Article
Endocrinology & Metabolism
Sanchita Agarwal, Elizabeth Shane, Thomas Lang, Stephanie Shiau, Mafo Kamanda-Kosseh, Mariana Bucovsky, Joan M. Lappe, Julie Stubby, Robert R. Recker, Yizhong Hu, Zexi Wang, X. Edward Guo, Adi Cohen
Summary: This study found that treatment with teriparatide followed by denosumab significantly increased volumetric bone mineral density and stiffness in premenopausal women with idiopathic osteoporosis. The sequential use of these treatments showed sustained increases in bone density and stiffness. These findings are encouraging for the use of this regimen in this population.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Medicine, General & Internal
Katharina Jaeckle, Sophia Lueken, Paul Jonathan Roch, Friederike Sophie Klockner, Max Reinhold, Marc-Pascal Meier, Thelonius Hawellek, Wolfgang Lehmann, Lukas Weiser
Summary: Osteoporosis is a disease with increased fracture risk, and early diagnosis is crucial. We tested the effect of contrast agent application on bone density measurements and found that it significantly altered the values. However, location-specific conversion factors can be established for diagnosis.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Clinical Neurology
Domenico Albano, Stefano Fusco, Laura Mascitti, Giorgio Buccimazza, Enrico Gallazzi, Salvatore Gitto, Luca Maria Sconfienza, Carmelo Messina
Summary: This study aimed to investigate the discrepancy in bone mineral density (BMD) values assessed by quantitative computed tomography between femurs in scoliotic and non-scoliotic patients. The results showed that scoliotic patients had lower BMD values on the convexity side of the spine. This suggests that scoliosis may lead to an imbalance in femoral BMD.
EUROPEAN SPINE JOURNAL
(2023)
Article
Endocrinology & Metabolism
Adi Cohen, Joseph Hostyk, Evan H. Baugh, Christie M. Buchovecky, Vimla S. Aggarwal, Robert R. Recker, Joan M. Lappe, David W. Dempster, Hua Zhou, Mafo Kamanda-Kosseh, Mariana Bucovsky, Julie Stubby, David B. Goldstein, Elizabeth Shane
Summary: The study identified likely pathogenic variants or relevant variants of uncertain significance in 8 out of 75 premenopausal women with idiopathic osteoporosis. These variants were consistent with diagnostic evaluations showing evidence of low bone formation rates or increased bone resorption. The majority of patients had no identifiable genetic etiology, indicating that further research is necessary to identify new genetic and non-genetic causes of early-onset osteoporosis.
Article
Endocrinology & Metabolism
Elizabeth Shane, Stephanie Shiau, Robert R. Recker, Joan M. Lappe, Sanchita Agarwal, Mafo Kamanda-Kosseh, Mariana Bucovsky, Julie Stubby, Adi Cohen
Summary: The study assessed the effects of denosumab in premenopausal women who completed a 24-month teriparatide treatment. Results showed statistically significant increases in bone mineral density at various sites after denosumab treatment following teriparatide, supporting the sequential use in increasing BMD in severe osteoporosis.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Orthopedics
Elena Boehm, Eduard Kraft, Johanna Theresia Biebl, Bernd Wegener, Robert Stahl, Isa Feist-Pagenstert
Summary: This study compared the sensitivity and discriminatory power of DXA and QCT in detecting osteoporosis and predicting fractures. The results indicate that QCT is more sensitive than DXA in predicting osteoporosis and fractures.
ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY
(2023)
Article
Medicine, General & Internal
Katharina Jaeckle, Friederike Klockner, Daniel Bernd Hoffmann, Paul Jonathan Roch, Maximilian Reinhold, Wolfgang Lehmann, Lukas Weiser
Summary: The study suggests that chronic hyponatremia affects bone quality and increases the prevalence of fractures after low-energy trauma, especially in patients over 65 years old. In the low-energy trauma group, there is a significant correlation between BMD and serum sodium.
MEDICINA-LITHUANIA
(2021)
Article
Endocrinology & Metabolism
Bert van Rietbergen, Emmanuel Biver, Thierry Chevalley, Keita Ito, Roland Chapurlat, Serge Ferrari
Summary: This study developed a new method using HR-pQCT imaging and 3D registration to identify changes in endosteal and periosteal boundaries of cortical bone during aging. The results showed significant endosteal retraction in females but not in males. Further investigation is needed to determine whether these changes are related to fracture risk in larger cohorts.
