Article
Endocrinology & Metabolism
Zhongyu Jian, Yu Huang, Yazhou He, Xi Jin, Hong Li, Sheyu Li, Kunjie Wang
Summary: The study found that higher genetically predicted lifelong circulating 25(OH)D levels are associated with higher calcium levels and KSD risk. The effects of 25(OH)D on KSD were partially attenuated but still significant in MVMR.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
David Gillis, Ari Hefter, Shalom Edri, David Strich
Summary: The aim of this study was to determine the optimal pediatric levels of 25-hydroxy-vitamin D (25OHD) for bone health. The study analyzed a large dataset of 49,935 25OHD tests from children sampled between 2009 and 2019. Significant correlations were found between 25OHD levels and parathyroid hormone (PTH) and calcium, indicating that increasing 25OHD levels up to at least 100 nmol/l can improve bone mineralization.
HORMONE AND METABOLIC RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Caroline A. Mcwhorter, Molly J. Mead, Megan D. Rodgers, Myla D. Ebeling, Judy R. Shary, Mathew J. Gregoski, Danforth A. Newton, John E. Baatz, Bruce W. Hollis, Martin Hewison, Carol L. Wagner
Summary: Pregnancy leads to increased synthesis of vitamin D binding protein (DBP) and higher concentrations of total vitamin D and metabolites. The ratio of free 25-hydroxyvitamin D (25(OH)D) to parathyroid hormone (PTH) appears to be a better predictor of pregnancy complications, such as gestational diabetes, compared to total 25(OH)D/PTH. Further research is needed to validate and explore this association.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2023)
Article
Orthopedics
Z. Qu, F. Yang, Y. Yan, J. Huang, J. Zhao, J. Hong, S. Li, G. Jiang, W. Wang, S. Yan
Summary: This study indicated an inverse causal relationship between serum PTH concentrations and development of OA, especially knee OA, but no evidence of the causal effect of serum 25(OH)D levels on OA was found. Further investigation is needed to explore potential mechanisms by which serum PTH affects OA.
OSTEOARTHRITIS AND CARTILAGE
(2021)
Article
Multidisciplinary Sciences
Ibrahim Al-Sumaih, Michael Donnelly, Ciaran O'Neill
Summary: This study identified three latent classes using finite mixture models, showing different patterns of associations between serum 25(OH)D levels and various characteristics.
Article
Environmental Sciences
Fatma Pinar Tabanli, Siddika Songuel Yalcin, Sedef Ramoglu, Sadiman Kiykac Altinbas, Anil Yirun, Aylin Balci Ozyurt, Funda Gucel, Pinar Erkekoglu, Kadriye Yurdakok
Summary: This study aimed to investigate the association between bisphenol A (BPA), 25-hydroxy vitamin D [25(OH)D], and 1 alpha,25 dihydroxy vitamin D [1,25( OH)(2)D] levels in cord blood of newborn babies. The results showed that both BPA exposure and insufficient vitamin D transfer via cord blood are common in newborns, but there is no correlation between BPA levels and vitamin D levels in cord blood.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Environmental Sciences
Fatma Pinar Tabanli, Siddika Songul Yalcin, Sedef Ramoglu, Sadiman Kiykac Altinbas, Anil Yirun, Aylin Balci ozyurt, Funda Gucel, Pinar Erkekoglu, Kadriye Yurdakok
Summary: This study investigated the association between BPA, 25(OH)D, and 1,25(OH)(2)D levels in cord blood of newborn babies. The study found that both BPA exposure and insufficient vitamin D transfer via cord blood are common in newborns, but BPA levels were not correlated with vitamin D levels in cord blood.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Veterinary Sciences
Dennis E. Jewell, Kiran S. Panickar
Summary: The optimum concentration of vitamin D for dogs is still debated, but a minimum concentration of 100 ng/mL (250 nM) of circulating vitamin D has been suggested for optimal health. The relationship between dietary intake of vitamin D-3 and circulating 25(OH) D in adult dogs has not been well studied. The safe upper limit of vitamin D in dog foods for adult maintenance is 3,200 IU/kg on a dry matter basis, but this guideline was not based on studies of adult maintenance requirements. Understanding the relationship between dietary vitamin D and circulating vitamin D is important for promoting health in dogs.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Endocrinology & Metabolism
