Article
Endocrinology & Metabolism
Ramy H. Bishay, Katherine T. Tonks, Jacob George, Dorit Samocha-Bonet, Gideon Meyerowitz-Katz, Donald J. Chisholm, David E. James, Jerry R. Greenfield
Summary: In obese individuals with insulin resistance, there was a significant decrease in glucose infusion rate/fat-free mass (GIR/FFM), and higher levels of visceral and liver fat, despite similar overall adiposity compared to insulin-sensitive individuals. Total bile acid (BA) concentrations were higher in the obese insulin-resistant group and individuals with type 2 diabetes compared to the insulin-sensitive obese group. Total BAs were positively associated with waist circumference, visceral fat, and fibroblast growth factor 21, and negatively associated with insulin sensitivity, abdominal subcutaneous fat, adiponectin, and liver fat. Conjugated BAs were also elevated in individuals with type 2 diabetes.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Clinical Neurology
Y. Yu, F. -L. Zhang, X. -L. Yan, P. Zhang, Z. -N. Guo, Y. Yang
Summary: This study found that the visceral adiposity index (VAI) was associated with carotid plaque and cervical artery stenosis (CAS) in the general population over 40 years old in northeast China, but showed little significance with increased intima-media thickness (IMT) in cervical arteries.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Nutrition & Dietetics
Valene Garr Barry, Mariah Stewart, Taraneh Soleymani, Renee A. Desmond, Amy M. Goss, Barbara A. Gower
Summary: The study concludes that prescribing a LCHF diet to middle-aged adults may be an optimal strategy for reducing disease risk, particularly for those with insulin resistance.
Article
Endocrinology & Metabolism
Yongcheng Ren, Lulu Cheng, Ranran Qie, Minghui Han, Lingzhen Kong, Wei Yan, Zheng Li, Yiduo Li, Yicun Lei
Summary: This study aimed to explore the associations between Chinese visceral adiposity index (CVAI) and comorbidity of hypertension and diabetes mellitus, as well as hypertension or diabetes mellitus alone, in elderly people. The results showed a linear and positive correlation between CVAI and HTN-DM comorbidity, HTN or DM, HTN, and DM. Insulin resistance played a key role in mediating these associations.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Multidisciplinary Sciences
Goh Eun Chung, Sohee Oh, Dong-Won Ahn, Su Hwan Kim, Yong Jin Jung, Ji Won Kim, Byeong Gwan Kim, Kook Lae Lee, Ji Bong Jeong
Summary: This study aimed to evaluate the effects of interactions between various body composition parameters, including obesity, visceral adiposity, and sarcopenia, on the risk of nonalcoholic fatty liver disease (NAFLD). The study found that there were significant interactions between obesity and visceral adiposity, as well as between obesity and sarcopenia, affecting NAFLD.
SCIENTIFIC REPORTS
(2023)
Article
Endocrinology & Metabolism
Chloe Rauzier, Dominic J. Chartrand, Natalie Almeras, Isabelle Lemieux, Eric Larose, Patrick Mathieu, Philippe Pibarot, Benoit Lamarche, Caroline Rheaume, Paul Poirier, Jean-Pierre Despres, Frederic Picard
Summary: This study investigates the differences in liver fat content among adults with visceral obesity and finds an inverse correlation between circulating IGFBP-2 levels and LF levels. These findings may reveal a potential role of IGFBP-2 in modulating non-alcoholic fatty liver disease in individuals with visceral obesity.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Health Care Sciences & Services
Patricia Lizett Rodriguez-Carrillo, Priscila Irene Aguirre-Tostado, Maciste H. Macias-Cervantes, Jorge Alejandro Alegria-Torres, Claudia Luevano-Contreras
Summary: The study proposed Mexican adiposity indices (MAIs) and biochemical-anthropometric indices (BAIs), that performed well in identifying CR and MetS in Mexican adults. The VFA cut-off value of 100.3 cm(2) was found to be effective in identifying CR in Mexican men.
Article
Endocrinology & Metabolism
N. Y. H. Ng, K. H. Liu, C. H. T. Tam, G. Jiang, F. Cheng, Y. Hou, T. T. Yau, R. Ozaki, M. H. Chan, C. K. Lim, D. S. Sahota, T. C. Li, L. P. Cheung, W. H. Tam, W. C. W. Chu, R. C. W. Ma
Summary: Mesenteric fat thickness is strongly correlated to cardiometabolic traits in both PCOS patients and healthy controls, with PCOS patients showing higher insulin resistance compared to controls at any given degree of visceral adiposity.
OBESITY RESEARCH & CLINICAL PRACTICE
(2021)
Article
Endocrinology & Metabolism
Pandora L. Wander, Costas A. Christophi, Maria Rosario G. Araneta, Edward J. Boyko, Daniel A. Enquobahrie, Dana Dabelea, Ronald B. Goldberg, Steven E. Kahn, Catherine Kim, Xavier Pi-Sunyer, William C. Knowler
Summary: This study found associations between adiposity and adiposity-related biomarkers with incident type 2 diabetes among parous women, including positive associations of alanine aminotransferase and VAT, and an inverse association with adiponectin. Leptin showed different effects on T2D risk in women with and without a history of gestational diabetes mellitus.
