Article
Oncology
Yi Jiang, Qinli Xie, Rong Chen
Summary: Hormone replacement therapy is associated with increased risk of breast cancer, especially for slim postmenopausal women.
CLINICAL BREAST CANCER
(2022)
Article
Endocrinology & Metabolism
Karin H. Nilsson, Jianyao Wu, Karin L. Gustafsson, Maha El Shahawy, Antti Koskela, Juha Tuukkanen, Jan Tuckermann, Petra Henning, Ulf H. Lerner, Claes Ohlsson, Sofia Moverare-Skrtic
Summary: Osteoblast-derived RSPO3 is a crucial regulator of vertebral trabecular bone. Our findings show that RSPO3 and estrogen regulate trabecular bone independent of each other, but that RSPO3 is necessary for a complete estrogenic effect on cortical bone.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2022)
Article
Biochemistry & Molecular Biology
Parameswaran Grace Luther Lalitkumar, Eva Lundstrom, Birgitta Bystrom, Dorina Ujvari, Daniel Murkes, Edneia Tani, Gunnar Soderqvist
Summary: Recent studies have shown that estradiol (E-2)/natural progesterone (P) has a lower risk of breast cancer compared to conjugated equine estrogens (CEE)/synthetic progestogens. Differences in the regulation of breast cancer-related gene expression may provide an explanation for this.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Hanting Liang, Wenting Qi, Ruizhi Jiajue, Yue Chi, Wei Liu, Ou Wang, Mei Li, Xiaoping Xing, Wei Yu, Yan Jiang, Weibo Xia
Summary: This study investigated the relationship between serum irisin level and fall risk, muscle strength, bone mineral density, and bone microarchitecture in Chinese postmenopausal women. The results showed that postmenopausal women with lower serum irisin levels had a higher fall risk, weaker muscle strength, and higher cortical porosity. Serum irisin level was also positively associated with cortical volumetric BMD, but it was affected by factors such as age.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Obstetrics & Gynecology
Mei-Lan Huang, Tsyh-Jyi Hsieh, Song-Shei Lin, Wen-Chuan Huang
Summary: The objective of this study was to determine the mean trabecular bone score (TBS) of postmenopausal Taiwanese women and to analyze its value in predicting osteoporosis. TBS was found to be weakly and negatively correlated with body mass index and moderately and positively correlated with lumbar spine BMD. A combination of BMD and TBS results predicted a higher number of individuals at a high risk of fracture compared to BMD result only.
MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY
(2022)
Article
Oncology
Chuner Jiang, Peng Wu, Xiangming He, Jianfen Ni, Xiaowen Ding, Xiaohong Xu, Fangzheng Wang, Dehong Zou
Summary: This study investigated the relationship between serum reproductive hormone concentrations and patient characteristics and hormone receptor status among postmenopausal Chinese women with breast cancer. The results showed that decreased serum LH and FSH levels were associated with increased ER and PR expressions and decreased HER2 expression in postmenopausal patients with breast cancer.
FRONTIERS IN ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Eunhae Shin, Dong Hui Lim, Tae-Young Chung, Gyule Han, Jung Eun Yoo, Keun Hye Jeon, Kyungdo Han, Dong Wook Shin
Summary: This study revealed that female reproductive factors such as late menarche, early menopause, short reproductive period, increasing parity, longer breastfeeding duration, and non-use of HRT or OC are associated with a higher risk of pterygium. Estrogen exposure through these reproductive factors appears to have a protective effect against pterygium in females.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Chae Won Chung, Hoon Sung Choi, Sung Hye Kong, Young Joo Park, Do Joon Park, Hwa Young Ahn, Sun Wook Cho
Summary: The study aimed to evaluate changes in bone mineral density (BMD) and trabecular bone score (TBS) in postmenopausal DTC patients receiving TSH suppression therapy. Results showed that TBS may better reflect bone health than BMD in this patient population.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Endocrinology & Metabolism
C. Vendrami, P. Marques-Vidal, E. Gonzalez Rodriguez, D. Hans, G. Waeber, O. Lamy
Summary: In euthyroid postmenopausal women, TSH levels are positively associated with trabecular bone score and negatively with incident fractures, without affecting bone mineral density.