Jiao Zuo, Ahmed A. Hasan, Carl-Friedrich Hocher, Philipp Kalk, Burkhard Kleuser, Bernhard K. Kraemer, Berthold Hocher
Summary: This study investigated the relationship between 25(OH)D and 1,25(OH)2D with PTH. The results showed a negative correlation between all forms of PTH and 25(OH)D, while there was no significant correlation between 1,25(OH)2D and PTH. This finding suggests an inhibitory effect of 25(OH)D on the synthesis of all forms of PTH in the chief cells of the parathyroid gland.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Nutrition & Dietetics
Katharina Otani, Kazuki Kanno, Taisuke Akutsu, Hironori Ohdaira, Yutaka Suzuki, Mitsuyoshi Urashima
Summary: This study used machine learning method MARS to explore the threshold levels of serum 25-hydroxyvitamin D and found that vitamin D supplementation improved bone health and 5-year relapse-free survival in patients with low baseline levels, but not in those with high baseline levels.
Article
Neurosciences
Zhizhong Zhang, Shuai Yuan, Susanna C. Larsson, Mengmeng Wang, Xinfeng Liu
Summary: Elevated serum calcium, 25-hydroxyvitamin D, and parathyroid hormone levels were found to be associated with an increased risk of aneurysmal subarachnoid hemorrhage (SAH) in this Mendelian randomization study. The study used genetic variants to predict these hormone levels and found that higher genetically predicted S-Ca and S-PTH levels were associated with an increased risk of aneurysmal SAH. However, there was no association between genetically predicted S-25OHD concentration and aneurysmal SAH.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Urology & Nephrology
Kittrawee Kritmetapak, Louis Losbanos, Taylor E. Berent, Susan L. Ashrafzadeh-Kian, Alicia Algeciras-Schimnich, Jolaine M. Hines, Ravinder J. Singh, Rajiv Kumar
Summary: In early stages of chronic kidney disease, compensatory decreases in circulating 1,25-hydroxyvitamin D and increases in circulating intact FGF23 and PTH facilitate the normalization of serum phosphate concentration, while no significant changes were observed in circulating intact FGF7. Further studies are needed to investigate whether other circulating phosphaturic peptides change in response to phosphate retention in CKD patients.
Article
Biochemistry & Molecular Biology
Pawel Brzeminski, Adrian Fabisiak, Radomir M. Slominski, Tae-Kang Kim, Zorica Janjetovic, Ewa Podgorska, Yuwei Song, Mohammad Saleem, Sivani B. Reddy, Shariq Qayyum, Yuhua Song, Robert C. Tuckey, Venkatram Atigadda, Anton M. Jetten, Rafal R. Sicinski, Chander Raman, Andrzej T. Slominski
Summary: This study established new routes for the chemical synthesis of vitamin D-3 and its hydroxy metabolites. The compounds showed similar properties in inhibiting cell proliferation and inducing cell differentiation, as well as effects on T-cell immune activity. They also interacted with nuclear receptors in a similar manner. The findings have important implications for studying the role of these compounds in the immune system and inflammatory diseases.
BIOORGANIC CHEMISTRY
(2022)
Article
Nutrition & Dietetics
Ning Xie, Jiale Xie, Ziwei Wang, Qiuai Shu, Haitao Shi, Jinhai Wang, Na Liu, Feng Xu, Jian Wu
Summary: This study utilized a two-sample Mendelian randomization (MR) analysis to explore the causal effects among calcium, vitamin D (Vit-D), parathyroid hormone (PTH), and irritable bowel syndrome (IBS). The results did not find any causal relationship between serum calcium, Vit-D levels, and the risk of IBS. However, there was an association between genetic predisposition to IBS and decreased levels of PTH.