Article
Medicine, General & Internal
Ibrahim Fuat Kayihan Kaya, Mehmet Ali Eryilmaz, Selma Pekgor, Orhan Kulahci
Summary: This study investigated the association between acne vulgaris and insulin resistance (IR) and visceral adiposity index (VAI). The results demonstrated that IR and VAI were similar both in the acne vulgaris and healthy control groups.
TURKISH JOURNAL OF MEDICAL SCIENCES
(2022)
Article
Pediatrics
Katherine Gonzalez-Ruiz, Jorge Enrique Correa-Bautista, Mikel Izquierdo, Antonio Garcia-Hermoso, Vicente Martinez-Vizcaino, Felipe Lobelo, Emilio Gonzalez-Jimenez, Jacqueline Schmidt-RioValle, Maria Correa-Rodriguez, Joaquin Fernandez-Irigoyen, Sara Palomino-Echeverria, Enrique Santamaria, Robinson Ramirez-Velez
Summary: The HEPAFIT study aimed to examine the impact of a 6-month physical education intervention on hepatic fat and cardiometabolic health outcomes in adolescents with excess adiposity. The study found that implementing a 6-month physical education exercise program, especially high-intensity or combined high and low-intensity, can improve hepatic fat storage and significantly reduce cardiometabolic markers in adolescents. Interventions involving supervised physical exercise may help to improve metabolism and fat deposition at the hepatic level, thus preventing the development of non-alcoholic fatty liver disease in adolescents.
Article
Pharmacology & Pharmacy
M. Apaydin, E. D. Kazan, S. Beysel, A. Sari, E. Ozgul, H. Cengiz, T. Demirci, M. Yilmazer
Summary: This study aimed to compare the VAI values of patients with PCOS, patients with IH, and a control group, finding significantly higher VAI values in patients with PCOS.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2022)
Article
Endocrinology & Metabolism
Angela Lehn-Stefan, Andreas Peter, Jurgen Machann, Fritz Schick, Elko Randrianarisoa, Martin Heni, Robert Wagner, Andreas L. Birkenfeld, Andreas Fritsche, Hans-Ulrich Haring, Harald Staiger, Norbert Stefan
Summary: Elevated plasma glutamate levels are associated with increased carotid intima media thickness (cIMT), independently of established cardiovascular disease (CVD) risk factors, and this relationship may be partially explained by IL-6-associated subclinical inflammation.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Obstetrics & Gynecology
Elisabeth Stamm, Pedro Marques-Vidal, Elena Gonzalez Rodriguez, Peter Vollenweider, Didier Hans, Olivier Lamy
Summary: For healthy postmenopausal women, body mass index and waist circumference show higher correlations with visceral adipose tissue (VAT) compared to BIA. VAT is the parameter most strongly associated with cardiometabolic risk factors.
MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY
(2022)
Article
Endocrinology & Metabolism
Min Gao, Qin Wang, Carmen Piernas, Nerys M. Astbury, Susan A. Jebb, Michael Holmes, Paul Aveyard
Summary: BMI and body fat are associated with COVID-19, but muscle mass is not. Central fat distribution shows a stronger association with COVID-19 than BMI in observational study, but no causality is found in Mendelian randomisation analysis. Metabolic consequences have strong associations with COVID-19 in observational study, but no evidence is found in Mendelian randomisation analysis. BMI retains a direct effect on COVID-19 in Mendelian randomisation analysis.
INTERNATIONAL JOURNAL OF OBESITY
(2022)
Article
Pediatrics
Cristina Garcia-Beltran, Rita Malpique, Belen Carbonetto, Pedro Gonzalez-Torres, Desiree Henares, Pedro Brotons, Carmen Munoz-Almagro, Abel Lopez-Bermejo, Francis de Zegher, Lourdes Ibanez
Summary: The gut microbiota composition in girls with PCOS differs significantly from healthy controls, with SPIOMET treatment showing the potential to normalize some of these anomalies.
Article
Endocrinology & Metabolism
Marta Diaz, Edurne Garde, Abel Lopez-Bermejo, Francis de Zegher, Lourdes Ibanez
BMJ OPEN DIABETES RESEARCH & CARE
(2020)
Article
Multidisciplinary Sciences
Francis de Zegher, Marta Diaz, Joan Villarroya, Montserrat Cairo, Abel Lopez-Bermejo, Francesc Villarroya, Lourdes Ibanez
Summary: The study found that young patients with early PCOS may have a relative deficit of GDF15, explaining their difficulties in controlling body adiposity. SPIOMET treatment can increase GDF15 concentrations and reduce inflammation levels.