OSTEOPOROSIS INTERNATIONAL
(2022)
Article
Endocrinology & Metabolism
Olga N. Fazullina, Anton Korbut, Vadim V. Klimontov
Summary: This study aimed to identify the clinical and body composition parameters that affect the trabecular bone score (TBS) in postmenopausal women with type 2 diabetes (T2D) and normal bone mineral density (BMD). The results showed that greater height and central adiposity were associated with impaired bone microarchitecture.
WORLD JOURNAL OF DIABETES
(2022)
Article
Multidisciplinary Sciences
Eva C. Herbst, Alessandro A. Felder, Lucinda A. E. Evans, Sara Ajami, Behzad Javaheri, Andrew A. Pitsillides
Summary: This study developed a semi-automated protocol for separating trabecular and cortical compartments in bone images obtained through X-ray micro-CT scans. The method eliminates user bias, is user-friendly across various datasets, and has been validated for use in complex bone analyses, making it a widely applicable tool in the field of skeletal research.
ROYAL SOCIETY OPEN SCIENCE
(2021)
Article
Rheumatology
Stefanie F. Pini, Emilio Pariente, Jose M. Olmos, Marta Martin-Millan, Raquel Pascua, Victor M. Martinez-Taboada, Jose L. Hernandez
Summary: This study aimed to assess the association between trabecular bone score (TBS) and diffuse idiopathic skeletal hyperostosis (DISH) in postmenopausal women. The results showed a significant association between DISH and TBS, with lower TBS values in DISH patients and a higher prevalence of osteoporosis and vertebral fractures.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2023)
Article
Endocrinology & Metabolism
Telma Palomo, Patricia Dreyer, Patricia Muszkat, Fernanda G. Weiler, Teresa C. P. Bonansea, Fernanda C. Domingues, Jose G. H. Vieira, Barbara C. Silva, Cynthia M. A. Brandao
Summary: This study investigates the relationship between glycemic status, bone mineral density (BMD), and trabecular bone score (TBS) in older women. The results show that higher HbA1c levels are associated with higher BMD in the hip sites and increased abdominal soft tissue thickness, while lower TBS values are observed. However, after adjusting for abdominal fat, the differences in TBS disappear, except in women with higher HbA1c levels and longer disease duration.
Article
Endocrinology & Metabolism
Boqi Lu, Liping Zhang
Summary: This study aimed to investigate the association of gestational diabetes mellitus (GDM) with osteoporosis, bone mineral density (BMD), and trabecular bone score (TBS) in postmenopausal women. The results showed that a history of GDM was associated with a higher risk of osteoporosis in postmenopausal women, particularly in postmenopausal obese women.
DIABETOLOGY & METABOLIC SYNDROME
(2023)
Article
Endocrinology & Metabolism
Nandipati Venkata Sandeep, Aneez Joseph, Kripa Elizabeth Cherian, Nitin Kapoor, Thomas Paul
Summary: This study suggests that teriparatide has a positive effect on bone mineral parameters and bone quality in postmenopausal women in South India.
THERAPEUTIC ADVANCES IN ENDOCRINOLOGY AND METABOLISM
(2022)
Article
Computer Science, Artificial Intelligence
Chen Zhao, Joyce H. Keyak, Jinshan Tang, Tadashi S. Kaneko, Sundeep Khosla, Shreyasee Amin, Elizabeth J. Atkinson, Lan-Juan Zhao, Michael J. Serou, Chaoyang Zhang, Hui Shen, Hong-Wen Deng, Weihua Zhou
Summary: In this study, we aimed to develop a deep-learning-based method for automatic proximal femur segmentation in quantitative computed tomography (QCT) images. We proposed a spatial transformation V-Net (ST-V-Net) that incorporates a shape prior into the segmentation network to improve model performance. Experimental results showed excellent performance of the proposed ST-V-Net for automatic proximal femur segmentation in QCT images.