Review
Nutrition & Dietetics
Luis Castano, Leire Madariaga, Gema Grau, Alejandro Garcia-Castano
Summary: Vitamin D is crucial for bone mineralization in children and deficiency is common. Certain medical conditions and genetic alterations can increase the risk of vitamin D deficiency rickets. Measurement of calcifediol levels is used to assess the status of the vitamin D endocrine system. Clinical trials have demonstrated the benefits of ensuring normal 25(OH)D levels and calcium intake in preventing or treating nutritional rickets in children.
Article
Transplantation
Solene M. Laville, Aymeric Couturier, Oriane Lambert, Marie Metzger, Nicolas Mansencal, Christian Jacquelinet, Maurice Laville, Luc Frimat, Denis Fouque, Christian Combe, Bruce M. Robinson, Benedicte Stengel, Sophie Liabeuf, Ziad A. Massy
Summary: This study aimed to determine the association between serum urea levels and adverse cardiovascular events and death in patients with chronic kidney disease (CKD) before renal replacement therapy (RRT). The study found that elevated serum urea levels were associated with increased risk of atheromatous and non-atheromatous cardiovascular events, as well as higher mortality rates.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Infectious Diseases
Paul Loubet, Linda Wittkop, Laetitia Ninove, Mathieu Chalouni, Benoit Barrou, Jean-Yves Blay, Maryvonne Hourmant, Eric Thouvenot, Martine Laville, Bruno Laviolle, Jean-Daniel Lelievre, Jacques Morel, Stephanie Nguyen Quoc, Jean-Philippe Spano, Benjamin Terrier, Anne Thiebaut, Jean-Francois Viallard, Francois Vrtovsnik, Sophie Circosta, Laure Esterle, Axel Levier, Philippe Vanhems, Eric Tartour, Beatrice Parfait, Xavier de Lamballerie, Odile Launay
Summary: This study aimed to investigate the 1-month humoral response to two or three doses of mRNA COVID-19 vaccine in specific populations compared with healthy adults. The results showed a lower humoral response in the specific populations. However, the third dose of the vaccine had a positive effect on the immune response.
CLINICAL MICROBIOLOGY AND INFECTION
(2023)
Article
Urology & Nephrology
Roberto Pecoits-Filho, Keith McCullough, Daniel Muenz, Carol Moreno Quinn, Jeff Budden, John Golden, Antonio Ramirez de Arellano, Frank-Peter Tillmann, Johannes Duttlinger, Viviane Calice-Silva, Ziad A. Massy, Brian Bieber, Bruce M. Robinson, Danilo Fliser, Helmut Reichel
Summary: This study describes the use of patiromer in patients with CKD stage 3-5 in Germany. The results show that most patients continue treatment with patiromer for at least 1 year and experience a reduction in serum potassium levels.
CLINICAL KIDNEY JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Patrick B. Mark, Juan J. Carrero, Kunihiro Matsushita, Yingying Sang, Shoshana H. Ballew, Morgan E. Grams, Josef Coresh, Aditya Surapaneni, Nigel J. Brunskill, John Chalmers, Lili Chan, Alex R. Chang, Rajkumar Chinnadurai, Gabriel Chodick, Massimo Cirillo, Dick de Zeeuw, Marie Evans, Amit X. Garg, Orlando M. Gutierrez, Hiddo J. L. Heerspink, Gunnar H. Heine, William G. Herrington, Junichi Ishigami, Florian Kronenberg, Jun Young Lee, Adeera Levin, Rupert W. Major, Angharad Marks, Girish N. Nadkarni, David M. J. Naimark, Christoph Nowak, Mahboob Rahman, Charumathi Sabanayagam, Mark Sarnak, Simon Sawhney, Markus P. Schneider, Varda Shalev, Jung-Im Shin, Moneeza K. Siddiqui, Nikita Stempniewicz, Keiichi Sumida, Jose M. Valdivielso, Jan van den Brand, Angela Yee-Moon Wang, David C. Wheeler, Lihua Zhang, Frank L. J. Visseren, Benedicte Stengel
Summary: This study investigated the association between cardiovascular disease (CVD) and future risk of kidney failure with replacement therapy (KFRT). It found that both prevalent and incident CVD were strongly associated with KFRT risk, with incident HF showing the strongest association.
