Review
Oncology
JoAnn Pinkerton
Summary: Following the release of the Women's Health Initiative data, women began using compounded bioidentical hormone therapy (cBHT) believing it to be safer and more effective than traditional hormone therapy. New guidelines recommend government-approved hormone therapy for symptomatic healthy menopausal women under 60 years old or within 10 years of menopause. Government-approved hormone therapies similar to premenopausal hormones are available with extensive data on pharmacokinetics, safety, and efficacy. Non-Food and Drug Administration-approved cBHTs lack such data and should only be used for women with allergies or unavailable formulations. Pellet therapy with supraphysiologic hormone dosing raises safety concerns.
Article
Obstetrics & Gynecology
Nanette Santoro, Jill Liss
Summary: The success of compounded bioidentical hormone therapy is due to the regulatory status and the dilemma facing clinicians, which requires targeted strategies to guide patients towards safer and more effective treatment options for menopausal symptoms.
CLINICAL OBSTETRICS AND GYNECOLOGY
(2021)
Review
Obstetrics & Gynecology
C. A. Stuenkel
Summary: The 2002 release of the Women's Health Initiative trial results sparked the rise of compounded hormone therapy and the growth of the compounding pharmacy industry. The 2020 findings and recommendations by the US National Academies of Science, Engineering, and Medicine provided a comprehensive review of the issue and offered recommendations in line with global menopause societies.
Article
Obstetrics & Gynecology
Cynthia A. Stuenkel
Summary: Bioidentical hormones have the same chemical and molecular structure as hormones produced in the human body. FDA-approved formulations are reliable, while nonapproved compounded preparations raise safety and efficacy concerns. The widespread use of compounded bioidentical hormone therapy without solid evidence is worrisome.
MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY
(2021)
Editorial Material
Pharmacology & Pharmacy
Robert B. MacArthur, Donald Mattison, Ruth M. Parker
Summary: This article describes the widespread use of compounded bioidentical hormone therapies (cBHT) and highlights the lack of sufficient evidence to support their overall clinical utility. The article suggests actions that pharmacists and regulators can take to promote safer use of cBHT. It summarizes the appeal, costs, and formulation challenges of this therapy and emphasizes the importance of ongoing efforts to improve safety and transparency.
JOURNAL OF THE AMERICAN PHARMACISTS ASSOCIATION
(2022)
Review
Obstetrics & Gynecology
Yi Liu, Ying Yuan, A. J. Day, Wen Zhang, Princy John, Danielle J. Ng, Daniel Banov
Summary: More information is needed regarding the safety and efficacy of compounded bioidentical hormone therapy (cBHT). Existing data suggests that cBHT does not have adverse effects on lipid profile or glucose metabolism. It appears to be beneficial for improving symptoms of vaginal atrophy, but further studies are needed to assess the risks of breast cancer, endometrial cancer, and cardiovascular disease.
MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY
(2022)
Review
Oncology
Florent Morfoisse, Audrey Zamora, Emmanuelle Marchaud, Manon Nougue, Leila H. Diallo, Florian David, Emilie Roussel, Eric Lacazette, Anne-Catherine Prats, Florence Tatin, Barbara Garmy-Susini
Summary: Lymphedema is a lifelong disease affecting the lymphatic system, characterized by swelling of the limbs and accumulation of fluid. While it predominantly affects women, particularly those who undergo hormone therapy after breast cancer surgery, the role of female hormones in secondary lymphedema is still poorly understood.