SCIENTIFIC REPORTS
(2021)
Article
Developmental Biology
Ariadna Gomez-Vilarrubla, Berta Mas-Pares, Marta Diaz, Silvia Xargay-Torrent, Gemma Carreras-Badosa, Mariona Jove, Meritxell Martin-Gari, Alexandra Bonmati-Santane, Francis de Zegher, Lourdes Ibanez, Abel Lopez-Bermejo, Judit Bassols
Summary: In this study, differences in placental fatty acid composition and estimated desaturase and elongase activities were observed between appropriate-for-gestational-age (AGA) and small-for-gestational-age (SGA) infants. Placentas from SGA infants had lower levels of omega-3 fatty acids and higher omega-6/omega-3 ratios, as well as lower elongase and higher desaturase activity compared to AGA infants. Further studies on the omega-3 fatty acid status in SGA infants may be warranted for prenatal interventions.
Article
Pediatrics
Marta Diaz, Albert Blasco-Roset, Joan Villarroya, Abel Lopez-Bermejo, Francis de Zegher, Francesc Villarroya, Lourdes Ibanez
Summary: The study evaluated DBI concentrations in appropriate-for-gestational-age (AGA) and small-for-gestational-age (SGA) infants at birth and at age 2, finding that while DBI levels were similar at birth, SGA infants had higher levels at age 2, which may be related to adiposity and insulin resistance.
Article
Endocrinology & Metabolism
Cristina Garcia-Beltran, Ruben Cereijo, Cristina Plou, Aleix Gavalda-Navarro, Rita Malpique, Joan Villarroya, Abel Lopez-Bermejo, Francis de Zegher, Lourdes Ibanez, Francesc Villarroya
Summary: This study reveals the relationship between brown adipose tissue (BAT) activity and adiposity measures and metabolic health in early infancy. The study found gender-specific differences in BAT activity and CXCL14 levels, which were negatively associated with adiposity measures in girls.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Correction
Multidisciplinary Sciences
Francis de Zegher, Marta Diaz, Joan Villarroya, Montserrat Cairo, Abel Lopez-Bermejo, Francesc Villarroya, Lourdes Ibanez
SCIENTIFIC REPORTS
(2021)
Article
Pediatrics
Marta Diaz, Gemma Carreras-Badosa, Joan Villarroya, Aleix Gavalda-Navarro, Judit Bassols, Francis de Zegher, Abel Lopez-Bermejo, Francesc Villarroya, Lourdes Ibanez
Summary: Circulating GDF15 concentrations significantly increase in LBW/catch-up girls after long-term metformin treatment, and are negatively associated with insulin, androgens, body fat, and visceral fat. Prepubertal intervention with metformin reduces central adiposity and insulin resistance.
PEDIATRIC RESEARCH
(2023)
Article
Nutrition & Dietetics
Carolina Gonzalez-Riano, Marcelo Santos, Marta Diaz, Cristina Garcia-Beltran, Carles Lerin, Coral Barbas, Lourdes Ibanez, David Sanchez-Infantes
Summary: Being born small or large for gestational age, combined with suboptimal early postnatal outcomes, can lead to future metabolic alterations. This pilot study investigated the relationships between birth weight, early postnatal outcomes, and cord blood serum lipidomes. The study found distinct cord blood lipidome patterns in different birth weight groups, which were associated with parameters related to growth and glucose homeostasis. These findings suggest that the lipidome patterns may play a role in adipose tissue remodeling and metabolic risks in the future.
Article
Medicine, Research & Experimental
Judit Bassols, Francis de Zegher, Marta Diaz, Gemma Carreras-Badosa, Cristina Garcia-Beltran, Elsa Puerto-Carranza, Cora Oliver-Vila, Paula Casano, Celine Alicia Franco, Rita Malpique, Abel Lopez-Bermejo, Lourdes Ibanez
Summary: This study aims to assess whether a low-dose combination of drugs can slow down accelerated maturation in girls with early puberty. The study shows that reducing ectopic fat accumulation can delay the development of early adrenarche/pubarche and the activation of the gonadotropic axis, thus delaying early puberty and reducing symptoms of adolescent polycystic ovary syndrome.
Article
Endocrinology & Metabolism
Marta Diaz, Francis de Zegher, Lourdes Ibanez
Summary: In non-obese adolescent girls with PCOS, the use of oral contraception (OC) for 6 months leads to a significant increase in serum follistatin levels, which is associated with worsened markers of insulin resistance and changes in liver fat.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
F. de Zegher, M. Diaz, L. Ibanez
Summary: This study found that the HOTAIR rs1443512 genotype not only influences the distribution of fat mass in adolescent girls with PCOS-without-obesity, but also the redistribution of fat mass during prolonged treatment with low-dose pioglitazone.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)
Article
Endocrinology & Metabolism
Lourdes Ibanez, Marta Diaz, Cristina Garcia-Beltran, Rita Malpique, Edurne Garde, Abel Lopez-Bermejo, Francis de Zegher
JOURNAL OF THE ENDOCRINE SOCIETY
(2020)