EUROPEAN HEART JOURNAL
(2023)
Article
Clinical Neurology
Marion Pepin, Helene Levassort, Julie Boucquemont, Oriane Lambert, Natalia Alencar de Pinho, Monica Turinici, Catherine Helmer, Marie Metzger, Lynda Cheddani, Luc Frimat, Christian Combe, Denis Fouque, Maurice Laville, Carole Ayav, Sophie Liabeuf, Christian Jacquelinet, Laurent Teillet, Benedicte Stengel, Ziad A. Massy
Summary: This study investigated the association between kidney function and cognitive function in patients with chronic kidney disease (CKD), as well as the influence of cardiovascular risk factors and depression on this association. The results showed that lower baseline kidney function was associated with worse cognitive performance and incident cognitive events, independently of demographics, cardiovascular risk factors, and depression.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Urology & Nephrology
Morgan E. Grams, Nigel J. Brunskill, Shoshana H. Ballew, Yingying Sang, Josef Coresh, Kunihiro Matsushita, Aditya Surapaneni, Samira Bell, Juan J. Carrero, Gabriel Chodick, Marie Evans, Hiddo J. L. Heerspink, Lesley A. Inker, Kunitoshi Iseki, Philip A. Kalra, H. Lester Kirchner, Brian J. Lee, Adeera Levin, Rupert W. Major, James Medcalf, Girish N. Nadkarni, David M. J. Naimark, Ana C. Ricardo, Simon Sawhney, Manish M. Sood, Natalie Staplin, Nikita Stempniewicz, Benedicte Stengel, Keiichi Sumida, Jamie P. Traynor, Jan van den Brand, Chi-Pang Wen, Mark Woodward, Jae Won Yang, Angela Yee-Moon Wang, Navdeep Tangri
Summary: The kidney failure risk equation (KFRE) accurately predicts kidney failure risk in people with GFR < 60 ml/min per 1.73 m(2) when using the CKD-EPI 2021 creatinine equation. Other modifications to the KFRE did not improve its performance.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Urology & Nephrology
Ziad A. Massy, Oriane Lambert, Marie Metzger, Mohammed Sedki, Adeline Chaubet, Benjamin Breuil, Acil Jaafer, Ivan Tack, Thao Nguyen-Khoa, Melinda Alves, Justyna Siwy, Harald Mischak, Francis Verbeke, Griet Glorieux, Yves-Edouard Herpe, Joost P. Schanstra, Benedicte Stengel, Julie Klein
Summary: The urinary peptidome (UP) analysis can classify patients with chronic kidney disease (CKD) and improve kidney failure (KF) risk prediction. The study found that the UP can predict KF with high accuracy, comparable to the currently used KF risk equation (KFRE).