Article
Orthopedics
Rachael Mary Cowan, Charlotte Louise Ganderton, Jillianne Cook, Adam Ivan Semciw, David Michel Long, Tania Pizzari
Summary: This study aimed to investigate the effects of MHT and exercise on tendon pain and function in postmenopausal women with GTPS. The results showed that MHT combined with exercise and education significantly improved symptom scores, especially for women with BMI <25. Education on avoiding gluteal tendon compression and load management played a crucial role in pain relief and functional improvement.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2022)
Review
Endocrinology & Metabolism
Yujuan Chai, Qihang Li, Yang Wang, Enxiang Tao, Tetsuya Asakawa
Summary: Postpartum depression is a common and distressing condition, but current tools for screening and diagnosis are inadequate. Issues to address in research include sample selection, detection methods, evaluation criteria, and diagnostic cost. Findings from this study provide guidance for future investigations of postpartum depression.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Immunology
Marina Averyanova, Polina Vishnyakova, Svetlana Yureneva, Oksana Yakushevskaya, Timur Fatkhudinov, Andrey Elchaninov, Gennady Sukhikh
Summary: This article explores the effects of sex hormones and menopausal hormone therapy (MHT) on the immune system in COVID-19 infections, discussing their regulatory mechanisms and impact on disease outcomes. The complex relationship between sex hormones and immune function, as well as the important role MHT plays in enhancing antiviral resistance and attenuating inflammatory responses, are highlighted.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Geriatrics & Gerontology
Juliana M. Kling, Maritza Dowling, Heather Bimonte-Nelson, Carey E. Gleason, Kejal Kantarci, Cynthia M. Stonnington, S. Mitch Harman, Frederick Naftolin, Lubna Pal, Marcelle Cedars, JoAnn E. Manson, Taryn T. James, Eliot A. Brinton, Virginia M. Miller
Summary: This study found that baseline estrone levels were inversely associated with certain cognitive functions in healthy, recently menopausal women, while other pituitary-ovarian hormone levels studied were not related to cognitive performance.
Review
Endocrinology & Metabolism
Lovlesh Thakur, Sunil Thakur
Summary: This review summarizes the role of miRNAs in endometrial cancer regulated by sex steroid hormone pathways. Dysregulation of miRNAs has been linked to abnormal sex steroid hormone signaling and the development of endometrial cancer. Various miRNAs have been identified as modulators of estrogen and progesterone receptor expression, and the miRNA expression profile has been shown to be a predictor of response to hormone therapy. Future studies should focus on elucidating the functional roles of specific miRNAs in sex steroid hormone signaling and identifying novel miRNA targets for hormone therapy in endometrial cancer management.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Rachel Wamboldt, Shirley Shuster, Bikrampal S. Sidhu
Summary: This article summarizes a case of successful lactation in a trans woman, in which hormonal augmentation was used to achieve milk production.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Multidisciplinary Sciences
Wei-Chuan Chang, Jen-Hung Wang, Dah-Ching Ding
Summary: This study found that in postmenopausal women in Taiwan, hormone therapy with oral conjugated equine estrogen (CEE) may be associated with a higher risk of ischemic stroke (IS) compared to estradiol (E2), especially when initiated within 5 years of menopause.
SCIENTIFIC REPORTS
(2021)
Review
Biochemistry & Molecular Biology
Onella Athnaiel, Santiago Cantillo, Stephania Paredes, Nebojsa Nick Knezevic
Summary: This article examines the impact of hormone replacement therapy on pain perception in the transgender community, particularly in relation to other pain-related conditions such as headaches, fibromyalgia, temporomandibular myalgia, and visceral pain.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Editorial Material
Immunology
Mackenzie L. Cottrell, Heather M. A. Prince, Amanda P. Schauer, Craig Sykes, Kaitlyn Maffuid, Amanda Poliseno, Tae-Wook Chun, Erin Huiting, Frank Z. Stanczyk, Anne F. Peery, Evan S. Dellon, Jessica L. Adams, Cindy Gay, Angela D. M. Kashuba
CLINICAL INFECTIOUS DISEASES
(2019)
Article
Oncology
