Article
Immunology
Fumiaki Kojima, Hiroki Sekiya, Yuka Hioki, Hitoshi Kashiwagi, Makoto Kubo, Masaki Nakamura, Shotaro Maehana, Yoshitaka Imamichi, Koh-Ichi Yuhki, Fumitaka Ushikubi, Hidero Kitasato, Takafumi Ichikawa
Summary: mPGES-1 is a key enzyme in the production of colonic PGE(2) and its deficiency can exacerbate colitis by affecting colonic T cell-mediated immunity. This suggests that mPGES-1 may impact both intestinal inflammation and T cell-mediated immunity associated with IBD.
INFLAMMATION AND REGENERATION
(2022)
Article
Multidisciplinary Sciences
Masahito Masato, Yasuyoshi Miyata, Hiroki Kurata, Hidenori Ito, Kensuke Mitsunari, Akihiro Asai, Yuichiro Nakamura, Kyohei Araki, Yuta Mukae, Tsuyoshi Matsuda, Junki Harada, Tomohiro Matsuo, Kojiro Ohba, Hideki Sakai
Summary: In this study using a mouse model of prostate cancer, it was found that feeding with the EP1 receptor antagonist delayed cancer progression by increasing apoptosis, resulting in a lower incidence of cancer and a lower percentage of poorly differentiated cancer cells in the experimental group compared to the control group at different time points. The results suggest that the EP1 receptor antagonist may be a novel chemopreventive agent for prostate cancer.
SCIENTIFIC REPORTS
(2021)
Review
Medicine, Research & Experimental
Madison N. Sluter, Qianqian Li, Nelufar Yasmen, Yu Chen, Lexiao Li, Ruida Hou, Ying Yu, Chao-Yie Yang, Bernd Meibohm, Jianxiong Jiang
Summary: The COX/PGE(2) signaling pathway is a critical target for anti-inflammatory therapeutic development in neurological diseases, but its medical use is limited due to cardiovascular and cerebrovascular complications. Modulating the mPGES-1 enzyme may provide a more specific approach to inhibit PGE(2)-elicited neuroinflammation in epilepsy, stroke, and glioma.
EXPERIMENTAL BIOLOGY AND MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Young Hun Kim, Kyung Jong Kim
Summary: The study aims to determine the expression of PGE(2) in colorectal cancer and its relation to relevant enzymes. The results showed that PGE(2) can be induced by stimuli and the activation of mPGES-1 is more closely related than that of COX-2 in the induction of PGE(2) in colon cancer.
ANNALS OF COLOPROCTOLOGY
(2022)
Article
Behavioral Sciences
Heberto Suarez-Roca, Lorena Leal, Jose Antonio Silva, Lorena Pinerua-Shuhaibar, Luis Quintero
BEHAVIOURAL BRAIN RESEARCH
(2008)
Article
Biochemistry & Molecular Biology
Sebastian A. Andujar, Biagina Migliore de Angel, Jaime E. Charris, Anita Israel, Heberto Suarez-Roca, Simon E. Lopez, Maria R. Garrido, Elvia Victoria Cabrera, Gonzalo Visbal, Cecire Rosales, Fernando D. Suvire, Ricardo D. Enriz, Jorge E. Angel-Guio
BIOORGANIC & MEDICINAL CHEMISTRY
(2008)
Article
Neurosciences
A. Urdaneta, A. Siso, B. Urdaneta, R. Cardenas, L. Quintero, R. Avila, H. Suarez-Roca
BRAIN RESEARCH BULLETIN
(2009)
Article
Neurosciences
H. Suarez-Roca, L. Quintero, R. Avila, S. Medina, M. De Freitas, R. Cardenas
BRAIN RESEARCH BULLETIN
(2014)
Article
Clinical Neurology
Lorena Pinerua-Shuhaibar, Nereida Villalobos, Nerio Delgado, Maria Angelina Rubio, Hebert Suarez-Roca
Article
Anesthesiology
Luis Quintero, Ricardo Cardenas, Heberto Suarez-Roca
Review
Anesthesiology
Heberto Suarez-Roca, Rebecca Y. Klinger, Mihai V. Podgoreanu, Ru-Rong Ji, Martin I. Sigurdsson, Nathan Waldron, Joseph P. Mathew, William Maixner
Article
Psychology, Clinical
Josymar Chacin-Fernandez, Margarita Chacin Fuenmayor, Lorena Pinerua-Shuhaibar, Heberto Suarez-Roca
HEALTH PSYCHOLOGY OPEN
(2019)
Article
Medicine, Research & Experimental
Mariana Rada, Ricardo Cardenas-Fernandez, Coram Guevara, Ana Cristina Fernandez, Heberto Suarez-Roca
INVESTIGACION CLINICA
(2018)
Article
Medicine, Research & Experimental
Rosa Elena Ferrer-Mavarez, Noribel Coromoto Urdaneta-Gutierrez, Nicole Porta-Knabenschuh, Lucia Chiquinquira Rodriguez-Villasmil, Cecire Carolina Rosales-Pena, Gustavo Adolfo Espinoza, Ligia Biagina Angel-Migliore, Katherin del Carmen Balza-Jimenez, Luis Eduardo Perdomo-Zavarce, Andres Rafael Faria-Quintero, Akram Samear Dabian-Makarem, Mariana Vanessa Zapata-Cardenas, Aaron Raul Linero-Arrieta, Gustavo Adolfo Acurero-Castellano, Anita Israel-Stern, Maria Rosario Garrido, Heberto Suarez-Roca, Biagina del Carmen Migliore de Angel, Simon Enrique Lopez-D'Sola, Jaime Charris-Charris, Maria Matilde Ramirez-Morani, Jorge Eduardo Angel-Guio
