Article
Cardiac & Cardiovascular Systems
Yuichi Sasaki, Yoshiyuki Ikeda, Yoshihiro Uchikado, Yuichi Akasaki, Junichi Sadoshima, Mitsuru Ohishi
Summary: This study demonstrated that estrogen-induced mitochondrial autophagy plays a key role in delaying vascular senescence. The Rab9-dependent alternative autophagy is responsible for estrogen-induced mitochondrial autophagy.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Cell Biology
Hiroki Yoshioka, Yurie Mikami, Sai Shankar Ramakrishnan, Akiko Suzuki, Junichi Iwata
Summary: The study indicates that excess intake of all-trans retinoic acid (atRA) causes cleft palate in mice through the induction of miR-124-3p, while miR-27a-3p and miR-27b-3p do not significantly affect cell proliferation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Immunology
Raquel D. N. Arifa, Camila B. Brito, Talles P. Paula, Renata L. Lima, Zelia Menezes-Garcia, Puebla Cassini-Vieira, Fabricio A. Vilas Boas, Celso M. Queiroz-Junior, Janine M. da Silva, Tarcilia A. da Silva, Luciola S. Barcelos, Caio T. Fagundes, Mauro M. Teixeira, Daniele G. Souza
Summary: Eosinophils play an important role in chemotherapy-induced intestinal mucositis, and inhibiting eosinophils can alleviate inflammation. Evasin-4, a chemokine receptor antagonist, reduces the accumulation of eosinophils and chemotherapy-induced mucositis.
Article
Dentistry, Oral Surgery & Medicine
C. Iwaya, A. Suzuki, J. Shim, C. G. Ambrose, J. Iwata
Summary: Tooth enamel is generated by ameloblasts. Failure in amelogenesis leads to enamel defects known as amelogenesis imperfecta. This study showed that mice with deficient autophagy in epithelial-derived tissues exhibited amelogenesis imperfecta, with reduced enamel density and thickness. Autophagy plays a crucial role in ameloblast differentiation and its failure results in amelogenesis imperfecta through ectopic NRF2 activation.
JOURNAL OF DENTAL RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Abigayle B. Simon, Cassandra C. Derella, Marsha Blackburn, Jeffrey Thomas, Lawrence C. Layman, Matthew S. Nicholson, Jennifer Waller, Ahmed Elmarakby, Karim M. Saad, Ryan A. Harris
Summary: The study found that women with type 1 diabetes have higher levels of estradiol in the late follicular phase, leading to increased oxidative stress and endothelial dysfunction. The use of oral contraceptive pills appears to benefit endothelial function in patients with type 1 diabetes.
CARDIOVASCULAR DIABETOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Sofia-Iris Bibli, Jiong Hu, Mario Looso, Andreas Weigert, Corina Ratiu, Janina Wittig, Maria Kyriaki Drekolia, Lukas Tombor, Voahanginirina Randriamboavonjy, Matthias S. Leisegang, Philipp Goymann, Fredy Delgado Lagos, Beate Fisslthaler, Sven Zukunft, Anastasia Kyselova, Alberto Fernando Oliveira Justo, Juliana Heidler, Diamantis Tsilimigras, Ralf P. Brandes, Stefanie Dimmeler, Andreas Papapetropoulos, Stefan Knapp, Stefan Offermanns, Ilka Wittig, Stephen L. Nishimura, Fragiska Sigala, Ingrid Fleming
Summary: This study investigated the S-sulfhydrome in human endothelial cells and found that S-sulfhydration plays a crucial role in regulating endothelial cell functions, especially in integrins and mechanotransduction. Impaired S-sulfhydration was associated with vascular dysfunction, while H2Sn supplementation improved vascular reactivity, suggesting a potential therapeutic target for vascular diseases.
Article
Microbiology
Gordon Y. C. Cheung, Justin S. Bae, Ryan Liu, Rachelle L. Hunt, Yue Zheng, Michael Otto
Summary: The study found that bacterial virulence and quorum-sensing regulation play crucial roles in staphylococcal sepsis, providing important guidance for developing anti-virulence drugs. It revealed a critical early stage in the development of bacterial sepsis where the battle between bacteria and leukocytes determines the outcome of the disease. This highlights the key role of invading pathogens and their virulence mechanisms in sepsis, challenging the traditional attribution of sepsis mainly to host factors.