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Article
Orthopedics
Ping Wang, Wei She, Zeqing Mao, Xing Zhou, Yu Li, Jinjin Niu, Min Jiang, Gang Huang
Summary: This study analyzed CT attenuation values and volumetric bone mineral density of T10-L3 vertebral bodies to predict bone density, determining optimal thresholds for distinguishing normal bone density and osteoporosis. The results showed a strong correlation between CT attenuation values and vBMD, with specific thresholds identified for each condition. Sagittal reconstruction of thoracic vertebrae combined with CT attenuation measurements showed promise in predicting bone mineral density in high-risk populations.
SKELETAL RADIOLOGY
(2021)
Article
Endocrinology & Metabolism
T. G. Goetz, N. Nair, S. Shiau, R. R. Recker, J. M. Lappe, D. W. Dempster, H. Zhou, B. Zhao, X. Guo, W. Shen, T. L. Nickolas, M. Kamanda-Kosseh, M. Bucovsky, J. Stubby, E. Shane, A. Cohen
Summary: The study revealed paradoxical relationships between serum IGF-1, bone, and fat in premenopausal women with idiopathic osteoporosis. Higher IGF-1 levels were associated with lower bone formation, higher body fat, and lower response to teriparatide, suggesting abnormal regulation of bone and fat may contribute to osteoporosis mechanisms.
OSTEOPOROSIS INTERNATIONAL
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xingyuan Yang, Ying Liu, Jing Liu, Lei Gao, Ping Zhang, Yan Wang, Wei Zhang
Summary: The study aims to explore the feasibility of the 9 zonal trabecular vBMD method for evaluating the first lumbar vertebral body (L1) in women aged 50-80 years and assess the distribution of trabecular vBMD in different zones of L1. The results showed no significant differences in vBMDs among the 9 zones and a negative correlation between age and global vBMD as well as the 9 zonal vBMDs. In terms of vBMD, the posterior region had higher density than the anterior region, and the foot and head regions had higher density than the middle region.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2023)
Article
Endocrinology & Metabolism
Sanchita Agarwal, Stephanie Shiau, Mafo Kamanda-Kosseh, Mariana Bucovsky, Nayoung Kil, Joan M. M. Lappe, Julie Stubby, Robert R. R. Recker, X. Edward Guo, Elizabeth Shane, Adi Cohen
Summary: Premenopausal women with idiopathic osteoporosis (PreMenIOP) have significant deficits in skeletal microstructure. Sequential treatment with teriparatide and denosumab improves bone mineral density and microarchitecture in PreMenIOP. Specifically, after teriparatide treatment, improvements in tibial and radial microarchitecture, density and whole-bone stiffness were observed. After denosumab treatment, increases in volumetric bone mineral density, microstructure and bone strength were seen at both tibia and radius. The findings support the use of sequential treatment with teriparatide followed by denosumab in PreMenIOP.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Endocrinology & Metabolism
Yufeng Ge, Yimin Chen, Gang Liu, Shiwen Zhu, Bo Li, Maoyi Tian, Jing Zhang, Xinbao Wu, Minghui Yang
Summary: This study aimed to investigate the association of hip bone mineral density with mortality risk after hip fracture. The results showed that all hip bone densities were significantly associated with mortality risks, and hip trochanter bone mineral density showed the strongest correlation.
CALCIFIED TISSUE INTERNATIONAL
(2023)
Article
Endocrinology & Metabolism
Michael Dieckmeyer, Maximilian Thomas Loeffler, Malek El Husseini, Anjany Sekuboyina, Bjoern Menze, Nico Sollmann, Maria Wostrack, Claus Zimmer, Thomas Baum, Jan Stefan Kirschke
Summary: This study aimed to establish and evaluate the diagnostic accuracy of vBMD threshold values at different spinal levels for predicting incident VF. The results showed that vBMD at each level of the thoracolumbar spine was significantly associated with incident VFs, indicating its potential as a risk assessment tool for VF.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
K. Tsaknakis, K. Jaeckle, K. A. Lueders, H. M. Lorenz, L. Braunschweig, A. K. Hell
Summary: In DMD adolescents with untreated advanced scoliosis, there is a significant decrease in vertebral bone mineral density compared to healthy age-matched controls.