INVESTIGACION CLINICA
(2015)
Article
Pharmacology & Pharmacy
Jorge E. Angel Guio, Ana Santiago, Roberto Rossi, Biagina Migliore de Angel, Silvia Barolo, Sebastian Andujar, Veronica Hernandez, Cecire Rosales, Jaime E. Charris, Heberto Suarez-Roca, Anita Israel, Maria M. Ramirez, Jose Ortega, Natividad Herrera Cano, Ricardo D. Enriz
LATIN AMERICAN JOURNAL OF PHARMACY
(2011)
Article
Medicine, Research & Experimental
Marylu Mora, Luis Quintero, Ricardo Cardenas, Heberto Suarez-Roca, Maria Zavala, Nola Montiel
INVESTIGACION CLINICA
(2009)
Article
Plant Sciences
D. Avila-Pena, N. Pena, L. Quintero, H. Suarez-Roca
JOURNAL OF ETHNOPHARMACOLOGY
(2007)
Meeting Abstract
Neurosciences
Rainer Heurich, Tamara King, Frank Porreca, Heberto Suarez-Roca, Srinivas Rao
BIOLOGICAL PSYCHIATRY
(2008)
Article
Neurosciences
Song Xue, Feng Kong, Yiying Song, Jia Liu
Summary: This study used resting-state functional magnetic resonance imaging to explore the relationship between individual's spontaneous neural activity and social interaction anxiety in a nonclinical population. The results showed that social interaction anxiety was correlated with the fractional amplitude of low-frequency fluctuations in several brain regions, and that emotional intelligence partially mediated this relationship. This study provides evidence for the neural basis of social interaction anxiety in the normal population and highlights the role of emotional intelligence in this anxiety.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Katsuyuki Yamaguchi, Takuya Yazawa
Summary: This study provides morphometric data on the development of the human medullary arcuate nucleus (AN) by examining the brains of preterm and perinatal infants. The results show that AN morphology demonstrates asymmetry and individual variability during the fetal period. The volume and neuronal number of AN increase exponentially with age, while neuronal density decreases exponentially. The AN may undergo neuron death and neuroblasts production after mid-gestation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zhan Zhou, Weixin Dai, Tianxiao Liu, Min Shi, Yi Wei, Lifei Chen, Yubo Xie
Summary: Studies have shown that propofol-induced neurotoxicity is caused by disruption of mitochondrial fission and fusion, leading to an energy supply imbalance for developing neurons. Healthy mitochondria released by astrocytes can migrate to compromised neurons to mitigate propofol-induced neurotoxicity, but the exact mechanisms involved still need further clarification.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
An Chen, Song Hao, Yongpeng Han, Yang Fang, Yibei Miao
Summary: This study explores the efficacy of two forms of BCI attention training games and finds that physical games may be more effective than video games. The research also offers valuable insights for future game design from a neuroscience perspective.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lina Liu, Luran Liu, Yunting Lu, Tianyuan Zhang, Wenting Zhao
Summary: This study reveals that GDI1 serves as a potential diagnostic biomarker for AD and inhibition of GDI1 can attenuate Aβ-induced neurotoxicity. The findings offer new insights for the treatment of AD.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zahra Gholami, Ava Soltani Hekmat, Ali Abbasi, Kazem Javanmardi
Summary: This study investigated the effects of alamandine on allodynia in a rat model and found the presence of MrgD receptors in the vlPAG and RVM regions. Microinjection of alamandine resulted in a significant increase in paw withdrawal threshold and could be blocked by an MrgD receptor antagonist. Upregulation of MrgD receptor expression following allodynia induction suggests a potential compensatory mechanism in response to pain.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Mingliang Xu, Lei Xia, Junjie Li, Yehong Du, Zhifang Dong
Summary: This study found that DHF effectively alleviates sevoflurane-induced cognitive impairment in developing mice by restoring the balance between tau O-GlcNAcylation and phosphorylation. Therefore, DHF has the potential to be a therapeutic agent for treating cognitive impairment associated with anesthetics, such as sevoflurane.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Tsubasa Mitsutake, Hisato Nakazono, Takanori Taniguchi, Hisayoshi Yoshizuka, Maiko Sakamoto