Article
Endocrinology & Metabolism
Mark Slayton, Bijinu Balakrishnan, Abhishek Gupta, Scott Jobe, Ishika Puri, Savannah Neely, Yoshikazu Tamori, David W. Russ, Gozde Yildirim, Shoshana Yakar, Vishva M. Sharma, Vishwajeet Puri
Summary: This study identifies Fsp27 as a novel protein associated with muscle metabolism. The Fsp27-knockout model reveals that Fsp27 plays a role in muscular-fat storage, muscle endurance, and muscle strength, ultimately impacting limb movement. Additionally, the study suggests a potential metabolic paradox in which Fsp27-knockout mice, presumed to be metabolically healthy based on glucose utilization and oxidative metabolism, exhibit impaired exercise capacity and muscular performance.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2022)
Article
Agronomy
Jian Ma, Congcong Li, Peng Gao, Yanhong Qiu, Mei Zong, Huijun Zhang, Jianshe Wang
Summary: By cloning and functional analysis of the melon MSO1 gene, it was found that this gene encodes an ARGONAUTE 7 protein, which plays an important role in the development of melon. The study also found that small RNAs and miRNAs in melon play important roles in regulating plant development.
THEORETICAL AND APPLIED GENETICS
(2022)
Article
Biochemistry & Molecular Biology
Rutambhara Purohit, Amal Kanti Bera
Summary: The interaction between Pannexin-1 (Panx1) channel and P2X7 receptor (P2X7R) has important cellular implications. ATP released through Panx1 activates P2X7R, which further activates Panx1. Previous studies have shown that Panx1-CT attenuates P2X7R-mediated Ca2+ influx and cell death. In this study, it was found that Panx1-CT inhibits P2X7R current, while full-length Panx1 initially reduces P2X7R current and then gradually increases it. Furthermore, Panx1-CT expression reduces mitochondrial depolarization, reactive oxygen species generation, Caspase 3 activation, and cell death, whereas overexpression of full-length Panx1 has the opposite effect. These findings indicate that Panx1 can modulate P2X7R-mediated cellular processes depending on the degree of P2X7R activation.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Developmental Biology
Ren Tanimoto, Kiyono Sekii, Kanako Morohaku, Jianzhen Li, David Pepin, Yayoi Obata
Summary: This study reveals that estrogen receptor 1 activated by estrogen binds to the 5' region of the Amh gene in cultured mouse fetal ovaries, upregulating its transcription and causing ectopic expression of AMH protein, which inhibits normal follicle formation. Additionally, the addition of AFP to the culture medium inhibits ectopic AMH expression via estrogen, leading to successful follicle formation in vitro.
Article
Pharmacology & Pharmacy
Yue-Yang Zhao, Yu-Qi Yang, Hong-Hao Sheng, Qing Tang, Ling Han, Su-Mei Wang, Wan-Yin Wu
Summary: In this study, it was found that FZKA induces ferroptosis in NSCLC cells by increasing lipid peroxidation and cellular Fe2+ Ion levels, while inhibiting GPX4 and system xc(-). Overexpressing GPX4 reversed the ferroptosis-inducing effect of FZKA, and these findings were validated in vivo using an animal model. These results reveal a novel molecular mechanism by which FZKA treats NSCLC by targeting GPX4.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Joman Javadi, Ghazal Heidari-Hamedani, Angelika Schmalzl, Tunde Szatmari, Muzaffer Metintas, Pontus Aspenstrom, Anders Hjerpe, Katalin Dobra
Summary: SDC-1 is a transmembrane proteoglycan that regulates the binding of growth factors and cytokines, impacting angiogenesis. Overexpression of SDC-1 inhibits proliferation, wound healing, and tube formation in endothelial cells in malignant mesothelioma. Silencing SDC-1 affects wound healing but not tube formation.