OSTEOPOROSIS INTERNATIONAL
(2022)
Article
Endocrinology & Metabolism
Alexandra Krez, Sanchita Agarwal, Mariana Bucovsky, Donald J. McMahon, Yizhong Hu, Marc Bessler, Beth Schrope, Angela Carrelli, Shannon Clare, Xiang-Dong Edward Guo, Shonni J. Silverberg, Emily M. Stein
Summary: The study revealed that African American and Latina women experienced substantial and progressive bone loss, deterioration of microarchitecture, and trabecular morphology following Roux-en-Y gastric bypass (RYGB) surgery. This study emphasizes the importance of further research to understand the long-term skeletal consequences of bariatric surgery in this population.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Yihan Li, Wei-Ju Tseng, Chantal M. J. de Bakker, Hongbo Zhao, Rebecca Chung, X. Sherry Liu
Summary: Postmenopausal osteoporosis is influenced by reduced estrogen levels during menopause, impacting bone remodeling, bone mass, and fracture risk. Peak bone mass and microstructure are important predictors of osteoporosis risk, with thicker trabeculae being associated with lower rates of bone loss in response to estrogen deficiency. Thicker trabeculae are less likely to disconnect or perforate, leading to a lower degree of bone loss.
Article
Endocrinology & Metabolism
Han Jo Kim, Alexander Dash, Matthew Cunningham, Frank Schwab, James Dowdell, Jonathan Harrison, Caroline Zaworski, Alexandra Krez, Virginie Lafage, Sanchita Agarwal, Brandon Carlson, Donald J. McMahon, Emily M. Stein
Summary: Patients who developed complications within the first six months following spine fusion surgery tend to have lower trabecular BMD, fewer and thinner trabeculae at both the radius and tibia, and thinner tibial cortices. Pre-operative DXA measurements are not predictive of complications.
Editorial Material
Endocrinology & Metabolism
Christopher J. Hernandez, Emily M. Stein, Eve Donnelly
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Oncology
Li-Wen Huang, Dong Sun, Thomas M. Link, Thomas Lang, Weiyun Ai, Lawrence D. Kaplan, Michael A. Steinman, Charalambos Andreadis
Summary: The study suggests that patients with aggressive B-cell NHL who receive R-CHOP-like therapy should be screened for fractures before treatment, and those with existing fractures should be considered for therapy to reduce the risk of new fractures.
SUPPORTIVE CARE IN CANCER
(2021)
Article
Endocrinology & Metabolism
A. Krez, J. Lane, A. Heilbronner, K. -H. Park-Min, K. Kaneko, T. Pannellini, D. Mintz, D. Hansen, D. J. McMahon, K. A. Kirou, G. Roboz, P. Desai, R. S. Bockman, E. M. Stein
Summary: This study found that the cumulative oral dose of glucocorticoids was the best predictor of multi-joint osteonecrosis. Patients with a second risk factor for osteonecrosis had a 12-fold increased risk of MJON. Further research is needed to develop optimal strategies for preventing and treating MJON.
OSTEOPOROSIS INTERNATIONAL
(2021)
Article
Geriatrics & Gerontology
Elisa A. Marques, Martine Elbejjani, Joao L. Viana, Vilmundur Gudnason, Gunnar Sigurdsson, Thomas Lang, Sigurdur Sigurdsson, Thor Aspelund, Kristin Siggeirsdottir, Lenore Launer, Gudny Eiriksdottir, Tamara B. Harris
Summary: This study found that in older adults with impaired kidney function, an accelerated decline in quadriceps cross-sectional area and muscular function were associated with an increased risk of hip fractures, while a faster decrease in quadriceps density and knee extension strength were not linked to fracture risk. This suggests that specific muscle measurements, such as quadriceps CSA and performance on the TUG test, may be useful predictors of hip fracture risk in this population.
EXPERIMENTAL GERONTOLOGY
(2021)
Article
Endocrinology & Metabolism
Tariq Chukir, Katherine Haseltine, Huong Do, Donald J. McMahon, Linda Russell, Emily M. Stein
Summary: It is unclear whether isolated osteoporosis at the 1/3 radius is associated with an increased risk of fragility fractures. This study found that postmenopausal women with 1/3 radius osteoporosis had osteopenic bone mineral density at other sites, and fracture prevalence was related to older age. Further research is needed to determine whether treatment should be considered to reduce fracture risk in older women with 1/3 radius osteoporosis.