KIDNEY INTERNATIONAL REPORTS
(2023)
Article
Genetics & Heredity
Krzysztof Kiryluk, Elena Sanchez-Rodriguez, Xu-Jie Zhou, Francesca Zanoni, Lili Liu, Nikol Mladkova, Atlas Khan, Maddalena Marasa, Jun Y. Zhang, Olivia Balderes, Simone Sanna-Cherchi, Andrew S. Bomback, Pietro A. Canetta, Gerald B. Appel, Jai Radhakrishnan, Hernan Trimarchi, Ben Sprangers, Daniel C. Cattran, Heather Reich, York Pei, Pietro Ravani, Kresimir Galesic, Dita Maixnerova, Vladimir Tesar, Benedicte Stengel, Marie Metzger, Guillaume Canaud, Nicolas Maillard, Francois Berthoux, Laureline Berthelot, Evangeline Pillebout, Renato Monteiro, Raoul Nelson, Robert J. Wyatt, William Smoyer, John Mahan, Al-Akash Samhar, Guillermo Hidalgo, Alejandro Quiroga, Patricia Weng, Raji Sreedharan, David Selewski, Keefe Davis, Mahmoud Kallash, Tetyana L. Vasylyeva, Michelle Rheault, Aftab Chishti, Daniel Ranch, Scott E. Wenderfer, Dmitry Samsonov, Donna J. Claes, Oleh Akchurin, Dimitrios Goumenos, Maria Stangou, Judit Nagy, Tibor Kovacs, Enrico Fiaccadori, Antonio Amoroso, Cristina Barlassina, Daniele Cusi, Lucia Del Vecchio, Giovanni Giorgio Battaglia, Monica Bodria, Emanuela Boer, Luisa Bono, Giuliano Boscutti, Gianluca Caridi, Francesca Lugani, GianMarco Ghiggeri, Rosanna Coppo, Licia Peruzzi, Vittoria Esposito, Ciro Esposito, Sandro Feriozzi, Rosaria Polci, Giovanni Frasca, Marco Galliani, Maurizio Garozzo, Adele Mitrotti, Loreto Gesualdo, Simona Granata, Gianluigi Zaza, Francesco Londrino, Riccardo Magistroni, Isabella Pisani, Andrea Magnano, Carmelita Marcantoni, Piergiorgio Messa, Renzo Mignani, Antonello Pani, Claudio Ponticelli, Dario Roccatello, Maurizio Salvadori, Erica Salvi, Domenico Santoro, Guido Gembillo, Silvana Savoldi, Donatella Spotti, Pasquale Zamboli, Claudia Izzi, Federico Alberici, Elisa Delbarba, Michal Florczak, Natalia Krata, Krzysztof Mucha, Leszek Paczek, Stanislaw Niemczyk, Barbara Moszczuk, Malgorzata Panczyk-Tomaszewska, Malgorzata Mizerska-Wasiak, Agnieszka Perkowska-Ptasinska, Teresa Baczkowska, Magdalena Durlik, Krzysztof Pawlaczyk, Przemyslaw Sikora, Marcin Zaniew, Dorota Kaminska, Magdalena Krajewska, Izabella Kuzmiuk-Glembin, Zbigniew Heleniak, Barbara Bullo-Piontecka, Tomasz Liberek, Alicja Debska-Slizien, Tomasz Hryszko, Anna Materna-Kiryluk, Monika Miklaszewska, Maria Szczepanska, Katarzyna Dyga, Edyta Machura, Katarzyna Siniewicz-Luzenczyk, Monika Pawlak-Bratkowska, Marcin Tkaczyk, Dariusz Runowski, Norbert Kwella, Dorota Drozdz, Ireneusz Habura, Florian Kronenberg, Larisa Prikhodina, David van Heel, Bertrand Fontaine, Chris Cotsapas, Cisca Wijmenga, Andre Franke, Vito Annese, Peter K. Gregersen, Sreeja Parameswaran, Matthew Weirauch, Leah Kottyan, John B. Harley, Hitoshi Suzuki, Ichiei Narita, Shin Goto, Hajeong Lee, Dong Ki Kim, Yon Su Kim, Jin-Ho Park, BeLong Cho, Murim Choi, Ans Van Wijk, Ana Huerta, Elisabet Ars, Jose Ballarin, Sigrid Lundberg, Bruno Vogt, Laila-Yasmin Mani, Yasar Caliskan, Jonathan Barratt, Thilini Abeygunaratne, Philip A. Kalra, Daniel P. Gale, Ulf Panzer, Thomas Rauen, Juergen Floege, Pascal Schlosser, Arif B. Ekici, Kai-Uwe Eckardt, Nan Chen, Jingyuan Xie, Richard P. Lifton, Ruth J. F. Loos, Eimear E. Kenny, Iuliana Ionita-Laza, Anna Koettgen, Bruce A. Julian, Jan Novak, Francesco Scolari, Hong Zhang, Ali G. Gharavi
Summary: Genome-wide association analyses have identified 30 risk loci for IgA nephropathy, a progressive form of kidney disease. Functional annotations of potential causal genes suggest inflammatory signaling pathways and cytokine ligand-receptor pairs as potential new drug targets. These findings provide valuable insights into the genetic basis of IgA nephropathy and offer potential avenues for developing therapeutic interventions.