COMPLEX & INTELLIGENT SYSTEMS
(2023)
Article
Medicine, General & Internal
Yi Zhu, Larissa G. P. Langhi Prata, Erin O. Wissler Gerdes, Jair Machado Espindola Netto, Tamar Pirtskhalava, Nino Giorgadze, Utkarsh Tripathi, Christina L. Inman, Kurt O. Johnson, Ailing Xue, Allyson K. Palmer, Tingjun Chen, Kalli Schaefer, Jamie N. Justice, Anoop M. Nambiar, Nicolas Musi, Stephen B. Kritchevsky, Jun Chen, Sundeep Khosla, Diana Jurk, Marissa J. Schafer, Tamar Tchkonia, James L. Kirkland
Summary: This study demonstrates that targeting senescent cells can increase a-Klotho levels in mice and humans, suggesting a potential therapeutic avenue for enhancing a-Klotho. Removing senescent cells can restore a-Klotho expression, offering a translational feasible strategy for developing orally-active small molecule interventions. Urinary a-Klotho may also serve as a useful biomarker for monitoring senolytic clinical trials.
Article
Genetics & Heredity
Japneet Kaur, Dominik Saul, Madison L. Doolittle, Jennifer L. Rowsey, Stephanie J. Vos, Joshua N. Farr, Sundeep Khosla, David G. Monroe
Summary: MicroRNAs (miRNAs) have potential applications as biomarkers and therapeutic agents in chronic diseases. Accurate normalization of miRNA expression data requires the selection of stable endogenous control miRNAs. This study used a systematic approach to select stable endogenous control miRNAs and validated their stability in bone tissues and aging cells. The results showed that Let-7f was the most stable miRNA, while U6 was the least stable. Using Let-7f as a normalizer significantly increased the expression of miR-34a, whereas using U6 resulted in reversed results. This research is important for increasing the reliability of miRNA expression data and preventing misinterpretation.
Article
Endocrinology & Metabolism
Madison L. Doolittle, Dominik Saul, Japneet Kaur, Jennifer L. Rowsey, Brittany Eckhardt, Stephanie Vos, Sarah Grain, Kveta Kroupova, Ming Ruan, Megan Weivoda, Merry Jo Oursler, Joshua N. Farr, David G. Monroe, Sundeep Khosla
Summary: This study found that osteocytic ER alpha is critical for estrogen action in female adult bone metabolism, but not in males. The reduction in bone formation, increased Sost expression, decreased osteoblast activity, and downregulation of Wnt target genes in ER alpha Delta Ocy mice provide a direct link between ER alpha and Wnt signaling.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Editorial Material
Endocrinology & Metabolism
Sundeep Khosla, Nicole C. Wright, Ann L. Elderkin, Douglas P. Kiel
LANCET DIABETES & ENDOCRINOLOGY
(2023)
Article
Geriatrics & Gerontology
Sara E. Espinoza, Sundeep Khosla, Joseph A. Baur, Rafael de Cabo, Nicolas Musi
Summary: The geroscience hypothesis suggests that targeting key hallmarks of aging can improve healthspan and prevent age-related diseases. Several pharmacological interventions, including senolytics, NAD(+) boosters, and metformin, are being studied for their potential benefits. Preclinical studies show that senolytic drugs improve healthspan in rodents, while increasing NAD(+) through supplementation appears to extend healthspan in model organisms. Metformin, on the other hand, has pleiotropic effects and is being examined for its potential to improve healthspan and prevent frailty in clinical trials. However, further research is needed to determine their efficacy, safety, target populations, and long-term outcomes.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Endocrinology & Metabolism
Japneet Kaur, Dominik Saul, Madison L. Doolittle, Joshua N. Farr, Sundeep Khosla, David G. Monroe
Summary: Aging is associated with an accumulation of senescent cells in various tissues, including bones. This study found that a specific miRNA, miR-19a-3p, decreases with age in mouse and human bones. Furthermore, inducing senescence in mouse bone marrow stromal cells also reduced the levels of miR-19a-3p. The study suggests that miR-19a-3p could be a potential therapeutic target for age-related bone loss.