Summary: The posterior parietal cortex plays a crucial role in postural stability, and transcranial electrical stimulation of this region can modulate physical control responses. This study found that cathodal stimulation significantly decreased joint angular velocity in multiple directions, while there were no significant differences with transcranial random noise stimulation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xishuai Yang, Wei Zhang, Xueli Chang, Zuopeng Li, Runquan Du, Junhong Guo
Summary: This study aims to evaluate the efficacy of low-dose rituximab (RTX) in patients with muscle-specific kinase antibody positive myasthenia gravis (MuSK-MG). The results showed that low-dose RTX treatment led to significant improvements in clinical symptoms and quality of life for patients with MuSK-MG.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Jian Zhang, Shunyuan Guo, Rong Tao, Fan Wang, Yihong Xie, Huizi Wang, Lan Ding, Yuejian Shen, Xiaoli Zhou, Junli Feng, Qing Shen
Summary: This study established an Alzheimer's disease (AD) model of zebrafish induced by AlCl3 and found that marine-derived plasmalogens (Pls) could alleviate cognitive impairments of AD zebrafish by reversing athletic impairment and altering the expression levels of genes related to oxidative stress, ferroptosis, synaptic dysfunction, and apoptosis.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lu Li, Jiaqi Ren, Qi Fang, Liqiang Yu, Jintao Wang
Summary: ICU-AW is a common and severe neuromuscular complication in critically ill patients. Electrophysiological examination is essential for accurate diagnosis and early prediction of the disease. This study aimed to establish and validate an ICU-AW predictive model in SIRS patients, providing a practical tool for early clinical prediction.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Ahmad Alipour, Roghayeh Mohammadi
Summary: The present study aimed to investigate the separate and combined effects of anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) and left dorsolateral prefrontal cortex (F3) regions on pain relief in patients with type-2 diabetes suffering from neuropathic pain (NP). The results showed that tDCS had the potential to induce pain relief in patients with type-2 diabetes suffering from NP. The mean perceived pain intensity in the posttest was lower in the M1 stimulation group than in the F3 stimulation group. However, more trials with larger sample sizes are necessary to define clinically relevant effects.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Eduardo J. Fusse, Franciele F. Scarante, Maria A. Vicente, Mariana M. Marrubia, Flavia Turcato, Davi S. Scomparin, Melissa A. Ribeiro, Maria J. Figueiredo, Tamires A. V. Brigante, Francisco S. Guimaraes, Alline C. Campos
Summary: Repeated exposure to psychosocial stress alters the endocannabinoid system and affects brain regions associated with emotional distress. Enhancing the effects of endocannabinoids through pharmacological inhibition induces an anti-stress behavioral effect, possibly mediated by the mTOR signaling pathway.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Giulia Agostoni, Luca Bischetti, Federica Repaci, Margherita Bechi, Marco Spangaro, Irene Ceccato, Elena Cavallini, Luca Fiorentino, Francesca Martini, Jacopo Sapienza, Mariachiara Buonocore, Michele Francesco D'Incalci, Federica Cocchi, Carmelo Guglielmino, Roberto Cavallaro, Marta Bosia, Valentina Bambini
Summary: This study found a general impairment in humor comprehension in individuals with schizophrenia, with mental jokes being more difficult for both patients and controls. Humor comprehension was closely associated with the patients' overall pragmatic and linguistic profile, while the association with Theory of Mind (ToM) was minimal. Another notable finding was the increased appreciation of humor in individuals with schizophrenia, who rated jokes as funnier than controls did, regardless of whether they were correctly or incorrectly completed. The funniness ratings were not predicted by any measure, suggesting a dimension of humor untied to cognition or psychopathology.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xiuping Gong, Qi Li, Yang Liu
Summary: This study demonstrates that Sev targets CREBBP to inhibit ALG13 transcription, leading to hippocampal damage and cognitive impairment.
NEUROSCIENCE LETTERS
(2024)