JOURNAL OF CLINICAL DENSITOMETRY
(2022)
Review
Endocrinology & Metabolism
A. Krez, Y. Liu, S. Kanbour, S. Clare, S. Waldman, E. M. Stein
Summary: Studies suggest that ESIs may cause bone loss, especially those investigating volumetric BMD. Larger doses appear to confer greater risk. Further prospective studies are needed to investigate the relationship between ESI and fracture risk.
OSTEOPOROSIS INTERNATIONAL
(2021)
Article
Endocrinology & Metabolism
Wei-Ju Tseng, Wonsae Lee, Hongbo Zhao, Yang Liu, Wenzheng Wang, Chantal Mj de Bakker, Yihan Li, Carlos Osuna, Wei Tong, Luqiang Wang, Xiaoyuan Ma, Ling Qin, X. Sherry Liu
Summary: Despite the potent effect of intermittent parathyroid hormone (PTH) treatment on promoting new bone formation, bone mineral density (BMD) rapidly decreases upon discontinuation of PTH administration. The responses to PTH treatment withdrawal vary in intact and estrogen-deficient rats, with the latter experiencing significant bone loss and microarchitecture deterioration. An extended anabolic period is observed in estrogen-deficient rats upon early PTH withdrawal, followed by adverse changes in bone cell activities.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Sara E. Sacher, Heather B. Hunt, Sashank Lekkala, Kelsie A. Lopez, Jesse Potts, Alison K. Heilbronner, Emily M. Stein, Christopher J. Hernandez, Eve Donnelly
Summary: Individuals with type 2 diabetes mellitus have an increased risk of fragility fracture despite normal to high bone mineral density. This study investigates the effect of type 2 diabetes mellitus on microdamage quantity and morphology in cancellous bone and relates it to cancellous microarchitecture. The results suggest that cancellous microarchitecture does not explain fracture risk in type 2 diabetes mellitus, indicating alterations in material matrix properties as a potential mechanism.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Engineering, Biomedical
Wen Sang, Yihan Li, Jane Guignon, X. Sherry Liu, Ani Ural
Summary: This study examined the structural role of osteocyte lacunae on the mechanical properties of the bone matrix, revealing significant linear relationships between lacunar area, density, size, and orientation with elastic modulus and ultimate strength. Parametric studies also showed strong correlations between elastic modulus and strength with lacunar density, size, and orientation. Additionally, simulations demonstrated that osteocyte lacunae guide crack propagation through local stress concentrations.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2022)
Review
Oncology
Kaichi Kaneko, Hao Chen, Matthew Kaufman, Isaak Sverdlov, Emily M. Stein, Kyung-Hyun Park-Min
Summary: Osteonecrosis is a complex and devastating complication of systemic lupus erythematosus, with variable prevalence in SLE patients. The use of high-dose glucocorticoid therapy is strongly associated with the development of osteonecrosis in SLE patients, although the exact pathophysiology and risk factors for osteonecrosis in this population are not fully understood.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Shaopeng Pei, Yilu Zhou, Yihan Li, Tala Azar, Wenzheng Wang, Do-Gyoon Kim, X. Sherry Liu
Summary: This review focuses on nanoindentation testing in musculoskeletal research, discussing its application, the factors affecting testing results, and other commonly used techniques for synchronized imaging and colocalized characterization.
PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY
(2022)
Article
Endocrinology & Metabolism
Wenzheng Wang, Tala Azar, Wei-Ju Tseng, Shaopeng Pei, Yilu Zhou, Xi Jiang, Nathaniel Dyment, X. Sherry Liu
Summary: This study investigated the temporal response of newly formed bone tissue and preexisting bone tissue to withdrawal from intermittent parathyroid hormone (PTH) treatment in an ovariectomized rat model. The results showed that modeling-based bone formation (MBF) sites had a greater contribution to the extended anabolic effect upon early withdrawal from PTH compared to remodeling-based bone formation (RBF) sites. Furthermore, newly formed bone tissue from MBF had greater resistance to PTH discontinuation-induced bone loss than those from RBF and preexisting bone.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)