Article
Endocrinology & Metabolism
Stefan Bartenschlager, Alexander Cavallaro, Tobias Pogarell, Oliver Chaudry, Michael Uder, Sundeep Khosla, Georg Schett, Klaus Engelke
Summary: Opportunistic screening is a promising technique for identifying individuals at high risk for osteoporotic fracture using CT scans. This study compared the performance of four existing phantomless calibration methods and found that precalibrated phantomless calibration methods performed well.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Multidisciplinary Sciences
Madison L. Doolittle, Dominik Saul, Japneet Kaur, Jennifer L. Rowsey, Stephanie J. Vos, Kevin D. Pavelko, Joshua N. Farr, David G. Monroe, Sundeep Khosla
Summary: The article provides a detailed characterization of senescent skeletal cells in vivo, identifying a population of senescent cells associated with age and increased in late osteoblasts/osteocytes and CD24(high) osteolineage cells. The authors also establish CD24 as a marker for skeletal cells cleared by senolytics.
NATURE COMMUNICATIONS
(2023)
Article
Endocrinology & Metabolism
Madison L. Doolittle, Sundeep Khosla, Dominik Saul
Summary: The regulation of bone mineral density (BMD) is influenced by genetics and age. Genome-wide association studies (GWAS) have identified many genes associated with BMD, but their specific mechanisms in different cell types and during aging are still unclear. By analyzing age-related transcriptomics and single-cell RNA-sequencing (scRNA-seq) datasets, this study investigated the cell-specific expression of GWAS candidate genes and identified enrichment in various cells related to bone metabolism. The findings provide potential therapeutic targets for osteoporosis treatment.
Article
Endocrinology & Metabolism
Madison L. L. Doolittle, Brittany A. A. Eckhardt, Stephanie J. J. Vos, Sarah Grain, Jennifer L. L. Rowsey, Ming Ruan, Dominik Saul, Joshua N. N. Farr, Megan M. M. Weivoda, Sundeep Khosla, David G. G. Monroe
Summary: Estrogen plays a crucial role in regulating bone mass, primarily through its action on ERalpha. Recent studies have shown that estrogen action in osteocytes is more important than in osteoclasts, and the loss of ERalpha in specific cell types results in decreased bone volume and reduced bone formation rate.
Article
Endocrinology & Metabolism
Pamela Rufus-Membere, Kara L. Holloway-Kew, Adolfo Diez-Perez, Natasha M. Appelman-Dijkstra, Mary L. Bouxsein, Erik F. Eriksen, Joshua N. Farr, Sundeep Khosla, Mark A. Kotowicz, Xavier Nogues, Mishaela Rubin, Julie A. Pasco
Summary: Impact microindentation (IMI) is a novel technique for assessing bone material strength index (BMSi) in vivo. The aim of this study was to define the reference intervals for men and women by evaluating healthy adults from multiple countries. BMSi values ranged from 48 to 101, with mean values of 84.4 +/- 6.9 for men and 79.0 +/- 9.1 for women.
CALCIFIED TISSUE INTERNATIONAL
(2023)
Meeting Abstract
Endocrinology & Metabolism
Japneet Kaur, Jennifer L. Rowsey, Stephanie J. Vos, Joshua N. Farr, Sundeep Khosla, David G. Monroe
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Meeting Abstract
Endocrinology & Metabolism
Japneet Kaur, Dominik Saul, Madison L. Doolittle, Jennifer L. Rowsey, Stephanie J. Vos, Joshua N. Farr, Sundeep Khosla, David G. Monroe
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Meeting Abstract
Endocrinology & Metabolism
Christine Lary, Elizabeth Atkinson, David Monroe, Archana Nagarajan, Katherine Motyl, Douglas Kiel, Sundeep Khosla
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)