Natalie R. Pritchett, Marlena Maziarz, Xiao-Ou Shu, Farin Kamangar, Sanford M. Dawsey, Jin-Hu Fan, Bu-Tian Ji, Yu-Tang Gao, Yong-Bing Xiang, You-Lin Qiao, Honglan Li, Gong Yang, Shao-Ming Wang, Frank Z. Stanczyk, Wong-Ho Chow, Hormuzd A. Katki, Wei Zheng, Qing Lan, Neal D. Freedman, Nat Rothman, Christian C. Abnet, Gwen Murphy
INTERNATIONAL JOURNAL OF CANCER
(2020)
Review
Endocrinology & Metabolism
Britton Trabert, Mark E. Sherman, Nagarajan Kaman, Frank Z. Stanczyk
Article
Oncology
Sarah R. Irvin, Elisabete Weiderpass, Frank Z. Stanczyk, Louise A. Brinton, Britton Trabert, HilDe langseth, Nicolas Wentzensen
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2020)
Article
Gastroenterology & Hepatology
Jessica L. Petrick, Andrea A. Florio, Xuehong Zhang, Anne Zeleniuch-Jacquotte, Jean Wactawski-Wende, Stephen K. Van den Eeden, Frank Z. Stanczyk, Tracey G. Simon, Rashmi Sinha, Howard D. Sesso, Catherine Schairer, Lynn Rosenberg, Thomas E. Rohan, Mark P. Purdue, Julie R. Palmer, Martha S. Linet, Linda M. Liao, I-Min Lee, Jill Koshiol, Cari M. Kitahara, Victoria A. Kirsh, Jonathan N. Hofmann, Chantal Guillemette, Barry Graubard, Edward Giovannucci, J. Michael Gaziano, Susan M. Gapster, Neal D. Freedman, Lawrence S. Engel, Dawn Q. Chong, Yu Chen, Andrew T. Chan, Patrick Caron, Julie E. Buring, Gary Bradwin, Laura E. Beane Freeman, Peter T. Campbell, Katherine A. McGlynn
Article
Immunology
Melanie R. Nicol, Mackenzie L. Cottrell, Amanda H. Corbett, Lameck Chinula, Gerald Tegha, Frank Z. Stanczyk, Stacey Hurst, Athena P. Kourtis, Jennifer H. Tang
AIDS RESEARCH AND HUMAN RETROVIRUSES
(2020)
Article
Gastroenterology & Hepatology
Jun Wang, Anna H. Wu, Frank Z. Stanczyk, Jacqueline Porcel, Mazen Noureddin, Norah A. Terrault, Lynne R. Wilkens, Veronica Wendy Setiawan
Summary: Findings from a large multiethnic study support the concept that menstrual and reproductive factors, as well as the use of exogenous hormones, are associated with the risk of NAFLD.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Geriatrics & Gerontology
H. Depypere, A. Dierickx, F. Vandevelde, F. Stanczyk, L. Ottoy, J. Delanghe, B. Lapauw
Article
Endocrinology & Metabolism
Susan Chadid, John R. Barber, William G. Nelson, Bora Gurel, M. Scott Lucia, Ian M. Thompson, Phyllis J. Goodman, Frank Z. Stanczyk, Howard L. Parnes, Scott M. Lippman, Angelo M. De Marzo, Elizabeth A. Platz
Article
Obstetrics & Gynecology
Intira Sriprasert, Naoko Kono, Roksana Karim, Howard N. Hodis, Frank Z. Stanczyk, Donna Shoupe, Wendy J. Mack
OBSTETRICS AND GYNECOLOGY
(2020)
Review
Obstetrics & Gynecology
F. Z. Stanczyk, H. Matharu, S. A. Winer
Summary: After the publication of the Women's Health Initiative trials, there has been a growing interest among patients and clinicians in potential alternatives to conventional hormone therapy. Custom-compounded steroid hormone preparations, formulated by compounding pharmacies, are commonly used as an alternative therapy. While many postmenopausal women consider these hormones as natural or bioidentical, the misconception that salivary hormone levels are equivalent to free hormones in blood still exists.
Article
Oncology
Herman Depypere, Yanrong Su, Nhi Dang, Bruce Poppe, Frank Stanczyk, Jaak Janssens, Jose Russo
Summary: Early full-time pregnancy reduces the risk of developing breast cancer, and r-hCG has a significant gene expression effect on breast tissues of BRCA1/2 carriers. This could offer a new strategy for breast cancer prevention.
EUROPEAN JOURNAL OF CANCER PREVENTION
(2021)
Article
Biochemistry & Molecular Biology
Frank Z. Stanczyk, Intira Sriprasert, Rachel Danis, Raj Pandian, Harpreet Matharu, Nicole Bender, Melissa Natavio
Summary: This study compared the effects of two combined oral contraceptive formulations on 25(OH)D levels and VDBP levels, revealing different impacts. LNG may have a suppressive effect on VDBP. Further research is needed to understand the influence of hormonal contraceptive formulations on vitamin D status and women's health.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2021)
Review
Obstetrics & Gynecology
Ravali A. Reddy, Victoria Cortessis, Christina Dancz, John Klutke, Frank Z. Stanczyk
MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY
(2020)
Article
Obstetrics & Gynecology
Roksana Karim, Ha M. Dang, Howard N. Hodis, Frank Z. Stanczyk, Roberta D. Brinton, Wendy J. Mack
MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY
(2020)