Review
Biochemistry & Molecular Biology
Xue Xiong, Bowen Li, Zhixiong Zhou, Guojing Gu, Mengjuan Li, Jun Liu, Hanwei Jiao
Summary: Brucellosis is a highly prevalent zoonotic disease caused by Brucella, which are gram-negative facultative intracellular parasitic bacteria. The virulence factor of Brucella, the Type IV secretion system encoded by the virB operon, subverts cellular pathways and induces host immune response by secreting effectors, promoting Brucella replication in host cells and inducing persistent infection. This paper summarizes the function and significance of the VirB system, focusing on its structure, effectors, and cellular pathways it subverts, providing new insights for clinical vaccine research and development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Nasrin Jangjoo Ghalat, Koroush Shahpasand, Mohammad Javan
Summary: In this study, we found increased levels of cis-phosphorylated tau (cis-p-tau) in a lyso-phosphatidylcholine-induced demyelination model, especially in axons and microglia. Clearance of cis-p-tau using an antibody resulted in decreased gliosis, protected myelin, and reduced axon degeneration, improving visual acuity and the integrity of the optic pathway.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Genetics & Heredity
Ziru Jiang, Kexin Zou, Xia Liu, Hangchao Gu, Yicong Meng, Jing Lin, Weihui Shi, Chuanjin Yu, Li Jin, Li Wang, Xinmei Liu, Jianzhong Sheng, Hefeng Huang, Guolian Ding
Summary: As individuals age, the expression of circadian clock genes in human granulosa cells decreases, with a negative correlation between mRNA expression levels and age. Older patients have lower serum anti-Mullerian hormone (AMH) levels, and the circadian rhythm in the ovaries of older mice significantly differs from that in young mice, while the circadian rhythm in the livers of older mice remains relatively consistent with that of young mice.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2021)
Correction
Physiology
Yaoyao Tu, Guangyong Zheng, Guolian Ding, Yanting Wu, Ji Xi, Yingzhou Ge, Hangchao Gu, Yingyu Wang, Jianzhong Sheng, Xinmei Liu, Li Jin, Hefeng Huang
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Zuwei Yang, Wenzhong Zhou, Chengliang Zhou, Yuzhong Zhou, Xinmei Liu, Guolian Ding, Yulian Hu, Jiexue Pan, Jianzhong Sheng, Li Jin, Hefeng Huang
Summary: This study found that the most prevalent phenotype of PCOS in Chinese women is normo-androgenic PCOS (NA-PCOS), and that there were no significant differences in intrafollicular steroid levels and product/precursor ratios between NA-PCOS and hyperandrogenic PCOS (HA-PCOS) women. However, HA-PCOS women did have significantly higher serum luteinizing hormone and testosterone levels compared to NA-PCOS women.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2021)
Article
Pediatrics
Chang-Fa Sun, Han Liu, Yan-Hui Hao, Hong-Tao Hu, Zhi-Yang Zhou, Ke-Xin Zou, Xin-Mei Liu, Jian-Zhong Sheng, Guo-Lian Ding, He-Feng Huang
Summary: This study investigated the relationship between anemia in different trimesters and neonatal outcomes, revealing that gestational anemia is a public health issue in China with only about a quarter of women able to be corrected. Anemia occurring in the first trimester, whether corrected or not, still led to lower birth weight, highlighting the importance of preventing anemia before pregnancy.
WORLD JOURNAL OF PEDIATRICS
(2021)
Article
Chemistry, Multidisciplinary
Yingyun Gong, Yanfeng Xue, Xin Li, Zhao Zhang, Wenjun Zhou, Paola Marcolongo, Angiolo Benedetti, Shengyong Mao, Leng Han, Guolian Ding, Zheng Sun
Summary: The rise of metabolic disorders in modern times is mainly attributed to the environment, while heritable effects of environmental chemicals on mammalian offspring's metabolic health are unclear. Research has found sex- and generation-specific heritable effects of inorganic arsenic on metabolic physiology, highlighting the importance of gene-environment interactions.
Article
Cell Biology
Ningxin Qin, Zhiyang Zhou, Wenlong Zhao, Kexin Zou, Weihui Shi, Chuanjin Yu, Xia Liu, Zehan Dong, Yiting Mao, Xinmei Liu, Jianzhong Sheng, Guolian Ding, Yanting Wu, Hefeng Huang
Summary: This study explored the impact of frozen and thawed embryo transfer (FET) on the glucose metabolism of offspring using a mouse model. Male mouse offspring conceived through FET showed impaired glucose tolerance and insulin resistance, along with disruption of hepatic insulin signaling pathways.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Guolian Ding, Xin Li, Xinguo Hou, Wenjun Zhou, Yingyun Gong, Fuqiang Liu, Yanlin He, Jia Song, Jing Wang, Paul Basil, Wenbo Li, Sichong Qian, Pradip Saha, Jinbang Wang, Chen Cui, Tingting Yang, Kexin Zou, Younghun Han, Christopher Amos, Yong Xu, Li Chen, Zheng Sun
Summary: The nuclear receptors REV-ERB-alpha and REV-ERB-beta in GABAergic neurons control the diurnal rhythm of insulin-mediated suppression of hepatic glucose production, peaking at waking. This mechanism is crucial for understanding the extended dawn phenomenon in type 2 diabetes.