Article
Multidisciplinary Sciences
Mathilde Prezelin-Reydit, Christian Combe, Denis Fouque, Luc Frimat, Christian Jacquelinet, Maurice Laville, Ziad Massy, Celine Lange, Carole Ayav, Roberto Pecoits-Filho, Sophie Liabeuf, Benedicte Stengel, Jerome Harambat, Karen Leffondre
Summary: We examined the correlation between uric acid levels and the risk of kidney failure and death in patients with chronic kidney disease (CKD). Higher uric acid levels above 10 mg/dl indicated an increased risk of kidney failure and death, while lower levels below 5 mg/dl were associated with death before kidney failure. These findings suggest that uric acid levels can serve as a potential marker for assessing the risk of adverse outcomes in CKD patients.
SCIENTIFIC REPORTS
(2023)
Article
Immunology
Oriol Manuel, Mirjam Laager, Cedric Hirzel, Dionysios Neofytos, Laura N. Walti, Gideon Hoenger, Isabelle Binet, Aurelia Schnyder, Susanne Stampf, Michael Koller, Matteo Mombelli, Min Jeong Kim, Matthias Hoffmann, Katrin Koenig, Christoph Hess, Anne-Valerie Burgener, Pietro E. Cippa, Kerstin Huebel, Thomas F. Mueller, Daniel Sidler, Suzan Dahdal, Franziska Suter-Riniker, Jean Villard, Andrea Zbinden, Giuseppe Pantaleo, Nasser Semmo, Karine Hadaya, Natalia Enriquez, Pascal R. Meylan, Marc Froissart, Dela Golshayan, Thomas Fehr, Uyen Huynh-Do, Manuel Pascual, Christian van Delden, Hans H. Hirsch, Peter Jueni, Nicolas J. Mueller, Swiss Transplant Cohort Study STCS
Summary: This study examined the use of immune monitoring to individualize the duration of antiviral prophylaxis after transplantation. The results showed that immune monitoring led to a significant reduction in prophylaxis duration, but did not establish noninferiority in terms of the primary outcome of CMV infection.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Urology & Nephrology
Lesley A. Inker, Hocine Tighiouart, Ogechi M. Adingwupu, Michael G. Shlipak, Alessandro Doria, Michelle M. Estrella, Marc Froissart, Vilmundur Gudnason, Anders Grubb, Roberto Kalil, Michael Mauer, Peter Rossing, Jesse Seegmiller, Josef Coresh, Andrew S. Levey
Summary: New CKD-EPI and EKFC eGFR equations have sufficient accuracy for clinical practice. Differences in performance across subgroups reflect diversity in source populations and use of variables. Using eGFR equations with both cystatin C and creatinine can improve accuracy and uniformity of GFR estimation.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Medicine, General & Internal
Frank Bienaime, Mordi Muorah, Marie Metzger, Melanie Broeuilh, Pascal Houiller, Martin Flamant, Jean-Philippe Haymann, Jacky Vonderscher, Gerard Friedlander, Jacques Mizrahi, Benedicte Stengel, Fabiola Terzi
Summary: This study rigorously validates multiple assays for relevant urinary biomarkers of CKD progression and identifies a combination of five biomarkers that can improve the prediction of CKD progression.
Article
Urology & Nephrology
Yeli Wang, Ogechi M. Adingwupu, Michael G. Shlipak, Alessandro Doria, Michelle M. Estrella, Marc Froissart, Vilmundur Gudnason, Anders Grubb, Roberto Kalil, Michael Mauer, Peter Rossing, Jesse Seegmiller, Josef Coresh, Andrew S. Levey, Lesley A. Inker
Summary: This study found that the combination of cystatin C and creatinine provides the most accurate estimates of glomerular filtration rate, especially when eGFRcr and eGFRcys are discordant.
