metabolism
Blandine Merle, Marie Cottard, Elisabeth Sornay-Rendu, Pawel Szulc, Roland Chapurlat
Summary: The study evaluates the prevalence of sarcopenia in spondyloarthritis (SpA) patients and its association with inflammation, disease activity, muscle performance, and quality of life. The results show that probable sarcopenia is significantly higher in SpA patients compared to controls. Probable sarcopenic SpA patients had higher inflammation and disease activity, impaired muscle performance, and lower quality of life. These findings suggest that muscle strength is an important aspect of SpA.
CALCIFIED TISSUE INTERNATIONAL
(2023)