Article
Endocrinology & Metabolism
Hong Zhu, Si-Si Luo, Yi Cheng, Yi-Shang Yan, Ke-Xin Zou, Guo-Lian Ding, Li Jin, He-Feng Huang
Summary: The study reveals that changes in the fetal pancreatic metabolome may be a significant mechanism for the increasing prevalence of diabetes caused by intrauterine hyperglycemia exposure.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Developmental Biology
Ning-Xin Qin, Yi-Ran Zhao, Wei-Hui Shi, Zhi-Yang Zhou, Ke-Xin Zou, Chuan-Jin Yu, Xia Liu, Ze-Han Dong, Yi-Ting Mao, Cheng-Liang Zhou, Jia-Le Yu, Xin-Mei Liu, Jian-Zhong Sheng, Guo-Lian Ding, Wen-Long Zhao, Yan-Ting Wu, He-Feng Huang
Summary: The study revealed that male offspring conceived by IVF-ET and IVF-FET exhibited increased anxiety and depression-like behaviors at 18 months old, which were associated with reduced expression levels of neurotrophins in the brain.
Article
Cell Biology
Si-si Luo, Ke-xin Zou, Hong Zhu, Yi Cheng, Yi-shang Yan, Jian-zhong Sheng, He-feng Huang, Guo-lian Ding
Summary: Growing evidence suggests that gestational diabetes mellitus (GDM) could affect the long-term neurocognitive health of offspring. Using a GDM mouse model, this study found that GDM altered metabolites in fetal brains, which in turn affected DNA methylation and gene regulation involved in cognition, providing a potential mechanism for the adverse neurocognitive effects of GDM in offspring.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yiting Mao, Yiran Zhao, Sisi Luo, Huixi Chen, Xia Liu, Ting Wu, Guolian Ding, Xinmei Liu, Jianzhong Sheng, Yicong Meng, Hefeng Huang
Summary: The study explores the metabolic phenotype of offspring from advanced paternal age and the inherited alterations in sperm, finding that paternal aging can lead to chronic metabolic risks in offspring and that these risks may be mediated through inherited alterations in sperm.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Article
Reproductive Biology
Xin-Yuan Li, Jie-Xue Pan, Hong Zhu, Guo-Lian Ding, He-Feng Huang
Summary: In recent years, there has been an increasing recognition of the developmental origins of diseases. It is suggested that many chronic diseases in adulthood, including diabetes, obesity, cardiovascular disease, and tumors, may develop early on. Germ cells play a crucial role in inheritance, and external influences during their differentiation and development can lead to damage and increase the risk of chronic disease development. This article further explores the concept of gamete and embryo origins of adult diseases, focusing on environmental insults on germ cells.
BIOLOGY OF REPRODUCTION
(2022)
Article
Multidisciplinary Sciences
Bin Chen, Ya-Rui Du, Hong Zhu, Mei-Ling Sun, Chao Wang, Yi Cheng, Haiyan Pang, Guolian Ding, Juan Gao, Yajing Tan, Xiaomei Tong, Pingping Lv, Feng Zhou, Qitao Zhan, Zhi-Mei Xu, Li Wang, Donghao Luo, Yinghui Ye, Li Jin, Songying Zhang, Yimin Zhu, Xiaona Lin, Yanting Wu, Luyang Jin, Yin Zhou, Caochong Yan, Jianzhong Sheng, Peter R. Flatt, Guo-Liang Xu, Hefeng Huang
Summary: Pregestational hyperglycemia increases the offspring's vulnerability to glucose intolerance. The insufficient demethylation by oocyte TET3 leads to hypermethylation in the paternal alleles of several insulin secretion genes. There is an environment-sensitive window in oocyte development that confers predisposition to glucose intolerance in the next generation.
Editorial Material
Multidisciplinary Sciences
Guolian Ding, Bin Chen, John R. McCarrey, Hefeng Huang
Review
Endocrinology & Metabolism
S. -s. Luo, H. Zhu, H-f. Huang, G. -l. Ding
Summary: The purpose of this review was to summarize the sex differences in glycolipid metabolic phenotypes in human and animal models after exposure to maternal hyperglycemia, and to provide an overview of the underlying mechanisms. Maternal hyperglycemia increases the risk of glycolipid metabolic disorders in offspring, and metabolic phenotypes exhibit sex differences in response to maternal hyperglycemia, which may be related to gonadal hormones, organic intrinsic differences, placenta, and epigenetic modifications.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)